SLC25A41

Functionⁱ

GO - Molecular functionⁱ

ATP transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Protein family/group databases

TCDBⁱ	2.A.29.23.6 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.23.6 the mitochondrial carrier (mc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 25 member 41
Gene namesⁱ	Name:SLC25A41Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000181240.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28533 SLC25A41
MIMⁱ	610822 gene
neXtProtⁱ	NX_Q8N5S1

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	96 – 113	Helical; Name=1Sequence analysisAdd BLAST	18
Transmembraneⁱ	151 – 170	Helical; Name=2Sequence analysisAdd BLAST	20
Transmembraneⁱ	194 – 207	Helical; Name=3Sequence analysisAdd BLAST	14
Transmembraneⁱ	245 – 263	Helical; Name=4Sequence analysisAdd BLAST	19
Transmembraneⁱ	282 – 306	Helical; Name=5Sequence analysisAdd BLAST	25
Transmembraneⁱ	342 – 361	Helical; Name=6Sequence analysisAdd BLAST	20

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	284427
Open Targets More...OpenTargetsⁱ	ENSG00000181240
PharmGKBⁱ	PA162403684

Polymorphism and mutation databases

BioMutaⁱ	SLC25A41
DMDMⁱ	172046142

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000319990	1 – 370	Solute carrier family 25 member 41Add BLAST		370

Proteomic databases

PaxDbⁱ	Q8N5S1
PeptideAtlas More...PeptideAtlasⁱ	Q8N5S1
PRIDEⁱ	Q8N5S1
ProteomicsDBⁱ	72088 72089 [Q8N5S1-2]

PTM databases

iPTMnetⁱ	Q8N5S1
PhosphoSitePlusⁱ	Q8N5S1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000181240 Expressed in 81 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_SLC25A41
Genevisibleⁱ	Q8N5S1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043591

HPAⁱ

HPA043591

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	129873, 90 interactors
STRINGⁱ	9606.ENSP00000322649

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N5S1
SMRⁱ	Q8N5S1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	90 – 176	Solcar 1Sequence analysisAdd BLAST	87
Repeatⁱ	184 – 269	Solcar 2Sequence analysisAdd BLAST	86
Repeatⁱ	280 – 367	Solcar 3Sequence analysisAdd BLAST	88

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	30 – 44	Pro-richSequence analysisAdd BLAST		15

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0036 Eukaryota ENOG410XQ4P LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137904
HOGENOMⁱ	HOG000165728
HOVERGENⁱ	HBG108464
InParanoidⁱ	Q8N5S1
KEGG Orthology (KO) More...KOⁱ	K14684
OMAⁱ	FCGVHGS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C8S
PhylomeDBⁱ	Q8N5S1
TreeFamⁱ	TF313492

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002067 Mit_carrier IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 11 Publication (identifier: Q8N5S1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAQPGEPQN TCSRIQTLFR RVKTLLIKAP PPPQPPPPPP SWNPGCTHVY 
        60         70         80         90        100
GYAFGHMHDN NLEHLPSQQV LDTGEQLMVP VEVLEVDNKE ALWKFLLSGA 
       110        120        130        140        150
MAGAVSRTGT APLDRAKVYM QVYSSKTNFT NLLGGLQSMV QEGGFRSLWR 
       160        170        180        190        200
GNGINVLKIA PEYAIKFSVF EQCKNYFCGI QGSPPFQERL LAGSLAVAIS 
       210        220        230        240        250
QTLINPMEVL KTRLTLRRTG QYKGLLDCAR QILQREGTRA LYRGYLPNML 
       260        270        280        290        300
GIIPYACTDL AVYEMLQCFW VKSGRDMGDP SGLVSLSSVT LSTTCGQMAS 
       310        320        330        340        350
YPLTLVRTRM QAQDTVEGSN PTMRGVLQRI LAQQGWLGLY RGMTPTLLKV 
       360        370
LPAGGISYVV YEAMKKTLGI

Length:370

Mass (Da):40,795

Last modified:February 26, 2008 - v2

Checksum:ⁱ818C9FC7CD5F6041

GO

Isoform 21 Publication (identifier: Q8N5S1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
121-242: QVYSSKTNFT...LQREGTRALY → QLLGRLRQEN...PRPSSTPWRC
243-370: Missing.

« Hide

        10         20         30         40         50
MGAQPGEPQN TCSRIQTLFR RVKTLLIKAP PPPQPPPPPP SWNPGCTHVY 
        60         70         80         90        100
GYAFGHMHDN NLEHLPSQQV LDTGEQLMVP VEVLEVDNKE ALWKFLLSGA 
       110        120        130        140        150
MAGAVSRTGT APLDRAKVYM QLLGRLRQEN RLNLGGGGCS EPRSPDRTPA 
       160        170        180        190        200
WATESTPPRR TSPTCWGGYR AWSRRAASAP CGGATASTCS RLLLSMPSSS 
       210        220        230        240 
PYSSSARITS VEYKGPRPSR SVSLLAPWLW PSPRPSSTPW RC

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:242

Mass (Da):26,397

Checksum:ⁱ0C76E27DF28893AE

GO

Sequence cautionⁱ

The sequence AAH31671 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAC05163 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050132	144	G → S. Corresponds to variant dbSNP:rs34488963Ensembl.		1
Natural variantⁱVAR_050133	258	T → S. Corresponds to variant dbSNP:rs11883242Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_052690	121 – 242	QVYSS…TRALY → QLLGRLRQENRLNLGGGGCS EPRSPDRTPAWATESTPPRR TSPTCWGGYRAWSRRAASAP CGGATASTCSRLLLSMPSSS PYSSSARITSVEYKGPRPSR SVSLLAPWLWPSPRPSSTPW RC in isoform 2. 1 PublicationAdd BLAST		122
Alternative sequenceⁱVSP_035524	243 – 370	Missing in isoform 2. 1 PublicationAdd BLAST		128

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK097761 mRNA Translation: BAC05163.1 Sequence problems. AC011539 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69092.1 CH471139 Genomic DNA Translation: EAW69094.1 CH471139 Genomic DNA Translation: EAW69093.1 BC031671 mRNA Translation: AAH31671.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45937.1 [Q8N5S1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001308227.1, NM_001321298.1 NP_775908.2, NM_173637.3 [Q8N5S1-1]
UniGeneⁱ	Hs.375135

Genome annotation databases

Ensemblⁱ	ENST00000321510; ENSP00000322649; ENSG00000181240 [Q8N5S1-1] ENST00000458275; ENSP00000405411; ENSG00000181240 [Q8N5S1-2] ENST00000597558; ENSP00000471238; ENSG00000181240 [Q8N5S1-1]
GeneIDⁱ	284427
KEGGⁱ	hsa:284427
UCSC genome browser More...UCSCⁱ	uc010dus.4 human [Q8N5S1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N5S1	SLC25A41 isoform 1		PANTR		370	UniRef90_Q8N5S1
Uncharacterized protein		PANPA		370
SLC25A41 isoform 1 (Fragment)		PONAB		370
Uncharacterized protein		MACMU		370
Uncharacterized protein		PAPAN		249
+14
Q8N5S1-2	SLC25A41 isoform 3 (Fragment)		PONAB		242	UniRef90_Q8N5S1-2
SLC25A41 isoform 3		PANTR		242

Protein	Similar proteins		Species	Score	Length	Source
Q8N5S1	Solute carrier family 25 member 41		MOUSE		312	UniRef50_Q8N5S1
Solute carrier family 25 member 41		BOVIN		349
Uncharacterized protein		CERAT		370
Uncharacterized protein		MANLE		370
Uncharacterized protein		MACMU		370
+114
Q8N5S1-2	SLC25A41 isoform 3 (Fragment)		PONAB		242	UniRef50_Q8N5S1-2
SLC25A41 isoform 3		PANTR		242

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK097761 mRNA Translation: BAC05163.1 Sequence problems. AC011539 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69092.1 CH471139 Genomic DNA Translation: EAW69094.1 CH471139 Genomic DNA Translation: EAW69093.1 BC031671 mRNA Translation: AAH31671.1 Different initiation.
CCDSⁱ	CCDS45937.1 [Q8N5S1-1]
RefSeqⁱ	NP_001308227.1, NM_001321298.1 NP_775908.2, NM_173637.3 [Q8N5S1-1]
UniGeneⁱ	Hs.375135

3D structure databases

ProteinModelPortalⁱ	Q8N5S1
SMRⁱ	Q8N5S1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129873, 90 interactors
STRINGⁱ	9606.ENSP00000322649

Protein family/group databases

TCDBⁱ	2.A.29.23.6 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.23.6 the mitochondrial carrier (mc) family

PTM databases

iPTMnetⁱ	Q8N5S1
PhosphoSitePlusⁱ	Q8N5S1

Polymorphism and mutation databases

BioMutaⁱ	SLC25A41
DMDMⁱ	172046142

Proteomic databases

PaxDbⁱ	Q8N5S1
PeptideAtlasⁱ	Q8N5S1
PRIDEⁱ	Q8N5S1
ProteomicsDBⁱ	72088 72089 [Q8N5S1-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	284427
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000321510; ENSP00000322649; ENSG00000181240 [Q8N5S1-1] ENST00000458275; ENSP00000405411; ENSG00000181240 [Q8N5S1-2] ENST00000597558; ENSP00000471238; ENSG00000181240 [Q8N5S1-1]
GeneIDⁱ	284427
KEGGⁱ	hsa:284427
UCSCⁱ	uc010dus.4 human [Q8N5S1-1]

Organism-specific databases

CTDⁱ	284427
DisGeNETⁱ	284427
EuPathDBⁱ	HostDB:ENSG00000181240.13
GeneCardsⁱ	SLC25A41
HGNCⁱ	HGNC:28533 SLC25A41
HPAⁱ	HPA043591
MIMⁱ	610822 gene
neXtProtⁱ	NX_Q8N5S1
OpenTargetsⁱ	ENSG00000181240
PharmGKBⁱ	PA162403684
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0036 Eukaryota ENOG410XQ4P LUCA
GeneTreeⁱ	ENSGT00880000137904
HOGENOMⁱ	HOG000165728
HOVERGENⁱ	HBG108464
InParanoidⁱ	Q8N5S1
KOⁱ	K14684
OMAⁱ	FCGVHGS
OrthoDBⁱ	EOG091G0C8S
PhylomeDBⁱ	Q8N5S1
TreeFamⁱ	TF313492

Miscellaneous databases

GenomeRNAiⁱ	284427
Protein Ontology More...PROⁱ	PR:Q8N5S1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000181240 Expressed in 81 organ(s), highest expression level in cerebellar hemisphere
CleanExⁱ	HS_SLC25A41
Genevisibleⁱ	Q8N5S1 HS

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002067 Mit_carrier IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit
Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
PRINTSⁱ	PR00926 MITOCARRIER
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S2541_HUMAN
Accessionⁱ	Q8N5S1Primary (citable) accession number: Q8N5S1 Secondary accession number(s): A8MQ40, D6W642, Q8N7R4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	February 26, 2008
	Last modified:	November 7, 2018
	This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniRef

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Supporting data

UniProtKB - Q8N5S1 (S2541_HUMAN)

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Solute carrier family 25 member 41

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ