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UniProtKB - Q8N6M6 (AMPO_HUMAN)

Entry version 142 (31 Jul 2019)
Sequence version 2 (15 Mar 2005)
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Protein

Aminopeptidase O

Gene

AOPEP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.1 Publication

Caution

The article describing the function, tissue specificity, activity regulation and biophysicochemical properties has been retracted due to concerns of image manipulation but the authors stand by the validity of the main results and conclusions.1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Strongly inhibited by ophenanthroline, a metalloprotease inhibitor. Inhibited by arphamenine A, a potent inhibitor of aminopeptidases. Not affected by AEBSF and E-64, which are common inhibitors of serine- and cysteine-proteases, respectively.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=6 µM for Arg-AMC1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi479Zinc; catalyticBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei480Proton acceptorBy similarity1
    Metal bindingi483Zinc; catalyticBy similarity1
    Metal bindingi502Zinc; catalyticBy similarity1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei586Transition state stabilizerBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q8N6M6

    Protein family/group databases

    MEROPS protease database

    More...    MEROPSi    		M01.028

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Aminopeptidase OCurated (EC:3.4.11.-1 Publication)
    Short name:
    AP-O
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:AOPEPImported
    Synonyms:C9orf3, ONPEP
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:1361 AOPEP

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q8N6M6

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		84909

    Open Targets

    More...    OpenTargetsi    		ENSG00000148120

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA25978

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL3831223

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		C9orf3

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		61211648

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000950911 – 819Aminopeptidase OAdd BLAST819

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q8N6M6

    PeptideAtlas

    More...    PeptideAtlasi    		Q8N6M6

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q8N6M6

    ProteomicsDB human proteome resource

    More...    ProteomicsDBi    		72195 [Q8N6M6-1]
    72196 [Q8N6M6-2]
    72197 [Q8N6M6-3]
    72198 [Q8N6M6-4]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q8N6M6

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q8N6M6

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Predominantly expressed in pancreas, placenta, liver, testis and heart. Expressed at lower level in brain, lung and kidney.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000148120 Expressed in 226 organ(s), highest expression level in thoracic aorta

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q8N6M6 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q8N6M6 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		HPA004633
    HPA072729

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		124346, 9 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q8N6M6, 11 interactors

    Molecular INTeraction database

    More...    MINTi    		Q8N6M6

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000364464

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi689 – 699Nucleolar localization signalBy similarityAdd BLAST11

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M1 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1047 Eukaryota
    COG0308 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000155211

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q8N6M6

    KEGG Orthology (KO)

    More...    KOi    		K09606

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		CFELTKE

    Database of Orthologous Groups

    More...    OrthoDBi    		775595at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q8N6M6

    TreeFam database of animal gene trees

    More...    TreeFami    		TF332004

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd09599 M1_LTA4H, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		1.25.40.320, 1 hit
    2.60.40.1730, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR042097 Aminopeptidase_N-like_N
    IPR033577 AOPep
    IPR016024 ARM-type_fold
    IPR038502 M1_LTA-4_hydro/amino_C_sf
    IPR034015 M1_LTA4H
    IPR015211 Peptidase_M1_C
    IPR014782 Peptidase_M1_dom

    The PANTHER Classification System

    More...    PANTHERi    		PTHR46627 PTHR46627, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF09127 Leuk-A4-hydro_C, 1 hit
    PF01433 Peptidase_M1, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM01263 Leuk-A4-hydro_C, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF48371 SSF48371, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8N6M6-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MDIQLDPARD DLPLMANTSH ILVKHYVLDL DVDFESQVIE GTIVLFLEDG 
            60         70         80         90        100
    NRFKKQNSSI EEACQSESNK ACKFGMPEPC HIPVTNARTF SSEMEYNDFA 
           110        120        130        140        150
    ICSKGEKDTS DKDGNHDNQE HASGISSSKY CCDTGNHGSE DFLLVLDCCD 
           160        170        180        190        200
    LSVLKVEEVD VAAVPGLEKF TRSPELTVVS EEFRNQIVRE LVTLPANRWR 
           210        220        230        240        250
    EQLDYYARCS QAPGCGELLF DTDTWSLQIR KTGAQTATDF PHAIRIWYKT 
           260        270        280        290        300
    KPEGRSVTWT SDQSGRPCVY TVGSPINNRA LFPCQEPPVA MSTWQATVRA 
           310        320        330        340        350
    AASFVVLMSG ENSAKPTQLW EECSSWYYYV TMPMPASTFT IAVGCWTEMK 
           360        370        380        390        400
    METWSSNDLA TERPFSPSEA NFRHVGVCSH MEYPCRFQNA SATTQEIIPH 
           410        420        430        440        450
    RVFAPVCLTG ACQETLLRLI PPCLSAAHSV LGAHPFSRLD VLIVPANFPS 
           460        470        480        490        500
    LGMASPHIMF LSQSILTGGN HLCGTRLCHE IAHAWFGLAI GARDWTEEWL 
           510        520        530        540        550
    SEGFATHLED VFWATAQQLA PYEAREQQEL RACLRWRRLQ DEMQCSPEEM 
           560        570        580        590        600
    QVLRPSKDKT GHTSDSGASV IKHGLNPEKI FMQVHYLKGY FLLRFLAKRL 
           610        620        630        640        650
    GDETYFSFLR KFVHTFHGQL ILSQDFLQML LENIPEEKRL ELSVENIYQD 
           660        670        680        690        700
    WLESSGIPKP LQRERRAGAE CGLARQVRAE VTKWIGVNRR PRKRKRREKE 
           710        720        730        740        750
    EVFEKLLPDQ LVLLLEHLLE QKTLSPRTLQ SLQRTYHLQD QDAEVRHRWC 
           760        770        780        790        800
    ELIVKHKFTK AYKSVERFLQ EDQAMGVYLY GELMVSEDAR QQQLARRCFE 
           810 
    RTKEQMDRSS AQVVAEMLF
    Length:819
    Mass (Da):93,572
    Last modified:March 15, 2005 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EB4F19295B92674
    GO
    Isoform 2 (identifier: Q8N6M6-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         455-553: Missing.

    Show »
    Length:720
    Mass (Da):82,105
    Checksum:i12A6A6169C56A627
    GO
    Isoform 3 (identifier: Q8N6M6-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         555-565: PSKDKTGHTSD → FPHVGGCSGSFS
         566-819: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:566
    Mass (Da):63,363
    Checksum:i3E9D4D00E45C2A46
    GO
    Isoform 4 (identifier: Q8N6M6-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         455-553: Missing.
         774-784: AMGVYLYGELM → VGVIFQQMGIL
         785-819: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:685
    Mass (Da):77,937
    Checksum:i57667BB61D258FD2
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    H0Y7M4H0Y7M4_HUMAN
    Aminopeptidase O
    AOPEP
    		184Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YCM2H0YCM2_HUMAN
    Aminopeptidase O
    AOPEP
    		180Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0A0MSU0A0A0A0MSU0_HUMAN
    Aminopeptidase O
    AOPEP
    		508Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0A0MST7A0A0A0MST7_HUMAN
    Aminopeptidase O
    AOPEP
    		601Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0Y7A8H0Y7A8_HUMAN
    Aminopeptidase O
    AOPEP
    		145Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    X6RBX4X6RBX4_HUMAN
    Aminopeptidase O
    AOPEP
    		140Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH20194 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
    The sequence BAB55210 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021511179V → A. Corresponds to variant dbSNP:rs16911679Ensembl.1
    Natural variantiVAR_057053179V → I. Corresponds to variant dbSNP:rs16911679Ensembl.1
    Natural variantiVAR_057054255R → Q. Corresponds to variant dbSNP:rs16911681Ensembl.1
    Natural variantiVAR_057055386R → C. Corresponds to variant dbSNP:rs34557833Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013161455 – 553Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST99
    Alternative sequenceiVSP_013162555 – 565PSKDKTGHTSD → FPHVGGCSGSFS in isoform 3. 1 PublicationAdd BLAST11
    Alternative sequenceiVSP_013163566 – 819Missing in isoform 3. 1 PublicationAdd BLAST254
    Alternative sequenceiVSP_013164774 – 784AMGVYLYGELM → VGVIFQQMGIL in isoform 4. 1 PublicationAdd BLAST11
    Alternative sequenceiVSP_013165785 – 819Missing in isoform 4. 1 PublicationAdd BLAST35

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AJ560639 mRNA Translation: CAD90259.1
    AK027581 mRNA Translation: BAB55210.1 Different initiation.
    AK057450 mRNA Translation: BAB71491.1
    AL157936 Genomic DNA No translation available.
    AL353768 Genomic DNA No translation available.
    AL354893 Genomic DNA No translation available.
    BC020194 mRNA Translation: AAH20194.1 Different initiation.
    BC029616 mRNA Translation: AAH29616.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS55327.1 [Q8N6M6-3]
    CCDS55328.1 [Q8N6M6-1]
    CCDS6713.1 [Q8N6M6-2]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001180258.1, NM_001193329.1 [Q8N6M6-1]
    NP_001180260.1, NM_001193331.2 [Q8N6M6-3]
    NP_116212.3, NM_032823.5 [Q8N6M6-2]
    XP_006717369.1, XM_006717306.1 [Q8N6M6-1]
    XP_016870719.1, XM_017015230.1 [Q8N6M6-1]
    XP_016870720.1, XM_017015231.1 [Q8N6M6-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000277198; ENSP00000277198; ENSG00000148120 [Q8N6M6-3]
    ENST00000297979; ENSP00000297979; ENSG00000148120 [Q8N6M6-2]
    ENST00000375315; ENSP00000364464; ENSG00000148120 [Q8N6M6-1]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		84909

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:84909

    UCSC genome browser

    More...    UCSCi    		uc004aux.3 human [Q8N6M6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AJ560639 mRNA Translation: CAD90259.1
    AK027581 mRNA Translation: BAB55210.1 Different initiation.
    AK057450 mRNA Translation: BAB71491.1
    AL157936 Genomic DNA No translation available.
    AL353768 Genomic DNA No translation available.
    AL354893 Genomic DNA No translation available.
    BC020194 mRNA Translation: AAH20194.1 Different initiation.
    BC029616 mRNA Translation: AAH29616.1
    CCDSiCCDS55327.1 [Q8N6M6-3]
    CCDS55328.1 [Q8N6M6-1]
    CCDS6713.1 [Q8N6M6-2]
    RefSeqiNP_001180258.1, NM_001193329.1 [Q8N6M6-1]
    NP_001180260.1, NM_001193331.2 [Q8N6M6-3]
    NP_116212.3, NM_032823.5 [Q8N6M6-2]
    XP_006717369.1, XM_006717306.1 [Q8N6M6-1]
    XP_016870719.1, XM_017015230.1 [Q8N6M6-1]
    XP_016870720.1, XM_017015231.1 [Q8N6M6-2]

    3D structure databases

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    SWISS-MODEL Interactive Workspace

    More...    SWISS-MODEL-Workspacei    		Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi124346, 9 interactors
    IntActiQ8N6M6, 11 interactors
    MINTiQ8N6M6
    STRINGi9606.ENSP00000364464

    Chemistry databases

    ChEMBLiCHEMBL3831223

    Protein family/group databases

    MEROPSiM01.028

    PTM databases

    iPTMnetiQ8N6M6
    PhosphoSitePlusiQ8N6M6

    Polymorphism and mutation databases

    BioMutaiC9orf3
    DMDMi61211648

    Proteomic databases

    PaxDbiQ8N6M6
    PeptideAtlasiQ8N6M6
    PRIDEiQ8N6M6
    ProteomicsDBi72195 [Q8N6M6-1]
    72196 [Q8N6M6-2]
    72197 [Q8N6M6-3]
    72198 [Q8N6M6-4]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000277198; ENSP00000277198; ENSG00000148120 [Q8N6M6-3]
    ENST00000297979; ENSP00000297979; ENSG00000148120 [Q8N6M6-2]
    ENST00000375315; ENSP00000364464; ENSG00000148120 [Q8N6M6-1]
    GeneIDi84909
    KEGGihsa:84909
    UCSCiuc004aux.3 human [Q8N6M6-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		84909
    DisGeNETi84909

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		C9orf3
    HGNCiHGNC:1361 AOPEP
    HPAiHPA004633
    HPA072729
    neXtProtiNX_Q8N6M6
    OpenTargetsiENSG00000148120
    PharmGKBiPA25978

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG1047 Eukaryota
    COG0308 LUCA
    GeneTreeiENSGT00940000155211
    InParanoidiQ8N6M6
    KOiK09606
    OMAiCFELTKE
    OrthoDBi775595at2759
    PhylomeDBiQ8N6M6
    TreeFamiTF332004

    Enzyme and pathway databases

    ReactomeiR-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
    SABIO-RKiQ8N6M6

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		C9orf3 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		84909

    Protein Ontology

    More...    PROi    		PR:Q8N6M6

    Gene expression databases

    BgeeiENSG00000148120 Expressed in 226 organ(s), highest expression level in thoracic aorta
    ExpressionAtlasiQ8N6M6 baseline and differential
    GenevisibleiQ8N6M6 HS

    Family and domain databases

    CDDicd09599 M1_LTA4H, 1 hit
    Gene3Di1.25.40.320, 1 hit
    2.60.40.1730, 1 hit
    InterProiView protein in InterPro
    IPR042097 Aminopeptidase_N-like_N
    IPR033577 AOPep
    IPR016024 ARM-type_fold
    IPR038502 M1_LTA-4_hydro/amino_C_sf
    IPR034015 M1_LTA4H
    IPR015211 Peptidase_M1_C
    IPR014782 Peptidase_M1_dom
    PANTHERiPTHR46627 PTHR46627, 1 hit
    PfamiView protein in Pfam
    PF09127 Leuk-A4-hydro_C, 1 hit
    PF01433 Peptidase_M1, 1 hit
    SMARTiView protein in SMART
    SM01263 Leuk-A4-hydro_C, 1 hit
    SUPFAMiSSF48371 SSF48371, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMPO_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N6M6
    Secondary accession number(s): Q5T9B1
    , Q5T9B3, Q5T9B4, Q8WUL6, Q96M23, Q96SS1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: July 31, 2019
    This is version 142 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    5. Peptidase families
      Classification of peptidase families and list of entries
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