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UniProtKB - Q8N6S5 (AR6P6_HUMAN)

Entry version 116 (18 Sep 2019)
Sequence version 1 (01 Oct 2002)
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Protein

ADP-ribosylation factor-like protein 6-interacting protein 6

Gene

ARL6IP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 6-interacting protein 6
Short name:
ARL-6-interacting protein 6
Short name:
Aip-6
Alternative name(s):
Phosphonoformate immuno-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARL6IP6
Synonyms:PFAAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24048 ARL6IP6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616495 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N6S5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		151188

MalaCards human disease database

More...MalaCardsi		ARL6IP6

Open Targets

More...OpenTargetsi		ENSG00000177917

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1556 Cutis marmorata telangiectatica congenita

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134866669

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N6S5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ARL6IP6

Domain mapping of disease mutations (DMDM)

More...DMDMi		74729171

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003073241 – 226ADP-ribosylation factor-like protein 6-interacting protein 6Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N6S5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N6S5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N6S5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N6S5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N6S5

PeptideAtlas

More...PeptideAtlasi		Q8N6S5

PRoteomics IDEntifications database

More...PRIDEi		Q8N6S5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72225

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N6S5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N6S5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8N6S5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000177917 Expressed in 203 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N6S5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N6S5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA014743

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9BZJ84EBI-2808844,EBI-12808020

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		127351, 22 interactors

Protein interaction database and analysis system

More...IntActi		Q8N6S5, 31 interactors

Molecular INTeraction database

More...MINTi		Q8N6S5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000315357

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ARL6IP6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IW0I Eukaryota
ENOG4111N8A LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009987

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000034034

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N6S5

Identification of Orthologs from Complete Genome Data

More...OMAi		QARRWPV

Database of Orthologous Groups

More...OrthoDBi		1552769at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N6S5

TreeFam database of animal gene trees

More...TreeFami		TF324669

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029383 ARL6IP6

The PANTHER Classification System

More...PANTHERi		PTHR28640 PTHR28640, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15062 ARL6IP6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8N6S5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFAESGWRS ALRRRGPGTP GPVARPSYSS FTQGDSWGEG EVDEEEGCDQ 
        60         70         80         90        100
VARDLRAEFS AGAWSEPRKR SVLPPDGNGS PVLPDKRNGI FPAAAGSRAQ 
       110        120        130        140        150
PRRWPVQVLS ILCSLLFAIL LAFLLAIAYL IVKELHAENL KNEDDVDTGL 
       160        170        180        190        200
LGFWTLLIIS LTAGFSCCSF SWTVTYFDSF EPGMFPPTPL SPARFKKLTG 
       210        220 
HSFHMGYSMA ILNGIVAALT VAWCLM
Length:226
Mass (Da):24,676
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB236F4490BE1FFF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C192H7C192_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP6
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0H7H7C0H7_HUMAN
ADP-ribosylation factor-like protei...
ARL6IP6
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21G → A in AAQ09943 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF530059 mRNA Translation: AAQ09943.1
AK315657 mRNA Translation: BAG38023.1
AC079344 Genomic DNA Translation: AAX93217.1
CH471058 Genomic DNA Translation: EAX11477.1
BC028741 mRNA Translation: AAH28741.1
BC070140 mRNA Translation: AAH70140.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2197.1

NCBI Reference Sequences

More...RefSeqi		NP_689735.1, NM_152522.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000326446; ENSP00000315357; ENSG00000177917

Database of genes from NCBI RefSeq genomes

More...GeneIDi		151188

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:151188

UCSC genome browser

More...UCSCi		uc002tyn.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530059 mRNA Translation: AAQ09943.1
AK315657 mRNA Translation: BAG38023.1
AC079344 Genomic DNA Translation: AAX93217.1
CH471058 Genomic DNA Translation: EAX11477.1
BC028741 mRNA Translation: AAH28741.1
BC070140 mRNA Translation: AAH70140.1
CCDSiCCDS2197.1
RefSeqiNP_689735.1, NM_152522.5

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi127351, 22 interactors
IntActiQ8N6S5, 31 interactors
MINTiQ8N6S5
STRINGi9606.ENSP00000315357

PTM databases

iPTMnetiQ8N6S5
PhosphoSitePlusiQ8N6S5
SwissPalmiQ8N6S5

Polymorphism and mutation databases

BioMutaiARL6IP6
DMDMi74729171

Proteomic databases

EPDiQ8N6S5
jPOSTiQ8N6S5
MassIVEiQ8N6S5
MaxQBiQ8N6S5
PaxDbiQ8N6S5
PeptideAtlasiQ8N6S5
PRIDEiQ8N6S5
ProteomicsDBi72225

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		151188

Genome annotation databases

EnsembliENST00000326446; ENSP00000315357; ENSG00000177917
GeneIDi151188
KEGGihsa:151188
UCSCiuc002tyn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		151188
DisGeNETi151188

GeneCards: human genes, protein and diseases

More...GeneCardsi		ARL6IP6
HGNCiHGNC:24048 ARL6IP6
HPAiHPA014743
MalaCardsiARL6IP6
MIMi616495 gene
neXtProtiNX_Q8N6S5
OpenTargetsiENSG00000177917
Orphaneti1556 Cutis marmorata telangiectatica congenita
PharmGKBiPA134866669

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IW0I Eukaryota
ENOG4111N8A LUCA
GeneTreeiENSGT00390000009987
HOGENOMiHOG000034034
InParanoidiQ8N6S5
OMAiQARRWPV
OrthoDBi1552769at2759
PhylomeDBiQ8N6S5
TreeFamiTF324669

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ARL6IP6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		151188
PharosiQ8N6S5

Protein Ontology

More...PROi		PR:Q8N6S5

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000177917 Expressed in 203 organ(s), highest expression level in placenta
ExpressionAtlasiQ8N6S5 baseline and differential
GenevisibleiQ8N6S5 HS

Family and domain databases

InterProiView protein in InterPro
IPR029383 ARL6IP6
PANTHERiPTHR28640 PTHR28640, 1 hit
PfamiView protein in Pfam
PF15062 ARL6IP6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAR6P6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N6S5
Secondary accession number(s): B2RDS6, Q7Z4G7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: September 18, 2019
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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