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UniProtKB - Q8N5Z0 (AADAT_HUMAN)

Entry version 162 (07 Apr 2021)
Sequence version 2 (13 Apr 2004)
Previous versions | rss
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Protein

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Gene

AADAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Kynurenine transaminase activity is competitively inhibited by aminoadipate, asparagine, glutamate, histidine, cysteine, lysine, 3-hydroxy-kynurenine and phenylalanine.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.9 mM for aminoadipate1 Publication
  2. KM=4.7 mM for kynurenine1 Publication
  3. KM=1.7 mM for methionine1 Publication
  4. KM=1.6 mM for glutamate1 Publication
  5. KM=1.8 mM for tyrosine1 Publication
  6. KM=1.2 mM for 2-oxoglutarate1 Publication
  7. KM=1.5 mM for 2-oxocaproic acid1 Publication
  8. KM=1.8 mM for phenylpyruvate1 Publication
  9. KM=1.4 mM for ino-3-pyruvate1 Publication

    pH dependencei

    Optimum pH is 7-9.1 Publication

    Temperature dependencei

    Optimum temperature is 50 degrees Celsius.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-lysine degradation via saccharopine pathway

    This protein is involved in step 4 of the subpathway that synthesizes glutaryl-CoA from L-lysine.
    Proteins known to be involved in the 6 steps of the subpathway in this organism are:
    1. Lysine ketoglutarate reductase (AASS), Alpha-aminoadipic semialdehyde synthase, mitochondrial (AASS), Lysine ketoglutarate reductase (AASS)
    2. Lysine ketoglutarate reductase (AASS), Alpha-aminoadipic semialdehyde synthase, mitochondrial (AASS), Lysine ketoglutarate reductase (AASS)
    3. no protein annotated in this organism
    4. Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (AADAT)
    5. no protein annotated in this organism
    6. Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST), Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST), Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST), Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (E2k)
    This subpathway is part of the pathway L-lysine degradation via saccharopine pathway, which is itself part of Amino-acid degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes glutaryl-CoA from L-lysine, the pathway L-lysine degradation via saccharopine pathway and in Amino-acid degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei20Substrate1
    Binding sitei74Substrate1
    Binding sitei142Substrate1
    Binding sitei202Substrate1
    Binding sitei399Substrate1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminotransferase, Transferase
    LigandPyridoxal phosphate

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:HS03239-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		2.6.1.39, 2681
    2.6.1.7, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q8N5Z0

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-71064, Lysine catabolism
    R-HSA-71240, Tryptophan catabolism

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q8N5Z0

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...    UniPathwayi    		UPA00868;UER00838

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
    Short name:
    KAT/AadAT
    Alternative name(s):
    2-aminoadipate aminotransferase
    2-aminoadipate transaminase (EC:2.6.1.39)
    Alpha-aminoadipate aminotransferase
    Short name:
    AadAT
    Kynurenine aminotransferase II
    Kynurenine--oxoglutarate aminotransferase II
    Kynurenine--oxoglutarate transaminase 2 (EC:2.6.1.7)
    Kynurenine--oxoglutarate transaminase II
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:AADATImported
    Synonyms:KAT2Imported, KYAT2Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:17929, AADAT

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		611754, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q8N5Z0

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000109576.13

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		51166

    Open Targets

    More...    OpenTargetsi    		ENSG00000109576

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA24364

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q8N5Z0, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL2046259

    Drug and drug target database

    More...    DrugBanki    		DB00142, Glutamic acid
    DB00114, Pyridoxal phosphate

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		AADAT

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		46395904

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002060230 – 425Kynurenine/alpha-aminoadipate aminotransferase, mitochondrialAdd BLAST396

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei69N6-acetyllysineBy similarity1
    Modified residuei179N6-acetyllysineBy similarity1
    Modified residuei263N6-(pyridoxal phosphate)lysine; alternate1
    Modified residuei263N6-acetyllysine; alternateBy similarity1
    Modified residuei263N6-succinyllysine; alternateBy similarity1
    Modified residuei339N6-acetyllysine; alternateBy similarity1
    Modified residuei339N6-succinyllysine; alternateBy similarity1
    Modified residuei367N6-acetyllysine; alternateBy similarity1
    Modified residuei367N6-succinyllysine; alternateBy similarity1
    Modified residuei422N6-acetyllysineBy similarity1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q8N5Z0

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q8N5Z0

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q8N5Z0

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q8N5Z0

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q8N5Z0

    PeptideAtlas

    More...    PeptideAtlasi    		Q8N5Z0

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q8N5Z0

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		72114 [Q8N5Z0-1]
    72115 [Q8N5Z0-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q8N5Z0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q8N5Z0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000109576, Expressed in liver and 165 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q8N5Z0, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q8N5Z0, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000109576, Tissue enriched (liver)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    3 Publications

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		119346, 21 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q8N5Z0, 1 interactor

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000423190

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q8N5Z0

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q8N5Z0, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1425
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q8N5Z0

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		Q8N5Z0

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0634, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00390000004594

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_017584_0_6_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q8N5Z0

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		MRLNFTY

    Database of Orthologous Groups

    More...    OrthoDBi    		1241781at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q8N5Z0

    TreeFam database of animal gene trees

    More...    TreeFami    		TF328598

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.40.640.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR004839, Aminotransferase_I/II
    IPR015424, PyrdxlP-dep_Trfase
    IPR015421, PyrdxlP-dep_Trfase_major

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00155, Aminotran_1_2, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF53383, SSF53383, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8N5Z0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MNYARFITAA SAARNPSPIR TMTDILSRGP KSMISLAGGL PNPNMFPFKT 
            60         70         80         90        100
    AVITVENGKT IQFGEEMMKR ALQYSPSAGI PELLSWLKQL QIKLHNPPTI 
           110        120        130        140        150
    HYPPSQGQMD LCVTSGSQQG LCKVFEMIIN PGDNVLLDEP AYSGTLQSLH 
           160        170        180        190        200
    PLGCNIINVA SDESGIVPDS LRDILSRWKP EDAKNPQKNT PKFLYTVPNG 
           210        220        230        240        250
    NNPTGNSLTS ERKKEIYELA RKYDFLIIED DPYYFLQFNK FRVPTFLSMD 
           260        270        280        290        300
    VDGRVIRADS FSKIISSGLR IGFLTGPKPL IERVILHIQV STLHPSTFNQ 
           310        320        330        340        350
    LMISQLLHEW GEEGFMAHVD RVIDFYSNQK DAILAAADKW LTGLAEWHVP 
           360        370        380        390        400
    AAGMFLWIKV KGINDVKELI EEKAVKMGVL MLPGNAFYVD SSAPSPYLRA 
           410        420 
    SFSSASPEQM DVAFQVLAQL IKESL
    Note: May be due to a competing donor splice site.
    Length:425
    Mass (Da):47,352
    Last modified:April 13, 2004 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i448CCAAB2173A7BA
    GO
    Isoform 2 (identifier: Q8N5Z0-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         23-23: T → SEKRA

    Show »
    Length:429
    Mass (Da):47,822
    Checksum:i0C5A6E51F1BD6F53
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    D6REB9D6REB9_HUMAN
    Kynurenine/alpha-aminoadipate amino...
    AADAT
    		220Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RFY7D6RFY7_HUMAN
    Kynurenine/alpha-aminoadipate amino...
    AADAT
    		209Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RC56D6RC56_HUMAN
    Kynurenine/alpha-aminoadipate amino...
    AADAT
    		180Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103P → Q in AAH31068 (PubMed:15489334).Curated1
    Sequence conflicti380L → S in BAG51596 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061005243V → I. Corresponds to variant dbSNP:rs56350236Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00987423T → SEKRA in isoform 2. 1 Publication1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF097994 mRNA Translation: AAF04623.1
    AF481738 mRNA Translation: AAM09683.1
    AK055952 mRNA Translation: BAG51596.1
    BC031068 mRNA Translation: AAH31068.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS3814.1 [Q8N5Z0-1]
    CCDS75209.1 [Q8N5Z0-2]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001273611.1, NM_001286682.1 [Q8N5Z0-2]
    NP_001273612.1, NM_001286683.1 [Q8N5Z0-1]
    NP_057312.1, NM_016228.3 [Q8N5Z0-1]
    NP_872603.1, NM_182662.1 [Q8N5Z0-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000337664; ENSP00000336808; ENSG00000109576 [Q8N5Z0-1]
    ENST00000353187; ENSP00000226840; ENSG00000109576 [Q8N5Z0-1]
    ENST00000509167; ENSP00000423190; ENSG00000109576 [Q8N5Z0-2]
    ENST00000515480; ENSP00000423341; ENSG00000109576 [Q8N5Z0-1]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		51166

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:51166

    UCSC genome browser

    More...    UCSCi    		uc003isr.4, human [Q8N5Z0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF097994 mRNA Translation: AAF04623.1
    AF481738 mRNA Translation: AAM09683.1
    AK055952 mRNA Translation: BAG51596.1
    BC031068 mRNA Translation: AAH31068.1
    CCDSiCCDS3814.1 [Q8N5Z0-1]
    CCDS75209.1 [Q8N5Z0-2]
    RefSeqiNP_001273611.1, NM_001286682.1 [Q8N5Z0-2]
    NP_001273612.1, NM_001286683.1 [Q8N5Z0-1]
    NP_057312.1, NM_016228.3 [Q8N5Z0-1]
    NP_872603.1, NM_182662.1 [Q8N5Z0-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2QLRX-ray2.30A/B/C/D1-425[»]
    2R2NX-ray1.95A/B/C/D1-425[»]
    2VGZX-ray2.30A/B2-425[»]
    2XH1X-ray2.10A/B1-425[»]
    3DC1X-ray2.50A/B/C/D1-425[»]
    3UE8X-ray3.22A/B1-425[»]
    4GDYX-ray2.89A/B1-425[»]
    4GE4X-ray2.41A/B1-425[»]
    4GE7X-ray2.10A/B1-425[»]
    4GE9X-ray2.43A/B/C/D1-425[»]
    4GEBX-ray2.15A/B1-425[»]
    5EFSX-ray1.83A1-425[»]
    5EUNX-ray1.82A1-425[»]
    5TF5X-ray1.81A/B1-425[»]
    6D0AX-ray1.47A1-425[»]
    6T8PX-ray2.02A/B1-425[»]
    6T8QX-ray2.51A1-425[»]
    SMRiQ8N5Z0
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi119346, 21 interactors
    IntActiQ8N5Z0, 1 interactor
    STRINGi9606.ENSP00000423190

    Chemistry databases

    BindingDBiQ8N5Z0
    ChEMBLiCHEMBL2046259
    DrugBankiDB00142, Glutamic acid
    DB00114, Pyridoxal phosphate

    PTM databases

    iPTMnetiQ8N5Z0
    PhosphoSitePlusiQ8N5Z0

    Genetic variation databases

    BioMutaiAADAT
    DMDMi46395904

    Proteomic databases

    EPDiQ8N5Z0
    jPOSTiQ8N5Z0
    MassIVEiQ8N5Z0
    MaxQBiQ8N5Z0
    PaxDbiQ8N5Z0
    PeptideAtlasiQ8N5Z0
    PRIDEiQ8N5Z0
    ProteomicsDBi72114 [Q8N5Z0-1]
    72115 [Q8N5Z0-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		17143, 322 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		51166

    Genome annotation databases

    EnsembliENST00000337664; ENSP00000336808; ENSG00000109576 [Q8N5Z0-1]
    ENST00000353187; ENSP00000226840; ENSG00000109576 [Q8N5Z0-1]
    ENST00000509167; ENSP00000423190; ENSG00000109576 [Q8N5Z0-2]
    ENST00000515480; ENSP00000423341; ENSG00000109576 [Q8N5Z0-1]
    GeneIDi51166
    KEGGihsa:51166
    UCSCiuc003isr.4, human [Q8N5Z0-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		51166
    DisGeNETi51166

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		AADAT
    HGNCiHGNC:17929, AADAT
    HPAiENSG00000109576, Tissue enriched (liver)
    MIMi611754, gene
    neXtProtiNX_Q8N5Z0
    OpenTargetsiENSG00000109576
    PharmGKBiPA24364
    VEuPathDBiHostDB:ENSG00000109576.13

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0634, Eukaryota
    GeneTreeiENSGT00390000004594
    HOGENOMiCLU_017584_0_6_1
    InParanoidiQ8N5Z0
    OMAiMRLNFTY
    OrthoDBi1241781at2759
    PhylomeDBiQ8N5Z0
    TreeFamiTF328598

    Enzyme and pathway databases

    UniPathwayiUPA00868;UER00838
    BioCyciMetaCyc:HS03239-MONOMER
    BRENDAi2.6.1.39, 2681
    2.6.1.7, 2681
    PathwayCommonsiQ8N5Z0
    ReactomeiR-HSA-71064, Lysine catabolism
    R-HSA-71240, Tryptophan catabolism
    SABIO-RKiQ8N5Z0

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		51166, 15 hits in 987 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		AADAT, human
    EvolutionaryTraceiQ8N5Z0

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		51166
    PharosiQ8N5Z0, Tchem

    Protein Ontology

    More...    PROi    		PR:Q8N5Z0
    RNActiQ8N5Z0, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000109576, Expressed in liver and 165 other tissues
    ExpressionAtlasiQ8N5Z0, baseline and differential
    GenevisibleiQ8N5Z0, HS

    Family and domain databases

    Gene3Di3.40.640.10, 1 hit
    InterProiView protein in InterPro
    IPR004839, Aminotransferase_I/II
    IPR015424, PyrdxlP-dep_Trfase
    IPR015421, PyrdxlP-dep_Trfase_major
    PfamiView protein in Pfam
    PF00155, Aminotran_1_2, 1 hit
    SUPFAMiSSF53383, SSF53383, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAADAT_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N5Z0
    Secondary accession number(s): B3KP84, Q9UL02
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: April 7, 2021
    This is version 162 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with genetic variants
      List of human entries with genetic variants
    3. Human variants curated from literature reports
      Index of human variants curated from literature reports
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families
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