UniProtKB - Q8N6M5 (ALLC_HUMAN)
Protein
Probable allantoicase
Gene
ALLC
Organism
Homo sapiens (Human)
Status
Functioni
The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.
Catalytic activityi
- EC:3.5.3.4
GO - Molecular functioni
- allantoicase activity Source: GO_Central
GO - Biological processi
- allantoin catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
PathwayCommonsi | Q8N6M5 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ALLC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17377, ALLC |
MIMi | 612396, gene |
neXtProti | NX_Q8N6M5 |
VEuPathDBi | HostDB:ENSG00000151360.9 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55821 |
OpenTargetsi | ENSG00000151360 |
PharmGKBi | PA24720 |
Miscellaneous databases
Pharosi | Q8N6M5, Tdark |
Genetic variation databases
BioMutai | ALLC |
DMDMi | 327478594 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000205905 | 1 – 391 | Probable allantoicaseAdd BLAST | 391 |
Proteomic databases
PaxDbi | Q8N6M5 |
PeptideAtlasi | Q8N6M5 |
PRIDEi | Q8N6M5 |
ProteomicsDBi | 5505 72193 [Q8N6M5-1] 72194 [Q8N6M5-2] |
PTM databases
iPTMneti | Q8N6M5 |
PhosphoSitePlusi | Q8N6M5 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120929, 2 interactors |
IntActi | Q8N6M5, 2 interactors |
MINTi | Q8N6M5 |
STRINGi | 9606.ENSP00000252505 |
Miscellaneous databases
RNActi | Q8N6M5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the allantoicase family.Curated
Phylogenomic databases
eggNOGi | KOG4145, Eukaryota |
GeneTreei | ENSGT00390000001793 |
HOGENOMi | CLU_038797_1_2_1 |
InParanoidi | Q8N6M5 |
OMAi | TLHFKGN |
OrthoDBi | 563639at2759 |
PhylomeDBi | Q8N6M5 |
TreeFami | TF324677 |
Family and domain databases
Gene3Di | 2.60.120.260, 2 hits |
HAMAPi | MF_00813, Allantoicase, 1 hit |
InterProi | View protein in InterPro IPR005164, Allantoicase IPR015908, Allantoicase_dom IPR008979, Galactose-bd-like_sf |
PANTHERi | PTHR12045, PTHR12045, 1 hit |
Pfami | View protein in Pfam PF03561, Allantoicase, 2 hits |
PIRSFi | PIRSF016516, Allantoicase, 1 hit |
SUPFAMi | SSF49785, SSF49785, 2 hits |
TIGRFAMsi | TIGR02961, allantoicase, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8N6M5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDMASESVGG KILFATDDFF APAENLIKSD SPCFKEHEYT EFGKWMDGWE
60 70 80 90 100
TRRKRIPGHD WCVLRLGIQG VIRGFDVDVS YFTGDYAPRV SIQAANLEED
110 120 130 140 150
KLPEIPERGT RTGAAATPEE FEAIAELKSD DWSYLVPMTE LKPGNPASGH
160 170 180 190 200
NYFLVNSQQR WTHIRLNIFP DGGIARLRVF GTGQKDWTAT DPKEPADLVA
210 220 230 240 250
IAFGGVCVGF SNAKFGHPNN IIGVGGAKSM ADGWETARRL DRPPILENDE
260 270 280 290 300
NGILLVPGCE WAVFRLAHPG VITRIEIDTK YFEGNAPDSC KVDGCILTTQ
310 320 330 340 350
EEEAVIRQKW ILPAHKWKPL LPVTKLSPNQ SHLFDSLTLE LQDVITHARL
360 370 380 390
TIVPDGGVSR LRLRGFPSSI CLLRPREKPM LKFSVSFKAN P
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 110 | T → I in AAH29652 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 110 | T → I in AAK72970 (PubMed:12036579).Curated | 1 | |
Sequence conflicti | 127 | L → P in AAK72970 (PubMed:12036579).Curated | 1 | |
Sequence conflicti | 301 | Missing in AAF67097 (PubMed:11054555).Curated | 1 | |
Sequence conflicti | 301 | Missing in AAH29652 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 301 | Missing in AAK72970 (PubMed:12036579).Curated | 1 |
Polymorphismi
Product of a polymorphic gene which also produces a longer 410-residue protein due to a polymorphism which affects Met-1, resulting in a longer protein starting at an upstream Met.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080299 | 1 | M → MADAPKEGRLTRFLDFTQLM. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015618 | 1 – 229 | Missing in isoform 2. 2 PublicationsAdd BLAST | 229 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF215924 mRNA Translation: AAF67097.1 AK302299 mRNA Translation: BAG63639.1 AC010907 Genomic DNA Translation: AAY24236.1 CH471053 Genomic DNA Translation: EAX01050.1 BC029652 mRNA Translation: AAH29652.1 BC035356 mRNA Translation: AAH35356.1 AF395820 mRNA Translation: AAK72970.1 |
CCDSi | CCDS46223.1 [Q8N6M5-1] |
RefSeqi | NP_060906.3, NM_018436.3 [Q8N6M5-1] |
Genome annotation databases
Ensembli | ENST00000252505; ENSP00000252505; ENSG00000151360 [Q8N6M5-1] |
GeneIDi | 55821 |
KEGGi | hsa:55821 |
UCSCi | uc010ewt.4, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF215924 mRNA Translation: AAF67097.1 AK302299 mRNA Translation: BAG63639.1 AC010907 Genomic DNA Translation: AAY24236.1 CH471053 Genomic DNA Translation: EAX01050.1 BC029652 mRNA Translation: AAH29652.1 BC035356 mRNA Translation: AAH35356.1 AF395820 mRNA Translation: AAK72970.1 |
CCDSi | CCDS46223.1 [Q8N6M5-1] |
RefSeqi | NP_060906.3, NM_018436.3 [Q8N6M5-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120929, 2 interactors |
IntActi | Q8N6M5, 2 interactors |
MINTi | Q8N6M5 |
STRINGi | 9606.ENSP00000252505 |
PTM databases
iPTMneti | Q8N6M5 |
PhosphoSitePlusi | Q8N6M5 |
Genetic variation databases
BioMutai | ALLC |
DMDMi | 327478594 |
Proteomic databases
PaxDbi | Q8N6M5 |
PeptideAtlasi | Q8N6M5 |
PRIDEi | Q8N6M5 |
ProteomicsDBi | 5505 72193 [Q8N6M5-1] 72194 [Q8N6M5-2] |
Protocols and materials databases
Antibodypediai | 26390, 92 antibodies |
Genome annotation databases
Ensembli | ENST00000252505; ENSP00000252505; ENSG00000151360 [Q8N6M5-1] |
GeneIDi | 55821 |
KEGGi | hsa:55821 |
UCSCi | uc010ewt.4, human |
Organism-specific databases
CTDi | 55821 |
DisGeNETi | 55821 |
GeneCardsi | ALLC |
HGNCi | HGNC:17377, ALLC |
MIMi | 612396, gene |
neXtProti | NX_Q8N6M5 |
OpenTargetsi | ENSG00000151360 |
PharmGKBi | PA24720 |
VEuPathDBi | HostDB:ENSG00000151360.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4145, Eukaryota |
GeneTreei | ENSGT00390000001793 |
HOGENOMi | CLU_038797_1_2_1 |
InParanoidi | Q8N6M5 |
OMAi | TLHFKGN |
OrthoDBi | 563639at2759 |
PhylomeDBi | Q8N6M5 |
TreeFami | TF324677 |
Enzyme and pathway databases
PathwayCommonsi | Q8N6M5 |
Miscellaneous databases
BioGRID-ORCSi | 55821, 8 hits in 987 CRISPR screens |
ChiTaRSi | ALLC, human |
GenomeRNAii | 55821 |
Pharosi | Q8N6M5, Tdark |
PROi | PR:Q8N6M5 |
RNActi | Q8N6M5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151360, Expressed in sperm and 94 other tissues |
Family and domain databases
Gene3Di | 2.60.120.260, 2 hits |
HAMAPi | MF_00813, Allantoicase, 1 hit |
InterProi | View protein in InterPro IPR005164, Allantoicase IPR015908, Allantoicase_dom IPR008979, Galactose-bd-like_sf |
PANTHERi | PTHR12045, PTHR12045, 1 hit |
Pfami | View protein in Pfam PF03561, Allantoicase, 2 hits |
PIRSFi | PIRSF016516, Allantoicase, 1 hit |
SUPFAMi | SSF49785, SSF49785, 2 hits |
TIGRFAMsi | TIGR02961, allantoicase, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ALLC_HUMAN | |
Accessioni | Q8N6M5Primary (citable) accession number: Q8N6M5 Secondary accession number(s): B4DY77 Q9NZA7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2005 |
Last sequence update: | April 25, 2018 | |
Last modified: | April 7, 2021 | |
This is version 134 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families