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Entry version 115 (13 Feb 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Acyl-CoA-binding domain-containing protein 7

Gene

ACBD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds medium- and long-chain acyl-CoA esters.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei15Acyl-CoA1
Binding sitei56Acyl-CoA1
Binding sitei75Acyl-CoA1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACBD7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000176244.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17715 ACBD7

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N6N7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000176244

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134884059

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACBD7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751066

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002475881 – 88Acyl-CoA-binding domain-containing protein 7Add BLAST88

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N6N7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N6N7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N6N7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N6N7

PeptideAtlas

More...
PeptideAtlasi
Q8N6N7

PRoteomics IDEntifications database

More...
PRIDEi
Q8N6N7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72208

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N6N7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N6N7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176244 Expressed in 80 organ(s), highest expression level in Ammon's horn

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043326
HPA062478

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
135940, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N6N7, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367453

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EPYX-ray2.00A/B1-88[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8N6N7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N6N7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8N6N7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 88ACBPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 34Acyl-CoA binding5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ACBD7 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0817 Eukaryota
COG4281 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161184

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261845

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000398

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N6N7

Identification of Orthologs from Complete Genome Data

More...
OMAi
DINIACP

Database of Orthologous Groups

More...
OrthoDBi
1588000at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N6N7

TreeFam database of animal gene trees

More...
TreeFami
TF335802

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00887 ACBP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00689 ACOABINDINGP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47027 SSF47027, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51228 ACB_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N6N7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALQADFDRA AEDVRKLKAR PDDGELKELY GLYKQAIVGD INIACPGMLD
60 70 80
LKGKAKWEAW NLKKGLSTED ATSAYISKAK ELIEKYGI
Length:88
Mass (Da):9,790
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF79EFF3BD7B2138B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK095538 mRNA Translation: BAG53080.1
AL590365 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86243.1
BC029526 mRNA Translation: AAH29526.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31153.1

NCBI Reference Sequences

More...
RefSeqi
NP_001034933.1, NM_001039844.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.644598

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356189; ENSP00000367453; ENSG00000176244

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
414149

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:414149

UCSC genome browser

More...
UCSCi
uc001inv.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095538 mRNA Translation: BAG53080.1
AL590365 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86243.1
BC029526 mRNA Translation: AAH29526.1
CCDSiCCDS31153.1
RefSeqiNP_001034933.1, NM_001039844.2
UniGeneiHs.644598

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EPYX-ray2.00A/B1-88[»]
ProteinModelPortaliQ8N6N7
SMRiQ8N6N7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135940, 12 interactors
IntActiQ8N6N7, 2 interactors
STRINGi9606.ENSP00000367453

PTM databases

iPTMnetiQ8N6N7
PhosphoSitePlusiQ8N6N7

Polymorphism and mutation databases

BioMutaiACBD7
DMDMi74751066

Proteomic databases

EPDiQ8N6N7
jPOSTiQ8N6N7
MaxQBiQ8N6N7
PaxDbiQ8N6N7
PeptideAtlasiQ8N6N7
PRIDEiQ8N6N7
ProteomicsDBi72208

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
414149
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356189; ENSP00000367453; ENSG00000176244
GeneIDi414149
KEGGihsa:414149
UCSCiuc001inv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
414149
EuPathDBiHostDB:ENSG00000176244.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ACBD7

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0018171
HGNCiHGNC:17715 ACBD7
HPAiHPA043326
HPA062478
neXtProtiNX_Q8N6N7
OpenTargetsiENSG00000176244
PharmGKBiPA134884059

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00940000161184
HOGENOMiHOG000261845
HOVERGENiHBG000398
InParanoidiQ8N6N7
OMAiDINIACP
OrthoDBi1588000at2759
PhylomeDBiQ8N6N7
TreeFamiTF335802

Enzyme and pathway databases

ReactomeiR-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Miscellaneous databases

EvolutionaryTraceiQ8N6N7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
414149

Protein Ontology

More...
PROi
PR:Q8N6N7

Gene expression databases

BgeeiENSG00000176244 Expressed in 80 organ(s), highest expression level in Ammon's horn

Family and domain databases

Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS51228 ACB_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACBD7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N6N7
Secondary accession number(s): A6NCI2, B3KTG8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: February 13, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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