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Protein

Inactive dipeptidyl peptidase 10

Gene

DPP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).3 Publications

Caution

Gly-651 is present instead of the conserved Ser which is expected to be an active site residue suggesting that this protein has no peptidase activity.Curated

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

ESTHERihuman-DPP10 DPP4N_Peptidase_S9
MEROPSiS09.974
TCDBi8.A.51.1.2 the dipeptidyl-aminopeptidase-like protein 6 beta subunit of kv4 channels (dpp6) family

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive dipeptidyl peptidase 10
Alternative name(s):
Dipeptidyl peptidase IV-related protein 3
Short name:
DPRP-3
Dipeptidyl peptidase X
Short name:
DPP X
Dipeptidyl peptidase-like protein 2
Short name:
DPL2
Gene namesi
Name:DPP10
Synonyms:DPRP3, KIAA1492
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000175497.16
HGNCiHGNC:20823 DPP10
MIMi608209 gene
neXtProtiNX_Q8N608

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini56 – 796ExtracellularSequence analysisAdd BLAST741

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Asthma (ASTHMA)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionThe most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
See also OMIM:600807

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi257N → Q: Abolishes sorting to the cell surface and dimerization. 1 Publication1

Keywords - Diseasei

Asthma

Organism-specific databases

DisGeNETi57628
MIMi600807 phenotype
OpenTargetsiENSG00000175497
PharmGKBiPA134991647

Polymorphism and mutation databases

BioMutaiDPP10
DMDMi296434483

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224171 – 796Inactive dipeptidyl peptidase 10Add BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi111N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi119N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei138PhosphotyrosineCombined sources1
Modified residuei143PhosphotyrosineCombined sources1
Glycosylationi257N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi342N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi748N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8N608
PaxDbiQ8N608
PeptideAtlasiQ8N608
PRIDEiQ8N608
ProteomicsDBi72119
72120 [Q8N608-2]

PTM databases

iPTMnetiQ8N608
PhosphoSitePlusiQ8N608

Expressioni

Tissue specificityi

Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.2 Publications

Gene expression databases

BgeeiENSG00000175497 Expressed in 117 organ(s), highest expression level in adrenal tissue
CleanExiHS_DPP10
ExpressionAtlasiQ8N608 baseline and differential
GenevisibleiQ8N608 HS

Organism-specific databases

HPAiHPA048767

Interactioni

Subunit structurei

May form oligomers. Interacts with KCND1 (Probable). Interacts with KCND2.Curated2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121672, 4 interactors
CORUMiQ8N608
IntActiQ8N608, 1 interactor
STRINGi9606.ENSP00000376855

Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8N608
SMRiQ8N608
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56Mediates effects on KCND2Add BLAST56

Sequence similaritiesi

Belongs to the peptidase S9B family. DPPIV subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2100 Eukaryota
COG1506 LUCA
GeneTreeiENSGT00760000119233
HOGENOMiHOG000231875
HOVERGENiHBG105877
InParanoidiQ8N608
OMAiVIYNIHT
OrthoDBiEOG091G0GBJ
PhylomeDBiQ8N608
TreeFamiTF313309

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist, which may have different subcellular locations.

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N608-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNQTASVSHH IKCQPSKTIK ELGSNSPPQR NWKGIAIALL VILVVCSLIT
60 70 80 90 100
MSVILLTPDE LTNSSETRLS LEDLFRKDFV LHDPEARWIN DTDVVYKSEN
110 120 130 140 150
GHVIKLNIET NATTLLLENT TFVTFKASRH SVSPDLKYVL LAYDVKQIFH
160 170 180 190 200
YSYTASYVIY NIHTREVWEL NPPEVEDSVL QYAAWGVQGQ QLIYIFENNI
210 220 230 240 250
YYQPDIKSSS LRLTSSGKEE IIFNGIADWL YEEELLHSHI AHWWSPDGER
260 270 280 290 300
LAFLMINDSL VPTMVIPRFT GALYPKGKQY PYPKAGQVNP TIKLYVVNLY
310 320 330 340 350
GPTHTLELMP PDSFKSREYY ITMVKWVSNT KTVVRWLNRA QNISILTVCE
360 370 380 390 400
TTTGACSKKY EMTSDTWLSQ QNEEPVFSRD GSKFFMTVPV KQGGRGEFHH
410 420 430 440 450
VAMFLIQSKS EQITVRHLTS GNWEVIKILA YDETTQKIYF LSTESSPRGR
460 470 480 490 500
QLYSASTEGL LNRQCISCNF MKEQCTYFDA SFSPMNQHFL LFCEGPRVPV
510 520 530 540 550
VSLHSTDNPA KYFILESNSM LKEAILKKKI GKPEIKILHI DDYELPLQLS
560 570 580 590 600
LPKDFMDRNQ YALLLIMDEE PGGQLVTDKF HIDWDSVLID MDNVIVARFD
610 620 630 640 650
GRGSGFQGLK ILQEIHRRLG SVEVKDQITA VKFLLKLPYI DSKRLSIFGK
660 670 680 690 700
GYGGYIASMI LKSDEKLFKC GSVVAPITDL KLYASAFSER YLGMPSKEES
710 720 730 740 750
TYQAASVLHN VHGLKEENIL IIHGTADTKV HFQHSAELIK HLIKAGVNYT
760 770 780 790
MQVYPDEGHN VSEKSKYHLY STILKFFSDC LKEEISVLPQ EPEEDE
Length:796
Mass (Da):90,888
Last modified:May 18, 2010 - v2
Checksum:i072CBD67D1FB478E
GO
Isoform 2 (identifier: Q8N608-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNQTASVSHHIKCQPSKTIK → MRKVESRGEGGRE

Show »
Length:789
Mass (Da):90,140
Checksum:iF1746DDCA46C0744
GO
Isoform 3 (identifier: Q8N608-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNQTASVSHHIKCQPSKTIK → MTAAKQEPQPTPGARASQAQPADQ

Show »
Length:800
Mass (Da):91,129
Checksum:iC837D61773C3E890
GO
Isoform 4 (identifier: Q8N608-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Note: Gene prediction based on EST data.
Show »
Length:746
Mass (Da):85,480
Checksum:iF71826F40623C64D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPP1J3KPP1_HUMAN
Inactive dipeptidyl peptidase 10
DPP10
258Annotation score:
C9J4M8C9J4M8_HUMAN
Inactive dipeptidyl peptidase 10
DPP10
60Annotation score:
J3KQK8J3KQK8_HUMAN
Inactive dipeptidyl peptidase 10
DPP10
97Annotation score:
F8WEB2F8WEB2_HUMAN
Inactive dipeptidyl peptidase 10
DPP10
60Annotation score:

Sequence cautioni

The sequence BAA96016 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288V → M in AAO17263 (PubMed:12662155).Curated1
Sequence conflicti288V → M in BAF82656 (PubMed:10819331).Curated1
Sequence conflicti288V → M in AAH30832 (PubMed:15815621).Curated1
Sequence conflicti687F → L in AAQ91190 (PubMed:12675227).Curated1
Isoform 3 (identifier: Q8N608-3)
Sequence conflicti4A → M in ABI16086 (PubMed:16899223).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057061340A → P2 PublicationsCorresponds to variant dbSNP:rs2053724Ensembl.1
Natural variantiVAR_059759401V → I7 PublicationsCorresponds to variant dbSNP:rs1446495Ensembl.1
Natural variantiVAR_057062517S → N. Corresponds to variant dbSNP:rs13421193Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0471521 – 50Missing in isoform 4. CuratedAdd BLAST50
Alternative sequenceiVSP_0138731 – 20MNQTA…SKTIK → MRKVESRGEGGRE in isoform 2. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_0444661 – 20MNQTA…SKTIK → MTAAKQEPQPTPGARASQAQ PADQ in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387785 mRNA Translation: AAQ91190.1
AY172661 mRNA Translation: AAO17263.2
AB040925 mRNA Translation: BAA96016.2 Different initiation.
DQ857322 mRNA Translation: ABI16086.1
AK289967 mRNA Translation: BAF82656.1
AC010885 Genomic DNA No translation available.
AC012071 Genomic DNA No translation available.
AC016721 Genomic DNA Translation: AAY15025.1
AC017040 Genomic DNA Translation: AAY15032.1
AC066593 Genomic DNA No translation available.
AC067947 Genomic DNA Translation: AAY14685.1
AC068542 Genomic DNA No translation available.
AC093610 Genomic DNA No translation available.
AC105422 Genomic DNA Translation: AAY24120.1
AC116620 Genomic DNA No translation available.
AC118276 Genomic DNA No translation available.
AC118664 Genomic DNA No translation available.
BC030832 mRNA Translation: AAH30832.1
CCDSiCCDS33278.1 [Q8N608-2]
CCDS46400.1 [Q8N608-1]
CCDS54388.1 [Q8N608-3]
CCDS54389.1 [Q8N608-4]
RefSeqiNP_001004360.2, NM_001004360.3
NP_001171505.1, NM_001178034.1
NP_001308835.1, NM_001321906.1
NP_001308840.1, NM_001321911.1
NP_001308841.1, NM_001321912.1
NP_001308842.1, NM_001321913.1
NP_001308843.1, NM_001321914.1
NP_065919.2, NM_020868.4
UniGeneiHs.580539
Hs.657379

Genome annotation databases

EnsembliENST00000310323; ENSP00000309066; ENSG00000175497 [Q8N608-2]
ENST00000393147; ENSP00000376855; ENSG00000175497 [Q8N608-3]
ENST00000409163; ENSP00000387038; ENSG00000175497 [Q8N608-4]
ENST00000410059; ENSP00000386565; ENSG00000175497 [Q8N608-1]
GeneIDi57628
KEGGihsa:57628
UCSCiuc002tla.3 human [Q8N608-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387785 mRNA Translation: AAQ91190.1
AY172661 mRNA Translation: AAO17263.2
AB040925 mRNA Translation: BAA96016.2 Different initiation.
DQ857322 mRNA Translation: ABI16086.1
AK289967 mRNA Translation: BAF82656.1
AC010885 Genomic DNA No translation available.
AC012071 Genomic DNA No translation available.
AC016721 Genomic DNA Translation: AAY15025.1
AC017040 Genomic DNA Translation: AAY15032.1
AC066593 Genomic DNA No translation available.
AC067947 Genomic DNA Translation: AAY14685.1
AC068542 Genomic DNA No translation available.
AC093610 Genomic DNA No translation available.
AC105422 Genomic DNA Translation: AAY24120.1
AC116620 Genomic DNA No translation available.
AC118276 Genomic DNA No translation available.
AC118664 Genomic DNA No translation available.
BC030832 mRNA Translation: AAH30832.1
CCDSiCCDS33278.1 [Q8N608-2]
CCDS46400.1 [Q8N608-1]
CCDS54388.1 [Q8N608-3]
CCDS54389.1 [Q8N608-4]
RefSeqiNP_001004360.2, NM_001004360.3
NP_001171505.1, NM_001178034.1
NP_001308835.1, NM_001321906.1
NP_001308840.1, NM_001321911.1
NP_001308841.1, NM_001321912.1
NP_001308842.1, NM_001321913.1
NP_001308843.1, NM_001321914.1
NP_065919.2, NM_020868.4
UniGeneiHs.580539
Hs.657379

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WJLX-ray3.40A/B65-783[»]
ProteinModelPortaliQ8N608
SMRiQ8N608
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121672, 4 interactors
CORUMiQ8N608
IntActiQ8N608, 1 interactor
STRINGi9606.ENSP00000376855

Protein family/group databases

ESTHERihuman-DPP10 DPP4N_Peptidase_S9
MEROPSiS09.974
TCDBi8.A.51.1.2 the dipeptidyl-aminopeptidase-like protein 6 beta subunit of kv4 channels (dpp6) family

PTM databases

iPTMnetiQ8N608
PhosphoSitePlusiQ8N608

Polymorphism and mutation databases

BioMutaiDPP10
DMDMi296434483

Proteomic databases

MaxQBiQ8N608
PaxDbiQ8N608
PeptideAtlasiQ8N608
PRIDEiQ8N608
ProteomicsDBi72119
72120 [Q8N608-2]

Protocols and materials databases

DNASUi57628
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310323; ENSP00000309066; ENSG00000175497 [Q8N608-2]
ENST00000393147; ENSP00000376855; ENSG00000175497 [Q8N608-3]
ENST00000409163; ENSP00000387038; ENSG00000175497 [Q8N608-4]
ENST00000410059; ENSP00000386565; ENSG00000175497 [Q8N608-1]
GeneIDi57628
KEGGihsa:57628
UCSCiuc002tla.3 human [Q8N608-1]

Organism-specific databases

CTDi57628
DisGeNETi57628
EuPathDBiHostDB:ENSG00000175497.16
GeneCardsiDPP10
HGNCiHGNC:20823 DPP10
HPAiHPA048767
MIMi600807 phenotype
608209 gene
neXtProtiNX_Q8N608
OpenTargetsiENSG00000175497
PharmGKBiPA134991647
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2100 Eukaryota
COG1506 LUCA
GeneTreeiENSGT00760000119233
HOGENOMiHOG000231875
HOVERGENiHBG105877
InParanoidiQ8N608
OMAiVIYNIHT
OrthoDBiEOG091G0GBJ
PhylomeDBiQ8N608
TreeFamiTF313309

Miscellaneous databases

ChiTaRSiDPP10 human
GeneWikiiDPP10
GenomeRNAii57628
PROiPR:Q8N608
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175497 Expressed in 117 organ(s), highest expression level in adrenal tissue
CleanExiHS_DPP10
ExpressionAtlasiQ8N608 baseline and differential
GenevisibleiQ8N608 HS

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPP10_HUMAN
AccessioniPrimary (citable) accession number: Q8N608
Secondary accession number(s): A8K1Q2
, J3KPP2, J3KQ46, Q0GLB8, Q53QT3, Q53S86, Q53SL8, Q53SS4, Q6TTV4, Q86YR9, Q9P236
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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