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Entry version 137 (02 Dec 2020)
Sequence version 2 (06 Mar 2007)
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Protein

Sterile alpha motif domain-containing protein 3

Gene

SAMD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N6K7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sterile alpha motif domain-containing protein 3
Short name:
SAM domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SAMD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000164483.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21574, SAMD3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N6K7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
154075

Open Targets

More...
OpenTargetsi
ENSG00000164483

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134880481

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N6K7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SAMD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
147668009

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002794961 – 520Sterile alpha motif domain-containing protein 3Add BLAST520

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N6K7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N6K7

PeptideAtlas

More...
PeptideAtlasi
Q8N6K7

PRoteomics IDEntifications database

More...
PRIDEi
Q8N6K7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72185 [Q8N6K7-1]
72186 [Q8N6K7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N6K7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N6K7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164483, Expressed in granulocyte and 117 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N6K7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N6K7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164483, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127533, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N6K7, 7 interactors

Molecular INTeraction database

More...
MINTi
Q8N6K7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000402092

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N6K7, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 71SAMPROSITE-ProRule annotationAdd BLAST68

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1945, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012396

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_040548_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N6K7

Identification of Orthologs from Complete Genome Data

More...
OMAi
IFDVHSP

Database of Orthologous Groups

More...
OrthoDBi
439825at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N6K7

TreeFam database of animal gene trees

More...
TreeFami
TF336040

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09526, SAM_Samd3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR042812, SAMD3
IPR042813, SAMD3_SAM

The PANTHER Classification System

More...
PANTHERi
PTHR47302, PTHR47302, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536, SAM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769, SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N6K7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METWSVEQVC SWLVEKNLGE LVHRFQEEEV SGAALLALND RMVQQLVKKI
60 70 80 90 100
GHQAVLMDLI KKYKQNTQGL KSPENPKKAA LVMQTEAARD YRDEESSSPA
110 120 130 140 150
RHGEQMPSFY PAENLDNGLI DQRVLKQRRN VKQILARSKA LQWTKSYVLP
160 170 180 190 200
EFPYDVKCML AEQKCPDHSM RIRIIEFLQA DMTKYLEGSL YPSTQQYNDV
210 220 230 240 250
VNALLQAHPF LDEDGCGFFL WKRALKDRFK YVRRPIEDDE QVIRNKCKFG
260 270 280 290 300
HRRGQTRKSL ADIRFDEIKL VQIKEEAVCF DSELDEHIKW FQQEYVKTEK
310 320 330 340 350
DWREIDKRMS QTLEIRRKMI GSRTPLKDIL KLFPFLKCPY QMFREFQLLT
360 370 380 390 400
RTDIYKKTRH ILESYSENIL TSFSVVDNPI NIVLQEKMKH YTDEDMLKYM
410 420 430 440 450
KMTATCLLLP DVFGDDPSLF VIMNEQVQVS TPVLEVKNPF NMEVCEFSLY
460 470 480 490 500
LERERLTKVD DCVTALAALV AAFHVFRIEC PRRLSQTFNF LETLIFDMHS
510 520
PYFPSLKEKE NEVGFQHPLT
Length:520
Mass (Da):61,237
Last modified:March 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i660A7C0CF9CC6261
GO
Isoform 2 (identifier: Q8N6K7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-221: FLW → AGV
     222-520: Missing.

Show »
Length:221
Mass (Da):25,303
Checksum:i8410F79CB4485F26
GO
Isoform 3 (identifier: Q8N6K7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRSSKLQSPSPSQEKQGVYLQETAM

Show »
Length:544
Mass (Da):63,899
Checksum:i5BB1EBB0E561D42A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PR45E9PR45_HUMAN
Sterile alpha motif domain-containi...
SAMD3
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR28E9PR28_HUMAN
Sterile alpha motif domain-containi...
SAMD3
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRU9E9PRU9_HUMAN
Sterile alpha motif domain-containi...
SAMD3
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS85E9PS85_HUMAN
Sterile alpha motif domain-containi...
SAMD3
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPN0E9PPN0_HUMAN
Sterile alpha motif domain-containi...
SAMD3
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEH9H0YEH9_HUMAN
Sterile alpha motif domain-containi...
SAMD3
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti276E → V in BAG63582 (PubMed:14702039).Curated1
Sequence conflicti472A → G in BAC03765 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03091094E → K1 PublicationCorresponds to variant dbSNP:rs17852709Ensembl.1
Natural variantiVAR_069418181D → N1 PublicationCorresponds to variant dbSNP:rs150968705Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0557381M → MRSSKLQSPSPSQEKQGVYL QETAM in isoform 3. 1 Publication1
Alternative sequenceiVSP_023459219 – 221FLW → AGV in isoform 2. 1 Publication3
Alternative sequenceiVSP_023460222 – 520Missing in isoform 2. 1 PublicationAdd BLAST299

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK091351 mRNA Translation: BAC03644.1
AK091882 mRNA Translation: BAC03765.1
AK302228 mRNA Translation: BAG63582.1
AL355581 Genomic DNA No translation available.
AL121947 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48069.1
CH471051 Genomic DNA Translation: EAW48070.1
BC029851 mRNA Translation: AAH29851.1
BC119757 mRNA Translation: AAI19758.1
BC119758 mRNA Translation: AAI19759.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34539.1 [Q8N6K7-1]
CCDS64525.1 [Q8N6K7-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001017373.2, NM_001017373.3 [Q8N6K7-1]
NP_001245204.1, NM_001258275.2 [Q8N6K7-1]
NP_001264114.1, NM_001277185.1 [Q8N6K7-3]
XP_016865795.1, XM_017010306.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324172; ENSP00000324874; ENSG00000164483 [Q8N6K7-2]
ENST00000368134; ENSP00000357116; ENSG00000164483 [Q8N6K7-1]
ENST00000437477; ENSP00000391163; ENSG00000164483 [Q8N6K7-1]
ENST00000439090; ENSP00000403565; ENSG00000164483 [Q8N6K7-1]
ENST00000457563; ENSP00000402092; ENSG00000164483 [Q8N6K7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
154075

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:154075

UCSC genome browser

More...
UCSCi
uc003qbw.5, human [Q8N6K7-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091351 mRNA Translation: BAC03644.1
AK091882 mRNA Translation: BAC03765.1
AK302228 mRNA Translation: BAG63582.1
AL355581 Genomic DNA No translation available.
AL121947 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48069.1
CH471051 Genomic DNA Translation: EAW48070.1
BC029851 mRNA Translation: AAH29851.1
BC119757 mRNA Translation: AAI19758.1
BC119758 mRNA Translation: AAI19759.1
CCDSiCCDS34539.1 [Q8N6K7-1]
CCDS64525.1 [Q8N6K7-3]
RefSeqiNP_001017373.2, NM_001017373.3 [Q8N6K7-1]
NP_001245204.1, NM_001258275.2 [Q8N6K7-1]
NP_001264114.1, NM_001277185.1 [Q8N6K7-3]
XP_016865795.1, XM_017010306.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127533, 10 interactors
IntActiQ8N6K7, 7 interactors
MINTiQ8N6K7
STRINGi9606.ENSP00000402092

PTM databases

iPTMnetiQ8N6K7
PhosphoSitePlusiQ8N6K7

Polymorphism and mutation databases

BioMutaiSAMD3
DMDMi147668009

Proteomic databases

EPDiQ8N6K7
PaxDbiQ8N6K7
PeptideAtlasiQ8N6K7
PRIDEiQ8N6K7
ProteomicsDBi72185 [Q8N6K7-1]
72186 [Q8N6K7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32851, 104 antibodies

The DNASU plasmid repository

More...
DNASUi
154075

Genome annotation databases

EnsembliENST00000324172; ENSP00000324874; ENSG00000164483 [Q8N6K7-2]
ENST00000368134; ENSP00000357116; ENSG00000164483 [Q8N6K7-1]
ENST00000437477; ENSP00000391163; ENSG00000164483 [Q8N6K7-1]
ENST00000439090; ENSP00000403565; ENSG00000164483 [Q8N6K7-1]
ENST00000457563; ENSP00000402092; ENSG00000164483 [Q8N6K7-3]
GeneIDi154075
KEGGihsa:154075
UCSCiuc003qbw.5, human [Q8N6K7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
154075
DisGeNETi154075
EuPathDBiHostDB:ENSG00000164483.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SAMD3
HGNCiHGNC:21574, SAMD3
HPAiENSG00000164483, Tissue enhanced (blood)
neXtProtiNX_Q8N6K7
OpenTargetsiENSG00000164483
PharmGKBiPA134880481

GenAtlas: human gene database

More...
GenAtlasi
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Phylogenomic databases

eggNOGiKOG1945, Eukaryota
GeneTreeiENSGT00390000012396
HOGENOMiCLU_040548_0_0_1
InParanoidiQ8N6K7
OMAiIFDVHSP
OrthoDBi439825at2759
PhylomeDBiQ8N6K7
TreeFamiTF336040

Enzyme and pathway databases

PathwayCommonsiQ8N6K7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
154075, 3 hits in 840 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SAMD3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
154075
PharosiQ8N6K7, Tdark

Protein Ontology

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PROi
PR:Q8N6K7
RNActiQ8N6K7, protein

Gene expression databases

BgeeiENSG00000164483, Expressed in granulocyte and 117 other tissues
ExpressionAtlasiQ8N6K7, baseline and differential
GenevisibleiQ8N6K7, HS

Family and domain databases

CDDicd09526, SAM_Samd3, 1 hit
Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR042812, SAMD3
IPR042813, SAMD3_SAM
PANTHERiPTHR47302, PTHR47302, 1 hit
PfamiView protein in Pfam
PF00536, SAM_1, 1 hit
SMARTiView protein in SMART
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAMD3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N6K7
Secondary accession number(s): B4DY20
, E1P576, J3KQK4, Q4VXD8, Q8NAY1, Q8NB96
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: December 2, 2020
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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