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Protein

Protein KASH5

Gene

CCDC155

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein KASH5
Alternative name(s):
Coiled-coil domain-containing protein 155
KASH domain-containing protein 5
Gene namesi
Name:CCDC155
Synonyms:KASH5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161609.9
HGNCiHGNC:26520 CCDC155
neXtProtiNX_Q8N6L0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 521CytoplasmicSequence analysisAdd BLAST521
Transmembranei522 – 542Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini543 – 562Perinuclear spaceSequence analysisAdd BLAST20

Keywords - Cellular componenti

Chromosome, Membrane, Nucleus, Telomere

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161609
PharmGKBiPA162381684

Polymorphism and mutation databases

BioMutaiCCDC155
DMDMi187671940

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003315271 – 562Protein KASH5Add BLAST562

Proteomic databases

PaxDbiQ8N6L0
PeptideAtlasiQ8N6L0
PRIDEiQ8N6L0
ProteomicsDBi72187

Expressioni

Gene expression databases

BgeeiENSG00000161609
CleanExiHS_CCDC155
ExpressionAtlasiQ8N6L0 baseline and differential
GenevisibleiQ8N6L0 HS

Organism-specific databases

HPAiHPA019937
HPA019940

Interactioni

Subunit structurei

Core component the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents is giving rise to specific assemblies. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. Interacts (via the last 22 AA) with SUN1; this interaction mediates its telomere localization by forming a SUN1:KASH5 LINC complex. Component of a probable SUN2:KASH5 LINC complex. Self-associates. Interacts with DYNC1H1, DCTN1, DYNC1I1/2 and PAFAH1B1; suggesting the association with the dynein-dynactin motor complex.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
B2R9H73EBI-749265,EBI-10175711
ABHD1Q96SE03EBI-749265,EBI-10293349
ADIPOQA8K6603EBI-749265,EBI-10174479
ADIPOQQ158483EBI-749265,EBI-10827839
ALG12P537303EBI-749265,EBI-28496From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
AQY1P0CD913EBI-749265,EBI-3820350From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
ATF7P175443EBI-749265,EBI-765623
ATP11P324533EBI-749265,EBI-3306From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
BAG5Q9UL155EBI-749265,EBI-356517
BAP2P380843EBI-749265,EBI-3414From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
BCL2L2Q928437EBI-749265,EBI-707714
BET1Q53XK03EBI-749265,EBI-10242927
C10orf4D3DR403EBI-749265,EBI-10176576
C17orf62Q9BQA95EBI-749265,EBI-2680384
CDC73Q6P1J96EBI-749265,EBI-930143
CDKL3Q8IVW43EBI-749265,EBI-3919850
CIB3Q96Q773EBI-749265,EBI-10292696
CLDN8P567483EBI-749265,EBI-10215641
CRABP2P293735EBI-749265,EBI-10204806
CXCL9Q073253EBI-749265,EBI-3911467
CYB5P403123EBI-749265,EBI-2095239From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
DGK1Q123823EBI-749265,EBI-36644From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
EMC6Q124313EBI-749265,EBI-2345238From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
EMDP504027EBI-749265,EBI-489887
ERV29P533373EBI-749265,EBI-23662From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
FAM161AQ3B8203EBI-749265,EBI-719941
FAM90A1Q86YD73EBI-749265,EBI-6658203
FATE1Q969F05EBI-749265,EBI-743099
FIS1Q9Y3D63EBI-749265,EBI-3385283
FTCDO959543EBI-749265,EBI-10192648
GABARAPL2P605203EBI-749265,EBI-720116
GALNT2Q104715EBI-749265,EBI-10226985
GCD7P325023EBI-749265,EBI-6260From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
GOS1P387363EBI-749265,EBI-24365From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
GOSR2O146535EBI-749265,EBI-4401517
GPATCH4Q5T3I05EBI-749265,EBI-2372076
GPR25O001555EBI-749265,EBI-10178951
GTT3P399963EBI-749265,EBI-22308From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
HMOX1Q96DI83EBI-749265,EBI-10284700
HXT5P386953EBI-749265,EBI-8778From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
ITM2BQ9Y2873EBI-749265,EBI-2866431
JAGN1Q8N5M95EBI-749265,EBI-10266796
LAC1P284963EBI-749265,EBI-26585From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
LARP1Q6PKG03EBI-749265,EBI-1052114
LCB3P470133EBI-749265,EBI-26081From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
LENG1Q96BZ83EBI-749265,EBI-726510
LHFPL5Q8TAF88EBI-749265,EBI-2820517
LIP1Q035793EBI-749265,EBI-27640From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
MALLQ130213EBI-749265,EBI-750078
MARCH2Q9P0N83EBI-749265,EBI-10317612
MFSD5Q6N0753EBI-749265,EBI-3920969
MMP14P502813EBI-749265,EBI-992788
MS4A1P118363EBI-749265,EBI-2808234
MSL1P405673EBI-749265,EBI-789From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
MTX2O754315EBI-749265,EBI-7415268
NAT1P129453EBI-749265,EBI-11868From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
NRIP3Q9NQ355EBI-749265,EBI-10311735
NSG1P388373EBI-749265,EBI-24733From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
NSG1P428575EBI-749265,EBI-6380741
OLFM4Q6UX063EBI-749265,EBI-2804156
PDGFRAP162343EBI-749265,EBI-2861522
PGA3Q127463EBI-749265,EBI-27973From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
PHO86P469563EBI-749265,EBI-13337From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
PIS1P061973EBI-749265,EBI-13458From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
PLP2Q049413EBI-749265,EBI-608347
PPP1R18Q6NYC85EBI-749265,EBI-2557469
RFT1P382063EBI-749265,EBI-15028From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
RIPPLY2Q5TAB77EBI-749265,EBI-10246897
RNF146Q9NTX73EBI-749265,EBI-722397
RNF146Q9NTX7-24EBI-749265,EBI-11750630
RSRC2Q7L4I2-23EBI-749265,EBI-10256202
RTP2Q5QGT73EBI-749265,EBI-10244780
SCS22Q6Q5953EBI-749265,EBI-2346131From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SCS3P530123EBI-749265,EBI-16742From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SED5Q015903EBI-749265,EBI-16930From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SENP2Q9HC625EBI-749265,EBI-714881
SERP2Q8N6R15EBI-749265,EBI-749270
SGT2Q121183EBI-749265,EBI-31784From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SGTAO437657EBI-749265,EBI-347996
SLC30A2Q9BRI38EBI-749265,EBI-8644112
SLC41A2Q96JW45EBI-749265,EBI-10290130
SLNO006313EBI-749265,EBI-10180786
SMCO4Q9NRQ53EBI-749265,EBI-8640191
SPC1P469653EBI-749265,EBI-17823From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SPC2Q049693EBI-749265,EBI-27827From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SSS1P351793EBI-749265,EBI-16406From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
SST2P119723EBI-749265,EBI-18232From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
STBD1O952103EBI-749265,EBI-2947137
STX5Q131905EBI-749265,EBI-714206
TCF25Q9BQ703EBI-749265,EBI-745182
TED1P405333EBI-749265,EBI-24998From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
TLG2Q081443EBI-749265,EBI-19302From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
TMEM11P171524EBI-749265,EBI-723946
TMEM14CQ9P0S93EBI-749265,EBI-2339195
TMEM199Q8N5113EBI-749265,EBI-10265825
TMEM41AQ96HV53EBI-749265,EBI-10288884
TMPRSS4Q9NRS43EBI-749265,EBI-10313040
TMPRSS4Q9NRS4-33EBI-749265,EBI-10312990
TRAF3IP3Q9Y2285EBI-749265,EBI-765817
TSHZ3Q63HK53EBI-749265,EBI-9053916
TVP15Q038603EBI-749265,EBI-37537From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
ULP1Q027243EBI-749265,EBI-20050From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
UPK2O005263EBI-749265,EBI-10179682
USA1Q037143EBI-749265,EBI-27760From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
VAMP1P237633EBI-749265,EBI-10201335
VAMP4O753793EBI-749265,EBI-744953
VAMP4O75379-23EBI-749265,EBI-10187996
VMA16P239683EBI-749265,EBI-20293From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
VPS73P531423EBI-749265,EBI-23899From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
YHR140WP388423EBI-749265,EBI-24752From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
YLR108CQ122593EBI-749265,EBI-30776From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
YNL146WP539063EBI-749265,EBI-28943From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
YPR159C-AQ8TGQ73EBI-749265,EBI-2343396From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
YPR174CQ066163EBI-749265,EBI-36065From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).
ZNF250P15622-33EBI-749265,EBI-10177272

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127094, 113 interactors
IntActiQ8N6L0, 158 interactors
MINTiQ8N6L0
STRINGi9606.ENSP00000404220

Structurei

3D structure databases

ProteinModelPortaliQ8N6L0
SMRiQ8N6L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili164 – 349Sequence analysisAdd BLAST186

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi448 – 451Poly-Glu4
Compositional biasi528 – 536Poly-Leu9

Domaini

The C-terminal 22 AA is required and sufficient for localization to telomeres at the nuclear envelope.By similarity

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWIE Eukaryota
ENOG4111U72 LUCA
GeneTreeiENSGT00420000029926
HOVERGENiHBG064472
InParanoidiQ8N6L0
KOiK22595
OMAiACDPQRT
OrthoDBiEOG091G06B2
PhylomeDBiQ8N6L0
TreeFamiTF337560

Family and domain databases

InterProiView protein in InterPro
IPR024950 DUSP
IPR011992 EF-hand-dom_pair
IPR028170 KASH5
IPR028168 KASH5_coiled-coil
PANTHERiPTHR10159 PTHR10159, 1 hit
PTHR10159:SF376 PTHR10159:SF376, 1 hit
PfamiView protein in Pfam
PF14662 KASH_CCD, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N6L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLPEGPVGG PTAEMYLRER PEEARLGMPV SLEEQILNST FEACDPQRTG
60 70 80 90 100
TVAVAQVLAY LEAVTGQGPQ DARLQTLANS LDPNGEGPKA TVDLDTFLVV
110 120 130 140 150
MRDWIAACQL HGGLELEEET AFQGALTSRQ LPSGCPEAEE PANLESFGGE
160 170 180 190 200
DPRPELQATA DLLSSLEDLE LSNRRLVGEN AKLQRSMETA EEGSARLGEE
210 220 230 240 250
ILALRKQLHS TQQALQFAKA MDEELEDLKT LARSLEEQNR SLLAQARQAE
260 270 280 290 300
KEQQHLVAEM ETLQEENGKL LAERDGVKKR SQELAMEKDT LKRQLFECEH
310 320 330 340 350
LICQRDTILS ERTRDVESLA QTLEEYRVTT QELRLEISRL EEQLSQTYEG
360 370 380 390 400
PDELPEGAQL RRVGWTELLP PSLGLEIEAI RQKQEVATAD LSNPLCGVWQ
410 420 430 440 450
WEEVIHETSE ETEFPSEAPA GGQRNFQGEP AHPEEGRKEP SMWLTRREEE
460 470 480 490 500
EDAESQVTAD LPVPLGAPRP GDIPENPPER PARRELQQAL VPVMKKLVPV
510 520 530 540 550
RRRAWGQLCL PPQRLRVTRH PLIPAPVLGL LLLLLLSVLL LGPSPPPTWP
560
HLQLCYLQPP PV
Length:562
Mass (Da):62,783
Last modified:April 29, 2008 - v2
Checksum:i39F47D3F236A9918
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059597116L → P. Corresponds to variant dbSNP:rs8102582Ensembl.1
Natural variantiVAR_059598129R → Q1 PublicationCorresponds to variant dbSNP:rs10405154Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057220 mRNA Translation: BAB71384.1
AC010619 Genomic DNA No translation available.
AC010643 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52478.1
BC029811 mRNA Translation: AAH29811.1
CCDSiCCDS46140.1
RefSeqiNP_653289.3, NM_144688.4
UniGeneiHs.662085
Hs.743867

Genome annotation databases

EnsembliENST00000447857; ENSP00000404220; ENSG00000161609
GeneIDi147872
KEGGihsa:147872
UCSCiuc002pnm.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKASH5_HUMAN
AccessioniPrimary (citable) accession number: Q8N6L0
Secondary accession number(s): Q96MC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 18, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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