UniProtKB - Q8N6Q1 (TMC5A_HUMAN)
Protein
Transmembrane and coiled-coil domain-containing protein 5A
Gene
TMCO5A
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane and coiled-coil domain-containing protein 5A |
Gene namesi | Name:TMCO5A Synonyms:TMCO5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28558, TMCO5A |
neXtProti | NX_Q8N6Q1 |
VEuPathDBi | HostDB:ENSG00000166069.13 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 224 – 244 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 145942 |
OpenTargetsi | ENSG00000166069 |
PharmGKBi | PA162405808 |
Miscellaneous databases
Pharosi | Q8N6Q1, Tdark |
Genetic variation databases
BioMutai | TMCO5A |
DMDMi | 74759950 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305153 | 1 – 288 | Transmembrane and coiled-coil domain-containing protein 5AAdd BLAST | 288 |
Proteomic databases
MassIVEi | Q8N6Q1 |
PaxDbi | Q8N6Q1 |
PeptideAtlasi | Q8N6Q1 |
PRIDEi | Q8N6Q1 |
ProteomicsDBi | 72210 [Q8N6Q1-1] 72211 [Q8N6Q1-2] |
PTM databases
iPTMneti | Q8N6Q1 |
PhosphoSitePlusi | Q8N6Q1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166069, Expressed in testis and 59 other tissues |
ExpressionAtlasi | Q8N6Q1, baseline and differential |
Genevisiblei | Q8N6Q1, HS |
Organism-specific databases
HPAi | ENSG00000166069, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Hide detailsQ8N6Q1
Protein-protein interaction databases
BioGRIDi | 126954, 9 interactors |
IntActi | Q8N6Q1, 8 interactors |
STRINGi | 9606.ENSP00000327234 |
Miscellaneous databases
RNActi | Q8N6Q1, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 10 – 192 | Sequence analysisAdd BLAST | 183 |
Sequence similaritiesi
Belongs to the TMCO5 family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502TDSB, Eukaryota |
GeneTreei | ENSGT00940000153380 |
HOGENOMi | CLU_061400_0_0_1 |
InParanoidi | Q8N6Q1 |
OMAi | RGILWKL |
PhylomeDBi | Q8N6Q1 |
TreeFami | TF337140 |
Family and domain databases
InterProi | View protein in InterPro IPR026617, SMCO2/5 |
PANTHERi | PTHR22422, PTHR22422, 1 hit |
Pfami | View protein in Pfam PF14992, TMCO5, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N6Q1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEISRLAQSK RNIISLNMDL ERDTQRIDEA NQKLLLKIQE REDKIQRLES
60 70 80 90 100
EIIQTRGLVE DEEWEKENRT TMERERALQE LEEETARLER KNKTLVHSIT
110 120 130 140 150
ELQQKLTRKS QKITNCEQSS PDGALEETKV KLQQLEASYA CQEKELLKVM
160 170 180 190 200
KEYAFVTQLC EDQALYIKKY QETLKKIEEE LEALFLEREV SKLVSMNPVE
210 220 230 240 250
KEHTSQNNEG TPTQKTARLF SKKIFCCLFF ITLFFIRLLS YMFFHVRFIN
260 270 280
PDLLVNVLPK VLGRSTLWKL RCFFFPSLTL ETEDMLPH
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YL40 | H0YL40_HUMAN | Transmembrane and coiled-coil domai... | TMCO5A | 190 | Annotation score: | ||
H0YLD3 | H0YLD3_HUMAN | Transmembrane and coiled-coil domai... | TMCO5A | 70 | Annotation score: | ||
H0YLN2 | H0YLN2_HUMAN | Transmembrane and coiled-coil domai... | TMCO5A | 144 | Annotation score: | ||
H0YLW5 | H0YLW5_HUMAN | Transmembrane and coiled-coil domai... | TMCO5A | 81 | Annotation score: | ||
H0YMD4 | H0YMD4_HUMAN | Transmembrane and coiled-coil domai... | TMCO5A | 190 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 | G → D in BAC04065 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 201 | K → E in BAC04065 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028246 | 224 – 228 | IFCCL → WASSF in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_028247 | 229 – 288 | Missing in isoform 2. 1 PublicationAdd BLAST | 60 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093126 mRNA Translation: BAC04065.1 BC029221 mRNA Translation: AAH29221.2 |
CCDSi | CCDS10046.1 [Q8N6Q1-1] CCDS81862.1 [Q8N6Q1-2] |
RefSeqi | NP_001317184.1, NM_001330255.1 [Q8N6Q1-2] NP_689666.2, NM_152453.3 [Q8N6Q1-1] XP_005254225.1, XM_005254168.3 |
Genome annotation databases
Ensembli | ENST00000319669; ENSP00000327234; ENSG00000166069 [Q8N6Q1-1] ENST00000559502; ENSP00000454112; ENSG00000166069 [Q8N6Q1-2] |
GeneIDi | 145942 |
KEGGi | hsa:145942 |
UCSCi | uc001zjv.1, human [Q8N6Q1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093126 mRNA Translation: BAC04065.1 BC029221 mRNA Translation: AAH29221.2 |
CCDSi | CCDS10046.1 [Q8N6Q1-1] CCDS81862.1 [Q8N6Q1-2] |
RefSeqi | NP_001317184.1, NM_001330255.1 [Q8N6Q1-2] NP_689666.2, NM_152453.3 [Q8N6Q1-1] XP_005254225.1, XM_005254168.3 |
3D structure databases
SMRi | Q8N6Q1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126954, 9 interactors |
IntActi | Q8N6Q1, 8 interactors |
STRINGi | 9606.ENSP00000327234 |
PTM databases
iPTMneti | Q8N6Q1 |
PhosphoSitePlusi | Q8N6Q1 |
Genetic variation databases
BioMutai | TMCO5A |
DMDMi | 74759950 |
Proteomic databases
MassIVEi | Q8N6Q1 |
PaxDbi | Q8N6Q1 |
PeptideAtlasi | Q8N6Q1 |
PRIDEi | Q8N6Q1 |
ProteomicsDBi | 72210 [Q8N6Q1-1] 72211 [Q8N6Q1-2] |
Protocols and materials databases
Antibodypediai | 67483, 26 antibodies |
Genome annotation databases
Ensembli | ENST00000319669; ENSP00000327234; ENSG00000166069 [Q8N6Q1-1] ENST00000559502; ENSP00000454112; ENSG00000166069 [Q8N6Q1-2] |
GeneIDi | 145942 |
KEGGi | hsa:145942 |
UCSCi | uc001zjv.1, human [Q8N6Q1-1] |
Organism-specific databases
CTDi | 145942 |
DisGeNETi | 145942 |
GeneCardsi | TMCO5A |
HGNCi | HGNC:28558, TMCO5A |
HPAi | ENSG00000166069, Tissue enriched (testis) |
neXtProti | NX_Q8N6Q1 |
OpenTargetsi | ENSG00000166069 |
PharmGKBi | PA162405808 |
VEuPathDBi | HostDB:ENSG00000166069.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TDSB, Eukaryota |
GeneTreei | ENSGT00940000153380 |
HOGENOMi | CLU_061400_0_0_1 |
InParanoidi | Q8N6Q1 |
OMAi | RGILWKL |
PhylomeDBi | Q8N6Q1 |
TreeFami | TF337140 |
Enzyme and pathway databases
PathwayCommonsi | Q8N6Q1 |
Miscellaneous databases
BioGRID-ORCSi | 145942, 6 hits in 978 CRISPR screens |
ChiTaRSi | TMCO5A, human |
GenomeRNAii | 145942 |
Pharosi | Q8N6Q1, Tdark |
PROi | PR:Q8N6Q1 |
RNActi | Q8N6Q1, protein |
Gene expression databases
Bgeei | ENSG00000166069, Expressed in testis and 59 other tissues |
ExpressionAtlasi | Q8N6Q1, baseline and differential |
Genevisiblei | Q8N6Q1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026617, SMCO2/5 |
PANTHERi | PTHR22422, PTHR22422, 1 hit |
Pfami | View protein in Pfam PF14992, TMCO5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TMC5A_HUMAN | |
Accessioni | Q8N6Q1Primary (citable) accession number: Q8N6Q1 Secondary accession number(s): Q8NA63 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | March 1, 2004 | |
Last modified: | April 7, 2021 | |
This is version 120 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families