CLDN19

Functionⁱ

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

By similarity

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB
structural molecule activity Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton reorganization
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
  Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
  Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
bicellular tight junction assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
cell adhesion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
negative regulation of cell migration
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
  Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
  Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
negative regulation of cell population proliferation
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
  Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
  Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
negative regulation of gene expression
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
  Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
  Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
negative regulation of wound healing
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
  Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
  Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
neuronal action potential propagation Source: Ensembl
positive regulation of cell junction assembly
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
  Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
  Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
positive regulation of gene expression
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
  Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
  Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
positive regulation of protein phosphorylation
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
  Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
  Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
regulation of transepithelial transport
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- "Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression."
  Peng S., Wang S.B., Singh D., Zhao P.Y., Davis K., Chen B., Adelman R.A., Rizzolo L.J.
  Exp Eye Res 151:179-189(2016) [PubMed] [Europe PMC] [Abstract]
response to stimulus Source: UniProtKB-KW
visual perception Source: UniProtKB-KW

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Sensory transduction, Vision
Ligand	Magnesium

Enzyme and pathway databases

PathwayCommonsⁱ	Q8N6F1
Reactomeⁱ	R-HSA-420029, Tight junction interactions

Protein family/group databases

TCDBⁱ	1.H.1.1.5, the claudin tight junction (claudin1) family

TCDBⁱ

1.H.1.1.5, the claudin tight junction (claudin1) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Claudin-19
Gene namesⁱ	Name:CLDN19
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2040, CLDN19
MIMⁱ	610036, gene
neXtProtⁱ	NX_Q8N6F1
VEuPathDBⁱ	HostDB:ENSG00000164007.10

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 7	CytoplasmicSequence analysis	7
Transmembraneⁱ	8 – 28	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	29 – 81	ExtracellularSequence analysisAdd BLAST	53
Transmembraneⁱ	82 – 102	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	103 – 117	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	118 – 138	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	139 – 160	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	161 – 181	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	182 – 224	CytoplasmicSequence analysisAdd BLAST	43

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hypomagnesemia 5, renal, with or without ocular involvement (HOMG5)1 Publication

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. The renal phenotype is virtually undistinguishable from that of patients with HOMG3.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_031239	20	G → D in HOMG5; perinuclear retention of the mutant protein. 1 PublicationCorresponds to variant dbSNP:rs118203979EnsemblClinVar.	1
Natural variantⁱVAR_031240	57	Q → E in HOMG5; the mutant protein inserts correctly into the cell membrane although subsequent analyzes suggested that dimer formation was disrupted. 1 PublicationCorresponds to variant dbSNP:rs118203980EnsemblClinVar.	1
Natural variantⁱVAR_031241	90	L → P in HOMG5. 1 PublicationCorresponds to variant dbSNP:rs118203981EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease variant, Primary hypomagnesemia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	149461
MalaCards human disease database More...MalaCardsⁱ	CLDN19
MIMⁱ	248190, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000164007
Orphanetⁱ	2196, Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis with severe ocular involvement
PharmGKBⁱ	PA26566

Miscellaneous databases

Pharosⁱ	Q8N6F1, Tbio

Pharosⁱ

Q8N6F1, Tbio

Genetic variation databases

BioMutaⁱ	CLDN19
DMDMⁱ	47606757

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144781	1 – 224	Claudin-19Add BLAST		224

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	54 ↔ 64	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

MassIVEⁱ	Q8N6F1
PaxDbⁱ	Q8N6F1
PeptideAtlas More...PeptideAtlasⁱ	Q8N6F1
PRIDEⁱ	Q8N6F1
ProteomicsDBⁱ	26945 72162 [Q8N6F1-1] 72163 [Q8N6F1-2]

PTM databases

PhosphoSitePlusⁱ	Q8N6F1

PhosphoSitePlusⁱ

Q8N6F1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000164007, Expressed in trigeminal ganglion and 166 other tissues
Genevisibleⁱ	Q8N6F1, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000164007, Group enriched (brain, kidney, placenta, retina)

HPAⁱ

ENSG00000164007, Group enriched (brain, kidney, placenta, retina)

Interactionⁱ

Binary interactionsⁱ

Isoform 2 [Q8N6F1-2]

With	#Exp.	IntAct
AQP6 [Q13520]	3	EBI-12256978,EBI-13059134
AQP9 [O43315]	3	EBI-12256978,EBI-17444777
BCL2L13 [Q9BXK5]	3	EBI-12256978,EBI-747430
BIK [Q13323]	3	EBI-12256978,EBI-700794
BSCL2 [J3KQ12]	3	EBI-12256978,EBI-11532900
BTN2A1 - isoform 4 [Q7KYR7-4]	3	EBI-12256978,EBI-17841208
CD200R1 - isoform 4 [Q8TD46-4]	3	EBI-12256978,EBI-12824513
CD53 [P19397]	3	EBI-12256978,EBI-6657396
CD74 - isoform p35 [P04233-2]	3	EBI-12256978,EBI-12222807
CLEC14A [Q86T13]	3	EBI-12256978,EBI-17710733
CLEC2D - isoform 2 [Q9UHP7-3]	3	EBI-12256978,EBI-11749983
CLRN1 [P58418]	3	EBI-12256978,EBI-17274839
CREB3 - isoform 1 [O43889-2]	3	EBI-12256978,EBI-625022
CXCR3 [P49682]	3	EBI-12256978,EBI-12836456
CYSRT1 [A8MQ03]	3	EBI-12256978,EBI-3867333
ERGIC3 [Q9Y282]	3	EBI-12256978,EBI-781551
FAM209A [Q5JX71]	3	EBI-12256978,EBI-18304435
FCGR1A [P12314]	3	EBI-12256978,EBI-2869867
FCGRT [P55899]	3	EBI-12256978,EBI-2833934
FKBP7 [Q9Y680]	3	EBI-12256978,EBI-3918971
FNDC9 [Q8TBE3]	3	EBI-12256978,EBI-12142257
GGT7 [Q9UJ14]	3	EBI-12256978,EBI-1058791
GJA8 [P48165]	3	EBI-12256978,EBI-17458373
GORAB [Q5T7V8]	3	EBI-12256978,EBI-3917143
GPR161 [Q8N6U8]	3	EBI-12256978,EBI-6255622
GPX8 [Q8TED1]	3	EBI-12256978,EBI-11721746
HSD17B13 [Q7Z5P4]	3	EBI-12256978,EBI-18053395
ICAM3 [P32942]	3	EBI-12256978,EBI-725421
IFNGR2 [P38484]	3	EBI-12256978,EBI-3905457
IL3RA [P26951]	3	EBI-12256978,EBI-1757512
KEL [P23276]	3	EBI-12256978,EBI-746662
KIR2DL3 [P43628]	3	EBI-12256978,EBI-8632435
KRT31 [Q15323]	3	EBI-12256978,EBI-948001
KRT34 [O76011]	3	EBI-12256978,EBI-1047093
LAPTM5 [Q13571]	3	EBI-12256978,EBI-2865663
LRRC25 [Q8N386]	3	EBI-12256978,EBI-11304917
LRRC4C [Q9HCJ2]	3	EBI-12256978,EBI-3925442
MFF - isoform 5 [Q9GZY8-5]	3	EBI-12256978,EBI-11956541
MS4A14 [Q96JA4]	3	EBI-12256978,EBI-12839612
MS4A4A [Q96JQ5]	3	EBI-12256978,EBI-12820341
MUC1 - isoform Y-LSP [P15941-11]	3	EBI-12256978,EBI-17263240
PDZK1IP1 [Q13113]	3	EBI-12256978,EBI-716063
PKD2L1 [Q9P0L9]	3	EBI-12256978,EBI-7956847
PLEKHB2 [Q96CS7]	3	EBI-12256978,EBI-373552
PVR [P15151]	3	EBI-12256978,EBI-3919694
SAR1A [Q9NR31]	3	EBI-12256978,EBI-3920694
SCARB2 [Q14108]	3	EBI-12256978,EBI-1564650
SGPL1 [O95470]	3	EBI-12256978,EBI-1046170
SLAMF6 [Q96DU3]	3	EBI-12256978,EBI-14058448
SLC10A1 [Q14973]	3	EBI-12256978,EBI-3923031
SLC35C2 - isoform 3 [Q9NQQ7-3]	3	EBI-12256978,EBI-17295964
SPACA1 [Q9HBV2]	3	EBI-12256978,EBI-17498703
STOM [P27105]	3	EBI-12256978,EBI-1211440
STOML3 [Q8TAV4]	3	EBI-12256978,EBI-12900395
SUSD3 [Q96L08]	3	EBI-12256978,EBI-18194029
SYNE4 - isoform 2 [Q8N205-2]	3	EBI-12256978,EBI-12099160
TM4SF18 [Q96CE8]	3	EBI-12256978,EBI-13351685
TMEM106C [Q9BVX2]	3	EBI-12256978,EBI-2821497
TMEM248 [Q9NWD8]	3	EBI-12256978,EBI-10314986
TMEM52B [Q4KMG9]	3	EBI-12256978,EBI-18178701
TMEM80 [Q96HE8]	3	EBI-12256978,EBI-11742770
TNFSF14 [O43557]	3	EBI-12256978,EBI-524131
Cldn10 [Q9Z0S6] from Mus musculus.	2	EBI-12256978,EBI-15799971

GO - Molecular functionⁱ

identical protein binding Source: UniProtKB

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	127213, 66 interactors
Database of interacting proteins More...DIPⁱ	DIP-48953N
IntActⁱ	Q8N6F1, 68 interactors
Molecular INTeraction database More...MINTⁱ	Q8N6F1
STRINGⁱ	9606.ENSP00000296387

Miscellaneous databases

RNActⁱ	Q8N6F1, protein

RNActⁱ

Q8N6F1, protein

Structureⁱ

3D structure databases

SMRⁱ	Q8N6F1
ModBaseⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	191 – 224	DisorderedSequence analysisAdd BLAST		34

Sequence similaritiesⁱ

Belongs to the claudin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG502QTG5, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158624
HOGENOMⁱ	CLU_076370_2_0_1
InParanoidⁱ	Q8N6F1
OMAⁱ	ARFEFGP
Database of Orthologous Groups More...OrthoDBⁱ	1244077at2759
PhylomeDBⁱ	Q8N6F1
TreeFamⁱ	TF331936

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187, Claudin IPR017974, Claudin_CS IPR004031, PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002, PTHR12002, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00822, PMP22_Claudin, 1 hit
PROSITEⁱ	View protein in PROSITE PS01346, CLAUDIN, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8N6F1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANSGLQLLG YFLALGGWVG IIASTALPQW KQSSYAGDAI ITAVGLYEGL 
        60         70         80         90        100
WMSCASQSTG QVQCKLYDSL LALDGHIQSA RALMVVAVLL GFVAMVLSVV 
       110        120        130        140        150
GMKCTRVGDS NPIAKGRVAI AGGALFILAG LCTLTAVSWY ATLVTQEFFN 
       160        170        180        190        200
PSTPVNARYE FGPALFVGWA SAGLAVLGGS FLCCTCPEPE RPNSSPQPYR 
       210        220 
PGPSAAAREP VVKLPASAKG PLGV

Length:224

Mass (Da):23,229

Last modified:May 24, 2004 - v2

Checksum:ⁱ60E1A21902415219

GO

Isoform 2 (identifier: Q8N6F1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
210-224: PVVKLPASAKGPLGV → YV

« Hide

        10         20         30         40         50
MANSGLQLLG YFLALGGWVG IIASTALPQW KQSSYAGDAI ITAVGLYEGL 
        60         70         80         90        100
WMSCASQSTG QVQCKLYDSL LALDGHIQSA RALMVVAVLL GFVAMVLSVV 
       110        120        130        140        150
GMKCTRVGDS NPIAKGRVAI AGGALFILAG LCTLTAVSWY ATLVTQEFFN 
       160        170        180        190        200
PSTPVNARYE FGPALFVGWA SAGLAVLGGS FLCCTCPEPE RPNSSPQPYR 
       210 
PGPSAAAREY V

Show »

Length:211

Mass (Da):22,077

Checksum:ⁱ8AE4544AA1CE6462

GO

Isoform 3 (identifier: Q8N6F1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
131-224: LCTLTAVSWY...PASAKGPLGV → MNLAQPCSWA...GQGHWGIGWA

« Hide

        10         20         30         40         50
MANSGLQLLG YFLALGGWVG IIASTALPQW KQSSYAGDAI ITAVGLYEGL 
        60         70         80         90        100
WMSCASQSTG QVQCKLYDSL LALDGHIQSA RALMVVAVLL GFVAMVLSVV 
       110        120        130        140        150
GMKCTRVGDS NPIAKGRVAI AGGALFILAG MNLAQPCSWA GPQLAWPCWA 
       160        170        180        190        200
APSSAAHARS QRDPTAAHSP IGLDPLLLPE STSELRLPWP APHPVAPLPS 
       210 
IQPASQHPGQ GHWGIGWA

Show »

Length:218

Mass (Da):22,721

Checksum:ⁱD87396823B61D780

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	46	L → P in BAC04691 (PubMed:14702039).Curated	1
Isoform 3 (identifier: Q8N6F1-3)
Sequence conflictⁱ	186	R → C in BAH12918 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_031238	13	L → F. Corresponds to variant dbSNP:rs12065961EnsemblClinVar.	1
Natural variantⁱVAR_031239	20	G → D in HOMG5; perinuclear retention of the mutant protein. 1 PublicationCorresponds to variant dbSNP:rs118203979EnsemblClinVar.	1
Natural variantⁱVAR_031240	57	Q → E in HOMG5; the mutant protein inserts correctly into the cell membrane although subsequent analyzes suggested that dimer formation was disrupted. 1 PublicationCorresponds to variant dbSNP:rs118203980EnsemblClinVar.	1
Natural variantⁱVAR_031241	90	L → P in HOMG5. 1 PublicationCorresponds to variant dbSNP:rs118203981EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044839	131 – 224	LCTLT…GPLGV → MNLAQPCSWAGPQLAWPCWA APSSAAHARSQRDPTAAHSP IGLDPLLLPESTSELRLPWP APHPVAPLPSIQPASQHPGQ GHWGIGWA in isoform 3. 1 PublicationAdd BLAST		94
Alternative sequenceⁱVSP_010342	210 – 224	PVVKL…GPLGV → YV in isoform 2. 2 PublicationsAdd BLAST		15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF497644 mRNA Translation: AAQ07256.1 AK096063 mRNA Translation: BAC04691.1 AK298992 mRNA Translation: BAH12918.1 AC098484 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07147.1 BC030524 mRNA Translation: AAH30524.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44125.1 [Q8N6F1-2] CCDS471.1 [Q8N6F1-1] CCDS53306.1 [Q8N6F1-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001116867.1, NM_001123395.1 [Q8N6F1-2] NP_001172046.1, NM_001185117.1 [Q8N6F1-3] NP_683763.2, NM_148960.2 [Q8N6F1-1]

Genome annotation databases

Ensemblⁱ	ENST00000296387; ENSP00000296387; ENSG00000164007 [Q8N6F1-1] ENST00000372539; ENSP00000361617; ENSG00000164007 [Q8N6F1-2] ENST00000539749; ENSP00000443229; ENSG00000164007 [Q8N6F1-3]
GeneIDⁱ	149461
KEGGⁱ	hsa:149461
UCSC genome browser More...UCSCⁱ	uc001cht.1, human [Q8N6F1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N6F1	Claudin		MACMU		224	UniRef100_Q8N6F1
Claudin		PONAB		224
Claudin		PANTR		224
Claudin		CERAT		224
Claudin		PAPAN		224
+6
Q8N6F1-2	Claudin		PONAB		211	UniRef100_A0A2J8SMJ8
Claudin		PANTR		211

Protein	Similar proteins		Species	Score	Length	Source
Q8N6F1	Claudin-19		RAT		224	UniRef90_Q8N6F1
Claudin		MACMU		224
Claudin		PONAB		224
Claudin		PANTR		224
Claudin		CERAT		224
+54
Q8N6F1-2	Claudin		RHIBE		211	UniRef90_A0A2K6LWR1
Claudin		PONAB		211
Claudin		PANTR		211
Claudin		NEOSC		211
Claudin (Fragment)		AILME		211
+5
Q8N6F1-3	Claudin		MACFA		218	UniRef90_Q8N6F1-3
Claudin		MACNE		218
Claudin		PANTR		218
Claudin		PANPA		218
Claudin		GORGO		218
+16

Protein	Similar proteins		Species	Score	Length	Source
Q8N6F1	Claudin-19		RAT		224	UniRef50_Q8N6F1
Claudin		MACMU		224
Claudin		PONAB		224
Claudin		PANTR		224
Claudin		CERAT		224
+62
Q8N6F1-2	Claudin		TAEGU		215	UniRef50_H1A3S3
Claudin 19		CROPO		204
claudin-19		ALLSI		168
Claudin		ICTPU		222
Claudin		ELEEL		222
+239
Q8N6F1-3	Claudin		MANLE		218	UniRef50_Q8N6F1-3
Claudin		PANTR		218
Claudin		COLAP		218
Claudin		PANPA		218
Claudin		MACFA		218
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF497644 mRNA Translation: AAQ07256.1 AK096063 mRNA Translation: BAC04691.1 AK298992 mRNA Translation: BAH12918.1 AC098484 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07147.1 BC030524 mRNA Translation: AAH30524.1
CCDSⁱ	CCDS44125.1 [Q8N6F1-2] CCDS471.1 [Q8N6F1-1] CCDS53306.1 [Q8N6F1-3]
RefSeqⁱ	NP_001116867.1, NM_001123395.1 [Q8N6F1-2] NP_001172046.1, NM_001185117.1 [Q8N6F1-3] NP_683763.2, NM_148960.2 [Q8N6F1-1]

3D structure databases

SMRⁱ	Q8N6F1
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	127213, 66 interactors
DIPⁱ	DIP-48953N
IntActⁱ	Q8N6F1, 68 interactors
MINTⁱ	Q8N6F1
STRINGⁱ	9606.ENSP00000296387

Protein family/group databases

TCDBⁱ	1.H.1.1.5, the claudin tight junction (claudin1) family

TCDBⁱ

1.H.1.1.5, the claudin tight junction (claudin1) family

PTM databases

PhosphoSitePlusⁱ	Q8N6F1

PhosphoSitePlusⁱ

Q8N6F1

Genetic variation databases

BioMutaⁱ	CLDN19
DMDMⁱ	47606757

Proteomic databases

MassIVEⁱ	Q8N6F1
PaxDbⁱ	Q8N6F1
PeptideAtlasⁱ	Q8N6F1
PRIDEⁱ	Q8N6F1
ProteomicsDBⁱ	26945 72162 [Q8N6F1-1] 72163 [Q8N6F1-2]

Protocols and materials databases

Antibodypediaⁱ	32237, 159 antibodies
The DNASU plasmid repository More...DNASUⁱ	149461

Genome annotation databases

Ensemblⁱ	ENST00000296387; ENSP00000296387; ENSG00000164007 [Q8N6F1-1] ENST00000372539; ENSP00000361617; ENSG00000164007 [Q8N6F1-2] ENST00000539749; ENSP00000443229; ENSG00000164007 [Q8N6F1-3]
GeneIDⁱ	149461
KEGGⁱ	hsa:149461
UCSCⁱ	uc001cht.1, human [Q8N6F1-1]

Organism-specific databases

CTDⁱ	149461
DisGeNETⁱ	149461
GeneCardsⁱ	CLDN19
HGNCⁱ	HGNC:2040, CLDN19
HPAⁱ	ENSG00000164007, Group enriched (brain, kidney, placenta, retina)
MalaCardsⁱ	CLDN19
MIMⁱ	248190, phenotype 610036, gene
neXtProtⁱ	NX_Q8N6F1
OpenTargetsⁱ	ENSG00000164007
Orphanetⁱ	2196, Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis with severe ocular involvement
PharmGKBⁱ	PA26566
VEuPathDBⁱ	HostDB:ENSG00000164007.10
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG502QTG5, Eukaryota
GeneTreeⁱ	ENSGT00940000158624
HOGENOMⁱ	CLU_076370_2_0_1
InParanoidⁱ	Q8N6F1
OMAⁱ	ARFEFGP
OrthoDBⁱ	1244077at2759
PhylomeDBⁱ	Q8N6F1
TreeFamⁱ	TF331936

Enzyme and pathway databases

PathwayCommonsⁱ	Q8N6F1
Reactomeⁱ	R-HSA-420029, Tight junction interactions

Miscellaneous databases

BioGRID-ORCSⁱ	149461, 14 hits in 980 CRISPR screens
GeneWikiⁱ	CLDN19
GenomeRNAiⁱ	149461
Pharosⁱ	Q8N6F1, Tbio
Protein Ontology More...PROⁱ	PR:Q8N6F1
RNActⁱ	Q8N6F1, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000164007, Expressed in trigeminal ganglion and 166 other tissues
Genevisibleⁱ	Q8N6F1, HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006187, Claudin IPR017974, Claudin_CS IPR004031, PMP22/EMP/MP20/Claudin
PANTHERⁱ	PTHR12002, PTHR12002, 1 hit
Pfamⁱ	View protein in Pfam PF00822, PMP22_Claudin, 1 hit
PROSITEⁱ	View protein in PROSITE PS01346, CLAUDIN, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLD19_HUMAN
Accessionⁱ	Q8N6F1Primary (citable) accession number: Q8N6F1 Secondary accession number(s): B7Z5I2 , F5H5P9, Q5QT57, Q8N8X0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
	Last sequence update:	May 24, 2004
	Last modified:	June 2, 2021
	This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N6F1 (CLD19_HUMAN)

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Claudin-19

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Isoform 2 [Q8N6F1-2]

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ