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Protein

RING finger protein 10

Gene

RNF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 267RING-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ8N5U6

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 10
Gene namesi
Name:RNF10
Synonyms:KIAA0262, RIE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000022840.15
HGNCiHGNC:10055 RNF10
MIMi615998 gene
neXtProtiNX_Q8N5U6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9921
OpenTargetsiENSG00000022840
PharmGKBiPA34419

Polymorphism and mutation databases

BioMutaiRNF10
DMDMi117949776

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595851 – 811RING finger protein 10Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei128PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N5U6
MaxQBiQ8N5U6
PaxDbiQ8N5U6
PeptideAtlasiQ8N5U6
PRIDEiQ8N5U6
ProteomicsDBi72099
72100 [Q8N5U6-2]

PTM databases

iPTMnetiQ8N5U6
PhosphoSitePlusiQ8N5U6

Expressioni

Gene expression databases

BgeeiENSG00000022840 Expressed in 232 organ(s), highest expression level in testis
CleanExiHS_RNF10
ExpressionAtlasiQ8N5U6 baseline and differential
GenevisibleiQ8N5U6 HS

Organism-specific databases

HPAiHPA052643

Interactioni

Subunit structurei

Interacts with MEOX2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF1P542742EBI-714023,EBI-710997

Protein-protein interaction databases

BioGridi115249, 56 interactors
IntActiQ8N5U6, 32 interactors
MINTiQ8N5U6
STRINGi9606.ENSP00000322242

Structurei

3D structure databases

ProteinModelPortaliQ8N5U6
SMRiQ8N5U6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni101 – 185Interaction with MEOX21 PublicationAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi19 – 110Ser-richAdd BLAST92

Sequence similaritiesi

Belongs to the RNF10 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 267RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2164 Eukaryota
ENOG410XTFS LUCA
GeneTreeiENSGT00390000001731
HOVERGENiHBG059523
InParanoidiQ8N5U6
OMAiPCLLHYL
OrthoDBiEOG091G05CI
PhylomeDBiQ8N5U6
TreeFamiTF323455

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039739 Mag2/Rnf10
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR12983 PTHR12983, 1 hit
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N5U6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP
60 70 80 90 100
KSDGKNSSGS KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG
110 120 130 140 150
GGSSKLFSSS FNGGRRDEVA EAQRAEFSPA QFSGPKKINL NHLLNFTFEP
160 170 180 190 200
RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL FLQANCQFVV SEDQDYTAHF
210 220 230 240 250
ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC GHIFCWACIL
260 270 280 290 300
HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE
310 320 330 340 350
KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV
360 370 380 390 400
ALEQQLAEEK HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE
410 420 430 440 450
QLVLMAPLAK ESVFQPRKGV LEYLSAFDEE TTEVCSLDTP SRPLALPLVE
460 470 480 490 500
EEEAVSEPEP EGLPEACDDL ELADDNLKEG TICTESSQQE PITKSGFTRL
510 520 530 540 550
SSSPCYYFYQ AEDGQHMFLH PVNVRCLVRE YGSLERSPEK ISATVVEIAG
560 570 580 590 600
YSMSEDVRQR HRYLSHLPLT CEFSICELAL QPPVVSKETL EMFSDDIEKR
610 620 630 640 650
KRQRQKKARE ERRRERRIEI EENKKQGKYP EVHIPLENLQ QFPAFNSYTC
660 670 680 690 700
SSDSALGPTS TEGHGALSIS PLSRSPGSHA DFLLTPLSPT ASQGSPSFCV
710 720 730 740 750
GSLEEDSPFP SFAQMLRVGK AKADVWPKTA PKKDENSLVP PAPVDSDGES
760 770 780 790 800
DNSDRVPVPS FQNSFSQAIE AAFMKLDTPA TSDPLSEEKG GKKRKKQKQK
810
LLFSTSVVHT K
Length:811
Mass (Da):89,927
Last modified:October 31, 2006 - v2
Checksum:i54BCB1F7D59AE1BA
GO
Isoform 2 (identifier: Q8N5U6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     418-418: K → KSLLQQ

Note: No experimental confirmation available.
Show »
Length:816
Mass (Da):90,497
Checksum:iB7018039E420F9C9
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YFN9H0YFN9_HUMAN
RING finger protein 10
RNF10
183Annotation score:
H0YGX5H0YGX5_HUMAN
RING finger protein 10
RNF10
261Annotation score:
F5H510F5H510_HUMAN
RING finger protein 10
RNF10
118Annotation score:
H0YF69H0YF69_HUMAN
RING finger protein 10
RNF10
137Annotation score:
H0YFQ9H0YFQ9_HUMAN
RING finger protein 10
RNF10
211Annotation score:
F5H3A4F5H3A4_HUMAN
RING finger protein 10
RNF10
99Annotation score:
H0YGL7H0YGL7_HUMAN
RING finger protein 10
RNF10
104Annotation score:
H0YG28H0YG28_HUMAN
RING finger protein 10
RNF10
146Annotation score:
F5H5Z1F5H5Z1_HUMAN
RING finger protein 10
RNF10
84Annotation score:
F5H5P6F5H5P6_HUMAN
RING finger protein 10
RNF10
124Annotation score:
There is more potential isoformShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028967332L → F1 PublicationCorresponds to variant dbSNP:rs17852961Ensembl.1
Natural variantiVAR_028968433E → D. Corresponds to variant dbSNP:rs16950277Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021478418K → KSLLQQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027196 mRNA Translation: BAA84708.1
D87451 mRNA Translation: BAA13392.2
BT006974 mRNA Translation: AAP35620.1
BC016622 mRNA Translation: AAH16622.1
BC031596 mRNA Translation: AAH31596.1
BC101709 mRNA Translation: AAI01710.1
BC101715 mRNA Translation: AAI01716.1
AL389976 mRNA Translation: CAB97533.1
CCDSiCCDS81746.1 [Q8N5U6-2]
CCDS9201.1 [Q8N5U6-1]
RefSeqiNP_001317403.1, NM_001330474.1 [Q8N5U6-2]
NP_055683.3, NM_014868.4 [Q8N5U6-1]
UniGeneiHs.442798

Genome annotation databases

EnsembliENST00000325954; ENSP00000322242; ENSG00000022840 [Q8N5U6-1]
ENST00000413266; ENSP00000415682; ENSG00000022840 [Q8N5U6-2]
GeneIDi9921
KEGGihsa:9921
UCSCiuc001typ.5 human [Q8N5U6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027196 mRNA Translation: BAA84708.1
D87451 mRNA Translation: BAA13392.2
BT006974 mRNA Translation: AAP35620.1
BC016622 mRNA Translation: AAH16622.1
BC031596 mRNA Translation: AAH31596.1
BC101709 mRNA Translation: AAI01710.1
BC101715 mRNA Translation: AAI01716.1
AL389976 mRNA Translation: CAB97533.1
CCDSiCCDS81746.1 [Q8N5U6-2]
CCDS9201.1 [Q8N5U6-1]
RefSeqiNP_001317403.1, NM_001330474.1 [Q8N5U6-2]
NP_055683.3, NM_014868.4 [Q8N5U6-1]
UniGeneiHs.442798

3D structure databases

ProteinModelPortaliQ8N5U6
SMRiQ8N5U6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115249, 56 interactors
IntActiQ8N5U6, 32 interactors
MINTiQ8N5U6
STRINGi9606.ENSP00000322242

PTM databases

iPTMnetiQ8N5U6
PhosphoSitePlusiQ8N5U6

Polymorphism and mutation databases

BioMutaiRNF10
DMDMi117949776

Proteomic databases

EPDiQ8N5U6
MaxQBiQ8N5U6
PaxDbiQ8N5U6
PeptideAtlasiQ8N5U6
PRIDEiQ8N5U6
ProteomicsDBi72099
72100 [Q8N5U6-2]

Protocols and materials databases

DNASUi9921
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325954; ENSP00000322242; ENSG00000022840 [Q8N5U6-1]
ENST00000413266; ENSP00000415682; ENSG00000022840 [Q8N5U6-2]
GeneIDi9921
KEGGihsa:9921
UCSCiuc001typ.5 human [Q8N5U6-1]

Organism-specific databases

CTDi9921
DisGeNETi9921
EuPathDBiHostDB:ENSG00000022840.15
GeneCardsiRNF10
HGNCiHGNC:10055 RNF10
HPAiHPA052643
MIMi615998 gene
neXtProtiNX_Q8N5U6
OpenTargetsiENSG00000022840
PharmGKBiPA34419
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2164 Eukaryota
ENOG410XTFS LUCA
GeneTreeiENSGT00390000001731
HOVERGENiHBG059523
InParanoidiQ8N5U6
OMAiPCLLHYL
OrthoDBiEOG091G05CI
PhylomeDBiQ8N5U6
TreeFamiTF323455

Enzyme and pathway databases

SIGNORiQ8N5U6

Miscellaneous databases

ChiTaRSiRNF10 human
GeneWikiiRNF10
GenomeRNAii9921
PROiPR:Q8N5U6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000022840 Expressed in 232 organ(s), highest expression level in testis
CleanExiHS_RNF10
ExpressionAtlasiQ8N5U6 baseline and differential
GenevisibleiQ8N5U6 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039739 Mag2/Rnf10
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR12983 PTHR12983, 1 hit
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNF10_HUMAN
AccessioniPrimary (citable) accession number: Q8N5U6
Secondary accession number(s): Q92550, Q9NPP8, Q9ULW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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