Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 122 (07 Oct 2020)
Sequence version 2 (18 May 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Lysoplasmalogenase

Gene

TMEM86B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Competitively inhibited by lysophosphatidic acid.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=45 µM for lysoplasmenyl-choline1 Publication
  2. KM=53 µM for lysoplasmenyl-ethanolamine1 Publication

    pH dependencei

    Optimum pH is 6.95 and 7.05 with lysoplasmenyl-ethanolamine and lysoplasmenyl-choline as substrates, respectively.1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:ENSG00000180089-MONOMER

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q8N661

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1482788, Acyl chain remodelling of PC

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000632

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Lysoplasmalogenase (EC:3.3.2.21 Publication)
    Alternative name(s):
    Transmembrane protein 86B
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:TMEM86B
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000180089.5

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:28448, TMEM86B

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    617806, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8N661

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
    Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
    Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
    Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
    Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
    Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
    Transmembranei198 – 218HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    255043

    Open Targets

    More...
    OpenTargetsi
    ENSG00000180089

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA142670738

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q8N661, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    TMEM86B

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    296452936

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002018411 – 226LysoplasmalogenaseAdd BLAST226

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8N661

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8N661

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8N661

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    72134

    PTM databases

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8N661

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000180089, Expressed in right lobe of liver and 112 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8N661, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000180089, Tissue enhanced (liver)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    Curated

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Q8N661
    With#Exp.IntAct
    AQP6 [Q13520]3EBI-2548832,EBI-13059134
    ARL13B [Q3SXY8]3EBI-2548832,EBI-11343438
    ARL6IP6 [Q8N6S5]3EBI-2548832,EBI-2808844
    ASGR2 - isoform 3 [P07307-3]3EBI-2548832,EBI-12808270
    BCL2L13 [Q9BXK5]6EBI-2548832,EBI-747430
    BIK [Q13323]3EBI-2548832,EBI-700794
    BMP10 [O95393]3EBI-2548832,EBI-3922513
    C2CD2L [O14523]3EBI-2548832,EBI-12822627
    CCDC167 [Q9P0B6]3EBI-2548832,EBI-9083477
    CCDC34 - isoform 2 [Q96HJ3-2]3EBI-2548832,EBI-17641690
    CCL4 [P13236]3EBI-2548832,EBI-2873970
    CD53 [P19397]3EBI-2548832,EBI-6657396
    CD79A [P11912]3EBI-2548832,EBI-7797864
    CLRN1 [P58418]3EBI-2548832,EBI-17274839
    CYB5B [O43169]3EBI-2548832,EBI-1058710
    DHRSX [Q8N5I4]3EBI-2548832,EBI-3923585
    DNAJC30 [Q96LL9]3EBI-2548832,EBI-8639143
    EBP [Q15125]3EBI-2548832,EBI-3915253
    ERGIC3 [Q9Y282]3EBI-2548832,EBI-781551
    ERP29 [P30040]3EBI-2548832,EBI-946830
    EVI2B - isoform 2 [P34910-2]3EBI-2548832,EBI-17640610
    F11R [Q9Y624]3EBI-2548832,EBI-742600
    FAM209A [Q5JX71]3EBI-2548832,EBI-18304435
    FAXDC2 [Q96IV6]3EBI-2548832,EBI-12142299
    FKBP7 [Q9Y680]3EBI-2548832,EBI-3918971
    FXYD6 [Q9H0Q3]3EBI-2548832,EBI-713304
    GJA1 [P17302]3EBI-2548832,EBI-1103439
    GJA4 [P35212]3EBI-2548832,EBI-6918707
    GJA8 [P48165]3EBI-2548832,EBI-17458373
    GOLM1 [Q8NBJ4]3EBI-2548832,EBI-712073
    GPR37L1 [O60883]3EBI-2548832,EBI-2927498
    GPX8 [Q8TED1]3EBI-2548832,EBI-11721746
    GUCA2A [Q02747]3EBI-2548832,EBI-12244272
    HIBADH [P31937]3EBI-2548832,EBI-11427100
    HSD17B13 [Q7Z5P4]3EBI-2548832,EBI-18053395
    IER3IP1 [Q9Y5U9]3EBI-2548832,EBI-725665
    IFITM3 [Q01628]3EBI-2548832,EBI-7932862
    KIR2DL3 [P43628]3EBI-2548832,EBI-8632435
    LAPTM4B [Q86VI4]3EBI-2548832,EBI-3267258
    LIME1 [Q9H400]3EBI-2548832,EBI-2830566
    LSS [P48449]3EBI-2548832,EBI-3930711
    LY6D [Q14210]3EBI-2548832,EBI-1965225
    MARCHF2 [Q9P0N8]3EBI-2548832,EBI-10317612
    MFF - isoform 5 [Q9GZY8-5]6EBI-2548832,EBI-11956541
    MGST3 [O14880]3EBI-2548832,EBI-724754
    MMGT1 [Q8N4V1]3EBI-2548832,EBI-6163737
    MS4A14 [Q96JA4]3EBI-2548832,EBI-12839612
    MSMO1 [Q15800]3EBI-2548832,EBI-949102
    MUC1 - isoform Y-LSP [P15941-11]3EBI-2548832,EBI-17263240
    NDUFAF1 [Q9Y375]3EBI-2548832,EBI-741874
    NEMP1 - isoform 2 [O14524-2]3EBI-2548832,EBI-10969203
    NINJ2 [Q9NZG7]3EBI-2548832,EBI-10317425
    ORMDL2 [Q53FV1]3EBI-2548832,EBI-11075081
    OTULINL [Q9NUU6]3EBI-2548832,EBI-6916492
    PEX11G [Q96HA9]3EBI-2548832,EBI-17284886
    PGRMC2 [O15173]3EBI-2548832,EBI-1050125
    PIGF [Q07326]3EBI-2548832,EBI-17180304
    PLN [P26678]3EBI-2548832,EBI-692836
    PTPN1 [P18031]3EBI-2548832,EBI-968788
    PTPN9 [P43378]3EBI-2548832,EBI-742898
    RHBDD1 [Q8TEB9]3EBI-2548832,EBI-9916444
    RHOT2 [Q8IXI1]3EBI-2548832,EBI-1396563
    RPRM [Q9NS64]3EBI-2548832,EBI-1052363
    RTP2 [Q5QGT7]3EBI-2548832,EBI-10244780
    SEC22B [O75396]3EBI-2548832,EBI-1058865
    SFRP1 [Q8N474]3EBI-2548832,EBI-3940687
    SFT2D1 [Q8WV19]3EBI-2548832,EBI-2854842
    SFXN5 [Q8TD22]3EBI-2548832,EBI-17274136
    SLC10A6 [Q3KNW5]3EBI-2548832,EBI-18159983
    SLC35G2 [Q8TBE7]3EBI-2548832,EBI-727304
    SLC39A9 [Q9NUM3]3EBI-2548832,EBI-2823239
    SMIM1 [B2RUZ4]3EBI-2548832,EBI-12188413
    SNORC [Q6UX34]3EBI-2548832,EBI-11957067
    SSMEM1 [Q8WWF3]3EBI-2548832,EBI-17280858
    STOM [P27105]3EBI-2548832,EBI-1211440
    STX12 [Q86Y82]3EBI-2548832,EBI-2691717
    STX6 [O43752]3EBI-2548832,EBI-2695795
    STX8 [Q9UNK0]3EBI-2548832,EBI-727240
    TEX29 [Q8N6K0]3EBI-2548832,EBI-19027521
    THAP4 [Q8WY91]3EBI-2548832,EBI-726691
    THBD [P07204]3EBI-2548832,EBI-941422
    TIMM23 [O14925]3EBI-2548832,EBI-1047996
    TMEM106A [Q96A25]3EBI-2548832,EBI-3915978
    TMEM107 [Q6UX40]3EBI-2548832,EBI-12845616
    TMEM120A [Q9BXJ8]3EBI-2548832,EBI-727322
    TMEM14A [Q9Y6G1]3EBI-2548832,EBI-2800360
    TMEM14C [Q9P0S9]3EBI-2548832,EBI-2339195
    TMEM203 [Q969S6]3EBI-2548832,EBI-12274070
    TMEM237 - isoform 2 [Q96Q45-2]5EBI-2548832,EBI-10982110
    TMEM248 [Q9NWD8]3EBI-2548832,EBI-10314986
    TMEM52B [Q4KMG9]3EBI-2548832,EBI-18178701
    TMEM60 [Q9H2L4]3EBI-2548832,EBI-2852148
    itself3EBI-2548832,EBI-2548832
    TMPRSS2 - isoform 2 [O15393-2]3EBI-2548832,EBI-12345267
    TMX2 [Q9Y320]3EBI-2548832,EBI-6447886
    TREX1 - isoform 1 [Q9NSU2-1]3EBI-2548832,EBI-16746122
    TSNARE1 [A0AVG3]3EBI-2548832,EBI-12003468
    USE1 [Q9NZ43]3EBI-2548832,EBI-742842
    VAMP2 [P63027]3EBI-2548832,EBI-520113
    VAMP3 [Q15836]3EBI-2548832,EBI-722343
    VAMP5 [O95183]3EBI-2548832,EBI-10191195
    VAPA [Q9P0L0]3EBI-2548832,EBI-1059156
    ZDHHC22 [Q8N966]3EBI-2548832,EBI-10268111
    Q96FB23EBI-2548832,EBI-2857623

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    129071, 106 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8N661, 104 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000321038

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q8N661, protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the TMEM86 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG4804, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000007101

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_079086_1_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8N661

    KEGG Orthology (KO)

    More...
    KOi
    K18575

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    AWDTFAQ

    Database of Orthologous Groups

    More...
    OrthoDBi
    1516092at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8N661

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF324663

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR012506, YhhN

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR31885, PTHR31885, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF07947, YhhN, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q8N661-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MDAGKAGQTL KTHCSAQRPD VCRWLSPFIL SCCVYFCLWI PEDQLSWFAA
    60 70 80 90 100
    LVKCLPVLCL AGFLWVMSPS GGYTQLLQGA LVCSAVGDAC LIWPAAFVPG
    110 120 130 140 150
    MAAFATAHLL YVWAFGFSPL QPGLLLLIIL APGPYLSLVL QHLEPDMVLP
    160 170 180 190 200
    VAAYGLILMA MLWRGLAQGG SAGWGALLFT LSDGVLAWDT FAQPLPHAHL
    210 220
    VIMTTYYAAQ LLITLSALRS PVPKTD
    Length:226
    Mass (Da):24,352
    Last modified:May 18, 2010 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD5344268F221275
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052343176A → T. Corresponds to variant dbSNP:rs35608872Ensembl.1
    Natural variantiVAR_052344199H → R1 PublicationCorresponds to variant dbSNP:rs4644955Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AC010327 Genomic DNA No translation available.
    BC023000 mRNA Translation: AAH23000.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS12920.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_776165.3, NM_173804.4

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000327042; ENSP00000321038; ENSG00000180089

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    255043

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:255043

    UCSC genome browser

    More...
    UCSCi
    uc002qju.4, human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC010327 Genomic DNA No translation available.
    BC023000 mRNA Translation: AAH23000.1
    CCDSiCCDS12920.1
    RefSeqiNP_776165.3, NM_173804.4

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi129071, 106 interactors
    IntActiQ8N661, 104 interactors
    STRINGi9606.ENSP00000321038

    Chemistry databases

    SwissLipidsiSLP:000000632

    PTM databases

    PhosphoSitePlusiQ8N661

    Polymorphism and mutation databases

    BioMutaiTMEM86B
    DMDMi296452936

    Proteomic databases

    PaxDbiQ8N661
    PeptideAtlasiQ8N661
    PRIDEiQ8N661
    ProteomicsDBi72134

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    33044, 13 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    255043

    Genome annotation databases

    EnsembliENST00000327042; ENSP00000321038; ENSG00000180089
    GeneIDi255043
    KEGGihsa:255043
    UCSCiuc002qju.4, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    255043
    DisGeNETi255043
    EuPathDBiHostDB:ENSG00000180089.5

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    TMEM86B
    HGNCiHGNC:28448, TMEM86B
    HPAiENSG00000180089, Tissue enhanced (liver)
    MIMi617806, gene
    neXtProtiNX_Q8N661
    OpenTargetsiENSG00000180089
    PharmGKBiPA142670738

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG4804, Eukaryota
    GeneTreeiENSGT00390000007101
    HOGENOMiCLU_079086_1_0_1
    InParanoidiQ8N661
    KOiK18575
    OMAiAWDTFAQ
    OrthoDBi1516092at2759
    PhylomeDBiQ8N661
    TreeFamiTF324663

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000180089-MONOMER
    PathwayCommonsiQ8N661
    ReactomeiR-HSA-1482788, Acyl chain remodelling of PC

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    255043, 6 hits in 874 CRISPR screens

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    255043
    PharosiQ8N661, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q8N661
    RNActiQ8N661, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000180089, Expressed in right lobe of liver and 112 other tissues
    GenevisibleiQ8N661, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR012506, YhhN
    PANTHERiPTHR31885, PTHR31885, 1 hit
    PfamiView protein in Pfam
    PF07947, YhhN, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM86B_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N661
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: May 18, 2010
    Last modified: October 7, 2020
    This is version 122 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again