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Protein

Acyl-CoA-binding domain-containing protein 7

Gene

ACBD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15Acyl-CoA1
Binding sitei56Acyl-CoA1
Binding sitei75Acyl-CoA1

GO - Molecular functioni

Keywordsi

LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 7
Gene namesi
Name:ACBD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000176244.6
HGNCiHGNC:17715 ACBD7
neXtProtiNX_Q8N6N7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176244
PharmGKBiPA134884059

Polymorphism and mutation databases

BioMutaiACBD7
DMDMi74751066

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002475881 – 88Acyl-CoA-binding domain-containing protein 7Add BLAST88

Proteomic databases

EPDiQ8N6N7
MaxQBiQ8N6N7
PaxDbiQ8N6N7
PeptideAtlasiQ8N6N7
PRIDEiQ8N6N7
ProteomicsDBi72208

PTM databases

iPTMnetiQ8N6N7
PhosphoSitePlusiQ8N6N7

Expressioni

Gene expression databases

BgeeiENSG00000176244
CleanExiHS_ACBD7

Organism-specific databases

HPAiHPA043326
HPA062478

Interactioni

Protein-protein interaction databases

BioGridi135940, 12 interactors
IntActiQ8N6N7, 2 interactors
STRINGi9606.ENSP00000367453

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 13Combined sources12
Helixi14 – 16Combined sources3
Helixi23 – 37Combined sources15
Turni46 – 49Combined sources4
Helixi51 – 61Combined sources11
Turni62 – 65Combined sources4
Helixi68 – 86Combined sources19

3D structure databases

ProteinModelPortaliQ8N6N7
SMRiQ8N6N7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N6N7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 88ACBPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 34Acyl-CoA binding5

Sequence similaritiesi

Belongs to the ACBD7 family.Curated

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00840000129776
HOGENOMiHOG000261845
HOVERGENiHBG000398
InParanoidiQ8N6N7
OMAiWEAWNLQ
OrthoDBiEOG091G0NXJ
PhylomeDBiQ8N6N7
TreeFamiTF335802

Family and domain databases

Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS51228 ACB_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N6N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQADFDRA AEDVRKLKAR PDDGELKELY GLYKQAIVGD INIACPGMLD
60 70 80
LKGKAKWEAW NLKKGLSTED ATSAYISKAK ELIEKYGI
Length:88
Mass (Da):9,790
Last modified:October 1, 2002 - v1
Checksum:iF79EFF3BD7B2138B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095538 mRNA Translation: BAG53080.1
AL590365 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86243.1
BC029526 mRNA Translation: AAH29526.1
CCDSiCCDS31153.1
RefSeqiNP_001034933.1, NM_001039844.2
UniGeneiHs.644598

Genome annotation databases

EnsembliENST00000356189; ENSP00000367453; ENSG00000176244
GeneIDi414149
KEGGihsa:414149
UCSCiuc001inv.4 human

Similar proteinsi

Entry informationi

Entry nameiACBD7_HUMAN
AccessioniPrimary (citable) accession number: Q8N6N7
Secondary accession number(s): A6NCI2, B3KTG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: July 18, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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