SIRT6

Functionⁱ

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD⁺ in the absence of acetylated substrate.By similarity5 Publications

Miscellaneous

The reported ADP-ribosyltransferase activity of sirtuins is likely some inefficient side reaction of the deacetylase activity and may not be physiologically relevant.By similarity

Catalytic activityⁱ

NAD⁺ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.PROSITE-ProRule annotation1 Publication

Cofactorⁱ

Zn²⁺By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	133	Proton acceptor	1
Metal bindingⁱ	141	ZincPROSITE-ProRule annotation1 Publication	1
Metal bindingⁱ	144	ZincPROSITE-ProRule annotation1 Publication	1
Metal bindingⁱ	166	ZincPROSITE-ProRule annotation1 Publication	1
Metal bindingⁱ	177	ZincPROSITE-ProRule annotation1 Publication	1
Binding siteⁱ	258	NAD; via amide nitrogen	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	52 – 71	NADAdd BLAST	20
Nucleotide bindingⁱ	113 – 116	NAD	4
Nucleotide bindingⁱ	214 – 216	NAD	3
Nucleotide bindingⁱ	240 – 242	NAD	3

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
NAD(P)+-protein-arginine ADP-ribosyltransferase activity Source: UniProtKB
NAD+ ADP-ribosyltransferase activity
Source: BHF-UCL
Traceable author statementⁱ
- 17456799
NAD+ binding Source: UniProtKB
NAD-dependent histone deacetylase activity Source: UniProtKB
NAD-dependent histone deacetylase activity (H3-K9 specific)
Source: UniProtKB
Inferred from direct assayⁱ
- 18337721
NAD-dependent protein deacetylase activity Source: Reactome
transcription corepressor activity Source: Ensembl
zinc ion binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

base-excision repair Source: Ensembl
glucose homeostasis Source: Ensembl
negative regulation of cell proliferation Source: Ensembl
negative regulation of glucose import Source: Ensembl
negative regulation of glycolytic process Source: Ensembl
negative regulation of transcription, DNA-templated Source: Ensembl
positive regulation blood vessel branching
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23201774
positive regulation of chondrocyte proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 25819580
positive regulation of chromatin silencing at telomere
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21847107
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 28723567
positive regulation of fibroblast proliferation Source: Ensembl
positive regulation of stem cell proliferation Source: Ensembl
positive regulation of telomere maintenance
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23201774
- 25819580
positive regulation of telomeric heterochromatin assembly
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21847107
positive regulation of vascular endothelial cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23201774
post-embryonic cardiac muscle cell growth involved in heart morphogenesis Source: Ensembl
protein ADP-ribosylation Source: UniProtKB
protein destabilization Source: Ensembl
regulation of double-strand break repair via homologous recombination
Source: UniProtKB
Inferred from direct assayⁱ
- 19135889
response to nutrient levels Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Ligand	Metal-binding, NAD, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-5693607 Processing of DNA double-strand break ends
SIGNORⁱ	Q8N6T7

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NAD-dependent protein deacetylase sirtuin-6 (EC:3.5.1.-) Alternative name(s): Regulatory protein SIR2 homolog 6 SIR2-like protein 6
Gene namesⁱ	Name:SIRT6 Synonyms:SIR2L6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000077463.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14934 SIRT6
MIMⁱ	606211 gene
neXtProtⁱ	NX_Q8N6T7

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	133	H → Y: Loss of enzyme activity. Abolishes RBBP8 deacetylation and promotion of DNA end resection after DNA damage. 2 Publications		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51548
Open Targets More...OpenTargetsⁱ	ENSG00000077463
PharmGKBⁱ	PA37939

Chemistry databases

ChEMBLⁱ	CHEMBL2163182
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2712

Polymorphism and mutation databases

BioMutaⁱ	SIRT6
DMDMⁱ	38258612

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000110269	2 – 355	NAD-dependent protein deacetylase sirtuin-6Add BLAST		354

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	10	PhosphoserineCombined sources	1
Modified residueⁱ	294	PhosphothreonineCombined sources	1
Modified residueⁱ	303	PhosphoserineCombined sources	1
Modified residueⁱ	330	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q8N6T7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N6T7
PaxDbⁱ	Q8N6T7
PeptideAtlas More...PeptideAtlasⁱ	Q8N6T7
PRIDEⁱ	Q8N6T7
ProteomicsDBⁱ	72232 72233 [Q8N6T7-2]

PTM databases

iPTMnetⁱ	Q8N6T7
PhosphoSitePlusⁱ	Q8N6T7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000077463 Expressed in 171 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasⁱ	Q8N6T7 baseline and differential
Genevisibleⁱ	Q8N6T7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049729 HPA071776

HPAⁱ

HPA049729
HPA071776

Interactionⁱ

Subunit structureⁱ

Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MYC	P01106	3	EBI-712415,EBI-447544
RELA	Q04206	4	EBI-712415,EBI-73886

Protein-protein interaction databases

BioGridⁱ	119603, 192 interactors
Database of interacting proteins More...DIPⁱ	DIP-47346N
IntActⁱ	Q8N6T7, 18 interactors
Molecular INTeraction database More...MINTⁱ	Q8N6T7
STRINGⁱ	9606.ENSP00000337332

Chemistry databases

BindingDBⁱ

Q8N6T7

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	5 – 8	Combined sources	4
Helixⁱ	27 – 43	Combined sources	17
Beta strandⁱ	47 – 51	Combined sources	5
Helixⁱ	53 – 59	Combined sources	7
Beta strandⁱ	64 – 66	Combined sources	3
Helixⁱ	70 – 75	Combined sources	6
Turnⁱ	86 – 88	Combined sources	3
Helixⁱ	93 – 103	Combined sources	11
Beta strandⁱ	108 – 112	Combined sources	5
Helixⁱ	118 – 121	Combined sources	4
Beta strandⁱ	122 – 125	Combined sources	4
Helixⁱ	126 – 128	Combined sources	3
Beta strandⁱ	129 – 131	Combined sources	3
Beta strandⁱ	138 – 141	Combined sources	4
Turnⁱ	142 – 144	Combined sources	3
Beta strandⁱ	147 – 149	Combined sources	3
Beta strandⁱ	161 – 165	Combined sources	5
Turnⁱ	171 – 174	Combined sources	4
Beta strandⁱ	180 – 183	Combined sources	4
Beta strandⁱ	188 – 190	Combined sources	3
Helixⁱ	194 – 206	Combined sources	13
Beta strandⁱ	208 – 214	Combined sources	7
Helixⁱ	222 – 224	Combined sources	3
Helixⁱ	225 – 229	Combined sources	5
Helixⁱ	230 – 232	Combined sources	3
Beta strandⁱ	235 – 239	Combined sources	5
Helixⁱ	247 – 249	Combined sources	3
Beta strandⁱ	251 – 254	Combined sources	4
Helixⁱ	258 – 268	Combined sources	11
Beta strandⁱ	278 – 280	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8N6T7
SMRⁱ	Q8N6T7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q8N6T7

EvolutionaryTraceⁱ

Q8N6T7

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	35 – 274	Deacetylase sirtuin-typePROSITE-ProRule annotationAdd BLAST		240

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	287 – 345	Pro-richAdd BLAST		59

Sequence similaritiesⁱ

Belongs to the sirtuin family. Class IV subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1905 Eukaryota COG0846 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063706
HOVERGENⁱ	HBG060028
InParanoidⁱ	Q8N6T7
KEGG Orthology (KO) More...KOⁱ	K11416
OMAⁱ	NVLDWEH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FOW
PhylomeDBⁱ	Q8N6T7
TreeFamⁱ	TF106184

Family and domain databases

InterProⁱ	View protein in InterPro IPR029035 DHS-like_NAD/FAD-binding_dom IPR003000 Sirtuin IPR026590 Ssirtuin_cat_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02146 SIR2, 2 hits
SUPFAMⁱ	SSF52467 SSF52467, 1 hit
PROSITEⁱ	View protein in PROSITE PS50305 SIRTUIN, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N6T7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH 
        60         70         80         90        100
TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ 
       110        120        130        140        150
LERVGLLRFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR 
       160        170        180        190        200
DTVVGTMGLK ATGRLCTVAK ARGLRACRGE LRDTILDWED SLPDRDLALA 
       210        220        230        240        250
DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN LQPTKHDRHA 
       260        270        280        290        300
DLRIHGYVDE VMTRLMKHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK 
       310        320        330        340        350
EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA 

KAVPS

Length:355

Mass (Da):39,119

Last modified:October 31, 2003 - v2

Checksum:ⁱ0C86AAC497130BBF

GO

Isoform 2 (identifier: Q8N6T7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
179-205: Missing.

« Hide

        10         20         30         40         50
MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH 
        60         70         80         90        100
TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ 
       110        120        130        140        150
LERVGLLRFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR 
       160        170        180        190        200
DTVVGTMGLK ATGRLCTVAK ARGLRACRNA DLSITLGTSL QIRPSGNLPL 
       210        220        230        240        250
ATKRRGGRLV IVNLQPTKHD RHADLRIHGY VDEVMTRLMK HLGLEIPAWD 
       260        270        280        290        300
GPRVLERALP PLPRPPTPKL EPKEESPTRI NGSIPAGPKQ EPCAQHNGSE 
       310        320 
PASPKRERPT SPAPHRPPKR VKAKAVPS

Note: No experimental confirmation available.

Show »

Length:328

Mass (Da):36,065

Checksum:ⁱ503805C898FD7769

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

M0QZ09	M0QZ09_HUMAN	NAD-dependent protein deacetylase s... NAD-dependent protein deacetylase sirtuin-6	SIRT6	275	Annotation score:
M0R1N9	M0R1N9_HUMAN	NAD-dependent protein deacetylase s... NAD-dependent protein deacetylase sirtuin-6 (Sirtuin (Silent mating type information regulation 2 homolog) 6 (S. cerevisiae), isoform CRA_i)	SIRT6 hCG_2004101	176	Annotation score:
M0R1F6	M0R1F6_HUMAN	NAD-dependent protein deacetylase s... NAD-dependent protein deacetylase sirtuin-6	SIRT6	186	Annotation score:
M0QXA0	M0QXA0_HUMAN	NAD-dependent protein deacetylase s... NAD-dependent protein deacetylase sirtuin-6	SIRT6	187	Annotation score:
M0R0B2	M0R0B2_HUMAN	NAD-dependent protein deacetylase s... NAD-dependent protein deacetylase sirtuin-6	SIRT6	43	Annotation score:

Sequence cautionⁱ

The sequence AAC34468 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence AAD15478 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence AAH04218 differs from that shown. Reason: Erroneous translation. Wrong choice of CCDS.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	42	W → R in CAG33481 (Ref. 3) Curated	1
Sequence conflictⁱ	249	H → Y in AAH04218 (PubMed:15489334).Curated	1
Sequence conflictⁱ	267	K → E in AAF43432 (PubMed:10873683).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_017154	46	S → N3 PublicationsCorresponds to variant dbSNP:rs352493Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_008733	179 – 205	Missing in isoform 2. 1 PublicationAdd BLAST		27

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF233396 mRNA Translation: AAF43432.1 AK074810 mRNA Translation: BAC11222.1 AK315048 mRNA Translation: BAG37527.1 CR457200 mRNA Translation: CAG33481.1 AC005620 Genomic DNA Translation: AAC34468.1 Sequence problems. AC006930 Genomic DNA Translation: AAD15478.1 Sequence problems. CH471139 Genomic DNA Translation: EAW69252.1 BC004218 mRNA Translation: AAH04218.1 Sequence problems. BC005026 mRNA Translation: AAH05026.1 BC028220 mRNA Translation: AAH28220.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12122.1 [Q8N6T7-1] CCDS54199.1 [Q8N6T7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001180214.1, NM_001193285.2 [Q8N6T7-2] NP_001307987.1, NM_001321058.1 NP_001307988.1, NM_001321059.1 NP_001307989.1, NM_001321060.1 NP_001307990.1, NM_001321061.1 NP_001307991.1, NM_001321062.1 NP_001307992.1, NM_001321063.1 NP_001307993.1, NM_001321064.1 NP_057623.2, NM_016539.3 [Q8N6T7-1]
UniGeneⁱ	Hs.423756

Genome annotation databases

Ensemblⁱ	ENST00000305232; ENSP00000305310; ENSG00000077463 [Q8N6T7-2] ENST00000337491; ENSP00000337332; ENSG00000077463 [Q8N6T7-1]
GeneIDⁱ	51548
KEGGⁱ	hsa:51548
UCSC genome browser More...UCSCⁱ	uc002lzo.4 human [Q8N6T7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N6T7	cDNA FLJ52470, highly similar to Mono-ADP-ribosyltransferase sirtuin-6		HUMAN		283	UniRef100_Q8N6T7
UPI00077D103B		HUMAN		220
UPI000DC663E7		HUMAN		316

Protein	Similar proteins		Species	Score	Length	Source
Q8N6T7	cDNA FLJ52470, highly similar to Mono-ADP-ribosyltransferase sirtuin-6		HUMAN		283	UniRef90_Q8N6T7
Sirtuin 6		FELCA		412
Sirtuin 6		AILME		361
Sirtuin 6		CANLF		361
NAD-dependent protein deacetylase sirtuin-6		LEPWE		359
+68
Q8N6T7-2	NAD-dependent protein deacetylase sirtuin-6 isoform X3		Enhydra lutris kenyoni		332	UniRef90_Q8N6T7-2
Sirtuin 6		FELCA		332
NAD-dependent protein deacetylase sirtuin-6 isoform X2		LIPVE		332
NAD-dependent protein deacetylase sirtuin-6 isoform 2		CALJA		328
SIRT6 isoform 2		PANTR		328
+23

Protein	Similar proteins		Species	Score	Length	Source
Q8N6T7	cDNA FLJ52470, highly similar to Mono-ADP-ribosyltransferase sirtuin-6		HUMAN		283	UniRef50_Q8N6T7
Sirtuin 6		FELCA		412
Sirtuin 6		AILME		361
Sirtuin 6		CANLF		361
NAD-dependent protein deacetylase sirtuin-6		NEOSC		359
+101
Q8N6T7-2	Sirtuin 6		FELCA		332	UniRef50_Q8N6T7-2
NAD-dependent protein deacetylase sirtuin-6 isoform X3		Enhydra lutris kenyoni		332
NAD-dependent protein deacetylase sirtuin-6 isoform X2		LIPVE		332
Sirtuin 6		SAIBB		328
NAD-dependent protein deacetylase sirtuin-6 isoform 2		CALJA		328
+66

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF233396 mRNA Translation: AAF43432.1 AK074810 mRNA Translation: BAC11222.1 AK315048 mRNA Translation: BAG37527.1 CR457200 mRNA Translation: CAG33481.1 AC005620 Genomic DNA Translation: AAC34468.1 Sequence problems. AC006930 Genomic DNA Translation: AAD15478.1 Sequence problems. CH471139 Genomic DNA Translation: EAW69252.1 BC004218 mRNA Translation: AAH04218.1 Sequence problems. BC005026 mRNA Translation: AAH05026.1 BC028220 mRNA Translation: AAH28220.1
CCDSⁱ	CCDS12122.1 [Q8N6T7-1] CCDS54199.1 [Q8N6T7-2]
RefSeqⁱ	NP_001180214.1, NM_001193285.2 [Q8N6T7-2] NP_001307987.1, NM_001321058.1 NP_001307988.1, NM_001321059.1 NP_001307989.1, NM_001321060.1 NP_001307990.1, NM_001321061.1 NP_001307991.1, NM_001321062.1 NP_001307992.1, NM_001321063.1 NP_001307993.1, NM_001321064.1 NP_057623.2, NM_016539.3 [Q8N6T7-1]
UniGeneⁱ	Hs.423756

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3K35	X-ray	2.00	A/B/C/D/E/F	3-318	[»]
	3PKI	X-ray	2.04	A/B/C/D/E/F	2-355	[»]
	3PKJ	X-ray	2.12	A/B/C/D/E/F	2-355	[»]
	3ZG6	X-ray	2.20	A	1-296	[»]
	5MF6	X-ray	1.87	A/B	13-308	[»]
	5MFP	X-ray	1.98	A/B	13-308	[»]
	5MFZ	X-ray	2.10	A/B	13-308	[»]
	5MGN	X-ray	2.07	A/B	13-308	[»]
	5X16	X-ray	1.97	A	3-318	[»]
ProteinModelPortalⁱ	Q8N6T7
SMRⁱ	Q8N6T7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119603, 192 interactors
DIPⁱ	DIP-47346N
IntActⁱ	Q8N6T7, 18 interactors
MINTⁱ	Q8N6T7
STRINGⁱ	9606.ENSP00000337332

Chemistry databases

BindingDBⁱ	Q8N6T7
ChEMBLⁱ	CHEMBL2163182
GuidetoPHARMACOLOGYⁱ	2712

PTM databases

iPTMnetⁱ	Q8N6T7
PhosphoSitePlusⁱ	Q8N6T7

Polymorphism and mutation databases

BioMutaⁱ	SIRT6
DMDMⁱ	38258612

Proteomic databases

EPDⁱ	Q8N6T7
MaxQBⁱ	Q8N6T7
PaxDbⁱ	Q8N6T7
PeptideAtlasⁱ	Q8N6T7
PRIDEⁱ	Q8N6T7
ProteomicsDBⁱ	72232 72233 [Q8N6T7-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51548
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000305232; ENSP00000305310; ENSG00000077463 [Q8N6T7-2] ENST00000337491; ENSP00000337332; ENSG00000077463 [Q8N6T7-1]
GeneIDⁱ	51548
KEGGⁱ	hsa:51548
UCSCⁱ	uc002lzo.4 human [Q8N6T7-1]

Organism-specific databases

CTDⁱ	51548
DisGeNETⁱ	51548
EuPathDBⁱ	HostDB:ENSG00000077463.14
GeneCardsⁱ	SIRT6
H-InvDBⁱ	HIX0014654
HGNCⁱ	HGNC:14934 SIRT6
HPAⁱ	HPA049729 HPA071776
MIMⁱ	606211 gene
neXtProtⁱ	NX_Q8N6T7
OpenTargetsⁱ	ENSG00000077463
PharmGKBⁱ	PA37939
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1905 Eukaryota COG0846 LUCA
GeneTreeⁱ	ENSGT00530000063706
HOVERGENⁱ	HBG060028
InParanoidⁱ	Q8N6T7
KOⁱ	K11416
OMAⁱ	NVLDWEH
OrthoDBⁱ	EOG091G0FOW
PhylomeDBⁱ	Q8N6T7
TreeFamⁱ	TF106184

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-5693607 Processing of DNA double-strand break ends
SIGNORⁱ	Q8N6T7

Miscellaneous databases

ChiTaRSⁱ	SIRT6 human
EvolutionaryTraceⁱ	Q8N6T7
GeneWikiⁱ	SIRT6
GenomeRNAiⁱ	51548
Protein Ontology More...PROⁱ	PR:Q8N6T7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000077463 Expressed in 171 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasⁱ	Q8N6T7 baseline and differential
Genevisibleⁱ	Q8N6T7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029035 DHS-like_NAD/FAD-binding_dom IPR003000 Sirtuin IPR026590 Ssirtuin_cat_dom
Pfamⁱ	View protein in Pfam PF02146 SIR2, 2 hits
SUPFAMⁱ	SSF52467 SSF52467, 1 hit
PROSITEⁱ	View protein in PROSITE PS50305 SIRTUIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SIR6_HUMAN
Accessionⁱ	Q8N6T7Primary (citable) accession number: Q8N6T7 Secondary accession number(s): B2RCD0 Q9UQD1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
	Last sequence update:	October 31, 2003
	Last modified:	November 7, 2018
	This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q8N6T7 (SIR6_HUMAN)

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NAD-dependent protein deacetylase sirtuin-6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

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Regions

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ