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Entry version 148 (11 Dec 2019)
Sequence version 2 (18 May 2010)
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Protein

Inactive dipeptidyl peptidase 10

Gene

DPP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).3 Publications

Caution

Gly-651 is present instead of the conserved Ser which is expected to be an active site residue suggesting that this protein has no peptidase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-DPP10 DPP4N_Peptidase_S9

MEROPS protease database

More...
MEROPSi
S09.974

Transport Classification Database

More...
TCDBi
8.A.51.1.2 the dipeptidyl-aminopeptidase-like protein 6 beta subunit of kv4 channels (dpp6) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive dipeptidyl peptidase 10
Alternative name(s):
Dipeptidyl peptidase IV-related protein 3
Short name:
DPRP-3
Dipeptidyl peptidase X
Short name:
DPP X
Dipeptidyl peptidase-like protein 2
Short name:
DPL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DPP10
Synonyms:DPRP3, KIAA1492
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000175497.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20823 DPP10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608209 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N608

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini56 – 796ExtracellularSequence analysisAdd BLAST741

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Asthma (ASTHMA)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionThe most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi257N → Q: Abolishes sorting to the cell surface and dimerization. 1 Publication1

Keywords - Diseasei

Asthma

Organism-specific databases

DisGeNET

More...
DisGeNETi
57628
MIMi600807 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000175497

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134991647

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N608 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DPP10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434483

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001224171 – 796Inactive dipeptidyl peptidase 10Add BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi90N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi111N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi119N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei138PhosphotyrosineCombined sources1
Modified residuei143PhosphotyrosineCombined sources1
Glycosylationi257N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi342N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi748N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylation is important for cell surface expression, specially at Asn-257, which is crucial.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N608

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N608

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N608

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N608

PeptideAtlas

More...
PeptideAtlasi
Q8N608

PRoteomics IDEntifications database

More...
PRIDEi
Q8N608

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72119 [Q8N608-1]
72120 [Q8N608-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2050

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N608

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N608

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175497 Expressed in 117 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N608 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N608 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048767

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form oligomers.

Interacts with KCND1 (Probable).

Interacts with KCND2.

Curated2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121672, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8N608

Protein interaction database and analysis system

More...
IntActi
Q8N608, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376855

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N608 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N608

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 56Mediates effects on KCND2Add BLAST56

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S9B family. DPPIV subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2100 Eukaryota
COG1506 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154657

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231875

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N608

KEGG Orthology (KO)

More...
KOi
K23014

Identification of Orthologs from Complete Genome Data

More...
OMAi
MYGERYM

Database of Orthologous Groups

More...
OrthoDBi
269253at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N608

TreeFam database of animal gene trees

More...
TreeFami
TF313309

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.140.10.30, 1 hit
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist, which may have different subcellular locations.

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N608-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNQTASVSHH IKCQPSKTIK ELGSNSPPQR NWKGIAIALL VILVVCSLIT
60 70 80 90 100
MSVILLTPDE LTNSSETRLS LEDLFRKDFV LHDPEARWIN DTDVVYKSEN
110 120 130 140 150
GHVIKLNIET NATTLLLENT TFVTFKASRH SVSPDLKYVL LAYDVKQIFH
160 170 180 190 200
YSYTASYVIY NIHTREVWEL NPPEVEDSVL QYAAWGVQGQ QLIYIFENNI
210 220 230 240 250
YYQPDIKSSS LRLTSSGKEE IIFNGIADWL YEEELLHSHI AHWWSPDGER
260 270 280 290 300
LAFLMINDSL VPTMVIPRFT GALYPKGKQY PYPKAGQVNP TIKLYVVNLY
310 320 330 340 350
GPTHTLELMP PDSFKSREYY ITMVKWVSNT KTVVRWLNRA QNISILTVCE
360 370 380 390 400
TTTGACSKKY EMTSDTWLSQ QNEEPVFSRD GSKFFMTVPV KQGGRGEFHH
410 420 430 440 450
VAMFLIQSKS EQITVRHLTS GNWEVIKILA YDETTQKIYF LSTESSPRGR
460 470 480 490 500
QLYSASTEGL LNRQCISCNF MKEQCTYFDA SFSPMNQHFL LFCEGPRVPV
510 520 530 540 550
VSLHSTDNPA KYFILESNSM LKEAILKKKI GKPEIKILHI DDYELPLQLS
560 570 580 590 600
LPKDFMDRNQ YALLLIMDEE PGGQLVTDKF HIDWDSVLID MDNVIVARFD
610 620 630 640 650
GRGSGFQGLK ILQEIHRRLG SVEVKDQITA VKFLLKLPYI DSKRLSIFGK
660 670 680 690 700
GYGGYIASMI LKSDEKLFKC GSVVAPITDL KLYASAFSER YLGMPSKEES
710 720 730 740 750
TYQAASVLHN VHGLKEENIL IIHGTADTKV HFQHSAELIK HLIKAGVNYT
760 770 780 790
MQVYPDEGHN VSEKSKYHLY STILKFFSDC LKEEISVLPQ EPEEDE
Length:796
Mass (Da):90,888
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i072CBD67D1FB478E
GO
Isoform 2 (identifier: Q8N608-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNQTASVSHHIKCQPSKTIK → MRKVESRGEGGRE

Show »
Length:789
Mass (Da):90,140
Checksum:iF1746DDCA46C0744
GO
Isoform 3 (identifier: Q8N608-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNQTASVSHHIKCQPSKTIK → MTAAKQEPQPTPGARASQAQPADQ

Show »
Length:800
Mass (Da):91,129
Checksum:iC837D61773C3E890
GO
Isoform 4 (identifier: Q8N608-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Show »
Length:746
Mass (Da):85,480
Checksum:iF71826F40623C64D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPP1J3KPP1_HUMAN
Inactive dipeptidyl peptidase 10
DPP10
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J4M8C9J4M8_HUMAN
Inactive dipeptidyl peptidase 10
DPP10
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQK8J3KQK8_HUMAN
Inactive dipeptidyl peptidase 10
DPP10
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEB2F8WEB2_HUMAN
Inactive dipeptidyl peptidase 10
DPP10
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA96016 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti288V → M in AAO17263 (PubMed:12662155).Curated1
Sequence conflicti288V → M in BAF82656 (PubMed:10819331).Curated1
Sequence conflicti288V → M in AAH30832 (PubMed:15815621).Curated1
Sequence conflicti687F → L in AAQ91190 (PubMed:12675227).Curated1
Isoform 3 (identifier: Q8N608-3)
Sequence conflicti4A → M in ABI16086 (PubMed:16899223).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057061340A → P2 PublicationsCorresponds to variant dbSNP:rs2053724Ensembl.1
Natural variantiVAR_059759401V → I7 PublicationsCorresponds to variant dbSNP:rs1446495Ensembl.1
Natural variantiVAR_057062517S → N. Corresponds to variant dbSNP:rs13421193Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0471521 – 50Missing in isoform 4. CuratedAdd BLAST50
Alternative sequenceiVSP_0138731 – 20MNQTA…SKTIK → MRKVESRGEGGRE in isoform 2. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_0444661 – 20MNQTA…SKTIK → MTAAKQEPQPTPGARASQAQ PADQ in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY387785 mRNA Translation: AAQ91190.1
AY172661 mRNA Translation: AAO17263.2
AB040925 mRNA Translation: BAA96016.2 Different initiation.
DQ857322 mRNA Translation: ABI16086.1
AK289967 mRNA Translation: BAF82656.1
AC010885 Genomic DNA No translation available.
AC012071 Genomic DNA No translation available.
AC016721 Genomic DNA Translation: AAY15025.1
AC017040 Genomic DNA Translation: AAY15032.1
AC066593 Genomic DNA No translation available.
AC067947 Genomic DNA Translation: AAY14685.1
AC068542 Genomic DNA No translation available.
AC093610 Genomic DNA No translation available.
AC105422 Genomic DNA Translation: AAY24120.1
AC116620 Genomic DNA No translation available.
AC118276 Genomic DNA No translation available.
AC118664 Genomic DNA No translation available.
BC030832 mRNA Translation: AAH30832.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33278.1 [Q8N608-2]
CCDS46400.1 [Q8N608-1]
CCDS54388.1 [Q8N608-3]
CCDS54389.1 [Q8N608-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001004360.2, NM_001004360.3 [Q8N608-2]
NP_001171505.1, NM_001178034.1
NP_001308835.1, NM_001321906.1
NP_001308840.1, NM_001321911.1 [Q8N608-4]
NP_001308841.1, NM_001321912.1
NP_001308842.1, NM_001321913.1
NP_001308843.1, NM_001321914.1
NP_065919.2, NM_020868.4 [Q8N608-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000310323; ENSP00000309066; ENSG00000175497 [Q8N608-2]
ENST00000393147; ENSP00000376855; ENSG00000175497 [Q8N608-3]
ENST00000409163; ENSP00000387038; ENSG00000175497 [Q8N608-4]
ENST00000410059; ENSP00000386565; ENSG00000175497 [Q8N608-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57628

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57628

UCSC genome browser

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UCSCi
uc002tla.3 human [Q8N608-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY387785 mRNA Translation: AAQ91190.1
AY172661 mRNA Translation: AAO17263.2
AB040925 mRNA Translation: BAA96016.2 Different initiation.
DQ857322 mRNA Translation: ABI16086.1
AK289967 mRNA Translation: BAF82656.1
AC010885 Genomic DNA No translation available.
AC012071 Genomic DNA No translation available.
AC016721 Genomic DNA Translation: AAY15025.1
AC017040 Genomic DNA Translation: AAY15032.1
AC066593 Genomic DNA No translation available.
AC067947 Genomic DNA Translation: AAY14685.1
AC068542 Genomic DNA No translation available.
AC093610 Genomic DNA No translation available.
AC105422 Genomic DNA Translation: AAY24120.1
AC116620 Genomic DNA No translation available.
AC118276 Genomic DNA No translation available.
AC118664 Genomic DNA No translation available.
BC030832 mRNA Translation: AAH30832.1
CCDSiCCDS33278.1 [Q8N608-2]
CCDS46400.1 [Q8N608-1]
CCDS54388.1 [Q8N608-3]
CCDS54389.1 [Q8N608-4]
RefSeqiNP_001004360.2, NM_001004360.3 [Q8N608-2]
NP_001171505.1, NM_001178034.1
NP_001308835.1, NM_001321906.1
NP_001308840.1, NM_001321911.1 [Q8N608-4]
NP_001308841.1, NM_001321912.1
NP_001308842.1, NM_001321913.1
NP_001308843.1, NM_001321914.1
NP_065919.2, NM_020868.4 [Q8N608-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WJLX-ray3.40A/B65-783[»]
SMRiQ8N608
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi121672, 4 interactors
CORUMiQ8N608
IntActiQ8N608, 1 interactor
STRINGi9606.ENSP00000376855

Protein family/group databases

ESTHERihuman-DPP10 DPP4N_Peptidase_S9
MEROPSiS09.974
TCDBi8.A.51.1.2 the dipeptidyl-aminopeptidase-like protein 6 beta subunit of kv4 channels (dpp6) family

PTM databases

GlyConnecti2050
iPTMnetiQ8N608
PhosphoSitePlusiQ8N608

Polymorphism and mutation databases

BioMutaiDPP10
DMDMi296434483

Proteomic databases

jPOSTiQ8N608
MassIVEiQ8N608
MaxQBiQ8N608
PaxDbiQ8N608
PeptideAtlasiQ8N608
PRIDEiQ8N608
ProteomicsDBi72119 [Q8N608-1]
72120 [Q8N608-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57628

Genome annotation databases

EnsembliENST00000310323; ENSP00000309066; ENSG00000175497 [Q8N608-2]
ENST00000393147; ENSP00000376855; ENSG00000175497 [Q8N608-3]
ENST00000409163; ENSP00000387038; ENSG00000175497 [Q8N608-4]
ENST00000410059; ENSP00000386565; ENSG00000175497 [Q8N608-1]
GeneIDi57628
KEGGihsa:57628
UCSCiuc002tla.3 human [Q8N608-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57628
DisGeNETi57628
EuPathDBiHostDB:ENSG00000175497.16

GeneCards: human genes, protein and diseases

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GeneCardsi
DPP10
HGNCiHGNC:20823 DPP10
HPAiHPA048767
MIMi600807 phenotype
608209 gene
neXtProtiNX_Q8N608
OpenTargetsiENSG00000175497
PharmGKBiPA134991647

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2100 Eukaryota
COG1506 LUCA
GeneTreeiENSGT00940000154657
HOGENOMiHOG000231875
InParanoidiQ8N608
KOiK23014
OMAiMYGERYM
OrthoDBi269253at2759
PhylomeDBiQ8N608
TreeFamiTF313309

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DPP10 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DPP10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57628
PharosiQ8N608 Tbio

Protein Ontology

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PROi
PR:Q8N608
RNActiQ8N608 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000175497 Expressed in 117 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiQ8N608 baseline and differential
GenevisibleiQ8N608 HS

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPP10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N608
Secondary accession number(s): A8K1Q2
, J3KPP2, J3KQ46, Q0GLB8, Q53QT3, Q53S86, Q53SL8, Q53SS4, Q6TTV4, Q86YR9, Q9P236
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 18, 2010
Last modified: December 11, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Peptidase families
    Classification of peptidase families and list of entries
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