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Protein

Interleukin-22 receptor subunit alpha-1

Gene

IL22RA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.6 Publications

Miscellaneous

Failure of medical and surgical therapy in Chronic rhinosinusitis with nasal polyps is associated with decreased expression of IL22RA1.

GO - Molecular functioni

  • interferon receptor activity Source: UniProtKB
  • interleukin-20 binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ8N6P7
SIGNORiQ8N6P7

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22 receptor subunit alpha-1
Short name:
IL-22 receptor subunit alpha-1
Short name:
IL-22R-alpha-1
Short name:
IL-22RA1
Alternative name(s):
Cytokine receptor class-II member 9
Cytokine receptor family 2 member 9
Short name:
CRF2-9
ZcytoR11
Gene namesi
Name:IL22RA1
Synonyms:IL22R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142677.3
HGNCiHGNC:13700 IL22RA1
MIMi605457 gene
neXtProtiNX_Q8N6P7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini16 – 228ExtracellularSequence analysisAdd BLAST213
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 574CytoplasmicSequence analysisAdd BLAST325

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi58K → A: Strongly reduced response to IL22. 1 Publication1
Mutagenesisi60Y → A or R: Loss of response to IL22. 1 Publication1

Organism-specific databases

DisGeNETi58985
OpenTargetsiENSG00000142677
PharmGKBiPA29823

Polymorphism and mutation databases

BioMutaiIL22RA1
DMDMi74751067

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000032432016 – 574Interleukin-22 receptor subunit alpha-1Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 791 Publication
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 2171 Publication
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N6P7
PeptideAtlasiQ8N6P7
PRIDEiQ8N6P7
ProteomicsDBi72209

PTM databases

iPTMnetiQ8N6P7
PhosphoSitePlusiQ8N6P7

Expressioni

Tissue specificityi

Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients.5 Publications

Inductioni

By IFNG/IFN-gamma in keratinocytes.1 Publication

Gene expression databases

BgeeiENSG00000142677
CleanExiHS_IL22RA1
GenevisibleiQ8N6P7 HS

Interactioni

Subunit structurei

Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1 alone.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121855, 26 interactors
DIPiDIP-42031N
IntActiQ8N6P7, 6 interactors
MINTiQ8N6P7
STRINGi9606.ENSP00000270800

Structurei

Secondary structure

1574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 23Combined sources3
Beta strandi25 – 33Combined sources9
Beta strandi36 – 43Combined sources8
Beta strandi49 – 59Combined sources11
Beta strandi72 – 80Combined sources9
Helixi83 – 85Combined sources3
Beta strandi92 – 100Combined sources9
Beta strandi105 – 109Combined sources5
Helixi115 – 118Combined sources4
Beta strandi126 – 130Combined sources5
Beta strandi132 – 139Combined sources8
Beta strandi143 – 147Combined sources5
Beta strandi153 – 155Combined sources3
Helixi156 – 159Combined sources4
Beta strandi164 – 170Combined sources7
Beta strandi177 – 190Combined sources14
Beta strandi196 – 205Combined sources10
Helixi206 – 208Combined sources3
Beta strandi215 – 220Combined sources6

3D structure databases

ProteinModelPortaliQ8N6P7
SMRiQ8N6P7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N6P7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 124Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST108
Domaini141 – 221Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF2U Eukaryota
ENOG4111CQU LUCA
GeneTreeiENSGT00530000063352
HOGENOMiHOG000060223
HOVERGENiHBG104189
InParanoidiQ8N6P7
KOiK05138
OMAiSVQIEGH
OrthoDBiEOG091G068P
PhylomeDBiQ8N6P7
TreeFamiTF334107

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
PfamiView protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N6P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLLTILTV GSLAAHAPED PSDLLQHVKF QSSNFENILT WDSGPEGTPD
60 70 80 90 100
TVYSIEYKTY GERDWVAKKG CQRITRKSCN LTVETGNLTE LYYARVTAVS
110 120 130 140 150
AGGRSATKMT DRFSSLQHTT LKPPDVTCIS KVRSIQMIVH PTPTPIRAGD
160 170 180 190 200
GHRLTLEDIF HDLFYHLELQ VNRTYQMHLG GKQREYEFFG LTPDTEFLGT
210 220 230 240 250
IMICVPTWAK ESAPYMCRVK TLPDRTWTYS FSGAFLFSMG FLVAVLCYLS
260 270 280 290 300
YRYVTKPPAP PNSLNVQRVL TFQPLRFIQE HVLIPVFDLS GPSSLAQPVQ
310 320 330 340 350
YSQIRVSGPR EPAGAPQRHS LSEITYLGQP DISILQPSNV PPPQILSPLS
360 370 380 390 400
YAPNAAPEVG PPSYAPQVTP EAQFPFYAPQ AISKVQPSSY APQATPDSWP
410 420 430 440 450
PSYGVCMEGS GKDSPTGTLS SPKHLRPKGQ LQKEPPAGSC MLGGLSLQEV
460 470 480 490 500
TSLAMEESQE AKSLHQPLGI CTDRTSDPNV LHSGEEGTPQ YLKGQLPLLS
510 520 530 540 550
SVQIEGHPMS LPLQPPSRPC SPSDQGPSPW GLLESLVCPK DEAKSPAPET
560 570
SDLEQPTELD SLFRGLALTV QWES
Length:574
Mass (Da):63,077
Last modified:October 1, 2002 - v1
Checksum:iD46CC71D496F3420
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117Q → R in BAF84893 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039699130S → P. Corresponds to variant dbSNP:rs34900099Ensembl.1
Natural variantiVAR_039700205V → I. Corresponds to variant dbSNP:rs16829204Ensembl.1
Natural variantiVAR_039701209A → S. Corresponds to variant dbSNP:rs34379702Ensembl.1
Natural variantiVAR_039702222L → P. Corresponds to variant dbSNP:rs34782294Ensembl.1
Natural variantiVAR_039703407M → V. Corresponds to variant dbSNP:rs35401673Ensembl.1
Natural variantiVAR_039704518R → G2 PublicationsCorresponds to variant dbSNP:rs3795299Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286095 mRNA Translation: AAG22073.1
AK292204 mRNA Translation: BAF84893.1
AK313971 mRNA Translation: BAG36686.1
AL590683 Genomic DNA No translation available.
AL591178 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95111.1
BC029273 mRNA Translation: AAH29273.1
CCDSiCCDS247.1
RefSeqiNP_067081.2, NM_021258.3
UniGeneiHs.110915

Genome annotation databases

EnsembliENST00000270800; ENSP00000270800; ENSG00000142677
GeneIDi58985
KEGGihsa:58985
UCSCiuc001biq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiI22R1_HUMAN
AccessioniPrimary (citable) accession number: Q8N6P7
Secondary accession number(s): A8K839, B2R9Y9, Q9HB22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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