Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat domain-containing protein 29

Gene

ANKRD29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 29
Gene namesi
Name:ANKRD29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000154065.16
HGNCiHGNC:27110 ANKRD29
neXtProtiNX_Q8N6D5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000154065
PharmGKBiPA134948058

Polymorphism and mutation databases

BioMutaiANKRD29
DMDMi109940219

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002439031 – 301Ankyrin repeat domain-containing protein 29Add BLAST301

Proteomic databases

PaxDbiQ8N6D5
PeptideAtlasiQ8N6D5
PRIDEiQ8N6D5
ProteomicsDBi72160
72161 [Q8N6D5-3]

PTM databases

iPTMnetiQ8N6D5
PhosphoSitePlusiQ8N6D5

Expressioni

Gene expression databases

BgeeiENSG00000154065 Expressed in 177 organ(s), highest expression level in right lung
CleanExiHS_ANKRD29
ExpressionAtlasiQ8N6D5 baseline and differential
GenevisibleiQ8N6D5 HS

Organism-specific databases

HPAiHPA041272
HPA049419

Interactioni

Protein-protein interaction databases

BioGridi127061, 7 interactors
IntActiQ8N6D5, 9 interactors
STRINGi9606.ENSP00000468354

Structurei

3D structure databases

ProteinModelPortaliQ8N6D5
SMRiQ8N6D5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 41ANK 1Add BLAST31
Repeati45 – 74ANK 2Add BLAST30
Repeati78 – 107ANK 3Add BLAST30
Repeati111 – 140ANK 4Add BLAST30
Repeati144 – 173ANK 5Add BLAST30
Repeati177 – 206ANK 6Add BLAST30
Repeati210 – 239ANK 7Add BLAST30
Repeati242 – 271ANK 8Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148967
HOGENOMiHOG000158359
HOVERGENiHBG080846
InParanoidiQ8N6D5
OMAiLIMQGAD
OrthoDBiEOG091G0D0L
PhylomeDBiQ8N6D5

Family and domain databases

CDDicd00204 ANK, 3 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 3 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 8 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N6D5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCRMSFKKET PLANAAFWAA RRGNLALLKL LLNSGRVDVD CRDSHGTTLL
60 70 80 90 100
MVAAYAGHID CVRELVLQGA DINLQRESGT TALFFAAQQG HNDVVRFLFG
110 120 130 140 150
FGASTEFRTK DGGTALLAAS QYGHMQVVET LLKHGANIHD QLYDGATALF
160 170 180 190 200
LAAQGGYLDV IRLLLASGAK VNQPRQDGTA PLWIASQMGH SEVVRVMLLR
210 220 230 240 250
GADRDAARND GTTALLKAAN KGYNDVIKEL LKFSPTLGIL KNGTSALHAA
260 270 280 290 300
VLSGNIKTVA LLLEAGADPS LRNKANELPA ELTKNERILR LLRSKEGPRK

S
Length:301
Mass (Da):32,442
Last modified:June 27, 2006 - v2
Checksum:i26B553175F6E2ED1
GO
Isoform 3 (identifier: Q8N6D5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-274: Missing.

Note: No experimental confirmation available.
Show »
Length:268
Mass (Da):29,158
Checksum:i5CBF876C344CF3F6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYT2V9GYT2_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD29
110Annotation score:
K7EQM1K7EQM1_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD29
126Annotation score:
K7EL63K7EL63_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD29
143Annotation score:

Sequence cautioni

The sequence BAC85555 differs from that shown. Intron retention.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03561095V → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs767831283Ensembl.1
Natural variantiVAR_026869112G → E1 PublicationCorresponds to variant dbSNP:rs17855552Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019488242 – 274Missing in isoform 3. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057782 mRNA Translation: BAB71569.1
AK123197 mRNA Translation: BAC85555.1 Sequence problems.
AK313667 mRNA Translation: BAG36419.1
AC010853 Genomic DNA No translation available.
CH471088 Genomic DNA Translation: EAX01160.1
BC030622 mRNA Translation: AAH30622.1
CCDSiCCDS11879.1 [Q8N6D5-1]
CCDS77164.1 [Q8N6D5-3]
RefSeqiNP_001295167.1, NM_001308238.1 [Q8N6D5-3]
NP_775776.2, NM_173505.3 [Q8N6D5-1]
UniGeneiHs.355689
Hs.374774

Genome annotation databases

EnsembliENST00000322980; ENSP00000323387; ENSG00000154065 [Q8N6D5-3]
ENST00000592179; ENSP00000468354; ENSG00000154065 [Q8N6D5-1]
GeneIDi147463
KEGGihsa:147463
UCSCiuc002kun.4 human [Q8N6D5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057782 mRNA Translation: BAB71569.1
AK123197 mRNA Translation: BAC85555.1 Sequence problems.
AK313667 mRNA Translation: BAG36419.1
AC010853 Genomic DNA No translation available.
CH471088 Genomic DNA Translation: EAX01160.1
BC030622 mRNA Translation: AAH30622.1
CCDSiCCDS11879.1 [Q8N6D5-1]
CCDS77164.1 [Q8N6D5-3]
RefSeqiNP_001295167.1, NM_001308238.1 [Q8N6D5-3]
NP_775776.2, NM_173505.3 [Q8N6D5-1]
UniGeneiHs.355689
Hs.374774

3D structure databases

ProteinModelPortaliQ8N6D5
SMRiQ8N6D5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127061, 7 interactors
IntActiQ8N6D5, 9 interactors
STRINGi9606.ENSP00000468354

PTM databases

iPTMnetiQ8N6D5
PhosphoSitePlusiQ8N6D5

Polymorphism and mutation databases

BioMutaiANKRD29
DMDMi109940219

Proteomic databases

PaxDbiQ8N6D5
PeptideAtlasiQ8N6D5
PRIDEiQ8N6D5
ProteomicsDBi72160
72161 [Q8N6D5-3]

Protocols and materials databases

DNASUi147463
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322980; ENSP00000323387; ENSG00000154065 [Q8N6D5-3]
ENST00000592179; ENSP00000468354; ENSG00000154065 [Q8N6D5-1]
GeneIDi147463
KEGGihsa:147463
UCSCiuc002kun.4 human [Q8N6D5-1]

Organism-specific databases

CTDi147463
EuPathDBiHostDB:ENSG00000154065.16
GeneCardsiANKRD29
HGNCiHGNC:27110 ANKRD29
HPAiHPA041272
HPA049419
neXtProtiNX_Q8N6D5
OpenTargetsiENSG00000154065
PharmGKBiPA134948058
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148967
HOGENOMiHOG000158359
HOVERGENiHBG080846
InParanoidiQ8N6D5
OMAiLIMQGAD
OrthoDBiEOG091G0D0L
PhylomeDBiQ8N6D5

Miscellaneous databases

ChiTaRSiANKRD29 human
GenomeRNAii147463
PROiPR:Q8N6D5

Gene expression databases

BgeeiENSG00000154065 Expressed in 177 organ(s), highest expression level in right lung
CleanExiHS_ANKRD29
ExpressionAtlasiQ8N6D5 baseline and differential
GenevisibleiQ8N6D5 HS

Family and domain databases

CDDicd00204 ANK, 3 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 3 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 8 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANR29_HUMAN
AccessioniPrimary (citable) accession number: Q8N6D5
Secondary accession number(s): B2R972, Q6ZWE8, Q96LU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 12, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again