UniProtKB - Q8N6S4 (AN13C_HUMAN)
Protein
Ankyrin repeat domain-containing protein 13C
Gene
ANKRD13C
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.1 Publication
GO - Molecular functioni
- signaling receptor binding Source: BHF-UCL
GO - Biological processi
- protein retention in ER lumen Source: BHF-UCL
- regulation of anoikis Source: BHF-UCL
- regulation of signaling receptor activity Source: BHF-UCL
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
PathwayCommonsi | Q8N6S4 |
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin repeat domain-containing protein 13C |
Gene namesi | Name:ANKRD13C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25374, ANKRD13C |
MIMi | 615125, gene |
neXtProti | NX_Q8N6S4 |
VEuPathDBi | HostDB:ENSG00000118454.12 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication
Note: Associated with the cytosolic side.
Endoplasmic reticulum
- endoplasmic reticulum Source: LIFEdb
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
- perinuclear region of cytoplasm Source: BHF-UCL
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000118454 |
PharmGKBi | PA142672617 |
Miscellaneous databases
Pharosi | Q8N6S4, Tbio |
Genetic variation databases
BioMutai | ANKRD13C |
DMDMi | 109940205 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000240645 | 1 – 541 | Ankyrin repeat domain-containing protein 13CAdd BLAST | 541 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 411 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8N6S4 |
jPOSTi | Q8N6S4 |
MassIVEi | Q8N6S4 |
MaxQBi | Q8N6S4 |
PaxDbi | Q8N6S4 |
PeptideAtlasi | Q8N6S4 |
PRIDEi | Q8N6S4 |
ProteomicsDBi | 72222 [Q8N6S4-1] 72223 [Q8N6S4-2] 72224 [Q8N6S4-3] |
PTM databases
iPTMneti | Q8N6S4 |
PhosphoSitePlusi | Q8N6S4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000118454, Expressed in calcaneal tendon and 211 other tissues |
Genevisiblei | Q8N6S4, HS |
Organism-specific databases
HPAi | ENSG00000118454, Low tissue specificity |
Interactioni
Binary interactionsi
Q8N6S4
With | #Exp. | IntAct |
---|---|---|
CLDND2 [Q8NHS1] | 3 | EBI-11959451,EBI-11959453 |
GO - Molecular functioni
- signaling receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 123534, 13 interactors |
IntActi | Q8N6S4, 7 interactors |
STRINGi | 9606.ENSP00000359982 |
Miscellaneous databases
RNActi | Q8N6S4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 111 – 142 | ANK 1Add BLAST | 32 | |
Repeati | 143 – 172 | ANK 2Add BLAST | 30 | |
Repeati | 176 – 205 | ANK 3Add BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 30 – 33 | Poly-Ala | 4 |
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0522, Eukaryota |
GeneTreei | ENSGT00950000182928 |
HOGENOMi | CLU_026137_1_0_1 |
InParanoidi | Q8N6S4 |
OMAi | YPMHQSV |
OrthoDBi | 425969at2759 |
PhylomeDBi | Q8N6S4 |
TreeFami | TF314176 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR021832, ANKRD13 IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
PANTHERi | PTHR12447, PTHR12447, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF11904, GPCR_chapero_1, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8N6S4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTGEKIRSLR RDHKPSKEEG DLLEPGDEEA AAALGGTFTR SRIGKGGKAC
60 70 80 90 100
HKIFSNHHHR LQLKAAPASS NPPGAPALPL HNSSVTANSQ SPALLAGTNP
110 120 130 140 150
VAVVADGGSC PAHYPVHECV FKGDVRRLSS LIRTHNIGQK DNHGNTPLHL
160 170 180 190 200
AVMLGNKECA HLLLAHNAPV KVKNAQGWSP LAEAISYGDR QMITALLRKL
210 220 230 240 250
KQQSRESVEE KRPRLLKALK ELGDFYLELH WDFQSWVPLL SRILPSDACK
260 270 280 290 300
IYKQGINIRL DTTLIDFTDM KCQRGDLSFI FNGDAAPSES FVVLDNEQKV
310 320 330 340 350
YQRIHHEESE METEEEVDIL MSSDIYSATL STKSISFTRA QTGWLFREDK
360 370 380 390 400
TERVGNFLAD FYLVNGLVLE SRKRREHLSE EDILRNKAIM ESLSKGGNIM
410 420 430 440 450
EQNFEPIRRQ SLTPPPQNTI TWEEYISAEN GKAPHLGREL VCKESKKTFK
460 470 480 490 500
ATIAMSQEFP LGIELLLNVL EVVAPFKHFN KLREFVQMKL PPGFPVKLDI
510 520 530 540
PVFPTITATV TFQEFRYDEF DGSIFTIPDD YKEDPSRFPD L
Sequence cautioni
The sequence BAG51959 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 369 | L → I in CAB66651 (PubMed:11230166).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026825 | 413 | T → S1 PublicationCorresponds to variant dbSNP:rs17852616Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019406 | 145 – 147 | NTP → EEC in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_019407 | 148 – 541 | Missing in isoform 3. 1 PublicationAdd BLAST | 394 | |
Alternative sequenceiVSP_019408 | 158 – 193 | ECAHL…DRQMI → V in isoform 2. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136717 mRNA Translation: CAB66651.1 AL158839 Genomic DNA No translation available. AL353771 Genomic DNA No translation available. AL354721 Genomic DNA No translation available. BC016937 mRNA Translation: AAH16937.1 BC028840 mRNA Translation: AAH28840.1 AK074187 mRNA Translation: BAG51959.1 Different initiation. |
CCDSi | CCDS648.2 [Q8N6S4-1] |
RefSeqi | NP_110443.3, NM_030816.4 [Q8N6S4-1] |
Genome annotation databases
Ensembli | ENST00000262346; ENSP00000262346; ENSG00000118454 [Q8N6S4-2] ENST00000370944; ENSP00000359982; ENSG00000118454 [Q8N6S4-1] |
GeneIDi | 81573 |
KEGGi | hsa:81573 |
UCSCi | uc001dex.5, human [Q8N6S4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136717 mRNA Translation: CAB66651.1 AL158839 Genomic DNA No translation available. AL353771 Genomic DNA No translation available. AL354721 Genomic DNA No translation available. BC016937 mRNA Translation: AAH16937.1 BC028840 mRNA Translation: AAH28840.1 AK074187 mRNA Translation: BAG51959.1 Different initiation. |
CCDSi | CCDS648.2 [Q8N6S4-1] |
RefSeqi | NP_110443.3, NM_030816.4 [Q8N6S4-1] |
3D structure databases
SMRi | Q8N6S4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123534, 13 interactors |
IntActi | Q8N6S4, 7 interactors |
STRINGi | 9606.ENSP00000359982 |
PTM databases
iPTMneti | Q8N6S4 |
PhosphoSitePlusi | Q8N6S4 |
Genetic variation databases
BioMutai | ANKRD13C |
DMDMi | 109940205 |
Proteomic databases
EPDi | Q8N6S4 |
jPOSTi | Q8N6S4 |
MassIVEi | Q8N6S4 |
MaxQBi | Q8N6S4 |
PaxDbi | Q8N6S4 |
PeptideAtlasi | Q8N6S4 |
PRIDEi | Q8N6S4 |
ProteomicsDBi | 72222 [Q8N6S4-1] 72223 [Q8N6S4-2] 72224 [Q8N6S4-3] |
Protocols and materials databases
Antibodypediai | 33431, 79 antibodies |
DNASUi | 81573 |
Genome annotation databases
Ensembli | ENST00000262346; ENSP00000262346; ENSG00000118454 [Q8N6S4-2] ENST00000370944; ENSP00000359982; ENSG00000118454 [Q8N6S4-1] |
GeneIDi | 81573 |
KEGGi | hsa:81573 |
UCSCi | uc001dex.5, human [Q8N6S4-1] |
Organism-specific databases
CTDi | 81573 |
GeneCardsi | ANKRD13C |
HGNCi | HGNC:25374, ANKRD13C |
HPAi | ENSG00000118454, Low tissue specificity |
MIMi | 615125, gene |
neXtProti | NX_Q8N6S4 |
OpenTargetsi | ENSG00000118454 |
PharmGKBi | PA142672617 |
VEuPathDBi | HostDB:ENSG00000118454.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0522, Eukaryota |
GeneTreei | ENSGT00950000182928 |
HOGENOMi | CLU_026137_1_0_1 |
InParanoidi | Q8N6S4 |
OMAi | YPMHQSV |
OrthoDBi | 425969at2759 |
PhylomeDBi | Q8N6S4 |
TreeFami | TF314176 |
Enzyme and pathway databases
PathwayCommonsi | Q8N6S4 |
Miscellaneous databases
BioGRID-ORCSi | 81573, 10 hits in 875 CRISPR screens |
ChiTaRSi | ANKRD13C, human |
GeneWikii | ANKRD13C |
GenomeRNAii | 81573 |
Pharosi | Q8N6S4, Tbio |
PROi | PR:Q8N6S4 |
RNActi | Q8N6S4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118454, Expressed in calcaneal tendon and 211 other tissues |
Genevisiblei | Q8N6S4, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR021832, ANKRD13 IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf |
PANTHERi | PTHR12447, PTHR12447, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF11904, GPCR_chapero_1, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AN13C_HUMAN | |
Accessioni | Q8N6S4Primary (citable) accession number: Q8N6S4 Secondary accession number(s): B3KQ97 Q9H0N9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | June 27, 2006 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants