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Entry version 155 (07 Oct 2020)
Sequence version 2 (11 Apr 2003)
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Protein

Leucine-zipper-like transcriptional regulator 1

Gene

LZTR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q8N653

SIGNOR Signaling Network Open Resource

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SIGNORi
Q8N653

UniPathway: a resource for the exploration and annotation of metabolic pathways

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UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-zipper-like transcriptional regulator 11 Publication
Short name:
LZTR-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LZTR11 PublicationImported
Synonyms:TCFL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000099949.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6742, LZTR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600574, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N653

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glioma (GLM)1 Publication
The protein represented in this entry may be involved in disease pathogenesis.
Disease descriptionGliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081294105W → R in GLM; increased Ras signaling. 1 Publication1
Natural variantiVAR_081301198R → G in GLM; increased Ras signaling; decreased ubiquitination of Ras. 1 Publication1
Natural variantiVAR_075659248G → R in NS10 and GLM; increased RAS-MAPK signaling; decreased ubiquitination of Ras; decreased stability; no effect on localization to Golgi apparatus. 4 PublicationsCorresponds to variant dbSNP:rs869320686EnsemblClinVar.1
Natural variantiVAR_081309288T → I in GLM; increased Ras signaling. 1 Publication1
Natural variantiVAR_081331810R → W in GLM; increased Ras signaling. 1 PublicationCorresponds to variant dbSNP:rs776893978Ensembl.1
Schwannomatosis 2 (SWNTS2)6 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA cancer predisposition syndrome in which patients develop multiple non-vestibular schwannomas, benign neoplasms that arise from Schwann cells of the cranial, peripheral, and autonomic nerves.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08129271H → R in SWNTS2; unknown pathological significance. 1 Publication1
Natural variantiVAR_08129381 – 840Missing in SWNTS2. 1 PublicationAdd BLAST760
Natural variantiVAR_071145122S → L in SWNTS2; increased Ras signaling; decreased binding to Ras. 3 PublicationsCorresponds to variant dbSNP:rs587777177EnsemblClinVar.1
Natural variantiVAR_081296125Missing in SWNTS2; unknown pathological significance. 1 Publication1
Natural variantiVAR_081298170R → Q in SWNTS2; increased RAS-MAPK signaling. 2 PublicationsCorresponds to variant dbSNP:rs781431741EnsemblClinVar.1
Natural variantiVAR_081300187L → R in SWNTS2; decreased binding to Ras. 2 Publications1
Natural variantiVAR_081302202M → R in SWNTS2; decreased binding to Ras. 2 Publications1
Natural variantiVAR_081304210 – 840Missing in NS2 and SWNTS2. 2 PublicationsAdd BLAST631
Natural variantiVAR_075660284R → C in NS10 and SWNTS2; increased RAS-MAPK signaling; decreased stability; no effect on localization to Golgi apparatus. 3 PublicationsCorresponds to variant dbSNP:rs797045165EnsemblClinVar.1
Natural variantiVAR_081308286G → R in SWNTS2; unknown pathological significance; no effect on stability. 2 PublicationsCorresponds to variant dbSNP:rs773016962EnsemblClinVar.1
Natural variantiVAR_081311322 – 840Missing in SWNTS2. 1 PublicationAdd BLAST519
Natural variantiVAR_081312340 – 840Missing in SWNTS2. 1 PublicationAdd BLAST501
Natural variantiVAR_081313392A → V in SWNTS2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767354230Ensembl.1
Natural variantiVAR_081314400M → R in SWNTS2; unknown pathological significance; no effect on stability; no effect on localization to Golgi apparatus. 2 Publications1
Natural variantiVAR_071146404G → R in SWNTS2; increased Ras signaling; decreased binding to Ras. 3 PublicationsCorresponds to variant dbSNP:rs1470449160Ensembl.1
Natural variantiVAR_071147456V → G in SWNTS2; increased Ras signaling; impaired subcellular location. 2 Publications1
Natural variantiVAR_081315465A → E in SWNTS2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs753757778Ensembl.1
Natural variantiVAR_071148466R → Q in SWNTS2; increased Ras signaling; decreased interaction with CUL3; impaired subcellular location; impaired subcellular location. 3 PublicationsCorresponds to variant dbSNP:rs587777180EnsemblClinVar.1
Natural variantiVAR_071149520P → L in SWNTS2; increased Ras signaling; impaired subcellular location. 2 PublicationsCorresponds to variant dbSNP:rs1569157089EnsemblClinVar.1
Natural variantiVAR_081316528L → R in SWNTS2; unknown pathological significance. 1 Publication1
Natural variantiVAR_081317539G → C in SWNTS2; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_081320603 – 840Missing in SWNTS2. 1 PublicationAdd BLAST238
Natural variantiVAR_081321654D → G in SWNTS2; unknown pathological significance. 1 Publication1
Natural variantiVAR_081322668D → Y in SWNTS2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs776005012EnsemblClinVar.1
Natural variantiVAR_071150688R → C in SWNTS2; increased Ras signaling; decreased interaction with CUL3; impaired subcellular location. 4 PublicationsCorresponds to variant dbSNP:rs587777178EnsemblClinVar.1
Natural variantiVAR_081325697R → W in SWNTS2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs751516987Ensembl.1
Natural variantiVAR_081329760C → R in SWNTS2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1419388177Ensembl.1
Natural variantiVAR_081330762 – 840Missing in SWNTS2. 2 PublicationsAdd BLAST79
Natural variantiVAR_081332812L → P in SWNTS2; decreased interaction with CUL3; impaired subcellular location; decreased ubiquitination of Ras. 1 PublicationCorresponds to variant dbSNP:rs773059569Ensembl.1
Natural variantiVAR_071151813S → I in SWNTS2; increased Ras signaling. 2 Publications1
Noonan syndrome 10 (NS10)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. NS10 inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075657119Y → C in NS10; increased Ras signaling. 2 Publications1
Natural variantiVAR_081297143N → S in NS10; unknown pathological significance. 1 Publication1
Natural variantiVAR_075658247S → N in NS10; increased RAS-MAPK signaling; decreased stability; no effect on localization to Golgi apparatus. 3 PublicationsCorresponds to variant dbSNP:rs797045166EnsemblClinVar.1
Natural variantiVAR_075659248G → R in NS10 and GLM; increased RAS-MAPK signaling; decreased ubiquitination of Ras; decreased stability; no effect on localization to Golgi apparatus. 4 PublicationsCorresponds to variant dbSNP:rs869320686EnsemblClinVar.1
Natural variantiVAR_081306253Missing in NS10; unknown pathological significance. 1 Publication1
Natural variantiVAR_081307283R → Q in NS10. 1 PublicationCorresponds to variant dbSNP:rs1223430276EnsemblClinVar.1
Natural variantiVAR_075660284R → C in NS10 and SWNTS2; increased RAS-MAPK signaling; decreased stability; no effect on localization to Golgi apparatus. 3 PublicationsCorresponds to variant dbSNP:rs797045165EnsemblClinVar.1
Natural variantiVAR_075661287H → Y in NS10; increased Ras signaling. 2 Publications1
Natural variantiVAR_081310294R → L in NS10; unknown pathological significance. 1 Publication1
Natural variantiVAR_081318554A → P in NS10; unknown pathological significance. 1 Publication1
Noonan syndrome 2 (NS2)3 Publications
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. NS2 inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081295121H → D in NS2; unknown pathological significance; no effect on RAS-MAPK signaling; no effect on stability. 2 PublicationsCorresponds to variant dbSNP:rs1569154492EnsemblClinVar.1
Natural variantiVAR_081299170R → W in NS2; when associated with T-205. 1 PublicationCorresponds to variant dbSNP:rs757502214Ensembl.1
Natural variantiVAR_081303205I → T in NS2; unknown pathological significance; when associated with W-170. 1 PublicationCorresponds to variant dbSNP:rs1287917092Ensembl.1
Natural variantiVAR_081304210 – 840Missing in NS2 and SWNTS2. 2 PublicationsAdd BLAST631
Natural variantiVAR_081305217E → A in NS2; unknown pathological significance; no effect on RAS-MAPK signaling; decreased stability. 2 Publications1
Natural variantiVAR_081319563E → Q in NS2; unknown pathological significance; no effect on RAS-MAPK signaling; strongly decreased stability. 2 PublicationsCorresponds to variant dbSNP:rs1374240053Ensembl.1
Natural variantiVAR_081323688R → G in NS2; unknown pathological significance. 1 Publication1
Natural variantiVAR_081324697R → Q in NS2. 1 PublicationCorresponds to variant dbSNP:rs370638947Ensembl.1
Natural variantiVAR_081326701P → H in NS2. 1 PublicationCorresponds to variant dbSNP:rs1327579827Ensembl.1
Natural variantiVAR_081327726 – 840Missing in NS2; decreased ubiquitination of Ras. 2 PublicationsAdd BLAST115
Natural variantiVAR_081328755R → Q in NS2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs762834512EnsemblClinVar.1
Natural variantiVAR_081333821I → T in NS2; unknown pathological significance; no effect on RAS-MAPK signaling; decreased localization to Golgi apparatus; no effect on stability. 2 PublicationsCorresponds to variant dbSNP:rs1275511136EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi91M → V: Increased RAS-MAPK signaling. 1 Publication1
Mutagenesisi193Y → H: Increased RAS-MAPK signaling. 1 Publication1
Mutagenesisi193Y → N: Increased RAS-MAPK signaling. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
8216

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
LZTR1

MalaCards human disease database

More...
MalaCardsi
LZTR1
MIMi137800, phenotype
605275, phenotype
615670, phenotype
616564, phenotype

Open Targets

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OpenTargetsi
ENSG00000099949

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
251579, Giant cell glioblastoma
251576, Gliosarcoma
648, Noonan syndrome
93921, Schwannomatosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30506

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N653, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
LZTR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
29839558

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001191352 – 840Leucine-zipper-like transcriptional regulator 1Add BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine upon induction of apoptosis, leading to its degradation by the proteasome.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N653

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8N653

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8N653

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8N653

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N653

PeptideAtlas

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PeptideAtlasi
Q8N653

PRoteomics IDEntifications database

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PRIDEi
Q8N653

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
72130

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8N653

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8N653

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal brain, heart, kidney, liver and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000099949, Expressed in adenohypophysis and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N653, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N653, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000099949, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:30442762).

Component of the BCR(LZTR1) E3 ubiquitin ligase complex, at least composed of CUL3, LZTR1 and RBX1 (PubMed:30442762, PubMed:30442766).

Interacts with Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762).

Interacts with RAF1 (PubMed:30368668).

Interacts with SHOC2 (PubMed:30368668).

Interacts with PPP1CB (PubMed:30368668).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
113852, 101 interactors

Protein interaction database and analysis system

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IntActi
Q8N653, 14 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000215739

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q8N653, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati79 – 128Kelch 1Sequence analysisAdd BLAST50
Repeati130 – 185Kelch 2Sequence analysisAdd BLAST56
Repeati187 – 238Kelch 3Sequence analysisAdd BLAST52
Repeati239 – 285Kelch 4Sequence analysisAdd BLAST47
Repeati295 – 341Kelch 5Sequence analysisAdd BLAST47
Repeati399 – 450Kelch 6Sequence analysisAdd BLAST52
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini443 – 537BTB 1PROSITE-ProRule annotationAdd BLAST95
Domaini667 – 736BTB 2PROSITE-ProRule annotationAdd BLAST70

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LZTR1 family.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4693, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158190

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_012081_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N653

KEGG Orthology (KO)

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KOi
K23330

Identification of Orthologs from Complete Genome Data

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OMAi
EKQFCDI

Database of Orthologous Groups

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OrthoDBi
1263405at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N653

TreeFam database of animal gene trees

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TreeFami
TF314081

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.120.10.80, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000210, BTB/POZ_dom
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR011498, Kelch_2
IPR011333, SKP1/BTB/POZ_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00651, BTB, 2 hits
PF01344, Kelch_1, 2 hits
PF07646, Kelch_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00225, BTB, 2 hits
SM00612, Kelch, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF117281, SSF117281, 2 hits
SSF54695, SSF54695, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50097, BTB, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

Q8N653-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPGSTGGQ IGAAALAGGA RSKVAPSVDF DHSCSDSVEY LTLNFGPFET
60 70 80 90 100
VHRWRRLPPC DEFVGARRSK HTVVAYKDAI YVFGGDNGKT MLNDLLRFDV
110 120 130 140 150
KDCSWCRAFT TGTPPAPRYH HSAVVYGSSM FVFGGYTGDI YSNSNLKNKN
160 170 180 190 200
DLFEYKFATG QWTEWKIEGR LPVARSAHGA TVYSDKLWIF AGYDGNARLN
210 220 230 240 250
DMWTIGLQDR ELTCWEEVAQ SGEIPPSCCN FPVAVCRDKM FVFSGQSGAK
260 270 280 290 300
ITNNLFQFEF KDKTWTRIPT EHLLRGSPPP PQRRYGHTMV AFDRHLYVFG
310 320 330 340 350
GAADNTLPNE LHCYDVDFQT WEVVQPSSDS EVGGAEVPER ACASEEVPTL
360 370 380 390 400
TYEERVGFKK SRDVFGLDFG TTSAKQPTQP ASELPSGRLF HAAAVISDAM
410 420 430 440 450
YIFGGTVDNN IRSGEMYRFQ FSCYPKCTLH EDYGRLWESR QFCDVEFVLG
460 470 480 490 500
EKEECVQGHV AIVTARSRWL RRKITQARER LAQKLEQEAA PVPREAPGVA
510 520 530 540 550
AGGARPPLLH VAIREAEARP FEVLMQFLYT DKIKYPRKGH VEDVLLIMDV
560 570 580 590 600
YKLALSFQLC RLEQLCRQYI EASVDLQNVL VVCESAARLQ LSQLKEHCLN
610 620 630 640 650
FVVKESHFNQ VIMMKEFERL SSPLIVEIVR RKQQPPPRTP LDQPVDIGTS
660 670 680 690 700
LIQDMKAYLE GAGAEFCDIT LLLDGHPRPA HKAILAARSS YFEAMFRSFM
710 720 730 740 750
PEDGQVNISI GEMVPSRQAF ESMLRYIYYG EVNMPPEDSL YLFAAPYYYG
760 770 780 790 800
FYNNRLQAYC KQNLEMNVTV QNVLQILEAA DKTQALDMKR HCLHIIVHQF
810 820 830 840
TKVSKLPTLR SLSQQLLLDI IDSLASHISD KQCAELGADI
Length:840
Mass (Da):94,719
Last modified:April 11, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAAF172940BAEA92B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C305H7C305_HUMAN
Leucine-zipper-like transcriptional...
LZTR1
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEQ8F8WEQ8_HUMAN
Leucine-zipper-like transcriptional...
LZTR1
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB67F8WB67_HUMAN
Leucine-zipper-like transcriptional...
LZTR1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCB6F8WCB6_HUMAN
Leucine-zipper-like transcriptional...
LZTR1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZQ9H7BZQ9_HUMAN
Leucine-zipper-like transcriptional...
LZTR1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0X1H7C0X1_HUMAN
Leucine-zipper-like transcriptional...
LZTR1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7K3A0A2R8Y7K3_HUMAN
Leucine-zipper-like transcriptional...
LZTR1
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCD2A0A2R8YCD2_HUMAN
Leucine-zipper-like transcriptional...
LZTR1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y656A0A2R8Y656_HUMAN
Leucine-zipper-like transcriptional...
LZTR1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4K9A0A2R8Y4K9_HUMAN
Leucine-zipper-like transcriptional...
LZTR1
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA07508 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti498G → S in BAA07508 (PubMed:7633402).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08129271H → R in SWNTS2; unknown pathological significance. 1 Publication1
Natural variantiVAR_08129381 – 840Missing in SWNTS2. 1 PublicationAdd BLAST760
Natural variantiVAR_081294105W → R in GLM; increased Ras signaling. 1 Publication1
Natural variantiVAR_075657119Y → C in NS10; increased Ras signaling. 2 Publications1
Natural variantiVAR_081295121H → D in NS2; unknown pathological significance; no effect on RAS-MAPK signaling; no effect on stability. 2 PublicationsCorresponds to variant dbSNP:rs1569154492EnsemblClinVar.1
Natural variantiVAR_071145122S → L in SWNTS2; increased Ras signaling; decreased binding to Ras. 3 PublicationsCorresponds to variant dbSNP:rs587777177EnsemblClinVar.1
Natural variantiVAR_081296125Missing in SWNTS2; unknown pathological significance. 1 Publication1
Natural variantiVAR_081297143N → S in NS10; unknown pathological significance. 1 Publication1
Natural variantiVAR_081298170R → Q in SWNTS2; increased RAS-MAPK signaling. 2 PublicationsCorresponds to variant dbSNP:rs781431741EnsemblClinVar.1
Natural variantiVAR_081299170R → W in NS2; when associated with T-205. 1 PublicationCorresponds to variant dbSNP:rs757502214Ensembl.1
Natural variantiVAR_081300187L → R in SWNTS2; decreased binding to Ras. 2 Publications1
Natural variantiVAR_081301198R → G in GLM; increased Ras signaling; decreased ubiquitination of Ras. 1 Publication1
Natural variantiVAR_081302202M → R in SWNTS2; decreased binding to Ras. 2 Publications1
Natural variantiVAR_081303205I → T in NS2; unknown pathological significance; when associated with W-170. 1 PublicationCorresponds to variant dbSNP:rs1287917092Ensembl.1
Natural variantiVAR_081304210 – 840Missing in NS2 and SWNTS2. 2 PublicationsAdd BLAST631
Natural variantiVAR_081305217E → A in NS2; unknown pathological significance; no effect on RAS-MAPK signaling; decreased stability. 2 Publications1
Natural variantiVAR_075658247S → N in NS10; increased RAS-MAPK signaling; decreased stability; no effect on localization to Golgi apparatus. 3 PublicationsCorresponds to variant dbSNP:rs797045166EnsemblClinVar.1
Natural variantiVAR_075659248G → R in NS10 and GLM; increased RAS-MAPK signaling; decreased ubiquitination of Ras; decreased stability; no effect on localization to Golgi apparatus. 4 PublicationsCorresponds to variant dbSNP:rs869320686EnsemblClinVar.1
Natural variantiVAR_081306253Missing in NS10; unknown pathological significance. 1 Publication1
Natural variantiVAR_081307283R → Q in NS10. 1 PublicationCorresponds to variant dbSNP:rs1223430276EnsemblClinVar.1
Natural variantiVAR_075660284R → C in NS10 and SWNTS2; increased RAS-MAPK signaling; decreased stability; no effect on localization to Golgi apparatus. 3 PublicationsCorresponds to variant dbSNP:rs797045165EnsemblClinVar.1
Natural variantiVAR_081308286G → R in SWNTS2; unknown pathological significance; no effect on stability. 2 PublicationsCorresponds to variant dbSNP:rs773016962EnsemblClinVar.1
Natural variantiVAR_075661287H → Y in NS10; increased Ras signaling. 2 Publications1
Natural variantiVAR_081309288T → I in GLM; increased Ras signaling. 1 Publication1
Natural variantiVAR_081310294R → L in NS10; unknown pathological significance. 1 Publication1
Natural variantiVAR_081311322 – 840Missing in SWNTS2. 1 PublicationAdd BLAST519
Natural variantiVAR_081312340 – 840Missing in SWNTS2. 1 PublicationAdd BLAST501
Natural variantiVAR_081313392A → V in SWNTS2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767354230Ensembl.1
Natural variantiVAR_081314400M → R in SWNTS2; unknown pathological significance; no effect on stability; no effect on localization to Golgi apparatus. 2 Publications1
Natural variantiVAR_071146404G → R in SWNTS2; increased Ras signaling; decreased binding to Ras. 3 PublicationsCorresponds to variant dbSNP:rs1470449160Ensembl.1
Natural variantiVAR_075662447F → L1 PublicationCorresponds to variant dbSNP:rs201016956Ensembl.1
Natural variantiVAR_071147456V → G in SWNTS2; increased Ras signaling; impaired subcellular location. 2 Publications1
Natural variantiVAR_081315465A → E in SWNTS2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs753757778Ensembl.1
Natural variantiVAR_071148466R → Q in SWNTS2; increased Ras signaling; decreased interaction with CUL3; impaired subcellular location; impaired subcellular location. 3 PublicationsCorresponds to variant dbSNP:rs587777180EnsemblClinVar.1
Natural variantiVAR_071149520P → L in SWNTS2; increased Ras signaling; impaired subcellular location. 2 PublicationsCorresponds to variant dbSNP:rs1569157089EnsemblClinVar.1
Natural variantiVAR_081316528L → R in SWNTS2; unknown pathological significance. 1 Publication1
Natural variantiVAR_081317539G → C in SWNTS2; unknown pathological significance; somatic mutation. 1 Publication1
Natural variantiVAR_081318554A → P in NS10; unknown pathological significance. 1 Publication1
Natural variantiVAR_081319563E → Q in NS2; unknown pathological significance; no effect on RAS-MAPK signaling; strongly decreased stability. 2 PublicationsCorresponds to variant dbSNP:rs1374240053Ensembl.1
Natural variantiVAR_081320603 – 840Missing in SWNTS2. 1 PublicationAdd BLAST238
Natural variantiVAR_075663647I → V1 PublicationCorresponds to variant dbSNP:rs148916790Ensembl.1
Natural variantiVAR_081321654D → G in SWNTS2; unknown pathological significance. 1 Publication1
Natural variantiVAR_081322668D → Y in SWNTS2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs776005012EnsemblClinVar.1
Natural variantiVAR_071150688R → C in SWNTS2; increased Ras signaling; decreased interaction with CUL3; impaired subcellular location. 4 PublicationsCorresponds to variant dbSNP:rs587777178EnsemblClinVar.1
Natural variantiVAR_081323688R → G in NS2; unknown pathological significance. 1 Publication1
Natural variantiVAR_081324697R → Q in NS2. 1 PublicationCorresponds to variant dbSNP:rs370638947Ensembl.1
Natural variantiVAR_081325697R → W in SWNTS2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs751516987Ensembl.1
Natural variantiVAR_081326701P → H in NS2. 1 PublicationCorresponds to variant dbSNP:rs1327579827Ensembl.1
Natural variantiVAR_081327726 – 840Missing in NS2; decreased ubiquitination of Ras. 2 PublicationsAdd BLAST115
Natural variantiVAR_081328755R → Q in NS2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs762834512EnsemblClinVar.1
Natural variantiVAR_081329760C → R in SWNTS2; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1419388177Ensembl.1
Natural variantiVAR_081330762 – 840Missing in SWNTS2. 2 PublicationsAdd BLAST79
Natural variantiVAR_081331810R → W in GLM; increased Ras signaling. 1 PublicationCorresponds to variant dbSNP:rs776893978Ensembl.1
Natural variantiVAR_081332812L → P in SWNTS2; decreased interaction with CUL3; impaired subcellular location; decreased ubiquitination of Ras. 1 PublicationCorresponds to variant dbSNP:rs773059569Ensembl.1
Natural variantiVAR_071151813S → I in SWNTS2; increased Ras signaling. 2 Publications1
Natural variantiVAR_081333821I → T in NS2; unknown pathological significance; no effect on RAS-MAPK signaling; decreased localization to Golgi apparatus; no effect on stability. 2 Publications