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UniProtKB - Q8N6F7 (GCSAM_HUMAN)

Protein

Germinal center-associated signaling and motility protein

Gene

GCSAM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • myosin II binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • negative regulation of lymphocyte migration Source: UniProtKB
  • regulation of B cell receptor signaling pathway Source: UniProtKB
View the complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Germinal center-associated signaling and motility protein
Alternative name(s):
Germinal center B-cell-expressed transcript 2 protein
Germinal center-associated lymphoma protein
Short name:
hGAL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GCSAM
Synonyms:GAL, GCET2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000174500.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:20253 GCSAM

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607792 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N6F7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi106 – 107YY → AA: Does not affect the interaction with SYK. 1 Publication2
Mutagenesisi128Y → F: Does not affect IL6 induced phosphorylation. Does not affect the interaction with SYK. 2 Publications1
Mutagenesisi148Y → F: Prevents IL6 induced phosphorylation. Does not affect the interaction with SYK. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		257144

Open Targets

More...OpenTargetsi		ENSG00000174500

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134980592

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GCSAM

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002562281 – 178Germinal center-associated signaling and motility proteinAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei99PhosphoserineBy similarity1
Modified residuei148PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N6F7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N6F7

PeptideAtlas

More...PeptideAtlasi		Q8N6F7

PRoteomics IDEntifications database

More...PRIDEi		Q8N6F7

ProteomicsDB human proteome resource

More...ProteomicsDBi		72164

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N6F7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N6F7

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8N6F7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by IL4/interleukin-4.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000174500 Expressed in 93 organ(s), highest expression level in skin of abdomen

CleanEx database of gene expression profiles

More...CleanExi		HS_GAL
HS_GCET2

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N6F7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N6F7 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA002473

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ACTB and MYH2; the interaction with MYH2 is increased by IL6-induced phosphorylation. Interacts (via C-terminus) with ARHGEF11 (via DH domain). Interacts with ARHGEF12. Interacts with SYK; the interaction increases after B-cell receptor stimulation, resulting in enhanced SYK autophosphorylation and activity.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926245EBI-10267082,EBI-743771

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		129200, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q8N6F7, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000419485

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q8N6F7

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410JBYS Eukaryota
ENOG41115IK LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158134

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000293224

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG081549

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N6F7

Identification of Orthologs from Complete Genome Data

More...OMAi		TSRCWDC

Database of Orthologous Groups

More...OrthoDBi		EOG091G0O8J

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N6F7

TreeFam database of animal gene trees

More...TreeFami		TF338596

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031364 GC_assoc_lym

The PANTHER Classification System

More...PANTHERi		PTHR35351 PTHR35351, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15666 HGAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N6F7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNSLLRENR RQQNTQEMPW NVRMQSPKQR TSRCWDHHIA EGCFCLPWKK 
        60         70         80         90        100
ILIFEKRQDS QNENERMSST PIQDNVDQTY SEELCYTLIN HRVLCTRPSG 
       110        120        130        140        150
NSAEEYYENV PCKAERPRES LGGTETEYSL LHMPSTDPRH ARSPEDEYEL 
       160        170 
LMPHRISSHF LQQPRPLMAP SETQFSHL
Length:178
Mass (Da):21,005
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7C91F3D4B78CD03
GO
Isoform 2 (identifier: Q8N6F7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-9: N → NSF

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):21,240
Checksum:iF28DC1F48452F889
GO
Isoform 3 (identifier: Q8N6F7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-48: Missing.

Note: Gene prediction based on EST data.
Show »
Length:163
Mass (Da):19,206
Checksum:i482C190FAF5BFCA5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JY41C9JY41_HUMAN
Germinal center-associated-signalin...
GCSAM
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IY73C9IY73_HUMAN
Germinal center-associated-signalin...
GCSAM
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3F7F2Z3F7_HUMAN
Germinal center-associated-signalin...
GCSAM
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0460859N → NSF in isoform 2. 1 Publication1
Alternative sequenceiVSP_04698434 – 48Missing in isoform 3. CuratedAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY212246 mRNA Translation: AAO22147.1
AF521911 mRNA Translation: AAO21701.1
AC128688 Genomic DNA No translation available.
BC030506 mRNA Translation: AAH30506.1
BM456595 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2964.1 [Q8N6F7-1]
CCDS54621.1 [Q8N6F7-3]
CCDS54622.1 [Q8N6F7-2]

NCBI Reference Sequences

More...RefSeqi		NP_001177188.1, NM_001190259.1 [Q8N6F7-2]
NP_001177189.1, NM_001190260.1 [Q8N6F7-3]
NP_689998.1, NM_152785.4 [Q8N6F7-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.49614

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000308910; ENSP00000309487; ENSG00000174500 [Q8N6F7-1]
ENST00000460387; ENSP00000420603; ENSG00000174500 [Q8N6F7-3]
ENST00000484193; ENSP00000419485; ENSG00000174500 [Q8N6F7-2]
ENST00000643065; ENSP00000493535; ENSG00000284925 [Q8N6F7-2]
ENST00000644247; ENSP00000494547; ENSG00000284925 [Q8N6F7-3]
ENST00000646639; ENSP00000496265; ENSG00000284925 [Q8N6F7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		257144

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:257144

UCSC genome browser

More...UCSCi		uc003dys.2 human [Q8N6F7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212246 mRNA Translation: AAO22147.1
AF521911 mRNA Translation: AAO21701.1
AC128688 Genomic DNA No translation available.
BC030506 mRNA Translation: AAH30506.1
BM456595 mRNA No translation available.
CCDSiCCDS2964.1 [Q8N6F7-1]
CCDS54621.1 [Q8N6F7-3]
CCDS54622.1 [Q8N6F7-2]
RefSeqiNP_001177188.1, NM_001190259.1 [Q8N6F7-2]
NP_001177189.1, NM_001190260.1 [Q8N6F7-3]
NP_689998.1, NM_152785.4 [Q8N6F7-1]
UniGeneiHs.49614

3D structure databases

ProteinModelPortaliQ8N6F7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129200, 1 interactor
IntActiQ8N6F7, 4 interactors
STRINGi9606.ENSP00000419485

PTM databases

iPTMnetiQ8N6F7
PhosphoSitePlusiQ8N6F7
SwissPalmiQ8N6F7

Polymorphism and mutation databases

BioMutaiGCSAM

Proteomic databases

MaxQBiQ8N6F7
PaxDbiQ8N6F7
PeptideAtlasiQ8N6F7
PRIDEiQ8N6F7
ProteomicsDBi72164

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		257144
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308910; ENSP00000309487; ENSG00000174500 [Q8N6F7-1]
ENST00000460387; ENSP00000420603; ENSG00000174500 [Q8N6F7-3]
ENST00000484193; ENSP00000419485; ENSG00000174500 [Q8N6F7-2]
ENST00000643065; ENSP00000493535; ENSG00000284925 [Q8N6F7-2]
ENST00000644247; ENSP00000494547; ENSG00000284925 [Q8N6F7-3]
ENST00000646639; ENSP00000496265; ENSG00000284925 [Q8N6F7-1]
GeneIDi257144
KEGGihsa:257144
UCSCiuc003dys.2 human [Q8N6F7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		257144
DisGeNETi257144
EuPathDBiHostDB:ENSG00000174500.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		GCSAM
HGNCiHGNC:20253 GCSAM
HPAiHPA002473
MIMi607792 gene
neXtProtiNX_Q8N6F7
OpenTargetsiENSG00000174500
PharmGKBiPA134980592

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410JBYS Eukaryota
ENOG41115IK LUCA
GeneTreeiENSGT00940000158134
HOGENOMiHOG000293224
HOVERGENiHBG081549
InParanoidiQ8N6F7
OMAiTSRCWDC
OrthoDBiEOG091G0O8J
PhylomeDBiQ8N6F7
TreeFamiTF338596

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		257144

Protein Ontology

More...PROi		PR:Q8N6F7

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000174500 Expressed in 93 organ(s), highest expression level in skin of abdomen
CleanExiHS_GAL
HS_GCET2
ExpressionAtlasiQ8N6F7 baseline and differential
GenevisibleiQ8N6F7 HS

Family and domain databases

InterProiView protein in InterPro
IPR031364 GC_assoc_lym
PANTHERiPTHR35351 PTHR35351, 1 hit
PfamiView protein in Pfam
PF15666 HGAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCSAM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N6F7
Secondary accession number(s): C9JD17, C9JUG6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2002
Last modified: December 5, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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