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Entry version 128 (13 Feb 2019)
Sequence version 2 (29 Apr 2008)
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Protein

Protein KASH5

Gene

CCDC155

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processMeiosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein KASH5
Alternative name(s):
Coiled-coil domain-containing protein 155
KASH domain-containing protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC155
Synonyms:KASH5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000161609.9

Human Gene Nomenclature Database

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HGNCi
HGNC:26520 CCDC155

Online Mendelian Inheritance in Man (OMIM)

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MIMi
618125 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8N6L0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 521CytoplasmicSequence analysisAdd BLAST521
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei522 – 542Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini543 – 562Perinuclear spaceSequence analysisAdd BLAST20

Keywords - Cellular componenti

Chromosome, Membrane, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000161609

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381684

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC155

Domain mapping of disease mutations (DMDM)

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DMDMi
187671940

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003315271 – 562Protein KASH5Add BLAST562

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N6L0

PeptideAtlas

More...
PeptideAtlasi
Q8N6L0

PRoteomics IDEntifications database

More...
PRIDEi
Q8N6L0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72187

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000161609 Expressed in 52 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N6L0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N6L0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019937
HPA019940

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Core component the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents is giving rise to specific assemblies. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. Interacts (via the last 22 AA) with SUN1; this interaction mediates its telomere localization by forming a SUN1:KASH5 LINC complex. Component of a probable SUN2:KASH5 LINC complex. Self-associates. Interacts with DYNC1H1, DCTN1, DYNC1I1/2 and PAFAH1B1; suggesting the association with the dynein-dynactin motor complex.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
B2R9H73EBI-749265,EBI-10175711
ABHD1Q96SE03EBI-749265,EBI-10293349
ADIPOQA8K6603EBI-749265,EBI-10174479
ADIPOQQ158483EBI-749265,EBI-10827839
ATF7P175443EBI-749265,EBI-765623
BAG5Q9UL155EBI-749265,EBI-356517
BCL2L2Q928437EBI-749265,EBI-707714
BET1Q53XK03EBI-749265,EBI-10242927
C10orf4D3DR403EBI-749265,EBI-10176576
CDC73Q6P1J96EBI-749265,EBI-930143
CDKL3Q8IVW43EBI-749265,EBI-3919850
CIB3Q96Q773EBI-749265,EBI-10292696
CLDN8P567483EBI-749265,EBI-10215641
CRABP2P293735EBI-749265,EBI-10204806
CXCL9Q073253EBI-749265,EBI-3911467
CYBC1Q9BQA95EBI-749265,EBI-2680384
EMDP504027EBI-749265,EBI-489887
FAM161AQ3B8203EBI-749265,EBI-719941
FAM90A1Q86YD73EBI-749265,EBI-6658203
FATE1Q969F05EBI-749265,EBI-743099
FIS1Q9Y3D63EBI-749265,EBI-3385283
FTCDO959543EBI-749265,EBI-10192648
GABARAPL2P605203EBI-749265,EBI-720116
GALNT2Q104715EBI-749265,EBI-10226985
GOSR2O146535EBI-749265,EBI-4401517
GPATCH4Q5T3I05EBI-749265,EBI-2372076
GPR25O001555EBI-749265,EBI-10178951
HMOX1Q96DI83EBI-749265,EBI-10284700
ITM2BQ9Y2873EBI-749265,EBI-2866431
JAGN1Q8N5M95EBI-749265,EBI-10266796
LARP1Q6PKG03EBI-749265,EBI-1052114
LENG1Q96BZ83EBI-749265,EBI-726510
LHFPL5Q8TAF88EBI-749265,EBI-2820517
MALLQ130213EBI-749265,EBI-750078
MARCH2Q9P0N83EBI-749265,EBI-10317612
MFSD5Q6N0753EBI-749265,EBI-3920969
MMP14P502813EBI-749265,EBI-992788
MS4A1P118363EBI-749265,EBI-2808234
MTX2O754315EBI-749265,EBI-7415268
NRIP3Q9NQ355EBI-749265,EBI-10311735
NSG1P428575EBI-749265,EBI-6380741
OLFM4Q6UX063EBI-749265,EBI-2804156
PDGFRAP162343EBI-749265,EBI-2861522
PLP2Q049413EBI-749265,EBI-608347
PPP1R18Q6NYC85EBI-749265,EBI-2557469
RIPPLY2Q5TAB77EBI-749265,EBI-10246897
RNF146Q9NTX73EBI-749265,EBI-722397
RNF146Q9NTX7-24EBI-749265,EBI-11750630
RSRC2Q7L4I2-23EBI-749265,EBI-10256202
RTP2Q5QGT73EBI-749265,EBI-10244780
SENP2Q9HC625EBI-749265,EBI-714881
SERP2Q8N6R15EBI-749265,EBI-749270
SGTAO437657EBI-749265,EBI-347996
SLC30A2Q9BRI38EBI-749265,EBI-8644112
SLC41A2Q96JW45EBI-749265,EBI-10290130
SLNO006313EBI-749265,EBI-10180786
SMCO4Q9NRQ53EBI-749265,EBI-8640191
STBD1O952103EBI-749265,EBI-2947137
STX5Q131905EBI-749265,EBI-714206
TCF25Q9BQ703EBI-749265,EBI-745182
TMEM11P171524EBI-749265,EBI-723946
TMEM14CQ9P0S93EBI-749265,EBI-2339195
TMEM199Q8N5113EBI-749265,EBI-10265825
TMEM41AQ96HV53EBI-749265,EBI-10288884
TMPRSS4Q9NRS43EBI-749265,EBI-10313040
TMPRSS4Q9NRS4-33EBI-749265,EBI-10312990
TRAF3IP3Q9Y2285EBI-749265,EBI-765817
TSHZ3Q63HK53EBI-749265,EBI-9053916
UPK2O005263EBI-749265,EBI-10179682
VAMP1P237633EBI-749265,EBI-10201335
VAMP4O753793EBI-749265,EBI-744953
VAMP4O75379-23EBI-749265,EBI-10187996
ZNF250P15622-33EBI-749265,EBI-10177272

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127094, 118 interactors

Protein interaction database and analysis system

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IntActi
Q8N6L0, 116 interactors

Molecular INTeraction database

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MINTi
Q8N6L0

STRING: functional protein association networks

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STRINGi
9606.ENSP00000404220

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8N6L0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N6L0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili164 – 349Sequence analysisAdd BLAST186

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi448 – 451Poly-Glu4
Compositional biasi528 – 536Poly-Leu9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal 22 AA is required and sufficient for localization to telomeres at the nuclear envelope.By similarity

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IWIE Eukaryota
ENOG4111U72 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00420000029926

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG064472

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N6L0

KEGG Orthology (KO)

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KOi
K22595

Identification of Orthologs from Complete Genome Data

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OMAi
PLCGVWQ

Database of Orthologous Groups

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OrthoDBi
335596at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N6L0

TreeFam database of animal gene trees

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TreeFami
TF337560

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024950 DUSP
IPR011992 EF-hand-dom_pair
IPR028170 KASH5
IPR028168 KASH5_coiled-coil
IPR039508 KASH5_EF-hand-like_dom

The PANTHER Classification System

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PANTHERi
PTHR10159 PTHR10159, 1 hit
PTHR10159:SF376 PTHR10159:SF376, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF14658 EF-hand_9, 1 hit
PF14662 KASH_CCD, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47473 SSF47473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q8N6L0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLPEGPVGG PTAEMYLRER PEEARLGMPV SLEEQILNST FEACDPQRTG
60 70 80 90 100
TVAVAQVLAY LEAVTGQGPQ DARLQTLANS LDPNGEGPKA TVDLDTFLVV
110 120 130 140 150
MRDWIAACQL HGGLELEEET AFQGALTSRQ LPSGCPEAEE PANLESFGGE
160 170 180 190 200
DPRPELQATA DLLSSLEDLE LSNRRLVGEN AKLQRSMETA EEGSARLGEE
210 220 230 240 250
ILALRKQLHS TQQALQFAKA MDEELEDLKT LARSLEEQNR SLLAQARQAE
260 270 280 290 300
KEQQHLVAEM ETLQEENGKL LAERDGVKKR SQELAMEKDT LKRQLFECEH
310 320 330 340 350
LICQRDTILS ERTRDVESLA QTLEEYRVTT QELRLEISRL EEQLSQTYEG
360 370 380 390 400
PDELPEGAQL RRVGWTELLP PSLGLEIEAI RQKQEVATAD LSNPLCGVWQ
410 420 430 440 450
WEEVIHETSE ETEFPSEAPA GGQRNFQGEP AHPEEGRKEP SMWLTRREEE
460 470 480 490 500
EDAESQVTAD LPVPLGAPRP GDIPENPPER PARRELQQAL VPVMKKLVPV
510 520 530 540 550
RRRAWGQLCL PPQRLRVTRH PLIPAPVLGL LLLLLLSVLL LGPSPPPTWP
560
HLQLCYLQPP PV
Length:562
Mass (Da):62,783
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39F47D3F236A9918
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXW9M0QXW9_HUMAN
Protein KASH5
CCDC155
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1C7M0R1C7_HUMAN
Protein KASH5
CCDC155
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZW6M0QZW6_HUMAN
Protein KASH5
CCDC155
524Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXT3M0QXT3_HUMAN
Protein KASH5
CCDC155
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX09M0QX09_HUMAN
Protein KASH5
CCDC155
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZT9M0QZT9_HUMAN
Protein KASH5
CCDC155
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059597116L → P. Corresponds to variant dbSNP:rs8102582Ensembl.1
Natural variantiVAR_059598129R → Q1 PublicationCorresponds to variant dbSNP:rs10405154Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK057220 mRNA Translation: BAB71384.1
AC010619 Genomic DNA No translation available.
AC010643 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52478.1
BC029811 mRNA Translation: AAH29811.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS46140.1

NCBI Reference Sequences

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RefSeqi
NP_653289.3, NM_144688.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.662085
Hs.743867

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000447857; ENSP00000404220; ENSG00000161609

Database of genes from NCBI RefSeq genomes

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GeneIDi
147872

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:147872

UCSC genome browser

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UCSCi
uc002pnm.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057220 mRNA Translation: BAB71384.1
AC010619 Genomic DNA No translation available.
AC010643 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52478.1
BC029811 mRNA Translation: AAH29811.1
CCDSiCCDS46140.1
RefSeqiNP_653289.3, NM_144688.4
UniGeneiHs.662085
Hs.743867

3D structure databases

ProteinModelPortaliQ8N6L0
SMRiQ8N6L0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127094, 118 interactors
IntActiQ8N6L0, 116 interactors
MINTiQ8N6L0
STRINGi9606.ENSP00000404220

Polymorphism and mutation databases

BioMutaiCCDC155
DMDMi187671940

Proteomic databases

PaxDbiQ8N6L0
PeptideAtlasiQ8N6L0
PRIDEiQ8N6L0
ProteomicsDBi72187

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
147872
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000447857; ENSP00000404220; ENSG00000161609
GeneIDi147872
KEGGihsa:147872
UCSCiuc002pnm.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
147872
EuPathDBiHostDB:ENSG00000161609.9

GeneCards: human genes, protein and diseases

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GeneCardsi
CCDC155
HGNCiHGNC:26520 CCDC155
HPAiHPA019937
HPA019940
MIMi618125 gene
neXtProtiNX_Q8N6L0
OpenTargetsiENSG00000161609
PharmGKBiPA162381684

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWIE Eukaryota
ENOG4111U72 LUCA
GeneTreeiENSGT00420000029926
HOVERGENiHBG064472
InParanoidiQ8N6L0
KOiK22595
OMAiPLCGVWQ
OrthoDBi335596at2759
PhylomeDBiQ8N6L0
TreeFamiTF337560

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CCDC155 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
147872

Protein Ontology

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PROi
PR:Q8N6L0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000161609 Expressed in 52 organ(s), highest expression level in right testis
ExpressionAtlasiQ8N6L0 baseline and differential
GenevisibleiQ8N6L0 HS

Family and domain databases

InterProiView protein in InterPro
IPR024950 DUSP
IPR011992 EF-hand-dom_pair
IPR028170 KASH5
IPR028168 KASH5_coiled-coil
IPR039508 KASH5_EF-hand-like_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PTHR10159:SF376 PTHR10159:SF376, 1 hit
PfamiView protein in Pfam
PF14658 EF-hand_9, 1 hit
PF14662 KASH_CCD, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKASH5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N6L0
Secondary accession number(s): Q96MC3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: February 13, 2019
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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