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UniProtKB - Q8N697 (S15A4_HUMAN)

Entry version 141 (02 Jun 2021)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
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Protein

Solute carrier family 15 member 4

Gene

SLC15A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352).

Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693).

Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity).

Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352).

Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095).

Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612).

Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity).

Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity).

By similarity5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=16.3 µM for L-histidine1 Publication
  2. KM=1690 µM for GlySar dipeptide1 Publication
  1. Vmax=1317 pmol/min/mg enzyme with L-histidine as substrate1 Publication
  2. Vmax=100 pmol/min/mg enzyme with GlySar dipeptide as substrate1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Innate immunity, Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N697

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-427975, Proton/oligopeptide cotransporters
R-HSA-6798695, Neutrophil degranulation

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.17.3.11, the proton-dependent oligopeptide transporter (pot/ptr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 15 member 4Curated
Alternative name(s):
Peptide transporter 41 Publication
Peptide/histidine transporter 12 Publications
Short name:
hPHT12 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC15A4Imported
Synonyms:PHT12 Publications, PTR41 Publication
ORF Names:FP12591
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23090, SLC15A4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615806, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N697

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000139370.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Transmembranei535 – 555HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi14 – 15LL → AA: Abolished localization to the lysosome membrane and promotes relocalization to the plasma membrane; when associated with 318-A-A-319. Does not affect interaction with TASL. 2 Publications2
Mutagenesisi44E → A: Does not affect interaction with TASL. 1 Publication1
Mutagenesisi47E → A: Does not affect interaction with TASL. 1 Publication1
Mutagenesisi318 – 319LV → AA: Abolished localization to the lysosome membrane and promotes relocalization to the plasma membrane; when associated with 14-A-A-15. 1 Publication2
Mutagenesisi465E → K: Abolished transmembrane transporter activity. Abolished interaction with TASL. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		121260

Open Targets

More...OpenTargetsi		ENSG00000139370

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134928948

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N697, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC15A4

Domain mapping of disease mutations (DMDM)

More...DMDMi		74751048

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003385991 – 577Solute carrier family 15 member 4Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei279PhosphoserineBy similarity1
Modified residuei298PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N697

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N697

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N697

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N697

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N697

PeptideAtlas

More...PeptideAtlasi		Q8N697

PRoteomics IDEntifications database

More...PRIDEi		Q8N697

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72148 [Q8N697-1]
72149 [Q8N697-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8N697, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N697

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N697

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8N697

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) and neural retina. Expressed in small intestine, stomach, duodenum, jejunum, ileum and colon.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000139370, Expressed in blood and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N697, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N697, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000139370, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TASL; leading to TASL recruitment to endolysosome.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125714, 25 interactors

Database of interacting proteins

More...DIPi		DIP-60839N

Protein interaction database and analysis system

More...IntActi		Q8N697, 51 interactors

Molecular INTeraction database

More...MINTi		Q8N697

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000266771

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N697, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1237, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159361

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009313_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N697

Identification of Orthologs from Complete Genome Data

More...OMAi		QMMGVWF

Database of Orthologous Groups

More...OrthoDBi		365203at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N697

TreeFam database of animal gene trees

More...TreeFami		TF330897

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036259, MFS_trans_sf
IPR000109, POT_fam
IPR018456, PTR2_symporter_CS

The PANTHER Classification System

More...PANTHERi		PTHR11654, PTHR11654, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00854, PTR2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01023, PTR2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N697-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGSGGGAGE RAPLLGARRA AAAAAAAGAF AGRRAACGAV LLTELLERAA 
        60         70         80         90        100
FYGITSNLVL FLNGAPFCWE GAQASEALLL FMGLTYLGSP FGGWLADARL 
       110        120        130        140        150
GRARAILLSL ALYLLGMLAF PLLAAPATRA ALCGSARLLN CTAPGPDAAA 
       160        170        180        190        200
RCCSPATFAG LVLVGLGVAT VKANITPFGA DQVKDRGPEA TRRFFNWFYW 
       210        220        230        240        250
SINLGAILSL GGIAYIQQNV SFVTGYAIPT VCVGLAFVVF LCGQSVFITK 
       260        270        280        290        300
PPDGSAFTDM FKILTYSCCS QKRSGERQSN GEGIGVFQQS SKQSLFDSCK 
       310        320        330        340        350
MSHGGPFTEE KVEDVKALVK IVPVFLALIP YWTVYFQMQT TYVLQSLHLR 
       360        370        380        390        400
IPEISNITTT PHTLPAAWLT MFDAVLILLL IPLKDKLVDP ILRRHGLLPS 
       410        420        430        440        450
SLKRIAVGMF FVMCSAFAAG ILESKRLNLV KEKTINQTIG NVVYHAADLS 
       460        470        480        490        500
LWWQVPQYLL IGISEIFASI AGLEFAYSAA PKSMQSAIMG LFFFFSGVGS 
       510        520        530        540        550
FVGSGLLALV SIKAIGWMSS HTDFGNINGC YLNYYFFLLA AIQGATLLLF 
       560        570 
LIISVKYDHH RDHQRSRANG VPTSRRA
Length:577
Mass (Da):62,034
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i701111038C752E70
GO
Isoform 2 (identifier: Q8N697-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-337: Missing.

Show »
Length:240
Mass (Da):26,606
Checksum:i2896131C1AB96FB0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYB7H7BYB7_HUMAN
Solute carrier family 15 member 4
SLC15A4
238Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B6ZDF2B6ZDF2_HUMAN
Solute carrier family 15 member 4
SLC15A4
155Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI46804 differs from that shown. Reason: Frameshift.Curated
The sequence AAK95565 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ04807 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24A → T in AAI46804 (PubMed:15489334).Curated1
Sequence conflicti34 – 35RA → LL in AAK95565 (Ref. 1) Curated2
Sequence conflicti44E → G in AAI46804 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051611239V → A. Corresponds to variant dbSNP:rs33990080Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0340521 – 337Missing in isoform 2. 2 PublicationsAdd BLAST337

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY050629 mRNA Translation: AAK95565.1 Frameshift.
AY038999 mRNA Translation: AAK72099.1
AF461893 mRNA Translation: AAQ04807.1 Frameshift.
AK095717 mRNA Translation: BAG53113.1
CH471054 Genomic DNA Translation: EAW98494.1
BC028394 mRNA Translation: AAH28394.2
BC146803 mRNA Translation: AAI46804.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9264.1 [Q8N697-1]

NCBI Reference Sequences

More...RefSeqi		NP_663623.1, NM_145648.3 [Q8N697-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000266771; ENSP00000266771; ENSG00000139370 [Q8N697-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		121260

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:121260

UCSC genome browser

More...UCSCi		uc001uhu.3, human [Q8N697-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050629 mRNA Translation: AAK95565.1 Frameshift.
AY038999 mRNA Translation: AAK72099.1
AF461893 mRNA Translation: AAQ04807.1 Frameshift.
AK095717 mRNA Translation: BAG53113.1
CH471054 Genomic DNA Translation: EAW98494.1
BC028394 mRNA Translation: AAH28394.2
BC146803 mRNA Translation: AAI46804.1 Frameshift.
CCDSiCCDS9264.1 [Q8N697-1]
RefSeqiNP_663623.1, NM_145648.3 [Q8N697-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125714, 25 interactors
DIPiDIP-60839N
IntActiQ8N697, 51 interactors
MINTiQ8N697
STRINGi9606.ENSP00000266771

Protein family/group databases

TCDBi2.A.17.3.11, the proton-dependent oligopeptide transporter (pot/ptr) family

PTM databases

GlyGeniQ8N697, 1 site
iPTMnetiQ8N697
PhosphoSitePlusiQ8N697
SwissPalmiQ8N697

Genetic variation databases

BioMutaiSLC15A4
DMDMi74751048

Proteomic databases

EPDiQ8N697
jPOSTiQ8N697
MassIVEiQ8N697
MaxQBiQ8N697
PaxDbiQ8N697
PeptideAtlasiQ8N697
PRIDEiQ8N697
ProteomicsDBi72148 [Q8N697-1]
72149 [Q8N697-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3084, 63 antibodies

The DNASU plasmid repository

More...DNASUi		121260

Genome annotation databases

EnsembliENST00000266771; ENSP00000266771; ENSG00000139370 [Q8N697-1]
GeneIDi121260
KEGGihsa:121260
UCSCiuc001uhu.3, human [Q8N697-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		121260
DisGeNETi121260

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC15A4
HGNCiHGNC:23090, SLC15A4
HPAiENSG00000139370, Low tissue specificity
MIMi615806, gene
neXtProtiNX_Q8N697
OpenTargetsiENSG00000139370
PharmGKBiPA134928948
VEuPathDBiHostDB:ENSG00000139370.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1237, Eukaryota
GeneTreeiENSGT00940000159361
HOGENOMiCLU_009313_6_1_1
InParanoidiQ8N697
OMAiQMMGVWF
OrthoDBi365203at2759
PhylomeDBiQ8N697
TreeFamiTF330897

Enzyme and pathway databases

PathwayCommonsiQ8N697
ReactomeiR-HSA-427975, Proton/oligopeptide cotransporters
R-HSA-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		121260, 7 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC15A4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		121260
PharosiQ8N697, Tbio

Protein Ontology

More...PROi		PR:Q8N697
RNActiQ8N697, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000139370, Expressed in blood and 222 other tissues
ExpressionAtlasiQ8N697, baseline and differential
GenevisibleiQ8N697, HS

Family and domain databases

InterProiView protein in InterPro
IPR036259, MFS_trans_sf
IPR000109, POT_fam
IPR018456, PTR2_symporter_CS
PANTHERiPTHR11654, PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854, PTR2, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS01023, PTR2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS15A4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N697
Secondary accession number(s): A6H8Y9
, B3KTK1, Q71M34, Q7Z5F8, Q8TAH0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2002
Last modified: June 2, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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