GNAO1

Functionⁱ

GO - Molecular functionⁱ

G-protein beta/gamma-subunit complex binding Source: InterPro
GTPase activity Source: InterPro
GTP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	TransducerSAAS annotation
Ligand	GTP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: GNAO1 proteinImported
Gene namesⁱ	Name:GNAO1Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA28771

PharmGKBⁱ

PA28771

PTM / Processingⁱ

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q8N6I9

PeptideAtlasⁱ

Q8N6I9

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q8N6I9 HS

Genevisibleⁱ

Q8N6I9 HS

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N6I9
SMRⁱ	Q8N6I9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG0082 Eukaryota ENOG410XNVQ LUCA
HOVERGENⁱ	HBG063184
KEGG Orthology (KO) More...KOⁱ	K04534

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00066 G-alpha, 1 hit
Gene3Dⁱ	1.10.400.10, 1 hit
InterProⁱ	View protein in InterPro IPR001408 Gprotein_alpha_I IPR001019 Gprotein_alpha_su IPR011025 GproteinA_insert IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR10218 PTHR10218, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00503 G-alpha, 1 hit
PRINTSⁱ	PR00318 GPROTEINA PR00441 GPROTEINAI
SMARTⁱ	View protein in SMART SM00275 G_alpha, 1 hit
SUPFAMⁱ	SSF47895 SSF47895, 1 hit SSF52540 SSF52540, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8N6I9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKIIHEDGFS GEDVKQYKPV VYSNTIQSLA AIVRAMDTLG IEYGDKERKA 
        60         70         80         90        100
DAKMVCDVVS RMEDTEPFSA ELLSAMMRLW GDSGIQECFN RSREYQLNDS 
       110        120        130        140        150
AKYYLDSLDR IGAADYQPTE QDILRTRVKT TGIVETHFTF KNLHFRLFDV 
       160        170        180        190        200
GGQRSERKKW IHCFEDVTAI IFCVALSGYD QVLHEDETTN RMHESLMLFD 
       210        220        230        240        250
SICNNKFFID TSIILFLNKK DLFGEKIKKS PLTICFPEYT GPNTYEDAAA 
       260        270        280        290        300
YIQAQFESKN RSPNKEIYCH MTCATDTNNI QVVFDAVTDI IIANNLRGCG 

LY

Length:302

Mass (Da):34,609

Last modified:March 1, 2004 - v2

Checksum:ⁱB6902F0B0AA8DE09

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC030027 mRNA Translation: AAH30027.2
NCBI Reference Sequences More...RefSeqⁱ	NP_066268.1, NM_020988.2 NP_620073.2, NM_138736.2
UniGeneⁱ	Hs.644524

Genome annotation databases

GeneIDⁱ	2775
KEGGⁱ	hsa:2775

Protein	Similar proteins		Species	Score	Length	Source
Q8N6I9	G protein subunit alpha o1		OTOGA		267	UniRef100_Q8N6I9
Guanine nucleotide-binding protein G(o) subunit alpha (Fragment)		HUMAN		142
GNAO1 isoform 23 (Fragment)		PONAB		142
GNAO1 isoform 12 (Fragment)		PANTR		142
Uncharacterized protein		RABIT		302
+13

Protein	Similar proteins		Species	Score	Length	Source
Q8N6I9	Guanine nucleotide-binding protein G(o) subunit alpha		RAT		354	UniRef90_P59215
Guanine nucleotide-binding protein G(o) subunit alpha		CRILO		354
Guanine nucleotide-binding protein G(o) subunit alpha		BOVIN		354
Guanine nucleotide-binding protein G(o) subunit alpha	)	HUMAN		354
Guanine nucleotide-binding protein G(o) subunit alpha	)	MOUSE		354
+343

Protein	Similar proteins		Species	Score	Length	Source
Q8N6I9	Guanine nucleotide-binding protein G(o) subunit alpha		RAT		354	UniRef50_P59215
Guanine nucleotide-binding protein G(o) subunit alpha		CRILO		354
Guanine nucleotide-binding protein G(o) subunit alpha		BOVIN		354
Guanine nucleotide-binding protein G(o) subunit alpha	)	MOUSE		354
Guanine nucleotide-binding protein G(o) subunit alpha	)	HUMAN		354
+554

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC030027 mRNA Translation: AAH30027.2
RefSeqⁱ	NP_066268.1, NM_020988.2 NP_620073.2, NM_138736.2
UniGeneⁱ	Hs.644524

3D structure databases

ProteinModelPortalⁱ	Q8N6I9
SMRⁱ	Q8N6I9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlasⁱ	Q8N6I9

PeptideAtlasⁱ

Q8N6I9

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2775
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	2775
KEGGⁱ	hsa:2775

Organism-specific databases

CTDⁱ	2775
PharmGKBⁱ	PA28771

Phylogenomic databases

eggNOGⁱ	KOG0082 Eukaryota ENOG410XNVQ LUCA
HOVERGENⁱ	HBG063184
KOⁱ	K04534

Miscellaneous databases

ChiTaRSⁱ	GNAO1 human
GenomeRNAiⁱ	2775

Gene expression databases

Genevisibleⁱ	Q8N6I9 HS

Genevisibleⁱ

Q8N6I9 HS

Family and domain databases

CDDⁱ	cd00066 G-alpha, 1 hit
Gene3Dⁱ	1.10.400.10, 1 hit
InterProⁱ	View protein in InterPro IPR001408 Gprotein_alpha_I IPR001019 Gprotein_alpha_su IPR011025 GproteinA_insert IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR10218 PTHR10218, 1 hit
Pfamⁱ	View protein in Pfam PF00503 G-alpha, 1 hit
PRINTSⁱ	PR00318 GPROTEINA PR00441 GPROTEINAI
SMARTⁱ	View protein in SMART SM00275 G_alpha, 1 hit
SUPFAMⁱ	SSF47895 SSF47895, 1 hit SSF52540 SSF52540, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q8N6I9_HUMAN
Accessionⁱ	Q8N6I9Primary (citable) accession number: Q8N6I9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 1, 2002
	Last sequence update:	March 1, 2004
	Last modified:	November 7, 2018
	This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - Q8N6I9 (Q8N6I9_HUMAN)

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GNAO1 protein

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Organism-specific databases

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProt is an ELIXIR core data resource

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Annotation systems

Supporting data

UniProtKB - Q8N6I9 (Q8N6I9_HUMAN)

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GNAO1 protein

GNAO1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ