C10orf53

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: UPF0728 protein C10orf53
Gene namesⁱ	Name:C10orf53
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000178645.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:27421 C10orf53
neXtProtⁱ	NX_Q8N6V4

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	282966
Open Targets More...OpenTargetsⁱ	ENSG00000178645
PharmGKBⁱ	PA134895627

Polymorphism and mutation databases

BioMutaⁱ	C10orf53
DMDMⁱ	224471890

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000089794	1 – 93	UPF0728 protein C10orf53Add BLAST		93

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q8N6V4
PRIDEⁱ	Q8N6V4
ProteomicsDBⁱ	72239 72240 [Q8N6V4-2] 72241 [Q8N6V4-3]

PTM databases

iPTMnetⁱ	Q8N6V4

iPTMnetⁱ

Q8N6V4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000178645
CleanExⁱ	HS_C10orf53
Genevisibleⁱ	Q8N6V4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037951

HPAⁱ

HPA037951

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	129425, 1 interactor

BioGridⁱ

129425, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N6V4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the UPF0728 family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002871
HOGENOMⁱ	HOG000095160
HOVERGENⁱ	HBG107691
InParanoidⁱ	Q8N6V4
OMAⁱ	VEHRTYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10RN
PhylomeDBⁱ	Q8N6V4
TreeFamⁱ	TF329673

Family and domain databases

InterProⁱ	View protein in InterPro IPR027885 UPF0728
PANTHERⁱ	PTHR28448 PTHR28448, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15092 UPF0728, 1 hit

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8N6V4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKNAVVILR YGPYSAAGLP VEHHTFRLQG LQAVLAIDGH EVILEKIEDW 
        60         70         80         90 
NVVELMVNEE VIFHCNIKDL EFGGDGKLDP LCEKARIAVL NAY

Note: No experimental confirmation available.

Length:93

Mass (Da):10,399

Last modified:March 3, 2009 - v3

Checksum:ⁱ0C706BDA1A4E238E

GO

Isoform 2 (identifier: Q8N6V4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
74-93: GDGKLDPLCEKARIAVLNAY → KPFGDASSQQFASSEESLNF

« Hide

        10         20         30         40         50
MPKNAVVILR YGPYSAAGLP VEHHTFRLQG LQAVLAIDGH EVILEKIEDW 
        60         70         80         90 
NVVELMVNEE VIFHCNIKDL EFGKPFGDAS SQQFASSEES LNF

Note: No experimental confirmation available.

Show »

Length:93

Mass (Da):10,429

Checksum:ⁱD9D0115927783D34

GO

Isoform 3 (identifier: Q8N6V4-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
74-93: GDGKLDPLCEKARIAVLNAY → KLTPSSDKRT...GLEKRGTQPY

« Hide

        10         20         30         40         50
MPKNAVVILR YGPYSAAGLP VEHHTFRLQG LQAVLAIDGH EVILEKIEDW 
        60         70         80         90        100
NVVELMVNEE VIFHCNIKDL EFGKLTPSSD KRTTSSSRLT FHQLSSPCGM 
       110        120        130        140        150
KVSPLQQFPQ KTQDLTCIVL AQIGSCIHFQ TNLCDLGWPG LDHMLISGLE 

KRGTQPY

Note: No experimental confirmation available.

Show »

Length:157

Mass (Da):17,557

Checksum:ⁱCA5498B0D5DC2172

GO

Isoform 4 (identifier: Q8N6V4-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
74-93: GDGKLDPLCEKARIAVLNAY → KLTPSSDKRT...GLEKRGTQPY

« Hide

        10         20         30         40         50
MPKNAVVILR YGPYSAAGLP VEHHTFRLQG LQAVLAIDGH EVILEKIEDW 
        60         70         80         90        100
NVVELMVNEE VIFHCNIKDL EFGKLTPSSD KRTTSSSRLT FHQLSSPCRM 
       110        120        130        140        150
KVSPLQQFPQ KTQDLTCTVL AQIGSCIHFQ TNLCDLGWPG LDHMLISGLE 

KRGTQPY

Note: No experimental confirmation available.Curated

Show »

Length:157

Mass (Da):17,644

Checksum:ⁱ407C34A5D5C93462

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Isoform 4 (identifier: Q8N6V4-4)
Sequence conflictⁱ	99	R → G in BI825648 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_036509	74 – 93	GDGKL…VLNAY → KPFGDASSQQFASSEESLNF in isoform 2. 1 PublicationAdd BLAST	20
Alternative sequenceⁱVSP_036867	74 – 93	GDGKL…VLNAY → KLTPSSDKRTTSSSRLTFHQ LSSPCGMKVSPLQQFPQKTQ DLTCIVLAQIGSCIHFQTNL CDLGWPGLDHMLISGLEKRG TQPY in isoform 3. 1 PublicationAdd BLAST	20
Alternative sequenceⁱVSP_046396	74 – 93	GDGKL…VLNAY → KLTPSSDKRTTSSSRLTFHQ LSSPCRMKVSPLQQFPQKTQ DLTCTVLAQIGSCIHFQTNL CDLGWPGLDHMLISGLEKRG TQPY in isoform 4. 1 PublicationAdd BLAST	20

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK091773 mRNA No translation available. AC069546 Genomic DNA No translation available. AC073366 Genomic DNA No translation available. CH471187 Genomic DNA Translation: EAW93083.1 CH471187 Genomic DNA Translation: EAW93085.1 BC028127 mRNA No translation available. BI825648 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31202.1 [Q8N6V4-4] CCDS41521.1 [Q8N6V4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001035892.1, NM_001042427.1 [Q8N6V4-1] NP_872360.2, NM_182554.2 [Q8N6V4-4]
UniGeneⁱ	Hs.131287

Genome annotation databases

Ensemblⁱ	ENST00000374111; ENSP00000363225; ENSG00000178645 [Q8N6V4-1] ENST00000374112; ENSP00000363226; ENSG00000178645 [Q8N6V4-4] ENST00000374113; ENSP00000363227; ENSG00000178645 [Q8N6V4-2] ENST00000535836; ENSP00000437726; ENSG00000178645 [Q8N6V4-4]
GeneIDⁱ	282966
KEGGⁱ	hsa:282966
UCSC genome browser More...UCSCⁱ	uc001jib.4 human [Q8N6V4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length
Q8N6V4	C10orf53 isoform 2		PANTR		93
Chromosome 10 open reading frame 53		PANPA		93
UPF0728 protein C10orf53 isoform b		CALJA		93
C10orf53 isoform 2		PONAB		93
Chromosome 10 open reading frame 53		SAIBB		93
+14
Q8N6V4-2	C10orf53 isoform 1		PONAB		93
C10orf53 isoform 1		PANTR		93
Q8N6V4-3	C10orf53 isoform 3		PANTR		157
Chromosome 10 open reading frame 53		PANPA		157
Chromosome 10 open reading frame 53		GORGO		157
Chromosome 10 open reading frame 53		NOMLE		156
Q8N6V4-4				157
+1
Q8N6V4-4	C10orf53 isoform 3		PANTR		157
Chromosome 10 open reading frame 53		PANPA		157
Chromosome 10 open reading frame 53		GORGO		157
Chromosome 10 open reading frame 53		NOMLE		156
Q8N6V4-3				157
+1

Protein	Similar proteins		Species	Score	Length
Q8N6V4	Chromosome 10 open reading frame 53		Cebus capucinus imitator		93
Chromosome 10 open reading frame 53		NOMLE		93
UPF0728 protein C10orf53 isoform b		CALJA		93
Chromosome 10 open reading frame 53		COLAP		93
Uncharacterized protein		MACMU		93
+101
Q8N6V4-2	C10orf53 isoform 1		PONAB		93
C10orf53 isoform 1		PANTR		93
UPI0003F0C18A		SACKO		92
Uncharacterized protein		Patagioenas fasciata monilis		92
UPI00034F43DF		XENTR		107
+2
Q8N6V4-3	C10orf53 isoform 3		PANTR		157
Chromosome 10 open reading frame 53		PANPA		157
Chromosome 10 open reading frame 53		GORGO		157
Chromosome 10 open reading frame 53		NOMLE		156
Chromosome 10 open reading frame 53		COLAP		131
+7
Q8N6V4-4	C10orf53 isoform 3		PANTR		157
Chromosome 10 open reading frame 53		PANPA		157
Chromosome 10 open reading frame 53		GORGO		157
Chromosome 10 open reading frame 53		NOMLE		156
Chromosome 10 open reading frame 53		COLAP		131
+7

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK091773 mRNA No translation available. AC069546 Genomic DNA No translation available. AC073366 Genomic DNA No translation available. CH471187 Genomic DNA Translation: EAW93083.1 CH471187 Genomic DNA Translation: EAW93085.1 BC028127 mRNA No translation available. BI825648 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31202.1 [Q8N6V4-4] CCDS41521.1 [Q8N6V4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001035892.1, NM_001042427.1 [Q8N6V4-1] NP_872360.2, NM_182554.2 [Q8N6V4-4]
UniGeneⁱ	Hs.131287

3D structure databases

ProteinModelPortalⁱ	Q8N6V4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129425, 1 interactor

BioGridⁱ

129425, 1 interactor

PTM databases

iPTMnetⁱ	Q8N6V4

iPTMnetⁱ

Q8N6V4

Polymorphism and mutation databases

BioMutaⁱ	C10orf53
DMDMⁱ	224471890

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q8N6V4
PRIDEⁱ	Q8N6V4
ProteomicsDBⁱ	72239 72240 [Q8N6V4-2] 72241 [Q8N6V4-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000374111; ENSP00000363225; ENSG00000178645 [Q8N6V4-1] ENST00000374112; ENSP00000363226; ENSG00000178645 [Q8N6V4-4] ENST00000374113; ENSP00000363227; ENSG00000178645 [Q8N6V4-2] ENST00000535836; ENSP00000437726; ENSG00000178645 [Q8N6V4-4]
GeneIDⁱ	282966
KEGGⁱ	hsa:282966
UCSC genome browser More...UCSCⁱ	uc001jib.4 human [Q8N6V4-1]

Organism-specific databases

CTDⁱ	282966
DisGeNET More...DisGeNETⁱ	282966
EuPathDBⁱ	HostDB:ENSG00000178645.12
GeneCardsⁱ	C10orf53
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:27421 C10orf53
Human Protein Atlas More...HPAⁱ	HPA037951
neXtProtⁱ	NX_Q8N6V4
Open Targets More...OpenTargetsⁱ	ENSG00000178645
PharmGKBⁱ	PA134895627
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002871
HOGENOMⁱ	HOG000095160
HOVERGENⁱ	HBG107691
InParanoidⁱ	Q8N6V4
OMAⁱ	VEHRTYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10RN
PhylomeDBⁱ	Q8N6V4
TreeFamⁱ	TF329673

Miscellaneous databases

GenomeRNAiⁱ	282966
Protein Ontology More...PROⁱ	PR:Q8N6V4

Gene expression databases

Bgeeⁱ	ENSG00000178645
CleanExⁱ	HS_C10orf53
Genevisibleⁱ	Q8N6V4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027885 UPF0728
PANTHERⁱ	PTHR28448 PTHR28448, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15092 UPF0728, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CJ053_HUMAN
Accessionⁱ	Q8N6V4Primary (citable) accession number: Q8N6V4 Secondary accession number(s): A6NI81, A6NLE0, B9ZVK6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
	Last sequence update:	March 3, 2009
	Last modified:	June 20, 2018
	This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N6V4 (CJ053_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

UPF0728 protein C10orf53

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ