ANKRD13C

Functionⁱ

Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.1 Publication

GO - Molecular functionⁱ

signaling receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20959461

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein retention in ER lumen
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20959461
regulation of anoikis
Source: BHF-UCL
Inferred from direct assayⁱ
- 20959461
regulation of receptor biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 20959461

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone

Molecular function

Chaperone

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ankyrin repeat domain-containing protein 13C
Gene namesⁱ	Name:ANKRD13C
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000118454.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25374 ANKRD13C
MIMⁱ	615125 gene
neXtProtⁱ	NX_Q8N6S4

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000118454
PharmGKBⁱ	PA142672617

Polymorphism and mutation databases

BioMutaⁱ	ANKRD13C
DMDMⁱ	109940205

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000240645	1 – 541	Ankyrin repeat domain-containing protein 13CAdd BLAST		541

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	411	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8N6S4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N6S4
PaxDbⁱ	Q8N6S4
PeptideAtlas More...PeptideAtlasⁱ	Q8N6S4
PRIDEⁱ	Q8N6S4
ProteomicsDBⁱ	72222 72223 [Q8N6S4-2] 72224 [Q8N6S4-3]

PTM databases

iPTMnetⁱ	Q8N6S4
PhosphoSitePlusⁱ	Q8N6S4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000118454 Expressed in 196 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_ANKRD13C
Genevisibleⁱ	Q8N6S4 HS

Interactionⁱ

GO - Molecular functionⁱ

signaling receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20959461

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123534, 11 interactors
IntActⁱ	Q8N6S4, 1 interactor
STRINGⁱ	9606.ENSP00000359982

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N6S4
SMRⁱ	Q8N6S4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	111 – 142	ANK 1Add BLAST	32
Repeatⁱ	143 – 172	ANK 2Add BLAST	30
Repeatⁱ	176 – 205	ANK 3Add BLAST	30

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	30 – 33	Poly-Ala		4

Keywords - Domainⁱ

ANK repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0522 Eukaryota ENOG410XNMS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00410000025381
HOGENOMⁱ	HOG000007095
HOVERGENⁱ	HBG101623
InParanoidⁱ	Q8N6S4
KEGG Orthology (KO) More...KOⁱ	K21437
OMAⁱ	YPMHQSV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06FU
PhylomeDBⁱ	Q8N6S4
TreeFamⁱ	TF314176

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 1 hit
Gene3Dⁱ	1.25.40.20, 1 hit
InterProⁱ	View protein in InterPro IPR021832 ANKRD13 IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf
PANTHERⁱ	PTHR12447 PTHR12447, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit PF11904 GPCR_chapero_1, 1 hit
SMARTⁱ	View protein in SMART SM00248 ANK, 2 hits
SUPFAMⁱ	SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8N6S4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGEKIRSLR RDHKPSKEEG DLLEPGDEEA AAALGGTFTR SRIGKGGKAC 
        60         70         80         90        100
HKIFSNHHHR LQLKAAPASS NPPGAPALPL HNSSVTANSQ SPALLAGTNP 
       110        120        130        140        150
VAVVADGGSC PAHYPVHECV FKGDVRRLSS LIRTHNIGQK DNHGNTPLHL 
       160        170        180        190        200
AVMLGNKECA HLLLAHNAPV KVKNAQGWSP LAEAISYGDR QMITALLRKL 
       210        220        230        240        250
KQQSRESVEE KRPRLLKALK ELGDFYLELH WDFQSWVPLL SRILPSDACK 
       260        270        280        290        300
IYKQGINIRL DTTLIDFTDM KCQRGDLSFI FNGDAAPSES FVVLDNEQKV 
       310        320        330        340        350
YQRIHHEESE METEEEVDIL MSSDIYSATL STKSISFTRA QTGWLFREDK 
       360        370        380        390        400
TERVGNFLAD FYLVNGLVLE SRKRREHLSE EDILRNKAIM ESLSKGGNIM 
       410        420        430        440        450
EQNFEPIRRQ SLTPPPQNTI TWEEYISAEN GKAPHLGREL VCKESKKTFK 
       460        470        480        490        500
ATIAMSQEFP LGIELLLNVL EVVAPFKHFN KLREFVQMKL PPGFPVKLDI 
       510        520        530        540 
PVFPTITATV TFQEFRYDEF DGSIFTIPDD YKEDPSRFPD L

Length:541

Mass (Da):60,818

Last modified:June 27, 2006 - v2

Checksum:ⁱ0215707FDFB92046

GO

Isoform 2 (identifier: Q8N6S4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
158-193: ECAHLLLAHNAPVKVKNAQGWSPLAEAISYGDRQMI → V

« Hide

        10         20         30         40         50
MTGEKIRSLR RDHKPSKEEG DLLEPGDEEA AAALGGTFTR SRIGKGGKAC 
        60         70         80         90        100
HKIFSNHHHR LQLKAAPASS NPPGAPALPL HNSSVTANSQ SPALLAGTNP 
       110        120        130        140        150
VAVVADGGSC PAHYPVHECV FKGDVRRLSS LIRTHNIGQK DNHGNTPLHL 
       160        170        180        190        200
AVMLGNKVTA LLRKLKQQSR ESVEEKRPRL LKALKELGDF YLELHWDFQS 
       210        220        230        240        250
WVPLLSRILP SDACKIYKQG INIRLDTTLI DFTDMKCQRG DLSFIFNGDA 
       260        270        280        290        300
APSESFVVLD NEQKVYQRIH HEESEMETEE EVDILMSSDI YSATLSTKSI 
       310        320        330        340        350
SFTRAQTGWL FREDKTERVG NFLADFYLVN GLVLESRKRR EHLSEEDILR 
       360        370        380        390        400
NKAIMESLSK GGNIMEQNFE PIRRQSLTPP PQNTITWEEY ISAENGKAPH 
       410        420        430        440        450
LGRELVCKES KKTFKATIAM SQEFPLGIEL LLNVLEVVAP FKHFNKLREF 
       460        470        480        490        500
VQMKLPPGFP VKLDIPVFPT ITATVTFQEF RYDEFDGSIF TIPDDYKEDP 

SRFPDL

Note: No experimental confirmation available.

Show »

Length:506

Mass (Da):57,003

Checksum:ⁱC907ED83B395E6BB

GO

Isoform 3 (identifier: Q8N6S4-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
145-147: NTP → EEC
148-541: Missing.

« Hide

        10         20         30         40         50
MTGEKIRSLR RDHKPSKEEG DLLEPGDEEA AAALGGTFTR SRIGKGGKAC 
        60         70         80         90        100
HKIFSNHHHR LQLKAAPASS NPPGAPALPL HNSSVTANSQ SPALLAGTNP 
       110        120        130        140 
VAVVADGGSC PAHYPVHECV FKGDVRRLSS LIRTHNIGQK DNHGEEC

Note: No experimental confirmation available.

Show »

Length:147

Mass (Da):15,550

Checksum:ⁱCC81CA5B6D459960

GO

Sequence cautionⁱ

The sequence BAG51959 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	369	L → I in CAB66651 (PubMed:11230166).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_026825	413	T → S1 PublicationCorresponds to variant dbSNP:rs17852616Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_019406	145 – 147	NTP → EEC in isoform 3. 1 Publication	3
Alternative sequenceⁱVSP_019407	148 – 541	Missing in isoform 3. 1 PublicationAdd BLAST	394
Alternative sequenceⁱVSP_019408	158 – 193	ECAHL…DRQMI → V in isoform 2. 1 PublicationAdd BLAST	36

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL136717 mRNA Translation: CAB66651.1 AL158839 Genomic DNA No translation available. AL353771 Genomic DNA No translation available. AL354721 Genomic DNA No translation available. BC016937 mRNA Translation: AAH16937.1 BC028840 mRNA Translation: AAH28840.1 AK074187 mRNA Translation: BAG51959.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS648.2 [Q8N6S4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_110443.3, NM_030816.4 [Q8N6S4-1]
UniGeneⁱ	Hs.744989

Genome annotation databases

Ensemblⁱ	ENST00000262346; ENSP00000262346; ENSG00000118454 [Q8N6S4-2] ENST00000370944; ENSP00000359982; ENSG00000118454 [Q8N6S4-1]
GeneIDⁱ	81573
KEGGⁱ	hsa:81573
UCSC genome browser More...UCSCⁱ	uc001dex.5 human [Q8N6S4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8N6S4	Ankyrin repeat domain-containing protein 13C		MOUSE		541	UniRef90_Q8N6S4
Ankyrin repeat domain 13C		RAT		555
Ankyrin repeat domain 13C		LOXAF		551
Ankyrin repeat domain 13C		RABIT		549
Ankyrin repeat domain 13C		AOTNA		549
+132
Q8N6S4-2	ankyrin repeat domain-containing protein 13C isoform X2		ODORO		511	UniRef90_Q8N6S4-2
ANKRD13C isoform 1		PANTR		506
ANKRD13C isoform 2		PONAB		506
Ankyrin repeat domain 13C		PANPA		506
Ankyrin repeat domain 13C		GORGO		506
+21

Protein	Similar proteins		Species	Score	Length	Source
Q8N6S4	Ankyrin repeat domain-containing protein 13C		MOUSE		541	UniRef50_Q8N6S4
Ankyrin repeat domain 13C		RAT		555
Ankyrin repeat domain 13C		LOXAF		551
Ankyrin repeat domain 13C		AOTNA		549
Ankyrin repeat domain 13C		RABIT		549
+167
Q8N6S4-2	ankyrin repeat domain-containing protein 13C isoform X2		ODORO		511	UniRef50_Q8N6S4-2
Ankyrin repeat domain 13C		AOTNA		506
Ankyrin repeat domain 13C		MACMU		506
Ankyrin repeat domain 13C		COLAP		506
Ankyrin repeat domain 13C		CERAT		506
+143

Entry informationⁱ

Entry nameⁱ	AN13C_HUMAN
Accessionⁱ	Q8N6S4Primary (citable) accession number: Q8N6S4 Secondary accession number(s): B3KQ97 , Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	June 27, 2006
	Last modified:	September 12, 2018
	This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N6S4 (AN13C_HUMAN)

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Ankyrin repeat domain-containing protein 13C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ