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Entry version 155 (29 Sep 2021)
Sequence version 2 (15 Mar 2005)
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Protein

Aminopeptidase O

Gene

AOPEP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Aminopeptidase which catalyzes the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates.

By similarity

Caution

A paper describing the function, enzyme activity and expression patterns of this protein has been retracted due to concerns of image manipulation.2 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi479Zinc; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei480Proton acceptorPROSITE-ProRule annotationBy similarity1
Metal bindingi483Zinc; catalyticBy similarity1
Metal bindingi502Zinc; catalyticBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei586Transition state stabilizerBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N6M6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q8N6M6

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M01.028

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aminopeptidase OCurated (EC:3.4.11.-By similarity)
Short name:
AP-O
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AOPEPImported
Synonyms:C9orf3, ONPEP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1361, AOPEP

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N6M6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000148120

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84909

Open Targets

More...
OpenTargetsi
ENSG00000148120

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25978

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N6M6, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3831223

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C9orf3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
61211648

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000950911 – 819Aminopeptidase OAdd BLAST819

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N6M6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N6M6

PeptideAtlas

More...
PeptideAtlasi
Q8N6M6

PRoteomics IDEntifications database

More...
PRIDEi
Q8N6M6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72195 [Q8N6M6-1]
72196 [Q8N6M6-2]
72197 [Q8N6M6-3]
72198 [Q8N6M6-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N6M6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N6M6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148120, Expressed in thoracic aorta and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N6M6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N6M6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000148120, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124346, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N6M6, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364464

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N6M6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi689 – 699Nucleolar localization signalBy similarityAdd BLAST11

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1047, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155211

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N6M6

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFMQVHY

Database of Orthologous Groups

More...
OrthoDBi
775595at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N6M6

TreeFam database of animal gene trees

More...
TreeFami
TF332004

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.390.10, 1 hit
1.25.40.320, 1 hit
2.60.40.1730, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042097, Aminopeptidase_N-like_N
IPR033577, AOPep
IPR016024, ARM-type_fold
IPR038502, M1_LTA-4_hydro/amino_C_sf
IPR015211, Peptidase_M1_C
IPR014782, Peptidase_M1_dom
IPR027268, Peptidase_M4/M1_CTD_sf

The PANTHER Classification System

More...
PANTHERi
PTHR46627, PTHR46627, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09127, Leuk-A4-hydro_C, 1 hit
PF01433, Peptidase_M1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01263, Leuk-A4-hydro_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF63737, SSF63737, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N6M6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDIQLDPARD DLPLMANTSH ILVKHYVLDL DVDFESQVIE GTIVLFLEDG
60 70 80 90 100
NRFKKQNSSI EEACQSESNK ACKFGMPEPC HIPVTNARTF SSEMEYNDFA
110 120 130 140 150
ICSKGEKDTS DKDGNHDNQE HASGISSSKY CCDTGNHGSE DFLLVLDCCD
160 170 180 190 200
LSVLKVEEVD VAAVPGLEKF TRSPELTVVS EEFRNQIVRE LVTLPANRWR
210 220 230 240 250
EQLDYYARCS QAPGCGELLF DTDTWSLQIR KTGAQTATDF PHAIRIWYKT
260 270 280 290 300
KPEGRSVTWT SDQSGRPCVY TVGSPINNRA LFPCQEPPVA MSTWQATVRA
310 320 330 340 350
AASFVVLMSG ENSAKPTQLW EECSSWYYYV TMPMPASTFT IAVGCWTEMK
360 370 380 390 400
METWSSNDLA TERPFSPSEA NFRHVGVCSH MEYPCRFQNA SATTQEIIPH
410 420 430 440 450
RVFAPVCLTG ACQETLLRLI PPCLSAAHSV LGAHPFSRLD VLIVPANFPS
460 470 480 490 500
LGMASPHIMF LSQSILTGGN HLCGTRLCHE IAHAWFGLAI GARDWTEEWL
510 520 530 540 550
SEGFATHLED VFWATAQQLA PYEAREQQEL RACLRWRRLQ DEMQCSPEEM
560 570 580 590 600
QVLRPSKDKT GHTSDSGASV IKHGLNPEKI FMQVHYLKGY FLLRFLAKRL
610 620 630 640 650
GDETYFSFLR KFVHTFHGQL ILSQDFLQML LENIPEEKRL ELSVENIYQD
660 670 680 690 700
WLESSGIPKP LQRERRAGAE CGLARQVRAE VTKWIGVNRR PRKRKRREKE
710 720 730 740 750
EVFEKLLPDQ LVLLLEHLLE QKTLSPRTLQ SLQRTYHLQD QDAEVRHRWC
760 770 780 790 800
ELIVKHKFTK AYKSVERFLQ EDQAMGVYLY GELMVSEDAR QQQLARRCFE
810
RTKEQMDRSS AQVVAEMLF
Length:819
Mass (Da):93,572
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EB4F19295B92674
GO
Isoform 2 (identifier: Q8N6M6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-553: Missing.

Show »
Length:720
Mass (Da):82,105
Checksum:i12A6A6169C56A627
GO
Isoform 3 (identifier: Q8N6M6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     555-565: PSKDKTGHTSD → FPHVGGCSGSFS
     566-819: Missing.

Show »
Length:566
Mass (Da):63,363
Checksum:i3E9D4D00E45C2A46
GO
Isoform 4 (identifier: Q8N6M6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-553: Missing.
     774-784: AMGVYLYGELM → VGVIFQQMGIL
     785-819: Missing.

Show »
Length:685
Mass (Da):77,937
Checksum:i57667BB61D258FD2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7M4H0Y7M4_HUMAN
Aminopeptidase O
AOPEP
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCM2H0YCM2_HUMAN
Aminopeptidase O
AOPEP
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSU0A0A0A0MSU0_HUMAN
Aminopeptidase O
AOPEP
508Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7A8H0Y7A8_HUMAN
Aminopeptidase O
AOPEP
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RBX4X6RBX4_HUMAN
Aminopeptidase O
AOPEP
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH20194 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB55210 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021511179V → A. Corresponds to variant dbSNP:rs16911679Ensembl.1
Natural variantiVAR_057053179V → I. Corresponds to variant dbSNP:rs16911679Ensembl.1
Natural variantiVAR_057054255R → Q. Corresponds to variant dbSNP:rs16911681Ensembl.1
Natural variantiVAR_057055386R → C. Corresponds to variant dbSNP:rs34557833Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013161455 – 553Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST99
Alternative sequenceiVSP_013162555 – 565PSKDKTGHTSD → FPHVGGCSGSFS in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_013163566 – 819Missing in isoform 3. 1 PublicationAdd BLAST254
Alternative sequenceiVSP_013164774 – 784AMGVYLYGELM → VGVIFQQMGIL in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_013165785 – 819Missing in isoform 4. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ560639 mRNA Translation: CAD90259.1
AK027581 mRNA Translation: BAB55210.1 Different initiation.
AK057450 mRNA Translation: BAB71491.1
AL157936 Genomic DNA No translation available.
AL353768 Genomic DNA No translation available.
AL354893 Genomic DNA No translation available.
BC020194 mRNA Translation: AAH20194.1 Different initiation.
BC029616 mRNA Translation: AAH29616.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55327.1 [Q8N6M6-3]
CCDS55328.1 [Q8N6M6-1]
CCDS6713.1 [Q8N6M6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001180258.1, NM_001193329.1 [Q8N6M6-1]
NP_001180260.1, NM_001193331.2 [Q8N6M6-3]
NP_116212.3, NM_032823.5 [Q8N6M6-2]
XP_006717369.1, XM_006717306.1 [Q8N6M6-1]
XP_016870719.1, XM_017015230.1 [Q8N6M6-1]
XP_016870720.1, XM_017015231.1 [Q8N6M6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000277198; ENSP00000277198; ENSG00000148120 [Q8N6M6-3]
ENST00000297979; ENSP00000297979; ENSG00000148120 [Q8N6M6-2]
ENST00000375315; ENSP00000364464; ENSG00000148120 [Q8N6M6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84909

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84909

UCSC genome browser

More...
UCSCi
uc004aux.3, human [Q8N6M6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ560639 mRNA Translation: CAD90259.1
AK027581 mRNA Translation: BAB55210.1 Different initiation.
AK057450 mRNA Translation: BAB71491.1
AL157936 Genomic DNA No translation available.
AL353768 Genomic DNA No translation available.
AL354893 Genomic DNA No translation available.
BC020194 mRNA Translation: AAH20194.1 Different initiation.
BC029616 mRNA Translation: AAH29616.1
CCDSiCCDS55327.1 [Q8N6M6-3]
CCDS55328.1 [Q8N6M6-1]
CCDS6713.1 [Q8N6M6-2]
RefSeqiNP_001180258.1, NM_001193329.1 [Q8N6M6-1]
NP_001180260.1, NM_001193331.2 [Q8N6M6-3]
NP_116212.3, NM_032823.5 [Q8N6M6-2]
XP_006717369.1, XM_006717306.1 [Q8N6M6-1]
XP_016870719.1, XM_017015230.1 [Q8N6M6-1]
XP_016870720.1, XM_017015231.1 [Q8N6M6-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124346, 20 interactors
IntActiQ8N6M6, 16 interactors
STRINGi9606.ENSP00000364464

Chemistry databases

ChEMBLiCHEMBL3831223

Protein family/group databases

MEROPSiM01.028

PTM databases

iPTMnetiQ8N6M6
PhosphoSitePlusiQ8N6M6

Genetic variation databases

BioMutaiC9orf3
DMDMi61211648

Proteomic databases

MassIVEiQ8N6M6
PaxDbiQ8N6M6
PeptideAtlasiQ8N6M6
PRIDEiQ8N6M6
ProteomicsDBi72195 [Q8N6M6-1]
72196 [Q8N6M6-2]
72197 [Q8N6M6-3]
72198 [Q8N6M6-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
985, 87 antibodies

The DNASU plasmid repository

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DNASUi
84909

Genome annotation databases

EnsembliENST00000277198; ENSP00000277198; ENSG00000148120 [Q8N6M6-3]
ENST00000297979; ENSP00000297979; ENSG00000148120 [Q8N6M6-2]
ENST00000375315; ENSP00000364464; ENSG00000148120 [Q8N6M6-1]
GeneIDi84909
KEGGihsa:84909
UCSCiuc004aux.3, human [Q8N6M6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84909
DisGeNETi84909

GeneCards: human genes, protein and diseases

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GeneCardsi
AOPEP
HGNCiHGNC:1361, AOPEP
HPAiENSG00000148120, Low tissue specificity
neXtProtiNX_Q8N6M6
OpenTargetsiENSG00000148120
PharmGKBiPA25978
VEuPathDBiHostDB:ENSG00000148120

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1047, Eukaryota
GeneTreeiENSGT00940000155211
InParanoidiQ8N6M6
OMAiPFMQVHY
OrthoDBi775595at2759
PhylomeDBiQ8N6M6
TreeFamiTF332004

Enzyme and pathway databases

PathwayCommonsiQ8N6M6
ReactomeiR-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins
SABIO-RKiQ8N6M6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84909, 3 hits in 1007 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
C9orf3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84909
PharosiQ8N6M6, Tbio

Protein Ontology

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PROi
PR:Q8N6M6
RNActiQ8N6M6, protein

Gene expression databases

BgeeiENSG00000148120, Expressed in thoracic aorta and 237 other tissues
ExpressionAtlasiQ8N6M6, baseline and differential
GenevisibleiQ8N6M6, HS

Family and domain databases

Gene3Di1.10.390.10, 1 hit
1.25.40.320, 1 hit
2.60.40.1730, 1 hit
InterProiView protein in InterPro
IPR042097, Aminopeptidase_N-like_N
IPR033577, AOPep
IPR016024, ARM-type_fold
IPR038502, M1_LTA-4_hydro/amino_C_sf
IPR015211, Peptidase_M1_C
IPR014782, Peptidase_M1_dom
IPR027268, Peptidase_M4/M1_CTD_sf
PANTHERiPTHR46627, PTHR46627, 1 hit
PfamiView protein in Pfam
PF09127, Leuk-A4-hydro_C, 1 hit
PF01433, Peptidase_M1, 1 hit
SMARTiView protein in SMART
SM01263, Leuk-A4-hydro_C, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF63737, SSF63737, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMPO_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N6M6
Secondary accession number(s): Q5T9B1
, Q5T9B3, Q5T9B4, Q8WUL6, Q96M23, Q96SS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 29, 2021
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. SIMILARITY comments
    Index of protein domains and families
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