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UniProtKB - Q8N6N3 (CA052_HUMAN)
Protein
UPF0690 protein C1orf52
Gene
C1orf52
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q8N6N3 |
SignaLinki | Q8N6N3 |
Names & Taxonomyi
Protein namesi | Recommended name: UPF0690 protein C1orf52Alternative name(s): BCL10-associated gene protein |
Gene namesi | Name:C1orf52 Synonyms:BAG ORF Names:GM117 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24871, C1orf52 |
neXtProti | NX_Q8N6N3 |
VEuPathDBi | HostDB:ENSG00000162642 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 148423 |
OpenTargetsi | ENSG00000162642 |
PharmGKBi | PA142672503 |
Miscellaneous databases
Pharosi | Q8N6N3, Tdark |
Genetic variation databases
BioMutai | C1orf52 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254630 | 1 – 182 | UPF0690 protein C1orf52Add BLAST | 182 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 67 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 132 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 158 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8N6N3 |
jPOSTi | Q8N6N3 |
MassIVEi | Q8N6N3 |
MaxQBi | Q8N6N3 |
PaxDbi | Q8N6N3 |
PeptideAtlasi | Q8N6N3 |
PRIDEi | Q8N6N3 |
ProteomicsDBi | 72204 [Q8N6N3-1] 72205 [Q8N6N3-2] 72206 [Q8N6N3-3] |
PTM databases
GlyGeni | Q8N6N3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8N6N3 |
PhosphoSitePlusi | Q8N6N3 |
Expressioni
Tissue specificityi
Expressed in all tissues tested including heart, placenta, liver, skeletal muscle, kidney and pancreas. Weak expression in brain and lung.1 Publication
Gene expression databases
Bgeei | ENSG00000162642, Expressed in epithelium of mammary gland and 217 other tissues |
Genevisiblei | Q8N6N3, HS |
Organism-specific databases
HPAi | ENSG00000162642, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127149, 42 interactors |
IntActi | Q8N6N3, 23 interactors |
MINTi | Q8N6N3 |
STRINGi | 9606.ENSP00000419417 |
Miscellaneous databases
RNActi | Q8N6N3, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 67 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 100 – 182 | DisorderedSequence analysisAdd BLAST | 83 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 47 – 61 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 161 – 182 | Basic and acidic residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the UPF0690 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QVJV, Eukaryota |
GeneTreei | ENSGT00390000017398 |
HOGENOMi | CLU_127170_0_0_1 |
InParanoidi | Q8N6N3 |
OMAi | PRWFRTA |
OrthoDBi | 1478094at2759 |
PhylomeDBi | Q8N6N3 |
TreeFami | TF333299 |
Family and domain databases
InterProi | View protein in InterPro IPR029089, DUF4660 |
Pfami | View protein in Pfam PF15559, DUF4660, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8N6N3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAEEKDPLS YFAAYGSSSS GSSDEEDNIE PEETSRRTPD PAKSAGGCRN
60 70 80 90 100
KAEKRLPGPD ELFRSVTRPA FLYNPLNKQI DWERHVVKAP EEPPKEFKIW
110 120 130 140 150
KSNYVPPPET YTTEKKPPPP ELDMAIKWSN IYEDNGDDAP QNAKKARLLP
160 170 180
EGEETLESDD EKDEHTSKKR KVEPGEPAKK KK
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021267 | 93 – 100 | PPKEFKIW → LLPETPSL in isoform 3. 3 Publications | 8 | |
Alternative sequenceiVSP_021268 | 101 – 182 | Missing in isoform 3. 3 PublicationsAdd BLAST | 82 | |
Alternative sequenceiVSP_021269 | 159 – 167 | DDEKDEHTS → ALEDLEIQN in isoform 2. 1 Publication | 9 | |
Alternative sequenceiVSP_021270 | 168 – 182 | Missing in isoform 2. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF387611 mRNA Translation: AAL91352.1 AF387612 mRNA Translation: AAL91353.1 AY486331 mRNA Translation: AAS57906.1 AY486332 mRNA Translation: AAS57907.1 AK126929 mRNA Translation: BAG54401.1 AL590113 Genomic DNA No translation available. BC029538 mRNA Translation: AAH29538.1 |
CCDSi | CCDS703.1 [Q8N6N3-1] |
RefSeqi | NP_932343.1, NM_198077.3 [Q8N6N3-1] |
Genome annotation databases
Ensembli | ENST00000344356; ENSP00000345092; ENSG00000162642 [Q8N6N3-2] ENST00000471115; ENSP00000419417; ENSG00000162642 |
GeneIDi | 148423 |
KEGGi | hsa:148423 |
MANE-Selecti | ENST00000471115.6; ENSP00000419417.1; NM_198077.4; NP_932343.1 |
UCSCi | uc001dkv.4, human [Q8N6N3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF387611 mRNA Translation: AAL91352.1 AF387612 mRNA Translation: AAL91353.1 AY486331 mRNA Translation: AAS57906.1 AY486332 mRNA Translation: AAS57907.1 AK126929 mRNA Translation: BAG54401.1 AL590113 Genomic DNA No translation available. BC029538 mRNA Translation: AAH29538.1 |
CCDSi | CCDS703.1 [Q8N6N3-1] |
RefSeqi | NP_932343.1, NM_198077.3 [Q8N6N3-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127149, 42 interactors |
IntActi | Q8N6N3, 23 interactors |
MINTi | Q8N6N3 |
STRINGi | 9606.ENSP00000419417 |
PTM databases
GlyGeni | Q8N6N3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8N6N3 |
PhosphoSitePlusi | Q8N6N3 |
Genetic variation databases
BioMutai | C1orf52 |
Proteomic databases
EPDi | Q8N6N3 |
jPOSTi | Q8N6N3 |
MassIVEi | Q8N6N3 |
MaxQBi | Q8N6N3 |
PaxDbi | Q8N6N3 |
PeptideAtlasi | Q8N6N3 |
PRIDEi | Q8N6N3 |
ProteomicsDBi | 72204 [Q8N6N3-1] 72205 [Q8N6N3-2] 72206 [Q8N6N3-3] |
Protocols and materials databases
Antibodypediai | 33566, 47 antibodies from 9 providers |
DNASUi | 148423 |
Genome annotation databases
Ensembli | ENST00000344356; ENSP00000345092; ENSG00000162642 [Q8N6N3-2] ENST00000471115; ENSP00000419417; ENSG00000162642 |
GeneIDi | 148423 |
KEGGi | hsa:148423 |
MANE-Selecti | ENST00000471115.6; ENSP00000419417.1; NM_198077.4; NP_932343.1 |
UCSCi | uc001dkv.4, human [Q8N6N3-1] |
Organism-specific databases
CTDi | 148423 |
DisGeNETi | 148423 |
GeneCardsi | C1orf52 |
HGNCi | HGNC:24871, C1orf52 |
HPAi | ENSG00000162642, Low tissue specificity |
neXtProti | NX_Q8N6N3 |
OpenTargetsi | ENSG00000162642 |
PharmGKBi | PA142672503 |
VEuPathDBi | HostDB:ENSG00000162642 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVJV, Eukaryota |
GeneTreei | ENSGT00390000017398 |
HOGENOMi | CLU_127170_0_0_1 |
InParanoidi | Q8N6N3 |
OMAi | PRWFRTA |
OrthoDBi | 1478094at2759 |
PhylomeDBi | Q8N6N3 |
TreeFami | TF333299 |
Enzyme and pathway databases
PathwayCommonsi | Q8N6N3 |
SignaLinki | Q8N6N3 |
Miscellaneous databases
BioGRID-ORCSi | 148423, 22 hits in 1015 CRISPR screens |
GenomeRNAii | 148423 |
Pharosi | Q8N6N3, Tdark |
PROi | PR:Q8N6N3 |
RNActi | Q8N6N3, protein |
Gene expression databases
Bgeei | ENSG00000162642, Expressed in epithelium of mammary gland and 217 other tissues |
Genevisiblei | Q8N6N3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029089, DUF4660 |
Pfami | View protein in Pfam PF15559, DUF4660, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CA052_HUMAN | |
Accessioni | Q8N6N3Primary (citable) accession number: Q8N6N3 Secondary accession number(s): B3KX89, Q8TDK5, Q8TDK6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families