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Protein

Beta-defensin 119

Gene

DEFB119

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.Curated

GO - Molecular functioni

  • lipopolysaccharide binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 119
Alternative name(s):
Beta-defensin 120
Beta-defensin 19
Short name:
DEFB-19
Beta-defensin 20
Short name:
DEFB-20
Defensin, beta 119
Defensin, beta 120
ESC42-RELA
Gene namesi
Name:DEFB119
Synonyms:DEFB120, DEFB19, DEFB20
ORF Names:UNQ2449/PRO5729
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000180483.6
HGNCiHGNC:18099 DEFB119
MIMi615997 gene
neXtProtiNX_Q8N690

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180483
PharmGKBiPA38495

Polymorphism and mutation databases

DMDMi41713338

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PeptideiPRO_000000698722 – 84Beta-defensin 119Add BLAST63

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 55By similarity
Disulfide bondi35 ↔ 49By similarity
Disulfide bondi39 ↔ 56By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PeptideAtlasiQ8N690
PRIDEiQ8N690
ProteomicsDBi72143
72144 [Q8N690-2]
72145 [Q8N690-3]

PTM databases

iPTMnetiQ8N690
PhosphoSitePlusiQ8N690

Expressioni

Tissue specificityi

Abundant expression in the male reproductive tract only. Abundant expressed in testis and the caput region of epididymis, but low in the corpus region.1 Publication

Gene expression databases

BgeeiENSG00000180483 Expressed in 70 organ(s), highest expression level in right testis
CleanExiHS_DEFB119
GenevisibleiQ8N690 HS

Organism-specific databases

HPAiHPA043059

Structurei

3D structure databases

ProteinModelPortaliQ8N690
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000000279
HOGENOMiHOG000112157
HOVERGENiHBG107794
InParanoidiQ8N690
OMAiNYQPCCL
OrthoDBiEOG091G12PY
PhylomeDBiQ8N690

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD866254 PD866254, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N690-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLLYLFLAI LLAIEEPVIS GKRHILRCMG NSGICRASCK KNEQPYLYCR
60 70 80
NCQSCCLQSY MRISISGKEE NTDWSYEKQW PRLP
Length:84
Mass (Da):9,822
Last modified:February 2, 2004 - v2
Checksum:i0C2828612A674AB1
GO
Isoform 2 (identifier: Q8N690-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-84: GKRHILRCMG...SYEKQWPRLP → VECWMDGHCR...PKMKTNITNR

Show »
Length:88
Mass (Da):10,107
Checksum:iBFFFB1573ACF71C7
GO
Isoform 3 (identifier: Q8N690-3) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     21-84: GKRHILRCMG...SYEKQWPRLP → ALVRTVGCCLDTARQTPHPSMHG

Note: Abundantly expressed in testis.
Show »
Length:43
Mass (Da):4,723
Checksum:i3604F302F01FDD51
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02987121 – 84GKRHI…WPRLP → VECWMDGHCRLLCKDGEDSI IRCRNRKRCCVPSRYLTIQP VTIHGILGWTTPQMSTTAPK MKTNITNR in isoform 2. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_04318821 – 84GKRHI…WPRLP → ALVRTVGCCLDTARQTPHPS MHG in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY122472 mRNA Translation: AAM93914.1
AY122473 mRNA Translation: AAM93915.1
AF479698 mRNA Translation: AAQ05837.1
AY501001 mRNA Translation: AAS87295.1
AY358860 mRNA Translation: AAQ89219.1
AL031650 Genomic DNA No translation available.
AL121751 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76448.1
CH471077 Genomic DNA Translation: EAW76451.1
BC062212 mRNA Translation: AAH62212.1
CCDSiCCDS13178.1 [Q8N690-1]
CCDS33455.1 [Q8N690-2]
RefSeqiNP_001258138.1, NM_001271209.1
NP_695021.2, NM_153289.3 [Q8N690-1]
NP_697018.1, NM_153323.4 [Q8N690-2]
UniGeneiHs.516998
Hs.743655

Genome annotation databases

EnsembliENST00000339144; ENSP00000345768; ENSG00000180483 [Q8N690-3]
ENST00000376315; ENSP00000365492; ENSG00000180483 [Q8N690-2]
ENST00000376321; ENSP00000365499; ENSG00000180483 [Q8N690-1]
GeneIDi245932
KEGGihsa:245932
UCSCiuc002wvt.5 human [Q8N690-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY122472 mRNA Translation: AAM93914.1
AY122473 mRNA Translation: AAM93915.1
AF479698 mRNA Translation: AAQ05837.1
AY501001 mRNA Translation: AAS87295.1
AY358860 mRNA Translation: AAQ89219.1
AL031650 Genomic DNA No translation available.
AL121751 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76448.1
CH471077 Genomic DNA Translation: EAW76451.1
BC062212 mRNA Translation: AAH62212.1
CCDSiCCDS13178.1 [Q8N690-1]
CCDS33455.1 [Q8N690-2]
RefSeqiNP_001258138.1, NM_001271209.1
NP_695021.2, NM_153289.3 [Q8N690-1]
NP_697018.1, NM_153323.4 [Q8N690-2]
UniGeneiHs.516998
Hs.743655

3D structure databases

ProteinModelPortaliQ8N690
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8N690
PhosphoSitePlusiQ8N690

Polymorphism and mutation databases

DMDMi41713338

Proteomic databases

PeptideAtlasiQ8N690
PRIDEiQ8N690
ProteomicsDBi72143
72144 [Q8N690-2]
72145 [Q8N690-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339144; ENSP00000345768; ENSG00000180483 [Q8N690-3]
ENST00000376315; ENSP00000365492; ENSG00000180483 [Q8N690-2]
ENST00000376321; ENSP00000365499; ENSG00000180483 [Q8N690-1]
GeneIDi245932
KEGGihsa:245932
UCSCiuc002wvt.5 human [Q8N690-1]

Organism-specific databases

CTDi245932
EuPathDBiHostDB:ENSG00000180483.6
GeneCardsiDEFB119
HGNCiHGNC:18099 DEFB119
HPAiHPA043059
MIMi615997 gene
neXtProtiNX_Q8N690
OpenTargetsiENSG00000180483
PharmGKBiPA38495
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000000279
HOGENOMiHOG000112157
HOVERGENiHBG107794
InParanoidiQ8N690
OMAiNYQPCCL
OrthoDBiEOG091G12PY
PhylomeDBiQ8N690

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Miscellaneous databases

GeneWikiiDEFB119
GenomeRNAii245932
PROiPR:Q8N690
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180483 Expressed in 70 organ(s), highest expression level in right testis
CleanExiHS_DEFB119
GenevisibleiQ8N690 HS

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD866254 PD866254, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDB119_HUMAN
AccessioniPrimary (citable) accession number: Q8N690
Secondary accession number(s): Q5GRG1
, Q5JWP1, Q5TH42, Q8N689
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: February 2, 2004
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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