UniProtKB - Q8N697 (S15A4_HUMAN)

BLAST

>sp|Q8N697|S15A4_HUMAN Solute carrier family 15 member 4 OS=Homo sapiens OX=9606 GN=SLC15A4 PE=1 SV=1
MEGSGGGAGERAPLLGARRAAAAAAAAGAFAGRRAACGAVLLTELLERAAFYGITSNLVL
FLNGAPFCWEGAQASEALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAF
PLLAAPATRAALCGSARLLNCTAPGPDAAARCCSPATFAGLVLVGLGVATVKANITPFGA
DQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQNVSFVTGYAIPTVCVGLAFVVF
LCGQSVFITKPPDGSAFTDMFKILTYSCCSQKRSGERQSNGEGIGVFQQSSKQSLFDSCK
MSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLRIPEISNITTT
PHTLPAAWLTMFDAVLILLLIPLKDKLVDPILRRHGLLPSSLKRIAVGMFFVMCSAFAAG
ILESKRLNLVKEKTINQTIGNVVYHAADLSLWWQVPQYLLIGISEIFASIAGLEFAYSAA
PKSMQSAIMGLFFFFSGVGSFVGSGLLALVSIKAIGWMSSHTDFGNINGCYLNYYFFLLA
AIQGATLLLFLIISVKYDHHRDHQRSRANGVPTSRRA

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History
Entry version 124 (07 Nov 2018)
Sequence version 1 (01 Oct 2002)
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Protein

Solute carrier family 15 member 4

Gene

SLC15A4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.1 Publication

GO - Molecular functionⁱ

L-histidine transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oligopeptide transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptide:proton symporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptide transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histidine transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ion transport Source: Reactome
neutrophil degranulation Source: Reactome
protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Peptide transport, Protein transport, Symport, Transport

Biological process

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-427975 Proton/oligopeptide cotransporters R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-427975 Proton/oligopeptide cotransporters
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

TCDBⁱ	2.A.17.3.11 the proton-dependent oligopeptide transporter (pot/ptr) family

TCDBⁱ

2.A.17.3.11 the proton-dependent oligopeptide transporter (pot/ptr) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 15 member 4 Alternative name(s): Peptide transporter 4 Peptide/histidine transporter 1 Short name: hPHT1
Gene namesⁱ	Name:SLC15A4 Synonyms:PHT1, PTR4 ORF Names:FP12591
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139370.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23090 SLC15A4
MIMⁱ	615806 gene
neXtProtⁱ	NX_Q8N697

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	49 – 69	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	76 – 96	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	105 – 125	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	158 – 178	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	194 – 214	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	222 – 242	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	318 – 338	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	363 – 383	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	405 – 425	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	459 – 479	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	490 – 510	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	535 – 555	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	121260
Open Targets More...OpenTargetsⁱ	ENSG00000139370
PharmGKBⁱ	PA134928948

Polymorphism and mutation databases

BioMutaⁱ	SLC15A4
DMDMⁱ	74751048

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000338599	1 – 577	Solute carrier family 15 member 4Add BLAST		577

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	279	PhosphoserineBy similarity		1
Modified residueⁱ	298	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8N697
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N697
PaxDbⁱ	Q8N697
PeptideAtlas More...PeptideAtlasⁱ	Q8N697
PRIDEⁱ	Q8N697
ProteomicsDBⁱ	72148 72149 [Q8N697-2]

PTM databases

iPTMnetⁱ	Q8N697
PhosphoSitePlusⁱ	Q8N697
SwissPalmⁱ	Q8N697

Expressionⁱ

Tissue specificityⁱ

Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) and neural retina. Expressed in small intestine, stomach, duodenum, jejunum, ileum and colon.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000139370 Expressed in 208 organ(s), highest expression level in blood
CleanExⁱ	HS_SLC15A4
ExpressionAtlasⁱ	Q8N697 baseline and differential
Genevisibleⁱ	Q8N697 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA016713

HPAⁱ

HPA016713

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NOD2	Q9HC29	2	EBI-4319594,EBI-7445625
SLC15A3	Q8IY34	2	EBI-4319594,EBI-12179023

Protein-protein interaction databases

BioGridⁱ	125714, 14 interactors
Database of interacting proteins More...DIPⁱ	DIP-60839N
IntActⁱ	Q8N697, 3 interactors
STRINGⁱ	9606.ENSP00000266771

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N697
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	8 – 39	Ala-richAdd BLAST		32

Sequence similaritiesⁱ

Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1237 Eukaryota COG3104 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062961
HOGENOMⁱ	HOG000143436
HOVERGENⁱ	HBG108431
InParanoidⁱ	Q8N697
KEGG Orthology (KO) More...KOⁱ	K14638
OMAⁱ	WLLHNQG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GF9
PhylomeDBⁱ	Q8N697
TreeFamⁱ	TF330897

Family and domain databases

InterProⁱ	View protein in InterPro IPR036259 MFS_trans_sf IPR000109 POT_fam IPR018456 PTR2_symporter_CS
PANTHERⁱ	PTHR11654 PTHR11654, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00854 PTR2, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
PROSITEⁱ	View protein in PROSITE PS01023 PTR2_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N697-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGSGGGAGE RAPLLGARRA AAAAAAAGAF AGRRAACGAV LLTELLERAA 
        60         70         80         90        100
FYGITSNLVL FLNGAPFCWE GAQASEALLL FMGLTYLGSP FGGWLADARL 
       110        120        130        140        150
GRARAILLSL ALYLLGMLAF PLLAAPATRA ALCGSARLLN CTAPGPDAAA 
       160        170        180        190        200
RCCSPATFAG LVLVGLGVAT VKANITPFGA DQVKDRGPEA TRRFFNWFYW 
       210        220        230        240        250
SINLGAILSL GGIAYIQQNV SFVTGYAIPT VCVGLAFVVF LCGQSVFITK 
       260        270        280        290        300
PPDGSAFTDM FKILTYSCCS QKRSGERQSN GEGIGVFQQS SKQSLFDSCK 
       310        320        330        340        350
MSHGGPFTEE KVEDVKALVK IVPVFLALIP YWTVYFQMQT TYVLQSLHLR 
       360        370        380        390        400
IPEISNITTT PHTLPAAWLT MFDAVLILLL IPLKDKLVDP ILRRHGLLPS 
       410        420        430        440        450
SLKRIAVGMF FVMCSAFAAG ILESKRLNLV KEKTINQTIG NVVYHAADLS 
       460        470        480        490        500
LWWQVPQYLL IGISEIFASI AGLEFAYSAA PKSMQSAIMG LFFFFSGVGS 
       510        520        530        540        550
FVGSGLLALV SIKAIGWMSS HTDFGNINGC YLNYYFFLLA AIQGATLLLF 
       560        570 
LIISVKYDHH RDHQRSRANG VPTSRRA

Length:577

Mass (Da):62,034

Last modified:October 1, 2002 - v1

Checksum:ⁱ701111038C752E70

Isoform 2 (identifier: Q8N697-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-337: Missing.

« Hide

        10         20         30         40         50
MQTTYVLQSL HLRIPEISNI TTTPHTLPAA WLTMFDAVLI LLLIPLKDKL 
        60         70         80         90        100
VDPILRRHGL LPSSLKRIAV GMFFVMCSAF AAGILESKRL NLVKEKTINQ 
       110        120        130        140        150
TIGNVVYHAA DLSLWWQVPQ YLLIGISEIF ASIAGLEFAY SAAPKSMQSA 
       160        170        180        190        200
IMGLFFFFSG VGSFVGSGLL ALVSIKAIGW MSSHTDFGNI NGCYLNYYFF 
       210        220        230        240
LLAAIQGATL LLFLIISVKY DHHRDHQRSR ANGVPTSRRA

Show »

Length:240

Mass (Da):26,606

Checksum:ⁱ2896131C1AB96FB0

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B6ZDF2	B6ZDF2_HUMAN	Solute carrier family 15 member 4 Solute carrier family 15 member 4	SLC15A4	155	Annotation score:
H7BYB7	H7BYB7_HUMAN	Solute carrier family 15 member 4 Solute carrier family 15 member 4	SLC15A4	238	Annotation score:

Sequence cautionⁱ

The sequence AAI46804 differs from that shown. Reason: Frameshift at position 342.Curated

The sequence AAK95565 differs from that shown. Reason: Frameshift at position 572.Curated

The sequence AAQ04807 differs from that shown. Reason: Frameshift at position 497.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	24	A → T in AAI46804 (PubMed:15489334).Curated	1
Sequence conflictⁱ	34 – 35	RA → LL in AAK95565 (Ref. 1) Curated	2
Sequence conflictⁱ	44	E → G in AAI46804 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051611	239	V → A. Corresponds to variant dbSNP:rs33990080Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_034052	1 – 337	Missing in isoform 2. 2 PublicationsAdd BLAST		337

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY050629 mRNA Translation: AAK95565.1 Frameshift. AY038999 mRNA Translation: AAK72099.1 AF461893 mRNA Translation: AAQ04807.1 Frameshift. AK095717 mRNA Translation: BAG53113.1 CH471054 Genomic DNA Translation: EAW98494.1 BC028394 mRNA Translation: AAH28394.2 BC146803 mRNA Translation: AAI46804.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9264.1 [Q8N697-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_663623.1, NM_145648.3 [Q8N697-1]
UniGeneⁱ	Hs.507260

Genome annotation databases

Ensemblⁱ	ENST00000266771; ENSP00000266771; ENSG00000139370 [Q8N697-1]
GeneIDⁱ	121260
KEGGⁱ	hsa:121260
UCSC genome browser More...UCSCⁱ	uc001uhu.3 human [Q8N697-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N697	Solute carrier family 15 member 4		GORGO		577	UniRef90_Q8N697
Uncharacterized protein		CALJA		577
SLC15A4 isoform 1		PONAB		577
SLC15A4 isoform 1		PANTR		575
Uncharacterized protein		Cebus capucinus imitator		573
+18

Protein	Similar proteins		Species	Score	Length	Source
Q8N697	Solute carrier family 15 member 4		BOVIN		566	UniRef50_Q8N697
SLC15A4 isoform 1		PONAB		577
Solute carrier family 15 member 4		GORGO		577
Uncharacterized protein		CALJA		577
SLC15A4 isoform 1		PANTR		575
+123

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY050629 mRNA Translation: AAK95565.1 Frameshift. AY038999 mRNA Translation: AAK72099.1 AF461893 mRNA Translation: AAQ04807.1 Frameshift. AK095717 mRNA Translation: BAG53113.1 CH471054 Genomic DNA Translation: EAW98494.1 BC028394 mRNA Translation: AAH28394.2 BC146803 mRNA Translation: AAI46804.1 Frameshift.
CCDSⁱ	CCDS9264.1 [Q8N697-1]
RefSeqⁱ	NP_663623.1, NM_145648.3 [Q8N697-1]
UniGeneⁱ	Hs.507260

3D structure databases

ProteinModelPortalⁱ	Q8N697
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125714, 14 interactors
DIPⁱ	DIP-60839N
IntActⁱ	Q8N697, 3 interactors
STRINGⁱ	9606.ENSP00000266771

Protein family/group databases

TCDBⁱ	2.A.17.3.11 the proton-dependent oligopeptide transporter (pot/ptr) family

TCDBⁱ

2.A.17.3.11 the proton-dependent oligopeptide transporter (pot/ptr) family

PTM databases

iPTMnetⁱ	Q8N697
PhosphoSitePlusⁱ	Q8N697
SwissPalmⁱ	Q8N697

Polymorphism and mutation databases

BioMutaⁱ	SLC15A4
DMDMⁱ	74751048

Proteomic databases

EPDⁱ	Q8N697
MaxQBⁱ	Q8N697
PaxDbⁱ	Q8N697
PeptideAtlasⁱ	Q8N697
PRIDEⁱ	Q8N697
ProteomicsDBⁱ	72148 72149 [Q8N697-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000266771; ENSP00000266771; ENSG00000139370 [Q8N697-1]
GeneIDⁱ	121260
KEGGⁱ	hsa:121260
UCSCⁱ	uc001uhu.3 human [Q8N697-1]

Organism-specific databases

CTDⁱ	121260
DisGeNETⁱ	121260
EuPathDBⁱ	HostDB:ENSG00000139370.10
GeneCardsⁱ	SLC15A4
HGNCⁱ	HGNC:23090 SLC15A4
HPAⁱ	HPA016713
MIMⁱ	615806 gene
neXtProtⁱ	NX_Q8N697
OpenTargetsⁱ	ENSG00000139370
PharmGKBⁱ	PA134928948
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1237 Eukaryota COG3104 LUCA
GeneTreeⁱ	ENSGT00530000062961
HOGENOMⁱ	HOG000143436
HOVERGENⁱ	HBG108431
InParanoidⁱ	Q8N697
KOⁱ	K14638
OMAⁱ	WLLHNQG
OrthoDBⁱ	EOG091G0GF9
PhylomeDBⁱ	Q8N697
TreeFamⁱ	TF330897

Enzyme and pathway databases

Reactomeⁱ	R-HSA-427975 Proton/oligopeptide cotransporters R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-427975 Proton/oligopeptide cotransporters
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	SLC15A4 human
GenomeRNAiⁱ	121260
Protein Ontology More...PROⁱ	PR:Q8N697
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139370 Expressed in 208 organ(s), highest expression level in blood
CleanExⁱ	HS_SLC15A4
ExpressionAtlasⁱ	Q8N697 baseline and differential
Genevisibleⁱ	Q8N697 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036259 MFS_trans_sf IPR000109 POT_fam IPR018456 PTR2_symporter_CS
PANTHERⁱ	PTHR11654 PTHR11654, 1 hit
Pfamⁱ	View protein in Pfam PF00854 PTR2, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
PROSITEⁱ	View protein in PROSITE PS01023 PTR2_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S15A4_HUMAN
Accessionⁱ	Q8N697Primary (citable) accession number: Q8N697 Secondary accession number(s): A6H8Y9 , B3KTK1, Q71M34, Q7Z5F8, Q8TAH0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q8N697 (S15A4_HUMAN)

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Solute carrier family 15 member 4

SLC15A4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ