Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 127 (11 Dec 2019)
Sequence version 2 (18 May 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Sodium-coupled monocarboxylate transporter 1

Gene

SLC5A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an electrogenic sodium (Na+) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na+:substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na+ gradient and hence contribute to the maintenance of the energy status and function of neurons.11 Publications

Miscellaneous

Increase of iodide influx inhibited by addition of perchlorate (NaClO4), a competitive inhibitor of iodide uptake catalyzed by sodium iodide symporter (NIS). Cotransport of monocarboxylates and nicotinate strongly inhibited by probenecid, nonsteroid anti-inflammatory drugs (ibuprofen, fenoprofen, ketprofen, naproxen) in a Na+-dependent manner or by prolonged exposure to external concentrations of monocarboxylates.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1442 µM for beta-D-hydroxybutyate1 Publication
  2. KM=2327 µM for beta-L-hydroxybutyate1 Publication
  3. KM=1088 µM for D-lactate1 Publication
  4. KM=184 µM for L-lactate1 Publication
  5. KM=387 µM for pyruvate1 Publication
  6. KM=213 µM for acetoacetate1 Publication
  7. KM=209 µM for alpha-ketoisocaproate1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processApoptosis, Ion transport, Sodium transport, Symport, Transport
    LigandSodium

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-197264 Nicotinamide salvaging
    R-HSA-428643 Organic anion transporters

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q8N695

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q8N695

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.21.5.3 the solute:sodium symporter (sss) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Sodium-coupled monocarboxylate transporter 1
    Alternative name(s):
    Apical iodide transporter
    Electrogenic sodium monocarboxylate cotransporter
    Sodium iodide-related cotransporter
    Solute carrier family 5 member 8
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC5A8Imported
    Synonyms:AITImported, SMCT2 Publications, SMCT11 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000256870.2

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:19119 SLC5A8

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    608044 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8N695

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9ExtracellularSequence analysis9
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
    Topological domaini31 – 51CytoplasmicSequence analysisAdd BLAST21
    Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
    Topological domaini73 – 83ExtracellularSequence analysisAdd BLAST11
    Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
    Topological domaini105 – 132CytoplasmicSequence analysisAdd BLAST28
    Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
    Topological domaini154 – 161ExtracellularSequence analysis8
    Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
    Topological domaini183 – 189CytoplasmicSequence analysis7
    Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
    Topological domaini211 – 239ExtracellularSequence analysisAdd BLAST29
    Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
    Topological domaini261 – 279CytoplasmicSequence analysisAdd BLAST19
    Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
    Topological domaini301 – 336ExtracellularSequence analysisAdd BLAST36
    Transmembranei337 – 359HelicalSequence analysisAdd BLAST23
    Topological domaini360 – 389CytoplasmicSequence analysisAdd BLAST30
    Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
    Topological domaini411 – 415ExtracellularSequence analysis5
    Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
    Topological domaini437 – 439CytoplasmicSequence analysis3
    Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
    Topological domaini461 – 518ExtracellularSequence analysisAdd BLAST58
    Transmembranei519 – 539HelicalSequence analysisAdd BLAST21
    Topological domaini540 – 610CytoplasmicSequence analysisAdd BLAST71

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    160728

    Open Targets

    More...
    OpenTargetsi
    ENSG00000256870

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134989874

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q8N695 Tchem

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB01762 Acetoacetic Acid
    DB08872 Gabapentin enacarbil
    DB08949 Inositol nicotinate
    DB00627 Niacin

    DrugCentral

    More...
    DrugCentrali
    Q8N695

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    922

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC5A8

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    296452898

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003344991 – 610Sodium-coupled monocarboxylate transporter 1Add BLAST610

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi485N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8N695

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q8N695

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8N695

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8N695

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8N695

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    72147

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8N695

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8N695

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors.10 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Down-regulated in some primary cancers; due to aberrant methylation in primary colon cancers, astrocytomas and oligodendrogliomas as well as in cancers of the colon, prostate and gastric regions, and glial cell lines. Expression reactivated on treatment with a demethylating drug, 5-azacytidine.4 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000256870 Expressed in 33 organ(s), highest expression level in thyroid gland

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8N695 HS

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    127763, 27 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8N695, 22 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000445340

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q8N695 protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi569 – 572Poly-LysSequence analysis4

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2349 Eukaryota
    COG0591 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000155166

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000261662

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8N695

    KEGG Orthology (KO)

    More...
    KOi
    K14388

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    YGCNSTY

    Database of Orthologous Groups

    More...
    OrthoDBi
    1180002at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8N695

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF316728

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd11519 SLC5sbd_SMCT1, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.20.1730.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR038377 Na/Glc_symporter_sf
    IPR001734 Na/solute_symporter
    IPR041992 SLC5sbd_SMCT1

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00474 SSF, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00813 sss, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50283 NA_SOLUT_SYMP_3, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q8N695-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MDTPRGIGTF VVWDYVVFAG MLVISAAIGI YYAFAGGGQQ TSKDFLMGGR
    60 70 80 90 100
    RMTAVPVALS LTASFMSAVT VLGTPSEVYR FGAIFSIFAF TYFFVVVISA
    110 120 130 140 150
    EVFLPVFYKL GITSTYEYLE LRFNKCVRLC GTVLFIVQTI LYTGIVIYAP
    160 170 180 190 200
    ALALNQVTGF DLWGAVVATG VVCTFYCTLG GLKAVIWTDV FQVGIMVAGF
    210 220 230 240 250
    ASVIIQAVVM QGGISTILND AYDGGRLNFW NFNPNPLQRH TFWTIIIGGT
    260 270 280 290 300
    FTWTSIYGVN QSQVQRYISC KSRFQAKLSL YINLVGLWAI LTCSVFCGLA
    310 320 330 340 350
    LYSRYHDCDP WTAKKVSAPD QLMPYLVLDI LQDYPGLPGL FVACAYSGTL
    360 370 380 390 400
    STVSSSINAL AAVTVEDLIK PYFRSLSERS LSWISQGMSV VYGALCIGMA
    410 420 430 440 450
    ALASLMGALL QAALSVFGMV GGPLMGLFAL GILVPFANSI GALVGLMAGF
    460 470 480 490 500
    AISLWVGIGA QIYPPLPERT LPLHLDIQGC NSTYNETNLM TTTEMPFTTS
    510 520 530 540 550
    VFQIYNVQRT PLMDNWYSLS YLYFSTVGTL VTLLVGILVS LSTGGRKQNL
    560 570 580 590 600
    DPRYILTKED FLSNFDIFKK KKHVLSYKSH PVEDGGTDNP AFNHIELNSD
    610
    QSGKSNGTRL
    Length:610
    Mass (Da):66,578
    Last modified:May 18, 2010 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47FF410B895DB692
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti490M → I in AAL88746 (PubMed:12107270).Curated1
    Sequence conflicti490M → I in AAP46193 (PubMed:12829793).Curated1
    Sequence conflicti490M → I in AAP46194 (PubMed:12829793).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057336193V → I2 PublicationsCorresponds to variant dbSNP:rs1709189Ensembl.1
    Natural variantiVAR_057337251F → V1 PublicationCorresponds to variant dbSNP:rs11834933Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY081220 mRNA Translation: AAL88746.1
    AF536216 mRNA Translation: AAP46193.1
    AF536217 Genomic DNA Translation: AAP46194.1
    AC079953 Genomic DNA No translation available.
    CH471054 Genomic DNA Translation: EAW97649.1
    BC110492 mRNA Translation: AAI10493.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS9080.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_666018.3, NM_145913.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000536262; ENSP00000445340; ENSG00000256870
    ENST00000572861; ENSP00000461697; ENSG00000262217

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    160728

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:160728

    UCSC genome browser

    More...
    UCSCi
    uc001thz.5 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY081220 mRNA Translation: AAL88746.1
    AF536216 mRNA Translation: AAP46193.1
    AF536217 Genomic DNA Translation: AAP46194.1
    AC079953 Genomic DNA No translation available.
    CH471054 Genomic DNA Translation: EAW97649.1
    BC110492 mRNA Translation: AAI10493.1
    CCDSiCCDS9080.1
    RefSeqiNP_666018.3, NM_145913.3

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi127763, 27 interactors
    IntActiQ8N695, 22 interactors
    STRINGi9606.ENSP00000445340

    Chemistry databases

    DrugBankiDB01762 Acetoacetic Acid
    DB08872 Gabapentin enacarbil
    DB08949 Inositol nicotinate
    DB00627 Niacin
    DrugCentraliQ8N695
    GuidetoPHARMACOLOGYi922

    Protein family/group databases

    TCDBi2.A.21.5.3 the solute:sodium symporter (sss) family

    PTM databases

    iPTMnetiQ8N695
    PhosphoSitePlusiQ8N695

    Polymorphism and mutation databases

    BioMutaiSLC5A8
    DMDMi296452898

    Proteomic databases

    jPOSTiQ8N695
    MassIVEiQ8N695
    PaxDbiQ8N695
    PeptideAtlasiQ8N695
    PRIDEiQ8N695
    ProteomicsDBi72147

    Genome annotation databases

    EnsembliENST00000536262; ENSP00000445340; ENSG00000256870
    ENST00000572861; ENSP00000461697; ENSG00000262217
    GeneIDi160728
    KEGGihsa:160728
    UCSCiuc001thz.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    160728
    DisGeNETi160728
    EuPathDBiHostDB:ENSG00000256870.2

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC5A8
    HGNCiHGNC:19119 SLC5A8
    MIMi608044 gene
    neXtProtiNX_Q8N695
    OpenTargetsiENSG00000256870
    PharmGKBiPA134989874

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2349 Eukaryota
    COG0591 LUCA
    GeneTreeiENSGT00940000155166
    HOGENOMiHOG000261662
    InParanoidiQ8N695
    KOiK14388
    OMAiYGCNSTY
    OrthoDBi1180002at2759
    PhylomeDBiQ8N695
    TreeFamiTF316728

    Enzyme and pathway databases

    ReactomeiR-HSA-197264 Nicotinamide salvaging
    R-HSA-428643 Organic anion transporters
    SABIO-RKiQ8N695
    SIGNORiQ8N695

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC5A8 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SLC5A8

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    160728
    PharosiQ8N695 Tchem

    Protein Ontology

    More...
    PROi
    PR:Q8N695
    RNActiQ8N695 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000256870 Expressed in 33 organ(s), highest expression level in thyroid gland
    GenevisibleiQ8N695 HS

    Family and domain databases

    CDDicd11519 SLC5sbd_SMCT1, 1 hit
    Gene3Di1.20.1730.10, 1 hit
    InterProiView protein in InterPro
    IPR038377 Na/Glc_symporter_sf
    IPR001734 Na/solute_symporter
    IPR041992 SLC5sbd_SMCT1
    PfamiView protein in Pfam
    PF00474 SSF, 1 hit
    TIGRFAMsiTIGR00813 sss, 1 hit
    PROSITEiView protein in PROSITE
    PS50283 NA_SOLUT_SYMP_3, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC5A8_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N695
    Secondary accession number(s): Q2TB99, Q7Z2H9
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 18, 2010
    Last modified: December 11, 2019
    This is version 127 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again