UniProtKB - Q8N6V4 (CJ053_HUMAN)
Protein
UPF0728 protein C10orf53
Gene
C10orf53
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: UPF0728 protein C10orf53 |
Gene namesi | Name:C10orf53 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27421, C10orf53 |
neXtProti | NX_Q8N6V4 |
VEuPathDBi | HostDB:ENSG00000178645.12 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 282966 |
OpenTargetsi | ENSG00000178645 |
PharmGKBi | PA134895627 |
Miscellaneous databases
Pharosi | Q8N6V4, Tdark |
Genetic variation databases
BioMutai | C10orf53 |
DMDMi | 224471890 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089794 | 1 – 93 | UPF0728 protein C10orf53Add BLAST | 93 |
Proteomic databases
MassIVEi | Q8N6V4 |
PeptideAtlasi | Q8N6V4 |
PRIDEi | Q8N6V4 |
ProteomicsDBi | 72239 [Q8N6V4-1] 72240 [Q8N6V4-2] 72241 [Q8N6V4-3] 7546 |
PTM databases
iPTMneti | Q8N6V4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000178645, Expressed in testis and 42 other tissues |
Genevisiblei | Q8N6V4, HS |
Organism-specific databases
HPAi | ENSG00000178645, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129425, 1 interactor |
Miscellaneous databases
RNActi | Q8N6V4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the UPF0728 family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000002871 |
HOGENOMi | CLU_189555_0_0_1 |
InParanoidi | Q8N6V4 |
OMAi | VEHRTYR |
OrthoDBi | 1360311at2759 |
PhylomeDBi | Q8N6V4 |
TreeFami | TF329673 |
Family and domain databases
InterProi | View protein in InterPro IPR027885, UPF0728 |
PANTHERi | PTHR28448, PTHR28448, 1 hit |
Pfami | View protein in Pfam PF15092, UPF0728, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8N6V4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPKNAVVILR YGPYSAAGLP VEHHTFRLQG LQAVLAIDGH EVILEKIEDW
60 70 80 90
NVVELMVNEE VIFHCNIKDL EFGGDGKLDP LCEKARIAVL NAY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 4 (identifier: Q8N6V4-4) | |||||
Sequence conflicti | 99 | R → G in BI825648 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036509 | 74 – 93 | GDGKL…VLNAY → KPFGDASSQQFASSEESLNF in isoform 2. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_036867 | 74 – 93 | GDGKL…VLNAY → KLTPSSDKRTTSSSRLTFHQ LSSPCGMKVSPLQQFPQKTQ DLTCIVLAQIGSCIHFQTNL CDLGWPGLDHMLISGLEKRG TQPY in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_046396 | 74 – 93 | GDGKL…VLNAY → KLTPSSDKRTTSSSRLTFHQ LSSPCRMKVSPLQQFPQKTQ DLTCTVLAQIGSCIHFQTNL CDLGWPGLDHMLISGLEKRG TQPY in isoform 4. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091773 mRNA No translation available. AC069546 Genomic DNA No translation available. AC073366 Genomic DNA No translation available. CH471187 Genomic DNA Translation: EAW93083.1 CH471187 Genomic DNA Translation: EAW93085.1 BC028127 mRNA No translation available. BI825648 mRNA No translation available. |
CCDSi | CCDS31202.1 [Q8N6V4-4] CCDS41521.1 [Q8N6V4-1] |
RefSeqi | NP_001035892.1, NM_001042427.1 [Q8N6V4-1] NP_872360.2, NM_182554.2 [Q8N6V4-4] |
Genome annotation databases
Ensembli | ENST00000374111; ENSP00000363225; ENSG00000178645 [Q8N6V4-1] ENST00000374112; ENSP00000363226; ENSG00000178645 [Q8N6V4-4] ENST00000374113; ENSP00000363227; ENSG00000178645 [Q8N6V4-2] ENST00000535836; ENSP00000437726; ENSG00000178645 [Q8N6V4-4] |
GeneIDi | 282966 |
KEGGi | hsa:282966 |
UCSCi | uc001jib.4, human [Q8N6V4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091773 mRNA No translation available. AC069546 Genomic DNA No translation available. AC073366 Genomic DNA No translation available. CH471187 Genomic DNA Translation: EAW93083.1 CH471187 Genomic DNA Translation: EAW93085.1 BC028127 mRNA No translation available. BI825648 mRNA No translation available. |
CCDSi | CCDS31202.1 [Q8N6V4-4] CCDS41521.1 [Q8N6V4-1] |
RefSeqi | NP_001035892.1, NM_001042427.1 [Q8N6V4-1] NP_872360.2, NM_182554.2 [Q8N6V4-4] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 129425, 1 interactor |
PTM databases
iPTMneti | Q8N6V4 |
Genetic variation databases
BioMutai | C10orf53 |
DMDMi | 224471890 |
Proteomic databases
MassIVEi | Q8N6V4 |
PeptideAtlasi | Q8N6V4 |
PRIDEi | Q8N6V4 |
ProteomicsDBi | 72239 [Q8N6V4-1] 72240 [Q8N6V4-2] 72241 [Q8N6V4-3] 7546 |
Protocols and materials databases
Antibodypediai | 50326, 31 antibodies |
Genome annotation databases
Ensembli | ENST00000374111; ENSP00000363225; ENSG00000178645 [Q8N6V4-1] ENST00000374112; ENSP00000363226; ENSG00000178645 [Q8N6V4-4] ENST00000374113; ENSP00000363227; ENSG00000178645 [Q8N6V4-2] ENST00000535836; ENSP00000437726; ENSG00000178645 [Q8N6V4-4] |
GeneIDi | 282966 |
KEGGi | hsa:282966 |
UCSCi | uc001jib.4, human [Q8N6V4-1] |
Organism-specific databases
CTDi | 282966 |
DisGeNETi | 282966 |
GeneCardsi | C10orf53 |
HGNCi | HGNC:27421, C10orf53 |
HPAi | ENSG00000178645, Tissue enriched (testis) |
neXtProti | NX_Q8N6V4 |
OpenTargetsi | ENSG00000178645 |
PharmGKBi | PA134895627 |
VEuPathDBi | HostDB:ENSG00000178645.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000002871 |
HOGENOMi | CLU_189555_0_0_1 |
InParanoidi | Q8N6V4 |
OMAi | VEHRTYR |
OrthoDBi | 1360311at2759 |
PhylomeDBi | Q8N6V4 |
TreeFami | TF329673 |
Enzyme and pathway databases
PathwayCommonsi | Q8N6V4 |
Miscellaneous databases
BioGRID-ORCSi | 282966, 1 hit in 855 CRISPR screens |
ChiTaRSi | C10orf53, human |
GenomeRNAii | 282966 |
Pharosi | Q8N6V4, Tdark |
PROi | PR:Q8N6V4 |
RNActi | Q8N6V4, protein |
Gene expression databases
Bgeei | ENSG00000178645, Expressed in testis and 42 other tissues |
Genevisiblei | Q8N6V4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027885, UPF0728 |
PANTHERi | PTHR28448, PTHR28448, 1 hit |
Pfami | View protein in Pfam PF15092, UPF0728, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CJ053_HUMAN | |
Accessioni | Q8N6V4Primary (citable) accession number: Q8N6V4 Secondary accession number(s): A6NI81, A6NLE0, B9ZVK6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | March 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 116 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries