UniProtKB - Q8N5S1 (S2541_HUMAN)
Mitochondrial carrier protein SCaMC-3L
SLC25A41
Functioni
Calcium-independent ATP-Mg/Pi exchanger that catalyzes the electroneutral exchange of Mg-ATP or free ADP against an hydrogenphosphate and participates in the net transport of adenine nucleotides across the mitochondria inner membrane.
By similarityCatalytic activityi
GO - Molecular functioni
- ADP transmembrane transporter activity Source: UniProtKB
- ATP transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- ADP transport Source: UniProtKB
- ATP transport Source: UniProtKB
- mitochondrial ADP transmembrane transport Source: UniProtKB
- mitochondrial ATP transmembrane transport Source: UniProtKB
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8N5S1 |
SignaLinki | Q8N5S1 |
Protein family/group databases
TCDBi | 2.A.29.23.6, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial carrier protein SCaMC-3LCuratedAlternative name(s): Mitochondrial ATP-Mg/Pi carrier protein SLC25A41Curated Small calcium-binding mitochondrial carrier protein 3-like Short name: SCaMC-3-likeBy similarity Short name: SCaMC-3LBy similarity Solute carrier family 25 member 41 |
Gene namesi | Name:SLC25A41Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28533, SLC25A41 |
MIMi | 610822, gene |
neXtProti | NX_Q8N5S1 |
VEuPathDBi | HostDB:ENSG00000181240 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 96 – 113 | Helical; Name=1Sequence analysisAdd BLAST | 18 | |
Transmembranei | 151 – 170 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Transmembranei | 194 – 207 | Helical; Name=3Sequence analysisAdd BLAST | 14 | |
Transmembranei | 245 – 263 | Helical; Name=4Sequence analysisAdd BLAST | 19 | |
Transmembranei | 282 – 306 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Transmembranei | 342 – 361 | Helical; Name=6Sequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 284427 |
OpenTargetsi | ENSG00000181240 |
PharmGKBi | PA162403684 |
Miscellaneous databases
Pharosi | Q8N5S1, Tdark |
Genetic variation databases
BioMutai | SLC25A41 |
DMDMi | 172046142 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000319990 | 1 – 370 | Mitochondrial carrier protein SCaMC-3LAdd BLAST | 370 |
Proteomic databases
MassIVEi | Q8N5S1 |
MaxQBi | Q8N5S1 |
PaxDbi | Q8N5S1 |
PeptideAtlasi | Q8N5S1 |
PRIDEi | Q8N5S1 |
PTM databases
iPTMneti | Q8N5S1 |
PhosphoSitePlusi | Q8N5S1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000181240, Expressed in cerebellar hemisphere and 104 other tissues |
Genevisiblei | Q8N5S1, HS |
Organism-specific databases
HPAi | ENSG00000181240, Group enriched (brain, choroid plexus, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129873, 89 interactors |
IntActi | Q8N5S1, 63 interactors |
STRINGi | 9606.ENSP00000322649 |
Miscellaneous databases
RNActi | Q8N5S1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 90 – 176 | Solcar 1Sequence analysisAdd BLAST | 87 | |
Repeati | 184 – 269 | Solcar 2Sequence analysisAdd BLAST | 86 | |
Repeati | 280 – 367 | Solcar 3Sequence analysisAdd BLAST | 88 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0036, Eukaryota |
GeneTreei | ENSGT00940000162419 |
HOGENOMi | CLU_015166_10_2_1 |
InParanoidi | Q8N5S1 |
OMAi | VHESPPF |
OrthoDBi | 442523at2759 |
PhylomeDBi | Q8N5S1 |
TreeFami | TF313492 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAQPGEPQN TCSRIQTLFR RVKTLLIKAP PPPQPPPPPP SWNPGCTHVY
60 70 80 90 100
GYAFGHMHDN NLEHLPSQQV LDTGEQLMVP VEVLEVDNKE ALWKFLLSGA
110 120 130 140 150
MAGAVSRTGT APLDRAKVYM QVYSSKTNFT NLLGGLQSMV QEGGFRSLWR
160 170 180 190 200
GNGINVLKIA PEYAIKFSVF EQCKNYFCGI QGSPPFQERL LAGSLAVAIS
210 220 230 240 250
QTLINPMEVL KTRLTLRRTG QYKGLLDCAR QILQREGTRA LYRGYLPNML
260 270 280 290 300
GIIPYACTDL AVYEMLQCFW VKSGRDMGDP SGLVSLSSVT LSTTCGQMAS
310 320 330 340 350
YPLTLVRTRM QAQDTVEGSN PTMRGVLQRI LAQQGWLGLY RGMTPTLLKV
360 370
LPAGGISYVV YEAMKKTLGI
The sequence of this isoform differs from the canonical sequence as follows:
121-242: QVYSSKTNFT...LQREGTRALY → QLLGRLRQEN...PRPSSTPWRC
243-370: Missing.
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050132 | 144 | G → S. Corresponds to variant dbSNP:rs34488963Ensembl. | 1 | |
Natural variantiVAR_050133 | 258 | T → S. Corresponds to variant dbSNP:rs11883242Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052690 | 121 – 242 | QVYSS…TRALY → QLLGRLRQENRLNLGGGGCS EPRSPDRTPAWATESTPPRR TSPTCWGGYRAWSRRAASAP CGGATASTCSRLLLSMPSSS PYSSSARITSVEYKGPRPSR SVSLLAPWLWPSPRPSSTPW RC in isoform 2. 1 PublicationAdd BLAST | 122 | |
Alternative sequenceiVSP_035524 | 243 – 370 | Missing in isoform 2. 1 PublicationAdd BLAST | 128 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097761 mRNA Translation: BAC05163.1 Sequence problems. AC011539 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69092.1 CH471139 Genomic DNA Translation: EAW69094.1 CH471139 Genomic DNA Translation: EAW69093.1 BC031671 mRNA Translation: AAH31671.1 Different initiation. |
CCDSi | CCDS45937.1 [Q8N5S1-1] |
RefSeqi | NP_001308227.1, NM_001321298.1 NP_775908.2, NM_173637.3 [Q8N5S1-1] |
Genome annotation databases
Ensembli | ENST00000321510; ENSP00000322649; ENSG00000181240 ENST00000458275; ENSP00000405411; ENSG00000181240 [Q8N5S1-2] ENST00000597558; ENSP00000471238; ENSG00000181240 |
GeneIDi | 284427 |
KEGGi | hsa:284427 |
MANE-Selecti | ENST00000321510.7; ENSP00000322649.5; NM_173637.4; NP_775908.2 |
UCSCi | uc010dus.4, human [Q8N5S1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097761 mRNA Translation: BAC05163.1 Sequence problems. AC011539 Genomic DNA No translation available. CH471139 Genomic DNA Translation: EAW69092.1 CH471139 Genomic DNA Translation: EAW69094.1 CH471139 Genomic DNA Translation: EAW69093.1 BC031671 mRNA Translation: AAH31671.1 Different initiation. |
CCDSi | CCDS45937.1 [Q8N5S1-1] |
RefSeqi | NP_001308227.1, NM_001321298.1 NP_775908.2, NM_173637.3 [Q8N5S1-1] |
3D structure databases
SMRi | Q8N5S1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129873, 89 interactors |
IntActi | Q8N5S1, 63 interactors |
STRINGi | 9606.ENSP00000322649 |
Protein family/group databases
TCDBi | 2.A.29.23.6, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | Q8N5S1 |
PhosphoSitePlusi | Q8N5S1 |
Genetic variation databases
BioMutai | SLC25A41 |
DMDMi | 172046142 |
Proteomic databases
MassIVEi | Q8N5S1 |
MaxQBi | Q8N5S1 |
PaxDbi | Q8N5S1 |
PeptideAtlasi | Q8N5S1 |
PRIDEi | Q8N5S1 |
Protocols and materials databases
Antibodypediai | 49970, 20 antibodies from 9 providers |
DNASUi | 284427 |
Genome annotation databases
Ensembli | ENST00000321510; ENSP00000322649; ENSG00000181240 ENST00000458275; ENSP00000405411; ENSG00000181240 [Q8N5S1-2] ENST00000597558; ENSP00000471238; ENSG00000181240 |
GeneIDi | 284427 |
KEGGi | hsa:284427 |
MANE-Selecti | ENST00000321510.7; ENSP00000322649.5; NM_173637.4; NP_775908.2 |
UCSCi | uc010dus.4, human [Q8N5S1-1] |
Organism-specific databases
CTDi | 284427 |
DisGeNETi | 284427 |
GeneCardsi | SLC25A41 |
HGNCi | HGNC:28533, SLC25A41 |
HPAi | ENSG00000181240, Group enriched (brain, choroid plexus, testis) |
MIMi | 610822, gene |
neXtProti | NX_Q8N5S1 |
OpenTargetsi | ENSG00000181240 |
PharmGKBi | PA162403684 |
VEuPathDBi | HostDB:ENSG00000181240 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0036, Eukaryota |
GeneTreei | ENSGT00940000162419 |
HOGENOMi | CLU_015166_10_2_1 |
InParanoidi | Q8N5S1 |
OMAi | VHESPPF |
OrthoDBi | 442523at2759 |
PhylomeDBi | Q8N5S1 |
TreeFami | TF313492 |
Enzyme and pathway databases
PathwayCommonsi | Q8N5S1 |
SignaLinki | Q8N5S1 |
Miscellaneous databases
BioGRID-ORCSi | 284427, 37 hits in 1045 CRISPR screens |
ChiTaRSi | SLC25A41, human |
GenomeRNAii | 284427 |
Pharosi | Q8N5S1, Tdark |
PROi | PR:Q8N5S1 |
RNActi | Q8N5S1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000181240, Expressed in cerebellar hemisphere and 104 other tissues |
Genevisiblei | Q8N5S1, HS |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | S2541_HUMAN | |
Accessioni | Q8N5S1Primary (citable) accession number: Q8N5S1 Secondary accession number(s): A8MQ40, D6W642, Q8N7R4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | February 23, 2022 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families