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UniProtKB - Q8N6V4 (CJ053_HUMAN)

Entry version 116 (10 Feb 2021)
Sequence version 3 (03 Mar 2009)
Previous versions | rss
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Protein

UPF0728 protein C10orf53

Gene

C10orf53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N6V4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UPF0728 protein C10orf53
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C10orf53
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:27421, C10orf53

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N6V4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000178645.12

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		282966

Open Targets

More...OpenTargetsi		ENSG00000178645

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134895627

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N6V4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C10orf53

Domain mapping of disease mutations (DMDM)

More...DMDMi		224471890

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897941 – 93UPF0728 protein C10orf53Add BLAST93

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N6V4

PeptideAtlas

More...PeptideAtlasi		Q8N6V4

PRoteomics IDEntifications database

More...PRIDEi		Q8N6V4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72239 [Q8N6V4-1]
72240 [Q8N6V4-2]
72241 [Q8N6V4-3]
7546

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N6V4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000178645, Expressed in testis and 42 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N6V4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000178645, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129425, 1 interactor

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N6V4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0728 family.Curated

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002871

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_189555_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N6V4

Identification of Orthologs from Complete Genome Data

More...OMAi		VEHRTYR

Database of Orthologous Groups

More...OrthoDBi		1360311at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N6V4

TreeFam database of animal gene trees

More...TreeFami		TF329673

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027885, UPF0728

The PANTHER Classification System

More...PANTHERi		PTHR28448, PTHR28448, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15092, UPF0728, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N6V4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKNAVVILR YGPYSAAGLP VEHHTFRLQG LQAVLAIDGH EVILEKIEDW 
        60         70         80         90 
NVVELMVNEE VIFHCNIKDL EFGGDGKLDP LCEKARIAVL NAY
Length:93
Mass (Da):10,399
Last modified:March 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C706BDA1A4E238E
GO
Isoform 2 (identifier: Q8N6V4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-93: GDGKLDPLCEKARIAVLNAY → KPFGDASSQQFASSEESLNF

Show »
Length:93
Mass (Da):10,429
Checksum:iD9D0115927783D34
GO
Isoform 3 (identifier: Q8N6V4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-93: GDGKLDPLCEKARIAVLNAY → KLTPSSDKRT...GLEKRGTQPY

Show »
Length:157
Mass (Da):17,557
Checksum:iCA5498B0D5DC2172
GO
Isoform 4 (identifier: Q8N6V4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-93: GDGKLDPLCEKARIAVLNAY → KLTPSSDKRT...GLEKRGTQPY

Show »
Length:157
Mass (Da):17,644
Checksum:i407C34A5D5C93462
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 4 (identifier: Q8N6V4-4)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti99R → G in BI825648 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03650974 – 93GDGKL…VLNAY → KPFGDASSQQFASSEESLNF in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_03686774 – 93GDGKL…VLNAY → KLTPSSDKRTTSSSRLTFHQ LSSPCGMKVSPLQQFPQKTQ DLTCIVLAQIGSCIHFQTNL CDLGWPGLDHMLISGLEKRG TQPY in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_04639674 – 93GDGKL…VLNAY → KLTPSSDKRTTSSSRLTFHQ LSSPCRMKVSPLQQFPQKTQ DLTCTVLAQIGSCIHFQTNL CDLGWPGLDHMLISGLEKRG TQPY in isoform 4. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK091773 mRNA No translation available.
AC069546 Genomic DNA No translation available.
AC073366 Genomic DNA No translation available.
CH471187 Genomic DNA Translation: EAW93083.1
CH471187 Genomic DNA Translation: EAW93085.1
BC028127 mRNA No translation available.
BI825648 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31202.1 [Q8N6V4-4]
CCDS41521.1 [Q8N6V4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001035892.1, NM_001042427.1 [Q8N6V4-1]
NP_872360.2, NM_182554.2 [Q8N6V4-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000374111; ENSP00000363225; ENSG00000178645 [Q8N6V4-1]
ENST00000374112; ENSP00000363226; ENSG00000178645 [Q8N6V4-4]
ENST00000374113; ENSP00000363227; ENSG00000178645 [Q8N6V4-2]
ENST00000535836; ENSP00000437726; ENSG00000178645 [Q8N6V4-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		282966

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:282966

UCSC genome browser

More...UCSCi		uc001jib.4, human [Q8N6V4-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091773 mRNA No translation available.
AC069546 Genomic DNA No translation available.
AC073366 Genomic DNA No translation available.
CH471187 Genomic DNA Translation: EAW93083.1
CH471187 Genomic DNA Translation: EAW93085.1
BC028127 mRNA No translation available.
BI825648 mRNA No translation available.
CCDSiCCDS31202.1 [Q8N6V4-4]
CCDS41521.1 [Q8N6V4-1]
RefSeqiNP_001035892.1, NM_001042427.1 [Q8N6V4-1]
NP_872360.2, NM_182554.2 [Q8N6V4-4]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi129425, 1 interactor

PTM databases

iPTMnetiQ8N6V4

Genetic variation databases

BioMutaiC10orf53
DMDMi224471890

Proteomic databases

MassIVEiQ8N6V4
PeptideAtlasiQ8N6V4
PRIDEiQ8N6V4
ProteomicsDBi72239 [Q8N6V4-1]
72240 [Q8N6V4-2]
72241 [Q8N6V4-3]
7546

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		50326, 31 antibodies

Genome annotation databases

EnsembliENST00000374111; ENSP00000363225; ENSG00000178645 [Q8N6V4-1]
ENST00000374112; ENSP00000363226; ENSG00000178645 [Q8N6V4-4]
ENST00000374113; ENSP00000363227; ENSG00000178645 [Q8N6V4-2]
ENST00000535836; ENSP00000437726; ENSG00000178645 [Q8N6V4-4]
GeneIDi282966
KEGGihsa:282966
UCSCiuc001jib.4, human [Q8N6V4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		282966
DisGeNETi282966

GeneCards: human genes, protein and diseases

More...GeneCardsi		C10orf53
HGNCiHGNC:27421, C10orf53
HPAiENSG00000178645, Tissue enriched (testis)
neXtProtiNX_Q8N6V4
OpenTargetsiENSG00000178645
PharmGKBiPA134895627
VEuPathDBiHostDB:ENSG00000178645.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00390000002871
HOGENOMiCLU_189555_0_0_1
InParanoidiQ8N6V4
OMAiVEHRTYR
OrthoDBi1360311at2759
PhylomeDBiQ8N6V4
TreeFamiTF329673

Enzyme and pathway databases

PathwayCommonsiQ8N6V4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		282966, 1 hit in 855 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C10orf53, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		282966
PharosiQ8N6V4, Tdark

Protein Ontology

More...PROi		PR:Q8N6V4
RNActiQ8N6V4, protein

Gene expression databases

BgeeiENSG00000178645, Expressed in testis and 42 other tissues
GenevisibleiQ8N6V4, HS

Family and domain databases

InterProiView protein in InterPro
IPR027885, UPF0728
PANTHERiPTHR28448, PTHR28448, 1 hit
PfamiView protein in Pfam
PF15092, UPF0728, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCJ053_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N6V4
Secondary accession number(s): A6NI81, A6NLE0, B9ZVK6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 3, 2009
Last modified: February 10, 2021
This is version 116 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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