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Protein

G-protein coupled receptor 161

Gene

GPR161

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-5610787 Hedgehog 'off' state
R-HSA-5632684 Hedgehog 'on' state

Protein family/group databases

TCDBi9.A.14.1.11 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 161
Alternative name(s):
G-protein coupled receptor RE2
Gene namesi
Name:GPR161
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143147.14
HGNCiHGNC:23694 GPR161
MIMi612250 gene
neXtProtiNX_Q8N6U8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 64CytoplasmicSequence analysisAdd BLAST13
Transmembranei65 – 85Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini86 – 101ExtracellularSequence analysisAdd BLAST16
Transmembranei102 – 123Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini124 – 143CytoplasmicSequence analysisAdd BLAST20
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 190ExtracellularSequence analysisAdd BLAST26
Transmembranei191 – 211Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini212 – 269CytoplasmicSequence analysisAdd BLAST58
Transmembranei270 – 290Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini291 – 306ExtracellularSequence analysisAdd BLAST16
Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini328 – 529CytoplasmicSequence analysisAdd BLAST202

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23432
MalaCardsiGPR161
OpenTargetsiENSG00000143147
Orphaneti95496 Pituitary stalk interruption syndrome
PharmGKBiPA134931474

Polymorphism and mutation databases

BioMutaiGPR161
DMDMi48428085

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696461 – 529G-protein coupled receptor 161Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N6U8
PeptideAtlasiQ8N6U8
PRIDEiQ8N6U8
ProteomicsDBi72236
72237 [Q8N6U8-2]
72238 [Q8N6U8-3]
TopDownProteomicsiQ8N6U8-1 [Q8N6U8-1]

PTM databases

iPTMnetiQ8N6U8
PhosphoSitePlusiQ8N6U8

Expressioni

Gene expression databases

BgeeiENSG00000143147 Expressed in 217 organ(s), highest expression level in forebrain
CleanExiHS_GPR161
ExpressionAtlasiQ8N6U8 baseline and differential
GenevisibleiQ8N6U8 HS

Organism-specific databases

HPAiHPA015576
HPA072047

Interactioni

Protein-protein interaction databases

BioGridi117000, 18 interactors
IntActiQ8N6U8, 6 interactors
STRINGi9606.ENSP00000271357

Structurei

3D structure databases

ProteinModelPortaliQ8N6U8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150937
HOGENOMiHOG000112777
HOVERGENiHBG051789
InParanoidiQ8N6U8
KOiK08439
OMAiIWCALLP
OrthoDBiEOG091G0G56
PhylomeDBiQ8N6U8
TreeFamiTF331895

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N6U8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLNSSLSCR KELSNLTEEE GGEGGVIITQ FIAIIVITIF VCLGNLVIVV
60 70 80 90 100
TLYKKSYLLT LSNKFVFSLT LSNFLLSVLV LPFVVTSSIR REWIFGVVWC
110 120 130 140 150
NFSALLYLLI SSASMLTLGV IAIDRYYAVL YPMVYPMKIT GNRAVMALVY
160 170 180 190 200
IWLHSLIGCL PPLFGWSSVE FDEFKWMCVA AWHREPGYTA FWQIWCALFP
210 220 230 240 250
FLVMLVCYGF IFRVARVKAR KVHCGTVVIV EEDAQRTGRK NSSTSTSSSG
260 270 280 290 300
SRRNAFQGVV YSANQCKALI TILVVLGAFM VTWGPYMVVI ASEALWGKSS
310 320 330 340 350
VSPSLETWAT WLSFASAVCH PLIYGLWNKT VRKELLGMCF GDRYYREPFV
360 370 380 390 400
QRQRTSRLFS ISNRITDLGL SPHLTALMAG GQPLGHSSST GDTGFSCSQD
410 420 430 440 450
SGTDMMLLED YTSDDNPPSH CTCPPKRRSS VTFEDEVEQI KEAAKNSILH
460 470 480 490 500
VKAEVHKSLD SYAASLAKAI EAEAKINLFG EEALPGVLVT ARTVPGGGFG
510 520
GRRGSRTLVS QRLQLQSIEE GDVLAAEQR
Length:529
Mass (Da):58,559
Last modified:October 1, 2002 - v1
Checksum:iFC7D1AC0894DC3F3
GO
Isoform 2 (identifier: Q8N6U8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-407: TDMML → NLRAL
     408-529: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):45,363
Checksum:i00078B8EB5BC1F21
GO
Isoform 3 (identifier: Q8N6U8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: No experimental confirmation available.
Show »
Length:397
Mass (Da):43,906
Checksum:i426288987F5CF53F
GO
Isoform 4 (identifier: Q8N6U8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: MSLNSSLSCR...TIFVCLGNLV → MGGRRCVPGT...APRLESVRTS
     48-125: Missing.

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):49,701
Checksum:i0FAEB6C663961C79
GO
Isoform 5 (identifier: Q8N6U8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: MSLNSSLSCR...LTLGVIAIDR → MLVPVGWMNES

Show »
Length:415
Mass (Da):46,021
Checksum:iDCC21C091A3A3B4B
GO
Isoform 6 (identifier: Q8N6U8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSARGVVQHALPTPRRGALTM

Show »
Length:549
Mass (Da):60,659
Checksum:i6FDA02198DEB9F8F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQW8A0A0A0MQW8_HUMAN
G protein-coupled receptor 161, iso...
GPR161 hCG_42392
546Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193Q → R in BAH12873 (PubMed:14702039).Curated1
Sequence conflicti195W → R in BAH13082 (PubMed:14702039).Curated1
Sequence conflicti324Y → N in BAH12873 (PubMed:14702039).Curated1
Sequence conflicti421C → S in BAH13082 (PubMed:14702039).Curated1
Sequence conflicti500G → V in BAH12873 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355611 – 132Missing in isoform 3. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_0453291 – 125MSLNS…IAIDR → MLVPVGWMNES in isoform 5. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_0447781 – 47MSLNS…LGNLV → MGGRRCVPGTLPMRAAPPGA KRLHVPLRAKGVGRSGHAPR LESVRTS in isoform 4. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_0462991M → MSARGVVQHALPTPRRGALT M in isoform 6. 1 Publication1
Alternative sequenceiVSP_04477948 – 125Missing in isoform 4. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_010560403 – 407TDMML → NLRAL in isoform 2. 1 Publication5
Alternative sequenceiVSP_010561408 – 529Missing in isoform 2. 1 PublicationAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275468 mRNA Translation: AAP32300.1
AF091890 mRNA Translation: AAC61598.1
AK056040 mRNA Translation: BAG51611.1
AK122656 mRNA Translation: BAG53646.1
AK298797 mRNA Translation: BAH12873.1
AK298850 mRNA Translation: BAH12884.1
AK299634 mRNA Translation: BAH13082.1
AL033532 Genomic DNA No translation available.
BC028163 mRNA Translation: AAH28163.1
CCDSiCCDS1268.1 [Q8N6U8-1]
CCDS58042.1 [Q8N6U8-3]
CCDS58043.1 [Q8N6U8-6]
CCDS58044.1 [Q8N6U8-4]
CCDS58045.1 [Q8N6U8-5]
RefSeqiNP_001254538.1, NM_001267609.1 [Q8N6U8-6]
NP_001254539.1, NM_001267610.1 [Q8N6U8-1]
NP_001254541.1, NM_001267612.1 [Q8N6U8-3]
NP_001254542.1, NM_001267613.1 [Q8N6U8-4]
NP_001254543.1, NM_001267614.1 [Q8N6U8-5]
NP_722561.1, NM_153832.2 [Q8N6U8-1]
XP_005245112.1, XM_005245055.2 [Q8N6U8-6]
XP_005245113.1, XM_005245056.2 [Q8N6U8-1]
XP_005245114.1, XM_005245057.4 [Q8N6U8-1]
XP_011507677.1, XM_011509375.2
XP_011507678.1, XM_011509376.2 [Q8N6U8-1]
XP_011507679.1, XM_011509377.1
XP_011507680.1, XM_011509378.1 [Q8N6U8-1]
XP_016856348.1, XM_017000859.1
XP_016856349.1, XM_017000860.1
XP_016856350.1, XM_017000861.1
XP_016856351.1, XM_017000862.1
UniGeneiHs.271809

Genome annotation databases

EnsembliENST00000367835; ENSP00000356809; ENSG00000143147 [Q8N6U8-1]
ENST00000367836; ENSP00000356810; ENSG00000143147 [Q8N6U8-3]
ENST00000367838; ENSP00000356812; ENSG00000143147 [Q8N6U8-1]
ENST00000537209; ENSP00000441039; ENSG00000143147 [Q8N6U8-6]
ENST00000539777; ENSP00000437576; ENSG00000143147 [Q8N6U8-4]
ENST00000546300; ENSP00000444348; ENSG00000143147 [Q8N6U8-5]
GeneIDi23432
KEGGihsa:23432
UCSCiuc001gfb.5 human [Q8N6U8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275468 mRNA Translation: AAP32300.1
AF091890 mRNA Translation: AAC61598.1
AK056040 mRNA Translation: BAG51611.1
AK122656 mRNA Translation: BAG53646.1
AK298797 mRNA Translation: BAH12873.1
AK298850 mRNA Translation: BAH12884.1
AK299634 mRNA Translation: BAH13082.1
AL033532 Genomic DNA No translation available.
BC028163 mRNA Translation: AAH28163.1
CCDSiCCDS1268.1 [Q8N6U8-1]
CCDS58042.1 [Q8N6U8-3]
CCDS58043.1 [Q8N6U8-6]
CCDS58044.1 [Q8N6U8-4]
CCDS58045.1 [Q8N6U8-5]
RefSeqiNP_001254538.1, NM_001267609.1 [Q8N6U8-6]
NP_001254539.1, NM_001267610.1 [Q8N6U8-1]
NP_001254541.1, NM_001267612.1 [Q8N6U8-3]
NP_001254542.1, NM_001267613.1 [Q8N6U8-4]
NP_001254543.1, NM_001267614.1 [Q8N6U8-5]
NP_722561.1, NM_153832.2 [Q8N6U8-1]
XP_005245112.1, XM_005245055.2 [Q8N6U8-6]
XP_005245113.1, XM_005245056.2 [Q8N6U8-1]
XP_005245114.1, XM_005245057.4 [Q8N6U8-1]
XP_011507677.1, XM_011509375.2
XP_011507678.1, XM_011509376.2 [Q8N6U8-1]
XP_011507679.1, XM_011509377.1
XP_011507680.1, XM_011509378.1 [Q8N6U8-1]
XP_016856348.1, XM_017000859.1
XP_016856349.1, XM_017000860.1
XP_016856350.1, XM_017000861.1
XP_016856351.1, XM_017000862.1
UniGeneiHs.271809

3D structure databases

ProteinModelPortaliQ8N6U8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117000, 18 interactors
IntActiQ8N6U8, 6 interactors
STRINGi9606.ENSP00000271357

Protein family/group databases

TCDBi9.A.14.1.11 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiQ8N6U8
PhosphoSitePlusiQ8N6U8

Polymorphism and mutation databases

BioMutaiGPR161
DMDMi48428085

Proteomic databases

PaxDbiQ8N6U8
PeptideAtlasiQ8N6U8
PRIDEiQ8N6U8
ProteomicsDBi72236
72237 [Q8N6U8-2]
72238 [Q8N6U8-3]
TopDownProteomicsiQ8N6U8-1 [Q8N6U8-1]

Protocols and materials databases

DNASUi23432
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367835; ENSP00000356809; ENSG00000143147 [Q8N6U8-1]
ENST00000367836; ENSP00000356810; ENSG00000143147 [Q8N6U8-3]
ENST00000367838; ENSP00000356812; ENSG00000143147 [Q8N6U8-1]
ENST00000537209; ENSP00000441039; ENSG00000143147 [Q8N6U8-6]
ENST00000539777; ENSP00000437576; ENSG00000143147 [Q8N6U8-4]
ENST00000546300; ENSP00000444348; ENSG00000143147 [Q8N6U8-5]
GeneIDi23432
KEGGihsa:23432
UCSCiuc001gfb.5 human [Q8N6U8-1]

Organism-specific databases

CTDi23432
DisGeNETi23432
EuPathDBiHostDB:ENSG00000143147.14
GeneCardsiGPR161
HGNCiHGNC:23694 GPR161
HPAiHPA015576
HPA072047
MalaCardsiGPR161
MIMi612250 gene
neXtProtiNX_Q8N6U8
OpenTargetsiENSG00000143147
Orphaneti95496 Pituitary stalk interruption syndrome
PharmGKBiPA134931474
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150937
HOGENOMiHOG000112777
HOVERGENiHBG051789
InParanoidiQ8N6U8
KOiK08439
OMAiIWCALLP
OrthoDBiEOG091G0G56
PhylomeDBiQ8N6U8
TreeFamiTF331895

Enzyme and pathway databases

ReactomeiR-HSA-5610787 Hedgehog 'off' state
R-HSA-5632684 Hedgehog 'on' state

Miscellaneous databases

ChiTaRSiGPR161 human
GeneWikiiGPR161
GenomeRNAii23432
PROiPR:Q8N6U8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143147 Expressed in 217 organ(s), highest expression level in forebrain
CleanExiHS_GPR161
ExpressionAtlasiQ8N6U8 baseline and differential
GenevisibleiQ8N6U8 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGP161_HUMAN
AccessioniPrimary (citable) accession number: Q8N6U8
Secondary accession number(s): B3KV34
, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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