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UniProtKB - Q8N614 (TM156_HUMAN)

Entry version 110 (10 Feb 2021)
Sequence version 2 (17 Apr 2007)
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Protein

Transmembrane protein 156

Gene

TMEM156

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N614

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 156
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM156
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26260, TMEM156

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N614

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000121895.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4CytoplasmicSequence analysis4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 211ExtracellularSequence analysisAdd BLAST186
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 296CytoplasmicSequence analysisAdd BLAST64

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		80008

Open Targets

More...OpenTargetsi		ENSG00000121895

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA145007464

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N614, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM156

Domain mapping of disease mutations (DMDM)

More...DMDMi		145566966

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002845051 – 296Transmembrane protein 156Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N614

PeptideAtlas

More...PeptideAtlasi		Q8N614

PRoteomics IDEntifications database

More...PRIDEi		Q8N614

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72125

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8N614, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N614

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N614

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000121895, Expressed in buccal mucosa cell and 156 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N614, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N614, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000121895, Group enriched (blood, brain, intestine, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123065, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q8N614, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000371364

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N614, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N614

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SAF3, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017929

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_081882_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N614

Identification of Orthologs from Complete Genome Data

More...OMAi		GKSINHT

Database of Orthologous Groups

More...OrthoDBi		1271265at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N614

TreeFam database of animal gene trees

More...TreeFami		TF336964

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029374, TMEM156

The PANTHER Classification System

More...PANTHERi		PTHR14788, PTHR14788, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15106, TMEM156, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N614-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKTALLKLF VAIVITFILI LPEYFKTPKE RTLELSCLEV CLQSNFTYSL 
        60         70         80         90        100
SSLNFSFVTF LQPVRETQII MRIFLNPSNF RNFTRTCQDI TGEFKMCSSC 
       110        120        130        140        150
LVCESKGNMD FISQEQTSKV LIRRGSMEVK ANDFHSPCQH FNFSVAPLVD 
       160        170        180        190        200
HLEEYNTTCH LKNHTGRSTI MEDEPSKEKS INYTCRIMEY PNDCIHISLH 
       210        220        230        240        250
LEMDIKNITC SMKITWYILV LLVFIFLIIL TIRKILEGQR RVQKWQSHRD 
       260        270        280        290 
KPTSVLLRGS DSEKLRALNV QVLSAETTQR LPLDQVQEVL PPIPEL
Length:296
Mass (Da):34,323
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54DE078ECC1BCE97
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNV8J3KNV8_HUMAN
Transmembrane protein 156
TMEM156
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03175648Y → C. Corresponds to variant dbSNP:rs35576563Ensembl.1
Natural variantiVAR_051430105S → P1 PublicationCorresponds to variant dbSNP:rs11542133Ensembl.1
Natural variantiVAR_031757212M → T. Corresponds to variant dbSNP:rs2276887Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK026888 mRNA Translation: BAB15583.1
BC030803 mRNA Translation: AAH30803.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3448.1

NCBI Reference Sequences

More...RefSeqi		NP_001290157.1, NM_001303228.1
NP_079219.1, NM_024943.2
XP_011512051.1, XM_011513749.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000381938; ENSP00000371364; ENSG00000121895

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80008

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80008

UCSC genome browser

More...UCSCi		uc003gto.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026888 mRNA Translation: BAB15583.1
BC030803 mRNA Translation: AAH30803.1
CCDSiCCDS3448.1
RefSeqiNP_001290157.1, NM_001303228.1
NP_079219.1, NM_024943.2
XP_011512051.1, XM_011513749.2

3D structure databases

SMRiQ8N614
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123065, 4 interactors
IntActiQ8N614, 3 interactors
STRINGi9606.ENSP00000371364

PTM databases

GlyGeniQ8N614, 3 sites
iPTMnetiQ8N614
PhosphoSitePlusiQ8N614

Genetic variation databases

BioMutaiTMEM156
DMDMi145566966

Proteomic databases

PaxDbiQ8N614
PeptideAtlasiQ8N614
PRIDEiQ8N614
ProteomicsDBi72125

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23382, 6 antibodies

Genome annotation databases

EnsembliENST00000381938; ENSP00000371364; ENSG00000121895
GeneIDi80008
KEGGihsa:80008
UCSCiuc003gto.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80008
DisGeNETi80008

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM156
HGNCiHGNC:26260, TMEM156
HPAiENSG00000121895, Group enriched (blood, brain, intestine, lymphoid tissue)
neXtProtiNX_Q8N614
OpenTargetsiENSG00000121895
PharmGKBiPA145007464
VEuPathDBiHostDB:ENSG00000121895.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SAF3, Eukaryota
GeneTreeiENSGT00390000017929
HOGENOMiCLU_081882_0_0_1
InParanoidiQ8N614
OMAiGKSINHT
OrthoDBi1271265at2759
PhylomeDBiQ8N614
TreeFamiTF336964

Enzyme and pathway databases

PathwayCommonsiQ8N614

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80008, 3 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM156, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80008
PharosiQ8N614, Tdark

Protein Ontology

More...PROi		PR:Q8N614
RNActiQ8N614, protein

Gene expression databases

BgeeiENSG00000121895, Expressed in buccal mucosa cell and 156 other tissues
ExpressionAtlasiQ8N614, baseline and differential
GenevisibleiQ8N614, HS

Family and domain databases

InterProiView protein in InterPro
IPR029374, TMEM156
PANTHERiPTHR14788, PTHR14788, 1 hit
PfamiView protein in Pfam
PF15106, TMEM156, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM156_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N614
Secondary accession number(s): Q9H5N9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: February 10, 2021
This is version 110 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
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