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Protein

Eukaryotic translation initiation factor 4E type 3

Gene

EIF4E3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E type 3
Short name:
eIF-4E type 3
Short name:
eIF-4E3
Short name:
eIF4E type 3
Short name:
eIF4E-3
Gene namesi
Name:EIF4E3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163412.12
HGNCiHGNC:31837 EIF4E3
MIMi609896 gene
neXtProtiNX_Q8N5X7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi317649
OpenTargetsiENSG00000163412
PharmGKBiPA134961880

Polymorphism and mutation databases

BioMutaiEIF4E3
DMDMi156633293

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876971 – 224Eukaryotic translation initiation factor 4E type 3Add BLAST224

Proteomic databases

EPDiQ8N5X7
MaxQBiQ8N5X7
PaxDbiQ8N5X7
PeptideAtlasiQ8N5X7
PRIDEiQ8N5X7
ProteomicsDBi72106
72107 [Q8N5X7-2]

PTM databases

iPTMnetiQ8N5X7
PhosphoSitePlusiQ8N5X7

Expressioni

Gene expression databases

BgeeiENSG00000163412 Expressed in 205 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_EIF4E3
ExpressionAtlasiQ8N5X7 baseline and differential
GenevisibleiQ8N5X7 HS

Organism-specific databases

HPAiHPA058649

Interactioni

Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity). EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi130428, 6 interactors
IntActiQ8N5X7, 3 interactors
STRINGi9606.ENSP00000393324

Structurei

3D structure databases

ProteinModelPortaliQ8N5X7
SMRiQ8N5X7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 1167-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni169 – 1747-methylguanosine-containing mRNA cap bindingBy similarity6

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IHHQ Eukaryota
COG5053 LUCA
GeneTreeiENSGT00520000055549
HOGENOMiHOG000059588
HOVERGENiHBG107990
InParanoidiQ8N5X7
OMAiPTQHYWN
OrthoDBiEOG091G0ISE
PhylomeDBiQ8N5X7

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N5X7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALPPAAAPP AGAREPPGSR AAAAAAAPEP PLGLQQLSAL QPEPGGVPLH
60 70 80 90 100
SSWTFWLDRS LPGATAAECA SNLKKIYTVQ TVQIFWSVYN NIPPVTSLPL
110 120 130 140 150
RCSYHLMRGE RRPLWEEESN AKGGVWKMKV PKDSTSTVWK ELLLATIGEQ
160 170 180 190 200
FTDCAAADDE VIGVSVSVRD REDVVQVWNV NASLVGEATV LEKIYELLPH
210 220
ITFKAVFYKP HEEHHAFEGG RGKH
Length:224
Mass (Da):24,441
Last modified:July 24, 2007 - v4
Checksum:iC724BF3A6438D728
GO
Isoform 2 (identifier: Q8N5X7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:118
Mass (Da):13,333
Checksum:i8CD9AFBAD53D0E01
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J7Z6C9J7Z6_HUMAN
Eukaryotic translation initiation f...
EIF4E3
93Annotation score:
C9JUY2C9JUY2_HUMAN
Eukaryotic translation initiation f...
EIF4E3
44Annotation score:
C9J6E5C9J6E5_HUMAN
Eukaryotic translation initiation f...
EIF4E3
51Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0256021 – 106Missing in isoform 2. 2 PublicationsAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126999 mRNA Translation: BAG54418.1
AK313656 mRNA Translation: BAG36410.1
AC134770 Genomic DNA No translation available.
BC031289 mRNA Translation: AAH31289.3
BC068443 mRNA Translation: AAH68443.1
CCDSiCCDS33786.1 [Q8N5X7-2]
CCDS46867.1 [Q8N5X7-1]
RefSeqiNP_001128121.1, NM_001134649.2 [Q8N5X7-2]
NP_001128122.1, NM_001134650.1 [Q8N5X7-2]
NP_001128123.1, NM_001134651.1 [Q8N5X7-1]
NP_001269815.1, NM_001282886.1 [Q8N5X7-2]
NP_775495.1, NM_173359.4 [Q8N5X7-2]
XP_016861767.1, XM_017006278.1
XP_016861768.1, XM_017006279.1
XP_016861769.1, XM_017006280.1
XP_016861770.1, XM_017006281.1
XP_016861771.1, XM_017006282.1 [Q8N5X7-2]
UniGeneiHs.581355

Genome annotation databases

EnsembliENST00000295612; ENSP00000295612; ENSG00000163412 [Q8N5X7-2]
ENST00000389826; ENSP00000374476; ENSG00000163412 [Q8N5X7-2]
ENST00000421769; ENSP00000411762; ENSG00000163412 [Q8N5X7-2]
ENST00000425534; ENSP00000393324; ENSG00000163412 [Q8N5X7-1]
ENST00000448225; ENSP00000410350; ENSG00000163412 [Q8N5X7-2]
GeneIDi317649
KEGGihsa:317649
UCSCiuc003dov.5 human [Q8N5X7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126999 mRNA Translation: BAG54418.1
AK313656 mRNA Translation: BAG36410.1
AC134770 Genomic DNA No translation available.
BC031289 mRNA Translation: AAH31289.3
BC068443 mRNA Translation: AAH68443.1
CCDSiCCDS33786.1 [Q8N5X7-2]
CCDS46867.1 [Q8N5X7-1]
RefSeqiNP_001128121.1, NM_001134649.2 [Q8N5X7-2]
NP_001128122.1, NM_001134650.1 [Q8N5X7-2]
NP_001128123.1, NM_001134651.1 [Q8N5X7-1]
NP_001269815.1, NM_001282886.1 [Q8N5X7-2]
NP_775495.1, NM_173359.4 [Q8N5X7-2]
XP_016861767.1, XM_017006278.1
XP_016861768.1, XM_017006279.1
XP_016861769.1, XM_017006280.1
XP_016861770.1, XM_017006281.1
XP_016861771.1, XM_017006282.1 [Q8N5X7-2]
UniGeneiHs.581355

3D structure databases

ProteinModelPortaliQ8N5X7
SMRiQ8N5X7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130428, 6 interactors
IntActiQ8N5X7, 3 interactors
STRINGi9606.ENSP00000393324

PTM databases

iPTMnetiQ8N5X7
PhosphoSitePlusiQ8N5X7

Polymorphism and mutation databases

BioMutaiEIF4E3
DMDMi156633293

Proteomic databases

EPDiQ8N5X7
MaxQBiQ8N5X7
PaxDbiQ8N5X7
PeptideAtlasiQ8N5X7
PRIDEiQ8N5X7
ProteomicsDBi72106
72107 [Q8N5X7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295612; ENSP00000295612; ENSG00000163412 [Q8N5X7-2]
ENST00000389826; ENSP00000374476; ENSG00000163412 [Q8N5X7-2]
ENST00000421769; ENSP00000411762; ENSG00000163412 [Q8N5X7-2]
ENST00000425534; ENSP00000393324; ENSG00000163412 [Q8N5X7-1]
ENST00000448225; ENSP00000410350; ENSG00000163412 [Q8N5X7-2]
GeneIDi317649
KEGGihsa:317649
UCSCiuc003dov.5 human [Q8N5X7-1]

Organism-specific databases

CTDi317649
DisGeNETi317649
EuPathDBiHostDB:ENSG00000163412.12
GeneCardsiEIF4E3
HGNCiHGNC:31837 EIF4E3
HPAiHPA058649
MIMi609896 gene
neXtProtiNX_Q8N5X7
OpenTargetsiENSG00000163412
PharmGKBiPA134961880
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHHQ Eukaryota
COG5053 LUCA
GeneTreeiENSGT00520000055549
HOGENOMiHOG000059588
HOVERGENiHBG107990
InParanoidiQ8N5X7
OMAiPTQHYWN
OrthoDBiEOG091G0ISE
PhylomeDBiQ8N5X7

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism

Miscellaneous databases

ChiTaRSiEIF4E3 human
GeneWikiiEIF4E3
GenomeRNAii317649
PROiPR:Q8N5X7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163412 Expressed in 205 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_EIF4E3
ExpressionAtlasiQ8N5X7 baseline and differential
GenevisibleiQ8N5X7 HS

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIF4E3_HUMAN
AccessioniPrimary (citable) accession number: Q8N5X7
Secondary accession number(s): B2R963, Q6NUT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: November 7, 2018
This is version 115 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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