UniProtKB - Q8N614 (TM156_HUMAN)
Protein
Transmembrane protein 156
Gene
TMEM156
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 156 |
Gene namesi | Name:TMEM156 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26260, TMEM156 |
neXtProti | NX_Q8N614 |
VEuPathDBi | HostDB:ENSG00000121895.7 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 4 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 5 – 25 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 26 – 211 | ExtracellularSequence analysisAdd BLAST | 186 | |
Transmembranei | 212 – 232 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 233 – 296 | CytoplasmicSequence analysisAdd BLAST | 64 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 80008 |
OpenTargetsi | ENSG00000121895 |
PharmGKBi | PA145007464 |
Miscellaneous databases
Pharosi | Q8N614, Tdark |
Genetic variation databases
BioMutai | TMEM156 |
DMDMi | 145566966 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284505 | 1 – 296 | Transmembrane protein 156Add BLAST | 296 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 45 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 156 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q8N614 |
PeptideAtlasi | Q8N614 |
PRIDEi | Q8N614 |
ProteomicsDBi | 72125 |
PTM databases
GlyGeni | Q8N614, 3 sites |
iPTMneti | Q8N614 |
PhosphoSitePlusi | Q8N614 |
Expressioni
Gene expression databases
Bgeei | ENSG00000121895, Expressed in buccal mucosa cell and 156 other tissues |
ExpressionAtlasi | Q8N614, baseline and differential |
Genevisiblei | Q8N614, HS |
Organism-specific databases
HPAi | ENSG00000121895, Group enriched (blood, brain, intestine, lymphoid tissue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123065, 4 interactors |
IntActi | Q8N614, 3 interactors |
STRINGi | 9606.ENSP00000371364 |
Miscellaneous databases
RNActi | Q8N614, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SAF3, Eukaryota |
GeneTreei | ENSGT00390000017929 |
HOGENOMi | CLU_081882_0_0_1 |
InParanoidi | Q8N614 |
OMAi | GKSINHT |
OrthoDBi | 1271265at2759 |
PhylomeDBi | Q8N614 |
TreeFami | TF336964 |
Family and domain databases
InterProi | View protein in InterPro IPR029374, TMEM156 |
PANTHERi | PTHR14788, PTHR14788, 1 hit |
Pfami | View protein in Pfam PF15106, TMEM156, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8N614-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKTALLKLF VAIVITFILI LPEYFKTPKE RTLELSCLEV CLQSNFTYSL
60 70 80 90 100
SSLNFSFVTF LQPVRETQII MRIFLNPSNF RNFTRTCQDI TGEFKMCSSC
110 120 130 140 150
LVCESKGNMD FISQEQTSKV LIRRGSMEVK ANDFHSPCQH FNFSVAPLVD
160 170 180 190 200
HLEEYNTTCH LKNHTGRSTI MEDEPSKEKS INYTCRIMEY PNDCIHISLH
210 220 230 240 250
LEMDIKNITC SMKITWYILV LLVFIFLIIL TIRKILEGQR RVQKWQSHRD
260 270 280 290
KPTSVLLRGS DSEKLRALNV QVLSAETTQR LPLDQVQEVL PPIPEL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketJ3KNV8 | J3KNV8_HUMAN | Transmembrane protein 156 | TMEM156 | 179 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031756 | 48 | Y → C. Corresponds to variant dbSNP:rs35576563Ensembl. | 1 | |
Natural variantiVAR_051430 | 105 | S → P1 PublicationCorresponds to variant dbSNP:rs11542133Ensembl. | 1 | |
Natural variantiVAR_031757 | 212 | M → T. Corresponds to variant dbSNP:rs2276887Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026888 mRNA Translation: BAB15583.1 BC030803 mRNA Translation: AAH30803.1 |
CCDSi | CCDS3448.1 |
RefSeqi | NP_001290157.1, NM_001303228.1 NP_079219.1, NM_024943.2 XP_011512051.1, XM_011513749.2 |
Genome annotation databases
Ensembli | ENST00000381938; ENSP00000371364; ENSG00000121895 |
GeneIDi | 80008 |
KEGGi | hsa:80008 |
UCSCi | uc003gto.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026888 mRNA Translation: BAB15583.1 BC030803 mRNA Translation: AAH30803.1 |
CCDSi | CCDS3448.1 |
RefSeqi | NP_001290157.1, NM_001303228.1 NP_079219.1, NM_024943.2 XP_011512051.1, XM_011513749.2 |
3D structure databases
SMRi | Q8N614 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123065, 4 interactors |
IntActi | Q8N614, 3 interactors |
STRINGi | 9606.ENSP00000371364 |
PTM databases
GlyGeni | Q8N614, 3 sites |
iPTMneti | Q8N614 |
PhosphoSitePlusi | Q8N614 |
Genetic variation databases
BioMutai | TMEM156 |
DMDMi | 145566966 |
Proteomic databases
PaxDbi | Q8N614 |
PeptideAtlasi | Q8N614 |
PRIDEi | Q8N614 |
ProteomicsDBi | 72125 |
Protocols and materials databases
Antibodypediai | 23382, 6 antibodies |
Genome annotation databases
Ensembli | ENST00000381938; ENSP00000371364; ENSG00000121895 |
GeneIDi | 80008 |
KEGGi | hsa:80008 |
UCSCi | uc003gto.4, human |
Organism-specific databases
CTDi | 80008 |
DisGeNETi | 80008 |
GeneCardsi | TMEM156 |
HGNCi | HGNC:26260, TMEM156 |
HPAi | ENSG00000121895, Group enriched (blood, brain, intestine, lymphoid tissue) |
neXtProti | NX_Q8N614 |
OpenTargetsi | ENSG00000121895 |
PharmGKBi | PA145007464 |
VEuPathDBi | HostDB:ENSG00000121895.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SAF3, Eukaryota |
GeneTreei | ENSGT00390000017929 |
HOGENOMi | CLU_081882_0_0_1 |
InParanoidi | Q8N614 |
OMAi | GKSINHT |
OrthoDBi | 1271265at2759 |
PhylomeDBi | Q8N614 |
TreeFami | TF336964 |
Enzyme and pathway databases
PathwayCommonsi | Q8N614 |
Miscellaneous databases
BioGRID-ORCSi | 80008, 3 hits in 876 CRISPR screens |
ChiTaRSi | TMEM156, human |
GenomeRNAii | 80008 |
Pharosi | Q8N614, Tdark |
PROi | PR:Q8N614 |
RNActi | Q8N614, protein |
Gene expression databases
Bgeei | ENSG00000121895, Expressed in buccal mucosa cell and 156 other tissues |
ExpressionAtlasi | Q8N614, baseline and differential |
Genevisiblei | Q8N614, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029374, TMEM156 |
PANTHERi | PTHR14788, PTHR14788, 1 hit |
Pfami | View protein in Pfam PF15106, TMEM156, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM156_HUMAN | |
Accessioni | Q8N614Primary (citable) accession number: Q8N614 Secondary accession number(s): Q9H5N9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | April 17, 2007 | |
Last modified: | February 10, 2021 | |
This is version 110 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants