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UniProtKB - Q8N6T7 (SIR6_HUMAN)

Entry version 173 (29 Sep 2021)
Sequence version 2 (31 Oct 2003)
Previous versions | rss
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Protein

NAD-dependent protein deacetylase sirtuin-6

Gene

SIRT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NAD-dependent protein deacetylase involved in various processes including telomere maintenance and gene expression, and consequently has roles in genomic stability, cell senescence and apoptosis (PubMed:18337721, PubMed:19135889, PubMed:19625767, PubMed:21362626).

Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate (PubMed:21362626).

Has deacetylase activity towards histone H3K9Ac and H3K56Ac (PubMed:19625767, PubMed:21362626).

Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle (PubMed:19625767).

May also be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance (PubMed:18337721).

Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes (PubMed:21362626).

Deacetylation of nucleosomes interferes with RELA binding to target DNA (PubMed:19135889).

Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis (By similarity).

Required for normal IGF1 serum levels and normal glucose homeostasis (By similarity).

Regulates the production of TNF protein (By similarity).

Has a role in the regulation of life span (By similarity).

By similarity4 Publications

Miscellaneous

The reported ADP-ribosyltransferase activity of sirtuins is likely some inefficient side reaction of the deacetylase activity and may not be physiologically relevant.By similarity

Caution

Upon DNA damage, was reported to promote DNA end resection via deacetylation of RBBP8. However, this study was later retracted.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei133Proton acceptor1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi141ZincPROSITE-ProRule annotation1 Publication1
Metal bindingi144ZincPROSITE-ProRule annotation1 Publication1
Metal bindingi166ZincPROSITE-ProRule annotation1 Publication1
Metal bindingi177ZincPROSITE-ProRule annotation1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei258NAD; via amide nitrogen1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi52 – 71NADAdd BLAST20
Nucleotide bindingi113 – 116NAD4
Nucleotide bindingi214 – 216NAD3
Nucleotide bindingi240 – 242NAD3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.1.B41, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N6T7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1912408, Pre-NOTCH Transcription and Translation
R-HSA-5693607, Processing of DNA double-strand break ends

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8N6T7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NAD-dependent protein deacetylase sirtuin-6 (EC:2.3.1.286)
Alternative name(s):
Regulatory protein SIR2 homolog 6
SIR2-like protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIRT6
Synonyms:SIR2L6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14934, SIRT6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606211, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N6T7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000077463

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi133H → Y: Loss of enzyme activity. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		51548

Open Targets

More...OpenTargetsi		ENSG00000077463

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		580933, Lethal brain and heart developmental defects

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37939

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N6T7, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2163182

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2712

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SIRT6

Domain mapping of disease mutations (DMDM)

More...DMDMi		38258612

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001102692 – 355NAD-dependent protein deacetylase sirtuin-6Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei294PhosphothreonineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei330PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N6T7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N6T7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N6T7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N6T7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N6T7

PeptideAtlas

More...PeptideAtlasi		Q8N6T7

PRoteomics IDEntifications database

More...PRIDEi		Q8N6T7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72232 [Q8N6T7-1]
72233 [Q8N6T7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N6T7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N6T7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000077463, Expressed in mucosa of transverse colon and 181 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N6T7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N6T7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000077463, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RELA.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119603, 208 interactors

Database of interacting proteins

More...DIPi		DIP-47346N

Protein interaction database and analysis system

More...IntActi		Q8N6T7, 71 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000337332

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8N6T7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N6T7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1355
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N6T7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8N6T7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 274Deacetylase sirtuin-typePROSITE-ProRule annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni284 – 355DisorderedSequence analysisAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sirtuin family. Class IV subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1905, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160088

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023643_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N6T7

Identification of Orthologs from Complete Genome Data

More...OMAi		EQCKKCR

Database of Orthologous Groups

More...OrthoDBi		1503290at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N6T7

TreeFam database of animal gene trees

More...TreeFami		TF106184

Family and domain databases

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00486

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR003000, Sirtuin
IPR026590, Ssirtuin_cat_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02146, SIR2, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52467, SSF52467, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50305, SIRTUIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N6T7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH 
        60         70         80         90        100
TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ 
       110        120        130        140        150
LERVGLLRFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR 
       160        170        180        190        200
DTVVGTMGLK ATGRLCTVAK ARGLRACRGE LRDTILDWED SLPDRDLALA 
       210        220        230        240        250
DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN LQPTKHDRHA 
       260        270        280        290        300
DLRIHGYVDE VMTRLMKHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK 
       310        320        330        340        350
EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA 

KAVPS
Length:355
Mass (Da):39,119
Last modified:October 31, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C86AAC497130BBF
GO
Isoform 2 (identifier: Q8N6T7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-205: Missing.

Show »
Length:328
Mass (Da):36,065
Checksum:i503805C898FD7769
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZ09M0QZ09_HUMAN
NAD-dependent protein deacetylase s...
SIRT6
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1N9M0R1N9_HUMAN
NAD-dependent protein deacetylase s...
SIRT6 hCG_2004101
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1F6M0R1F6_HUMAN
NAD-dependent protein deacetylase s...
SIRT6
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXA0M0QXA0_HUMAN
NAD-dependent protein deacetylase s...
SIRT6
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0B2M0R0B2_HUMAN
NAD-dependent protein deacetylase s...
SIRT6
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC34468 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAD15478 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH04218 differs from that shown. Reason: Erroneous translation. Wrong choice of CCDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti42W → R in CAG33481 (Ref. 3) Curated1
Sequence conflicti249H → Y in AAH04218 (PubMed:15489334).Curated1
Sequence conflicti267K → E in AAF43432 (PubMed:10873683).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01715446S → N3 PublicationsCorresponds to variant dbSNP:rs352493Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008733179 – 205Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF233396 mRNA Translation: AAF43432.1
AK074810 mRNA Translation: BAC11222.1
AK315048 mRNA Translation: BAG37527.1
CR457200 mRNA Translation: CAG33481.1
AC005620 Genomic DNA Translation: AAC34468.1 Sequence problems.
AC006930 Genomic DNA Translation: AAD15478.1 Sequence problems.
CH471139 Genomic DNA Translation: EAW69252.1
BC004218 mRNA Translation: AAH04218.1 Sequence problems.
BC005026 mRNA Translation: AAH05026.1
BC028220 mRNA Translation: AAH28220.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12122.1 [Q8N6T7-1]
CCDS54199.1 [Q8N6T7-2]

NCBI Reference Sequences

More...RefSeqi		NP_001180214.1, NM_001193285.2 [Q8N6T7-2]
NP_001307987.1, NM_001321058.1
NP_001307988.1, NM_001321059.1
NP_001307989.1, NM_001321060.1
NP_001307990.1, NM_001321061.1
NP_001307991.1, NM_001321062.1
NP_001307992.1, NM_001321063.1
NP_001307993.1, NM_001321064.1
NP_057623.2, NM_016539.3 [Q8N6T7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000305232; ENSP00000305310; ENSG00000077463 [Q8N6T7-2]
ENST00000337491; ENSP00000337332; ENSG00000077463 [Q8N6T7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51548

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51548

UCSC genome browser

More...UCSCi		uc002lzo.4, human [Q8N6T7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233396 mRNA Translation: AAF43432.1
AK074810 mRNA Translation: BAC11222.1
AK315048 mRNA Translation: BAG37527.1
CR457200 mRNA Translation: CAG33481.1
AC005620 Genomic DNA Translation: AAC34468.1 Sequence problems.
AC006930 Genomic DNA Translation: AAD15478.1 Sequence problems.
CH471139 Genomic DNA Translation: EAW69252.1
BC004218 mRNA Translation: AAH04218.1 Sequence problems.
BC005026 mRNA Translation: AAH05026.1
BC028220 mRNA Translation: AAH28220.1
CCDSiCCDS12122.1 [Q8N6T7-1]
CCDS54199.1 [Q8N6T7-2]
RefSeqiNP_001180214.1, NM_001193285.2 [Q8N6T7-2]
NP_001307987.1, NM_001321058.1
NP_001307988.1, NM_001321059.1
NP_001307989.1, NM_001321060.1
NP_001307990.1, NM_001321061.1
NP_001307991.1, NM_001321062.1
NP_001307992.1, NM_001321063.1
NP_001307993.1, NM_001321064.1
NP_057623.2, NM_016539.3 [Q8N6T7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3K35X-ray2.00A/B/C/D/E/F3-318[»]
3PKIX-ray2.04A/B/C/D/E/F2-355[»]
3PKJX-ray2.12A/B/C/D/E/F2-355[»]
3ZG6X-ray2.20A1-296[»]
5MF6X-ray1.87A/B13-308[»]
5MFPX-ray1.98A/B13-308[»]
5MFZX-ray2.10A/B13-308[»]
5MGNX-ray2.07A/B13-308[»]
5X16X-ray1.97A3-318[»]
5Y2FX-ray2.53A3-318[»]
6HOYX-ray1.70A/B13-308[»]
6QCDX-ray1.84A/B13-308[»]
6QCEX-ray1.90A/B13-308[»]
6QCHX-ray2.10A/B13-308[»]
6QCJX-ray2.01A/B13-308[»]
6XUYX-ray2.13A/B13-308[»]
6XV1X-ray1.95A/B13-308[»]
6XV6X-ray1.75A/B/C/D/E/F3-318[»]
6XVGX-ray2.10A/B/C/D/E/F3-318[»]
6ZU4X-ray2.46A/B13-308[»]
7CL0X-ray2.53A1-355[»]
7CL1X-ray3.20A1-355[»]
SMRiQ8N6T7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119603, 208 interactors
DIPiDIP-47346N
IntActiQ8N6T7, 71 interactors
STRINGi9606.ENSP00000337332

Chemistry databases

BindingDBiQ8N6T7
ChEMBLiCHEMBL2163182
GuidetoPHARMACOLOGYi2712

PTM databases

iPTMnetiQ8N6T7
PhosphoSitePlusiQ8N6T7

Genetic variation databases

BioMutaiSIRT6
DMDMi38258612

Proteomic databases

EPDiQ8N6T7
jPOSTiQ8N6T7
MassIVEiQ8N6T7
MaxQBiQ8N6T7
PaxDbiQ8N6T7
PeptideAtlasiQ8N6T7
PRIDEiQ8N6T7
ProteomicsDBi72232 [Q8N6T7-1]
72233 [Q8N6T7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11389, 697 antibodies

The DNASU plasmid repository

More...DNASUi		51548

Genome annotation databases

EnsembliENST00000305232; ENSP00000305310; ENSG00000077463 [Q8N6T7-2]
ENST00000337491; ENSP00000337332; ENSG00000077463 [Q8N6T7-1]
GeneIDi51548
KEGGihsa:51548
UCSCiuc002lzo.4, human [Q8N6T7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51548
DisGeNETi51548

GeneCards: human genes, protein and diseases

More...GeneCardsi		SIRT6
HGNCiHGNC:14934, SIRT6
HPAiENSG00000077463, Low tissue specificity
MIMi606211, gene
neXtProtiNX_Q8N6T7
OpenTargetsiENSG00000077463
Orphaneti580933, Lethal brain and heart developmental defects
PharmGKBiPA37939
VEuPathDBiHostDB:ENSG00000077463

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1905, Eukaryota
GeneTreeiENSGT00940000160088
HOGENOMiCLU_023643_6_0_1
InParanoidiQ8N6T7
OMAiEQCKKCR
OrthoDBi1503290at2759
PhylomeDBiQ8N6T7
TreeFamiTF106184

Enzyme and pathway databases

BRENDAi2.3.1.B41, 2681
PathwayCommonsiQ8N6T7
ReactomeiR-HSA-1912408, Pre-NOTCH Transcription and Translation
R-HSA-5693607, Processing of DNA double-strand break ends
SIGNORiQ8N6T7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51548, 18 hits in 1032 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SIRT6, human
EvolutionaryTraceiQ8N6T7

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SIRT6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51548
PharosiQ8N6T7, Tchem

Protein Ontology

More...PROi		PR:Q8N6T7
RNActiQ8N6T7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000077463, Expressed in mucosa of transverse colon and 181 other tissues
ExpressionAtlasiQ8N6T7, baseline and differential
GenevisibleiQ8N6T7, HS

Family and domain databases

IDEALiIID00486
InterProiView protein in InterPro
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR003000, Sirtuin
IPR026590, Ssirtuin_cat_dom
PfamiView protein in Pfam
PF02146, SIR2, 2 hits
SUPFAMiSSF52467, SSF52467, 1 hit
PROSITEiView protein in PROSITE
PS50305, SIRTUIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIR6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N6T7
Secondary accession number(s): B2RCD0
, O75291, Q6IAF5, Q6PK99, Q8NCD2, Q9BSI5, Q9BWP3, Q9NRC7, Q9UQD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: September 29, 2021
This is version 173 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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