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Protein

Neuroblastoma breakpoint family member 15

Gene

NBPF15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 15Imported
Alternative name(s):
Neuroblastoma breakpoint family member 16Imported
Gene namesi
Name:NBPF15Imported
Synonyms:NBPF16Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000266338.6
HGNCiHGNC:28791 NBPF15
MIMi610414 gene
614005 gene
neXtProtiNX_Q8N660

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000266338
PharmGKBiPA142671274

Polymorphism and mutation databases

DMDMi223590098

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880491 – 670Neuroblastoma breakpoint family member 15Add BLAST670

Proteomic databases

EPDiQ8N660
MaxQBiQ8N660
PaxDbiQ8N660
PeptideAtlasiQ8N660
PRIDEiQ8N660
ProteomicsDBi63994
72133

PTM databases

iPTMnetiQ8N660
PhosphoSitePlusiQ8N660

Expressioni

Tissue specificityi

Ubiquitously expressed with a higher expression observed in breast and liver. Also expressed in neuroblastoma cell line.1 Publication

Gene expression databases

BgeeiENSG00000266338 Expressed in 92 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_NBPF15
GenevisibleiQ8N660 HS

Organism-specific databases

HPAiHPA042595
HPA043105
HPA043692
HPA044023
HPA046971
HPA058050

Interactioni

Protein-protein interaction databases

BioGridi129901, 1 interactor
IntActiQ8N660, 2 interactors
MINTiQ8N660
STRINGi9606.ENSP00000358188

Structurei

3D structure databases

ProteinModelPortaliQ8N660
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 257NBPF 1PROSITE-ProRule annotationAdd BLAST93
Domaini258 – 329NBPF 2PROSITE-ProRule annotationAdd BLAST72
Domaini330 – 421NBPF 3PROSITE-ProRule annotationAdd BLAST92
Domaini424 – 479NBPF 4PROSITE-ProRule annotationAdd BLAST56
Domaini480 – 572NBPF 5PROSITE-ProRule annotationAdd BLAST93
Domaini573 – 670NBPF 6PROSITE-ProRule annotationAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili70 – 130Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi264 – 268Poly-Glu5
Compositional biasi279 – 284Poly-Glu6
Compositional biasi486 – 489Poly-Glu4

Sequence similaritiesi

Belongs to the NBPF family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410KG3F Eukaryota
ENOG4110SQ7 LUCA
GeneTreeiENSGT00420000029746
HOGENOMiHOG000049041
HOVERGENiHBG058300
InParanoidiQ8N660
OMAiERYLTYS
OrthoDBiEOG091G03WI
PhylomeDBiQ8N660
TreeFamiTF341151

Family and domain databases

InterProiView protein in InterPro
IPR010630 NBPF_dom
PfamiView protein in Pfam
PF06758 DUF1220, 6 hits
SMARTiView protein in SMART
SM01148 DUF1220, 6 hits
PROSITEiView protein in PROSITE
PS51316 NBPF, 6 hits

Sequencei

Sequence statusi: Complete.

Q8N660-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVSAGPLSS EKAEMNILEI NEKLRPQLAE KKQQFRNLKE KCFLTQLAGF
60 70 80 90 100
LANRQKKYKY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH
110 120 130 140 150
AQERELTQLR EKLREGRDAS RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE
160 170 180 190 200
GCRLTQHLVQ KLSPENDNDD DEDVQVEVAE KVQKSSAPRE MQKAEEKEVP
210 220 230 240 250
EDSLEECAIT CSNSHGPYDS NQPHKKTKIT FEEDKVDSTL IGSSSHVEWE
260 270 280 290 300
DAVHIIPENE SDDEEEEEKG PVSPRNLQES EEEEVPQESW DEGYSTLSIP
310 320 330 340 350
PEMLASYQSY SSTFHSLEEQ QVCMAVDIGR HRWDQVKKED QEATGPRLSR
360 370 380 390 400
ELLDEKEPEV LQDSLDRCYS TPSGCLELTD SCQPYRSAFY VLEQQRVGLA
410 420 430 440 450
IDMDEIEKYQ EVEEDQDPSC PRLSRELLDE KEPEVLQDSL DRCYSTPSDY
460 470 480 490 500
LELPDLGQPY SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QGPPCPRLSR
510 520 530 540 550
ELLEVVEPEV LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS
560 570 580 590 600
LDVGEIEKKG KGKKRRGRRS KKKRRRGRKE GEDDNPPCPR LYGVLMEVEE
610 620 630 640 650
PEVLQDSLDR CYSTPSMYFE QPDSFQHYRS VFYSFEEEHI SFALYVDNRF
660 670
FTLTVTSLHL VFQMGVIFPQ
Length:670
Mass (Da):77,563
Last modified:February 10, 2009 - v2
Checksum:i80944E05C2FC4511
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti477D → A in AAH23087 (PubMed:15489334).Curated1
Sequence conflicti518C → Y in CAI16654 (PubMed:16710414).Curated1
Sequence conflicti592Y → N in CAI16654 (PubMed:16710414).Curated1
Sequence conflicti621Q → L in CAI16654 (PubMed:16710414).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032383615P → Q. Corresponds to variant dbSNP:rs6695216Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF379630 mRNA Translation: AAO15398.1
AY894566 mRNA Translation: AAX85105.1
AC246785 Genomic DNA No translation available.
AL592492 Genomic DNA Translation: CAI16654.1
AL954711 Genomic DNA Translation: CAM22821.1
BC023087 mRNA Translation: AAH23087.1
CCDSiCCDS72852.1
RefSeqiNP_001164226.1, NM_001170755.2
NP_775909.2, NM_173638.4
XP_016856566.1, XM_017001077.1
UniGeneiHs.523572
Hs.656782
Hs.714127

Genome annotation databases

EnsembliENST00000488031; ENSP00000481835; ENSG00000266338
ENST00000577412; ENSP00000462600; ENSG00000266338
ENST00000581897; ENSP00000463178; ENSG00000266338
GeneIDi284565
KEGGihsa:284565
UCSCiuc010pay.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF379630 mRNA Translation: AAO15398.1
AY894566 mRNA Translation: AAX85105.1
AC246785 Genomic DNA No translation available.
AL592492 Genomic DNA Translation: CAI16654.1
AL954711 Genomic DNA Translation: CAM22821.1
BC023087 mRNA Translation: AAH23087.1
CCDSiCCDS72852.1
RefSeqiNP_001164226.1, NM_001170755.2
NP_775909.2, NM_173638.4
XP_016856566.1, XM_017001077.1
UniGeneiHs.523572
Hs.656782
Hs.714127

3D structure databases

ProteinModelPortaliQ8N660
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129901, 1 interactor
IntActiQ8N660, 2 interactors
MINTiQ8N660
STRINGi9606.ENSP00000358188

PTM databases

iPTMnetiQ8N660
PhosphoSitePlusiQ8N660

Polymorphism and mutation databases

DMDMi223590098

Proteomic databases

EPDiQ8N660
MaxQBiQ8N660
PaxDbiQ8N660
PeptideAtlasiQ8N660
PRIDEiQ8N660
ProteomicsDBi63994
72133

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000488031; ENSP00000481835; ENSG00000266338
ENST00000577412; ENSP00000462600; ENSG00000266338
ENST00000581897; ENSP00000463178; ENSG00000266338
GeneIDi284565
KEGGihsa:284565
UCSCiuc010pay.3 human

Organism-specific databases

CTDi284565
EuPathDBiHostDB:ENSG00000266338.6
GeneCardsiNBPF15
H-InvDBiHIX0023175
HGNCiHGNC:28791 NBPF15
HPAiHPA042595
HPA043105
HPA043692
HPA044023
HPA046971
HPA058050
MIMi610414 gene
614005 gene
neXtProtiNX_Q8N660
OpenTargetsiENSG00000266338
PharmGKBiPA142671274
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KG3F Eukaryota
ENOG4110SQ7 LUCA
GeneTreeiENSGT00420000029746
HOGENOMiHOG000049041
HOVERGENiHBG058300
InParanoidiQ8N660
OMAiERYLTYS
OrthoDBiEOG091G03WI
PhylomeDBiQ8N660
TreeFamiTF341151

Miscellaneous databases

ChiTaRSiNBPF15 human
GenomeRNAii284565
PROiPR:Q8N660
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000266338 Expressed in 92 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_NBPF15
GenevisibleiQ8N660 HS

Family and domain databases

InterProiView protein in InterPro
IPR010630 NBPF_dom
PfamiView protein in Pfam
PF06758 DUF1220, 6 hits
SMARTiView protein in SMART
SM01148 DUF1220, 6 hits
PROSITEiView protein in PROSITE
PS51316 NBPF, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNBPFF_HUMAN
AccessioniPrimary (citable) accession number: Q8N660
Secondary accession number(s): A8MPT6
, Q3BBV9, Q5SXJ2, Q8IX77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 10, 2009
Last modified: September 12, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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