UniProtKB - Q8N6Q1 (TMC5A_HUMAN)

BLAST

>sp|Q8N6Q1|TMC5A_HUMAN Transmembrane and coiled-coil domain-containing protein 5A OS=Homo sapiens OX=9606 GN=TMCO5A PE=2 SV=2
MEISRLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVE
DEEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQSS
PDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCEDQALYIKKYQETLKKIEEE
LEALFLEREVSKLVSMNPVEKEHTSQNNEGTPTQKTARLFSKKIFCCLFFITLFFIRLLS
YMFFHVRFINPDLLVNVLPKVLGRSTLWKLRCFFFPSLTLETEDMLPH

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History
Entry version 104 (12 Sep 2018)
Sequence version 2 (01 Mar 2004)
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Protein

Transmembrane and coiled-coil domain-containing protein 5A

Gene

TMCO5A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane and coiled-coil domain-containing protein 5A
Gene namesⁱ	Name:TMCO5A Synonyms:TMCO5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000166069.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28558 TMCO5A
neXtProtⁱ	NX_Q8N6Q1

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	224 – 244	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	145942
Open Targets More...OpenTargetsⁱ	ENSG00000166069
PharmGKBⁱ	PA162405808

Polymorphism and mutation databases

BioMutaⁱ	TMCO5A
DMDMⁱ	74759950

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000305153	1 – 288	Transmembrane and coiled-coil domain-containing protein 5AAdd BLAST		288

Proteomic databases

PaxDbⁱ	Q8N6Q1
PeptideAtlas More...PeptideAtlasⁱ	Q8N6Q1
PRIDEⁱ	Q8N6Q1
ProteomicsDBⁱ	72210 72211 [Q8N6Q1-2]

PTM databases

iPTMnetⁱ	Q8N6Q1
PhosphoSitePlusⁱ	Q8N6Q1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000166069 Expressed in 41 organ(s), highest expression level in testis
CleanExⁱ	HS_TMCO5A
ExpressionAtlasⁱ	Q8N6Q1 baseline and differential
Genevisibleⁱ	Q8N6Q1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA056530

HPAⁱ

HPA056530

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q8N6Q1, 7 interactors
STRINGⁱ	9606.ENSP00000327234

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N6Q1
SMRⁱ	Q8N6Q1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	10 – 192	Sequence analysisAdd BLAST		183

Sequence similaritiesⁱ

Belongs to the TMCO5 family.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFCD Eukaryota ENOG411142W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004036
HOGENOMⁱ	HOG000154632
HOVERGENⁱ	HBG067207
InParanoidⁱ	Q8N6Q1
OMAⁱ	WKLRCFL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JAH
PhylomeDBⁱ	Q8N6Q1
TreeFamⁱ	TF337140

Family and domain databases

InterProⁱ	View protein in InterPro IPR026617 SMCO2/5
PANTHERⁱ	PTHR22422 PTHR22422, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14992 TMCO5, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N6Q1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEISRLAQSK RNIISLNMDL ERDTQRIDEA NQKLLLKIQE REDKIQRLES 
        60         70         80         90        100
EIIQTRGLVE DEEWEKENRT TMERERALQE LEEETARLER KNKTLVHSIT 
       110        120        130        140        150
ELQQKLTRKS QKITNCEQSS PDGALEETKV KLQQLEASYA CQEKELLKVM 
       160        170        180        190        200
KEYAFVTQLC EDQALYIKKY QETLKKIEEE LEALFLEREV SKLVSMNPVE 
       210        220        230        240        250
KEHTSQNNEG TPTQKTARLF SKKIFCCLFF ITLFFIRLLS YMFFHVRFIN 
       260        270        280 
PDLLVNVLPK VLGRSTLWKL RCFFFPSLTL ETEDMLPH

Length:288

Mass (Da):34,174

Last modified:March 1, 2004 - v2

Checksum:ⁱ348D002915DF1132

Isoform 2 (identifier: Q8N6Q1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
224-228: IFCCL → WASSF
229-288: Missing.

« Hide

        10         20         30         40         50
MEISRLAQSK RNIISLNMDL ERDTQRIDEA NQKLLLKIQE REDKIQRLES 
        60         70         80         90        100
EIIQTRGLVE DEEWEKENRT TMERERALQE LEEETARLER KNKTLVHSIT 
       110        120        130        140        150
ELQQKLTRKS QKITNCEQSS PDGALEETKV KLQQLEASYA CQEKELLKVM 
       160        170        180        190        200
KEYAFVTQLC EDQALYIKKY QETLKKIEEE LEALFLEREV SKLVSMNPVE 
       210        220 
KEHTSQNNEG TPTQKTARLF SKKWASSF

Note: No experimental confirmation available.

Show »

Length:228

Mass (Da):26,910

Checksum:ⁱ5B98B16AB2BAF022

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YL40	H0YL40_HUMAN	Transmembrane and coiled-coil domai... Transmembrane and coiled-coil domain-containing protein 5A	TMCO5A	190	Annotation score:
H0YMD4	H0YMD4_HUMAN	Transmembrane and coiled-coil domai... Transmembrane and coiled-coil domain-containing protein 5A	TMCO5A	190	Annotation score:
H0YLW5	H0YLW5_HUMAN	Transmembrane and coiled-coil domai... Transmembrane and coiled-coil domain-containing protein 5A	TMCO5A	81	Annotation score:
H0YLN2	H0YLN2_HUMAN	Transmembrane and coiled-coil domai... Transmembrane and coiled-coil domain-containing protein 5A	TMCO5A	144	Annotation score:
H0YLD3	H0YLD3_HUMAN	Transmembrane and coiled-coil domai... Transmembrane and coiled-coil domain-containing protein 5A	TMCO5A	70	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	57	G → D in BAC04065 (PubMed:14702039).Curated		1
Sequence conflictⁱ	201	K → E in BAC04065 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_028246	224 – 228	IFCCL → WASSF in isoform 2. 1 Publication		5
Alternative sequenceⁱVSP_028247	229 – 288	Missing in isoform 2. 1 PublicationAdd BLAST		60

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK093126 mRNA Translation: BAC04065.1 BC029221 mRNA Translation: AAH29221.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10046.1 [Q8N6Q1-1] CCDS81862.1 [Q8N6Q1-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001317184.1, NM_001330255.1 [Q8N6Q1-2] NP_689666.2, NM_152453.3 [Q8N6Q1-1] XP_005254225.1, XM_005254168.3 [Q8N6Q1-1]
UniGeneⁱ	Hs.179646

Genome annotation databases

Ensemblⁱ	ENST00000319669; ENSP00000327234; ENSG00000166069 [Q8N6Q1-1] ENST00000559502; ENSP00000454112; ENSG00000166069 [Q8N6Q1-2]
GeneIDⁱ	145942
KEGGⁱ	hsa:145942
UCSC genome browser More...UCSCⁱ	uc001zjv.1 human [Q8N6Q1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N6Q1	Testicular tissue protein Li 205		HUMAN		288	UniRef100_Q8N6Q1
Transmembrane and coiled-coil domain-containing protein 5A (Fragment)		HUMAN		70
Transmembrane and coiled-coil domain-containing protein 5A (Fragment)		HUMAN		81
Transmembrane and coiled-coil domain-containing protein 5A		HUMAN		190
Transmembrane and coiled-coil domain-containing protein 5A (Fragment)		HUMAN		144

Protein	Similar proteins		Species	Score	Length	Source
Q8N6Q1	Testicular tissue protein Li 205		HUMAN		288	UniRef90_Q8N6Q1
Uncharacterized protein		MACFA		288
TMCO5A isoform 8		PONAB		288
Uncharacterized protein		MACMU		288
Uncharacterized protein		MACNE		288
+34
Q8N6Q1-2	Uncharacterized protein		COLAP		228	UniRef90_Q8N6Q1-2
TMCO5A isoform 3		PONAB		228
Uncharacterized protein		MACMU		228
Transmembrane and coiled-coil domains 5A		GORGO		228
Uncharacterized protein		CERAT		228
+14

Protein	Similar proteins		Species	Score	Length	Source
Q8N6Q1	Transmembrane and coiled-coil domain-containing protein 5A		MOUSE		303	UniRef50_Q9D9D5
Transmembrane and coiled-coil domains 5A		RAT		297
LOW QUALITY PROTEIN: transmembrane and coiled-coil domain-containing protein 5A		Enhydra lutris kenyoni		343
Transmembrane and coiled-coil domains 5A		MUSPF		304
transmembrane and coiled-coil domain-containing protein 5A		URSMA		303
+147
Q8N6Q1-2	Uncharacterized protein		PAPAN		228	UniRef50_Q8N6Q1-2
Uncharacterized protein		CERAT		228
Uncharacterized protein		MANLE		228
Transmembrane and coiled-coil domains 5A		GORGO		228
Uncharacterized protein		MACMU		228
+17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK093126 mRNA Translation: BAC04065.1 BC029221 mRNA Translation: AAH29221.2
CCDSⁱ	CCDS10046.1 [Q8N6Q1-1] CCDS81862.1 [Q8N6Q1-2]
RefSeqⁱ	NP_001317184.1, NM_001330255.1 [Q8N6Q1-2] NP_689666.2, NM_152453.3 [Q8N6Q1-1] XP_005254225.1, XM_005254168.3 [Q8N6Q1-1]
UniGeneⁱ	Hs.179646

3D structure databases

ProteinModelPortalⁱ	Q8N6Q1
SMRⁱ	Q8N6Q1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8N6Q1, 7 interactors
STRINGⁱ	9606.ENSP00000327234

PTM databases

iPTMnetⁱ	Q8N6Q1
PhosphoSitePlusⁱ	Q8N6Q1

Polymorphism and mutation databases

BioMutaⁱ	TMCO5A
DMDMⁱ	74759950

Proteomic databases

PaxDbⁱ	Q8N6Q1
PeptideAtlasⁱ	Q8N6Q1
PRIDEⁱ	Q8N6Q1
ProteomicsDBⁱ	72210 72211 [Q8N6Q1-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000319669; ENSP00000327234; ENSG00000166069 [Q8N6Q1-1] ENST00000559502; ENSP00000454112; ENSG00000166069 [Q8N6Q1-2]
GeneIDⁱ	145942
KEGGⁱ	hsa:145942
UCSCⁱ	uc001zjv.1 human [Q8N6Q1-1]

Organism-specific databases

CTDⁱ	145942
DisGeNETⁱ	145942
EuPathDBⁱ	HostDB:ENSG00000166069.13
GeneCardsⁱ	TMCO5A
HGNCⁱ	HGNC:28558 TMCO5A
HPAⁱ	HPA056530
neXtProtⁱ	NX_Q8N6Q1
OpenTargetsⁱ	ENSG00000166069
PharmGKBⁱ	PA162405808
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFCD Eukaryota ENOG411142W LUCA
GeneTreeⁱ	ENSGT00390000004036
HOGENOMⁱ	HOG000154632
HOVERGENⁱ	HBG067207
InParanoidⁱ	Q8N6Q1
OMAⁱ	WKLRCFL
OrthoDBⁱ	EOG091G0JAH
PhylomeDBⁱ	Q8N6Q1
TreeFamⁱ	TF337140

Miscellaneous databases

ChiTaRSⁱ	TMCO5A human
GenomeRNAiⁱ	145942
Protein Ontology More...PROⁱ	PR:Q8N6Q1

Gene expression databases

Bgeeⁱ	ENSG00000166069 Expressed in 41 organ(s), highest expression level in testis
CleanExⁱ	HS_TMCO5A
ExpressionAtlasⁱ	Q8N6Q1 baseline and differential
Genevisibleⁱ	Q8N6Q1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026617 SMCO2/5
PANTHERⁱ	PTHR22422 PTHR22422, 1 hit
Pfamⁱ	View protein in Pfam PF14992 TMCO5, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TMC5A_HUMAN
Accessionⁱ	Q8N6Q1Primary (citable) accession number: Q8N6Q1 Secondary accession number(s): Q8NA63
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	March 1, 2004
	Last modified:	September 12, 2018
	This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N6Q1 (TMC5A_HUMAN)

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Transmembrane and coiled-coil domain-containing protein 5A

TMCO5A

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ