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Entry version 129 (07 Oct 2020)
Sequence version 4 (24 Jul 2007)
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Protein

Eukaryotic translation initiation factor 4E type 3

Gene

EIF4E3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N5X7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169408, ISG15 antiviral mechanism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E type 3
Short name:
eIF-4E type 3
Short name:
eIF-4E3
Short name:
eIF4E type 3
Short name:
eIF4E-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF4E3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163412.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:31837, EIF4E3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609896, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N5X7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
317649

Open Targets

More...
OpenTargetsi
ENSG00000163412

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134961880

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N5X7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF4E3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156633293

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002876971 – 224Eukaryotic translation initiation factor 4E type 3Add BLAST224

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N5X7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N5X7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N5X7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N5X7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N5X7

PeptideAtlas

More...
PeptideAtlasi
Q8N5X7

PRoteomics IDEntifications database

More...
PRIDEi
Q8N5X7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72106 [Q8N5X7-1]
72107 [Q8N5X7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N5X7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N5X7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163412, Expressed in quadriceps femoris and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N5X7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N5X7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000163412, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity). EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
130428, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N5X7, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000393324

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N5X7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N5X7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni115 – 1167-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni169 – 1747-methylguanosine-containing mRNA cap bindingBy similarity6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPP4, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155865

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_043552_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N5X7

Identification of Orthologs from Complete Genome Data

More...
OMAi
VQDFWRY

Database of Orthologous Groups

More...
OrthoDBi
1394271at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N5X7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.760.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023398, TIF_eIF4e-like
IPR001040, TIF_eIF_4E

The PANTHER Classification System

More...
PANTHERi
PTHR11960, PTHR11960, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01652, IF4E, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55418, SSF55418, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N5X7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALPPAAAPP AGAREPPGSR AAAAAAAPEP PLGLQQLSAL QPEPGGVPLH
60 70 80 90 100
SSWTFWLDRS LPGATAAECA SNLKKIYTVQ TVQIFWSVYN NIPPVTSLPL
110 120 130 140 150
RCSYHLMRGE RRPLWEEESN AKGGVWKMKV PKDSTSTVWK ELLLATIGEQ
160 170 180 190 200
FTDCAAADDE VIGVSVSVRD REDVVQVWNV NASLVGEATV LEKIYELLPH
210 220
ITFKAVFYKP HEEHHAFEGG RGKH
Length:224
Mass (Da):24,441
Last modified:July 24, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC724BF3A6438D728
GO
Isoform 2 (identifier: Q8N5X7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:118
Mass (Da):13,333
Checksum:i8CD9AFBAD53D0E01
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J7Z6C9J7Z6_HUMAN
Eukaryotic translation initiation f...
EIF4E3
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6E5C9J6E5_HUMAN
Eukaryotic translation initiation f...
EIF4E3
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUY2C9JUY2_HUMAN
Eukaryotic translation initiation f...
EIF4E3
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0256021 – 106Missing in isoform 2. 2 PublicationsAdd BLAST106

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK126999 mRNA Translation: BAG54418.1
AK313656 mRNA Translation: BAG36410.1
AC134770 Genomic DNA No translation available.
BC031289 mRNA Translation: AAH31289.3
BC068443 mRNA Translation: AAH68443.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33786.1 [Q8N5X7-2]
CCDS46867.1 [Q8N5X7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001128121.1, NM_001134649.2 [Q8N5X7-2]
NP_001128122.1, NM_001134650.1 [Q8N5X7-2]
NP_001128123.1, NM_001134651.1 [Q8N5X7-1]
NP_001269815.1, NM_001282886.1 [Q8N5X7-2]
NP_775495.1, NM_173359.4 [Q8N5X7-2]
XP_016861767.1, XM_017006278.1
XP_016861768.1, XM_017006279.1
XP_016861769.1, XM_017006280.1
XP_016861770.1, XM_017006281.1
XP_016861771.1, XM_017006282.1 [Q8N5X7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295612; ENSP00000295612; ENSG00000163412 [Q8N5X7-2]
ENST00000389826; ENSP00000374476; ENSG00000163412 [Q8N5X7-2]
ENST00000421769; ENSP00000411762; ENSG00000163412 [Q8N5X7-2]
ENST00000425534; ENSP00000393324; ENSG00000163412 [Q8N5X7-1]
ENST00000448225; ENSP00000410350; ENSG00000163412 [Q8N5X7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
317649

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:317649

UCSC genome browser

More...
UCSCi
uc003dov.5, human [Q8N5X7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126999 mRNA Translation: BAG54418.1
AK313656 mRNA Translation: BAG36410.1
AC134770 Genomic DNA No translation available.
BC031289 mRNA Translation: AAH31289.3
BC068443 mRNA Translation: AAH68443.1
CCDSiCCDS33786.1 [Q8N5X7-2]
CCDS46867.1 [Q8N5X7-1]
RefSeqiNP_001128121.1, NM_001134649.2 [Q8N5X7-2]
NP_001128122.1, NM_001134650.1 [Q8N5X7-2]
NP_001128123.1, NM_001134651.1 [Q8N5X7-1]
NP_001269815.1, NM_001282886.1 [Q8N5X7-2]
NP_775495.1, NM_173359.4 [Q8N5X7-2]
XP_016861767.1, XM_017006278.1
XP_016861768.1, XM_017006279.1
XP_016861769.1, XM_017006280.1
XP_016861770.1, XM_017006281.1
XP_016861771.1, XM_017006282.1 [Q8N5X7-2]

3D structure databases

SMRiQ8N5X7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi130428, 7 interactors
IntActiQ8N5X7, 6 interactors
STRINGi9606.ENSP00000393324

PTM databases

iPTMnetiQ8N5X7
PhosphoSitePlusiQ8N5X7

Polymorphism and mutation databases

BioMutaiEIF4E3
DMDMi156633293

Proteomic databases

EPDiQ8N5X7
jPOSTiQ8N5X7
MassIVEiQ8N5X7
MaxQBiQ8N5X7
PaxDbiQ8N5X7
PeptideAtlasiQ8N5X7
PRIDEiQ8N5X7
ProteomicsDBi72106 [Q8N5X7-1]
72107 [Q8N5X7-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q8N5X7, 5 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31921, 98 antibodies

Genome annotation databases

EnsembliENST00000295612; ENSP00000295612; ENSG00000163412 [Q8N5X7-2]
ENST00000389826; ENSP00000374476; ENSG00000163412 [Q8N5X7-2]
ENST00000421769; ENSP00000411762; ENSG00000163412 [Q8N5X7-2]
ENST00000425534; ENSP00000393324; ENSG00000163412 [Q8N5X7-1]
ENST00000448225; ENSP00000410350; ENSG00000163412 [Q8N5X7-2]
GeneIDi317649
KEGGihsa:317649
UCSCiuc003dov.5, human [Q8N5X7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
317649
DisGeNETi317649
EuPathDBiHostDB:ENSG00000163412.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EIF4E3
HGNCiHGNC:31837, EIF4E3
HPAiENSG00000163412, Low tissue specificity
MIMi609896, gene
neXtProtiNX_Q8N5X7
OpenTargetsiENSG00000163412
PharmGKBiPA134961880

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QPP4, Eukaryota
GeneTreeiENSGT00940000155865
HOGENOMiCLU_043552_5_1_1
InParanoidiQ8N5X7
OMAiVQDFWRY
OrthoDBi1394271at2759
PhylomeDBiQ8N5X7

Enzyme and pathway databases

PathwayCommonsiQ8N5X7
ReactomeiR-HSA-1169408, ISG15 antiviral mechanism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
317649, 5 hits in 867 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EIF4E3, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
EIF4E3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
317649
PharosiQ8N5X7, Tbio

Protein Ontology

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PROi
PR:Q8N5X7
RNActiQ8N5X7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163412, Expressed in quadriceps femoris and 221 other tissues
ExpressionAtlasiQ8N5X7, baseline and differential
GenevisibleiQ8N5X7, HS

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398, TIF_eIF4e-like
IPR001040, TIF_eIF_4E
PANTHERiPTHR11960, PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652, IF4E, 1 hit
SUPFAMiSSF55418, SSF55418, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF4E3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N5X7
Secondary accession number(s): B2R963, Q6NUT1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 7, 2020
This is version 129 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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