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UniProtKB - Q8N6S5 (AR6P6_HUMAN)
Protein
ADP-ribosylation factor-like protein 6-interacting protein 6
Gene
ARL6IP6
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: ADP-ribosylation factor-like protein 6-interacting protein 6Short name: ARL-6-interacting protein 6 Short name: Aip-6 Alternative name(s): Phosphonoformate immuno-associated protein 1 |
Gene namesi | Name:ARL6IP6 Synonyms:PFAAP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24048, ARL6IP6 |
MIMi | 616495, gene |
neXtProti | NX_Q8N6S5 |
VEuPathDBi | HostDB:ENSG00000177917 |
Subcellular locationi
Nucleus
- Nucleus inner membrane By similarity; Multi-pass membrane protein Sequence analysis
Nucleus
- nuclear inner membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 111 – 131 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 150 – 170 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 205 – 225 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 151188 |
MalaCardsi | ARL6IP6 |
OpenTargetsi | ENSG00000177917 |
Orphaneti | 1556, Cutis marmorata telangiectatica congenita |
PharmGKBi | PA134866669 |
Miscellaneous databases
Pharosi | Q8N6S5, Tdark |
Genetic variation databases
BioMutai | ARL6IP6 |
DMDMi | 74729171 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307324 | 1 – 226 | ADP-ribosylation factor-like protein 6-interacting protein 6Add BLAST | 226 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 36 | PhosphoserineCombined sources | 1 | |
Modified residuei | 60 | PhosphoserineCombined sources | 1 | |
Modified residuei | 65 | PhosphoserineCombined sources | 1 | |
Modified residuei | 80 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8N6S5 |
jPOSTi | Q8N6S5 |
MassIVEi | Q8N6S5 |
MaxQBi | Q8N6S5 |
PaxDbi | Q8N6S5 |
PeptideAtlasi | Q8N6S5 |
PRIDEi | Q8N6S5 |
ProteomicsDBi | 72225 |
PTM databases
iPTMneti | Q8N6S5 |
PhosphoSitePlusi | Q8N6S5 |
SwissPalmi | Q8N6S5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177917, Expressed in ventricular zone and 216 other tissues |
ExpressionAtlasi | Q8N6S5, baseline and differential |
Genevisiblei | Q8N6S5, HS |
Organism-specific databases
HPAi | ENSG00000177917, Low tissue specificity |
Interactioni
Binary interactionsi
Q8N6S5
Protein-protein interaction databases
BioGRIDi | 127351, 60 interactors |
IntActi | Q8N6S5, 32 interactors |
MINTi | Q8N6S5 |
STRINGi | 9606.ENSP00000315357 |
Miscellaneous databases
RNActi | Q8N6S5, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 48 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 66 – 85 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the ARL6IP6 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S1PC, Eukaryota |
GeneTreei | ENSGT00390000009987 |
HOGENOMi | CLU_1229535_0_0_1 |
InParanoidi | Q8N6S5 |
OMAi | QARRWPV |
OrthoDBi | 1552769at2759 |
PhylomeDBi | Q8N6S5 |
TreeFami | TF324669 |
Family and domain databases
InterProi | View protein in InterPro IPR029383, ARL6IP6 |
PANTHERi | PTHR28640, PTHR28640, 1 hit |
Pfami | View protein in Pfam PF15062, ARL6IP6, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8N6S5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFAESGWRS ALRRRGPGTP GPVARPSYSS FTQGDSWGEG EVDEEEGCDQ
60 70 80 90 100
VARDLRAEFS AGAWSEPRKR SVLPPDGNGS PVLPDKRNGI FPAAAGSRAQ
110 120 130 140 150
PRRWPVQVLS ILCSLLFAIL LAFLLAIAYL IVKELHAENL KNEDDVDTGL
160 170 180 190 200
LGFWTLLIIS LTAGFSCCSF SWTVTYFDSF EPGMFPPTPL SPARFKKLTG
210 220
HSFHMGYSMA ILNGIVAALT VAWCLM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C192 | H7C192_HUMAN | ADP-ribosylation factor-like protei... | ARL6IP6 | 66 | Annotation score: | ||
H7C0H7 | H7C0H7_HUMAN | ADP-ribosylation factor-like protei... | ARL6IP6 | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 | G → A in AAQ09943 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF530059 mRNA Translation: AAQ09943.1 AK315657 mRNA Translation: BAG38023.1 AC079344 Genomic DNA Translation: AAX93217.1 CH471058 Genomic DNA Translation: EAX11477.1 BC028741 mRNA Translation: AAH28741.1 BC070140 mRNA Translation: AAH70140.1 |
CCDSi | CCDS2197.1 |
RefSeqi | NP_689735.1, NM_152522.5 |
Genome annotation databases
Ensembli | ENST00000326446; ENSP00000315357; ENSG00000177917 |
GeneIDi | 151188 |
KEGGi | hsa:151188 |
MANE-Selecti | ENST00000326446.10; ENSP00000315357.5; NM_152522.7; NP_689735.1 |
UCSCi | uc002tyn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF530059 mRNA Translation: AAQ09943.1 AK315657 mRNA Translation: BAG38023.1 AC079344 Genomic DNA Translation: AAX93217.1 CH471058 Genomic DNA Translation: EAX11477.1 BC028741 mRNA Translation: AAH28741.1 BC070140 mRNA Translation: AAH70140.1 |
CCDSi | CCDS2197.1 |
RefSeqi | NP_689735.1, NM_152522.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127351, 60 interactors |
IntActi | Q8N6S5, 32 interactors |
MINTi | Q8N6S5 |
STRINGi | 9606.ENSP00000315357 |
PTM databases
iPTMneti | Q8N6S5 |
PhosphoSitePlusi | Q8N6S5 |
SwissPalmi | Q8N6S5 |
Genetic variation databases
BioMutai | ARL6IP6 |
DMDMi | 74729171 |
Proteomic databases
EPDi | Q8N6S5 |
jPOSTi | Q8N6S5 |
MassIVEi | Q8N6S5 |
MaxQBi | Q8N6S5 |
PaxDbi | Q8N6S5 |
PeptideAtlasi | Q8N6S5 |
PRIDEi | Q8N6S5 |
ProteomicsDBi | 72225 |
Protocols and materials databases
Antibodypediai | 3110, 101 antibodies from 23 providers |
DNASUi | 151188 |
Genome annotation databases
Ensembli | ENST00000326446; ENSP00000315357; ENSG00000177917 |
GeneIDi | 151188 |
KEGGi | hsa:151188 |
MANE-Selecti | ENST00000326446.10; ENSP00000315357.5; NM_152522.7; NP_689735.1 |
UCSCi | uc002tyn.4, human |
Organism-specific databases
CTDi | 151188 |
DisGeNETi | 151188 |
GeneCardsi | ARL6IP6 |
HGNCi | HGNC:24048, ARL6IP6 |
HPAi | ENSG00000177917, Low tissue specificity |
MalaCardsi | ARL6IP6 |
MIMi | 616495, gene |
neXtProti | NX_Q8N6S5 |
OpenTargetsi | ENSG00000177917 |
Orphaneti | 1556, Cutis marmorata telangiectatica congenita |
PharmGKBi | PA134866669 |
VEuPathDBi | HostDB:ENSG00000177917 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1PC, Eukaryota |
GeneTreei | ENSGT00390000009987 |
HOGENOMi | CLU_1229535_0_0_1 |
InParanoidi | Q8N6S5 |
OMAi | QARRWPV |
OrthoDBi | 1552769at2759 |
PhylomeDBi | Q8N6S5 |
TreeFami | TF324669 |
Enzyme and pathway databases
PathwayCommonsi | Q8N6S5 |
SignaLinki | Q8N6S5 |
Miscellaneous databases
BioGRID-ORCSi | 151188, 13 hits in 1048 CRISPR screens |
ChiTaRSi | ARL6IP6, human |
GenomeRNAii | 151188 |
Pharosi | Q8N6S5, Tdark |
PROi | PR:Q8N6S5 |
RNActi | Q8N6S5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177917, Expressed in ventricular zone and 216 other tissues |
ExpressionAtlasi | Q8N6S5, baseline and differential |
Genevisiblei | Q8N6S5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029383, ARL6IP6 |
PANTHERi | PTHR28640, PTHR28640, 1 hit |
Pfami | View protein in Pfam PF15062, ARL6IP6, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AR6P6_HUMAN | |
Accessioni | Q8N6S5Primary (citable) accession number: Q8N6S5 Secondary accession number(s): B2RDS6, Q7Z4G7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families