Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane and coiled-coil domain-containing protein 5A

Gene

TMCO5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 5A
Gene namesi
Name:TMCO5A
Synonyms:TMCO5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166069.13
HGNCiHGNC:28558 TMCO5A
neXtProtiNX_Q8N6Q1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi145942
OpenTargetsiENSG00000166069
PharmGKBiPA162405808

Polymorphism and mutation databases

BioMutaiTMCO5A
DMDMi74759950

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051531 – 288Transmembrane and coiled-coil domain-containing protein 5AAdd BLAST288

Proteomic databases

PaxDbiQ8N6Q1
PeptideAtlasiQ8N6Q1
PRIDEiQ8N6Q1
ProteomicsDBi72210
72211 [Q8N6Q1-2]

PTM databases

iPTMnetiQ8N6Q1
PhosphoSitePlusiQ8N6Q1

Expressioni

Gene expression databases

BgeeiENSG00000166069 Expressed in 41 organ(s), highest expression level in testis
CleanExiHS_TMCO5A
ExpressionAtlasiQ8N6Q1 baseline and differential
GenevisibleiQ8N6Q1 HS

Organism-specific databases

HPAiHPA056530

Interactioni

Protein-protein interaction databases

IntActiQ8N6Q1, 7 interactors
STRINGi9606.ENSP00000327234

Structurei

3D structure databases

ProteinModelPortaliQ8N6Q1
SMRiQ8N6Q1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili10 – 192Sequence analysisAdd BLAST183

Sequence similaritiesi

Belongs to the TMCO5 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFCD Eukaryota
ENOG411142W LUCA
GeneTreeiENSGT00390000004036
HOGENOMiHOG000154632
HOVERGENiHBG067207
InParanoidiQ8N6Q1
OMAiWKLRCFL
OrthoDBiEOG091G0JAH
PhylomeDBiQ8N6Q1
TreeFamiTF337140

Family and domain databases

InterProiView protein in InterPro
IPR026617 SMCO2/5
PANTHERiPTHR22422 PTHR22422, 1 hit
PfamiView protein in Pfam
PF14992 TMCO5, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N6Q1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEISRLAQSK RNIISLNMDL ERDTQRIDEA NQKLLLKIQE REDKIQRLES
60 70 80 90 100
EIIQTRGLVE DEEWEKENRT TMERERALQE LEEETARLER KNKTLVHSIT
110 120 130 140 150
ELQQKLTRKS QKITNCEQSS PDGALEETKV KLQQLEASYA CQEKELLKVM
160 170 180 190 200
KEYAFVTQLC EDQALYIKKY QETLKKIEEE LEALFLEREV SKLVSMNPVE
210 220 230 240 250
KEHTSQNNEG TPTQKTARLF SKKIFCCLFF ITLFFIRLLS YMFFHVRFIN
260 270 280
PDLLVNVLPK VLGRSTLWKL RCFFFPSLTL ETEDMLPH
Length:288
Mass (Da):34,174
Last modified:March 1, 2004 - v2
Checksum:i348D002915DF1132
GO
Isoform 2 (identifier: Q8N6Q1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-228: IFCCL → WASSF
     229-288: Missing.

Note: No experimental confirmation available.
Show »
Length:228
Mass (Da):26,910
Checksum:i5B98B16AB2BAF022
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YL40H0YL40_HUMAN
Transmembrane and coiled-coil domai...
TMCO5A
190Annotation score:
H0YMD4H0YMD4_HUMAN
Transmembrane and coiled-coil domai...
TMCO5A
190Annotation score:
H0YLW5H0YLW5_HUMAN
Transmembrane and coiled-coil domai...
TMCO5A
81Annotation score:
H0YLN2H0YLN2_HUMAN
Transmembrane and coiled-coil domai...
TMCO5A
144Annotation score:
H0YLD3H0YLD3_HUMAN
Transmembrane and coiled-coil domai...
TMCO5A
70Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57G → D in BAC04065 (PubMed:14702039).Curated1
Sequence conflicti201K → E in BAC04065 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028246224 – 228IFCCL → WASSF in isoform 2. 1 Publication5
Alternative sequenceiVSP_028247229 – 288Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093126 mRNA Translation: BAC04065.1
BC029221 mRNA Translation: AAH29221.2
CCDSiCCDS10046.1 [Q8N6Q1-1]
CCDS81862.1 [Q8N6Q1-2]
RefSeqiNP_001317184.1, NM_001330255.1 [Q8N6Q1-2]
NP_689666.2, NM_152453.3 [Q8N6Q1-1]
XP_005254225.1, XM_005254168.3 [Q8N6Q1-1]
UniGeneiHs.179646

Genome annotation databases

EnsembliENST00000319669; ENSP00000327234; ENSG00000166069 [Q8N6Q1-1]
ENST00000559502; ENSP00000454112; ENSG00000166069 [Q8N6Q1-2]
GeneIDi145942
KEGGihsa:145942
UCSCiuc001zjv.1 human [Q8N6Q1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093126 mRNA Translation: BAC04065.1
BC029221 mRNA Translation: AAH29221.2
CCDSiCCDS10046.1 [Q8N6Q1-1]
CCDS81862.1 [Q8N6Q1-2]
RefSeqiNP_001317184.1, NM_001330255.1 [Q8N6Q1-2]
NP_689666.2, NM_152453.3 [Q8N6Q1-1]
XP_005254225.1, XM_005254168.3 [Q8N6Q1-1]
UniGeneiHs.179646

3D structure databases

ProteinModelPortaliQ8N6Q1
SMRiQ8N6Q1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N6Q1, 7 interactors
STRINGi9606.ENSP00000327234

PTM databases

iPTMnetiQ8N6Q1
PhosphoSitePlusiQ8N6Q1

Polymorphism and mutation databases

BioMutaiTMCO5A
DMDMi74759950

Proteomic databases

PaxDbiQ8N6Q1
PeptideAtlasiQ8N6Q1
PRIDEiQ8N6Q1
ProteomicsDBi72210
72211 [Q8N6Q1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319669; ENSP00000327234; ENSG00000166069 [Q8N6Q1-1]
ENST00000559502; ENSP00000454112; ENSG00000166069 [Q8N6Q1-2]
GeneIDi145942
KEGGihsa:145942
UCSCiuc001zjv.1 human [Q8N6Q1-1]

Organism-specific databases

CTDi145942
DisGeNETi145942
EuPathDBiHostDB:ENSG00000166069.13
GeneCardsiTMCO5A
HGNCiHGNC:28558 TMCO5A
HPAiHPA056530
neXtProtiNX_Q8N6Q1
OpenTargetsiENSG00000166069
PharmGKBiPA162405808
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFCD Eukaryota
ENOG411142W LUCA
GeneTreeiENSGT00390000004036
HOGENOMiHOG000154632
HOVERGENiHBG067207
InParanoidiQ8N6Q1
OMAiWKLRCFL
OrthoDBiEOG091G0JAH
PhylomeDBiQ8N6Q1
TreeFamiTF337140

Miscellaneous databases

ChiTaRSiTMCO5A human
GenomeRNAii145942
PROiPR:Q8N6Q1

Gene expression databases

BgeeiENSG00000166069 Expressed in 41 organ(s), highest expression level in testis
CleanExiHS_TMCO5A
ExpressionAtlasiQ8N6Q1 baseline and differential
GenevisibleiQ8N6Q1 HS

Family and domain databases

InterProiView protein in InterPro
IPR026617 SMCO2/5
PANTHERiPTHR22422 PTHR22422, 1 hit
PfamiView protein in Pfam
PF14992 TMCO5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMC5A_HUMAN
AccessioniPrimary (citable) accession number: Q8N6Q1
Secondary accession number(s): Q8NA63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2004
Last modified: September 12, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again