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Protein

Fat storage-inducing transmembrane protein 2

Gene

FITM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization.2 Publications

GO - Biological processi

  • cellular triglyceride homeostasis Source: BHF-UCL
  • cytoskeleton organization Source: UniProtKB
  • lipid droplet organization Source: UniProtKB
  • phospholipid biosynthetic process Source: GO_Central
  • positive regulation of sequestering of triglyceride Source: BHF-UCL
  • regulation of cell morphogenesis Source: UniProtKB
  • regulation of triglyceride biosynthetic process Source: BHF-UCL
  • sequestering of triglyceride Source: Ensembl

Enzyme and pathway databases

ReactomeiR-HSA-8964572 Lipid particle organization

Protein family/group databases

TCDBi9.B.287.1.1 the fat storage-inducing transmembrane protein 2 (fit2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Fat storage-inducing transmembrane protein 2
Alternative name(s):
Fat-inducing protein 2
Gene namesi
Name:FITM2
Synonyms:C20orf142, FIT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000197296.5
HGNCiHGNC:16135 FITM2
MIMi612029 gene
neXtProtiNX_Q8N6M3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 57ExtracellularSequence analysisAdd BLAST13
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 93CytoplasmicSequence analysisAdd BLAST15
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 145ExtracellularSequence analysisAdd BLAST31
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 190CytoplasmicSequence analysisAdd BLAST24
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 218ExtracellularSequence analysis7
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 262CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197296
PharmGKBiPA25685

Polymorphism and mutation databases

BioMutaiFITM2
DMDMi28212210

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000210351 – 262Fat storage-inducing transmembrane protein 2Add BLAST262

Proteomic databases

EPDiQ8N6M3
MaxQBiQ8N6M3
PaxDbiQ8N6M3
PeptideAtlasiQ8N6M3
PRIDEiQ8N6M3
ProteomicsDBi72192

PTM databases

iPTMnetiQ8N6M3
PhosphoSitePlusiQ8N6M3

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000197296 Expressed in 197 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_C20orf142
GenevisibleiQ8N6M3 HS

Interactioni

Protein-protein interaction databases

BioGridi126125, 33 interactors
IntActiQ8N6M3, 4 interactors
MINTiQ8N6M3
STRINGi9606.ENSP00000380037

Structurei

3D structure databases

ProteinModelPortaliQ8N6M3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FIT family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3750 Eukaryota
ENOG4111CNJ LUCA
GeneTreeiENSGT00530000063693
HOGENOMiHOG000089942
InParanoidiQ8N6M3
OMAiERCAWFL
OrthoDBiEOG091G0F0P
PhylomeDBiQ8N6M3

Family and domain databases

InterProiView protein in InterPro
IPR019388 FIT
PANTHERiPTHR23129 PTHR23129, 1 hit
PfamiView protein in Pfam
PF10261 Scs3p, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N6M3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHLERCEWL LRGTLVRAAV RRYLPWALVA SMLAGSLLKE LSPLPESYLS
60 70 80 90 100
NKRNVLNVYF VKVAWAWTFC LLLPFIALTN YHLTGKAGLV LRRLSTLLVG
110 120 130 140 150
TAIWYICTSI FSNIEHYTGS CYQSPALEGV RKEHQSKQQC HQEGGFWHGF
160 170 180 190 200
DISGHSFLLT FCALMIVEEM SVLHEVKTDR SHCLHTAITT LVVALGILTF
210 220 230 240 250
IWVLMFLCTA VYFHNLSQKV FGTLFGLLSW YGTYGFWYPK AFSPGLPPQS
260
CSLNLKQDSY KK
Length:262
Mass (Da):29,855
Last modified:October 1, 2002 - v1
Checksum:i3822E7CEFBB6CDEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117382 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75929.1
BC130446 mRNA Translation: AAI30447.1
BC136640 mRNA Translation: AAI36641.1
BC029662 mRNA No translation available.
CCDSiCCDS33473.1
RefSeqiNP_001073941.1, NM_001080472.3
UniGeneiHs.632269

Genome annotation databases

EnsembliENST00000396825; ENSP00000380037; ENSG00000197296
GeneIDi128486
KEGGihsa:128486
UCSCiuc002xlr.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117382 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75929.1
BC130446 mRNA Translation: AAI30447.1
BC136640 mRNA Translation: AAI36641.1
BC029662 mRNA No translation available.
CCDSiCCDS33473.1
RefSeqiNP_001073941.1, NM_001080472.3
UniGeneiHs.632269

3D structure databases

ProteinModelPortaliQ8N6M3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126125, 33 interactors
IntActiQ8N6M3, 4 interactors
MINTiQ8N6M3
STRINGi9606.ENSP00000380037

Protein family/group databases

TCDBi9.B.287.1.1 the fat storage-inducing transmembrane protein 2 (fit2) family

PTM databases

iPTMnetiQ8N6M3
PhosphoSitePlusiQ8N6M3

Polymorphism and mutation databases

BioMutaiFITM2
DMDMi28212210

Proteomic databases

EPDiQ8N6M3
MaxQBiQ8N6M3
PaxDbiQ8N6M3
PeptideAtlasiQ8N6M3
PRIDEiQ8N6M3
ProteomicsDBi72192

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396825; ENSP00000380037; ENSG00000197296
GeneIDi128486
KEGGihsa:128486
UCSCiuc002xlr.2 human

Organism-specific databases

CTDi128486
EuPathDBiHostDB:ENSG00000197296.5
GeneCardsiFITM2
HGNCiHGNC:16135 FITM2
MIMi612029 gene
neXtProtiNX_Q8N6M3
OpenTargetsiENSG00000197296
PharmGKBiPA25685
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3750 Eukaryota
ENOG4111CNJ LUCA
GeneTreeiENSGT00530000063693
HOGENOMiHOG000089942
InParanoidiQ8N6M3
OMAiERCAWFL
OrthoDBiEOG091G0F0P
PhylomeDBiQ8N6M3

Enzyme and pathway databases

ReactomeiR-HSA-8964572 Lipid particle organization

Miscellaneous databases

ChiTaRSiFITM2 human
GenomeRNAii128486
PROiPR:Q8N6M3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197296 Expressed in 197 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_C20orf142
GenevisibleiQ8N6M3 HS

Family and domain databases

InterProiView protein in InterPro
IPR019388 FIT
PANTHERiPTHR23129 PTHR23129, 1 hit
PfamiView protein in Pfam
PF10261 Scs3p, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFITM2_HUMAN
AccessioniPrimary (citable) accession number: Q8N6M3
Secondary accession number(s): A1L492
, B9EGQ4, Q5TE59, Q9H3Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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