UniProtKB - Q8N5R6 (CCD33_HUMAN)
Coiled-coil domain-containing protein 33
CCDC33
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 33Alternative name(s): Cancer/testis antigen 61 Short name: CT61 |
Gene namesi | Name:CCDC33 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26552, CCDC33 |
MIMi | 618525, gene |
neXtProti | NX_Q8N5R6 |
VEuPathDBi | HostDB:ENSG00000140481.13 |
Subcellular locationi
Peroxisome
- peroxisome Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 80125 |
OpenTargetsi | ENSG00000140481 |
PharmGKBi | PA142672188 |
Miscellaneous databases
Pharosi | Q8N5R6, Tdark |
Genetic variation databases
BioMutai | CCDC33 |
DMDMi | 205646145 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307643 | 1 – 958 | Coiled-coil domain-containing protein 33Add BLAST | 958 |
Proteomic databases
EPDi | Q8N5R6 |
PaxDbi | Q8N5R6 |
PeptideAtlasi | Q8N5R6 |
PRIDEi | Q8N5R6 |
ProteomicsDBi | 72082 [Q8N5R6-1] 72083 [Q8N5R6-2] 72084 [Q8N5R6-4] 72085 [Q8N5R6-5] 72086 [Q8N5R6-6] |
PTM databases
iPTMneti | Q8N5R6 |
PhosphoSitePlusi | Q8N5R6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000140481, Expressed in right uterine tube and 84 other tissues |
ExpressionAtlasi | Q8N5R6, baseline and differential |
Genevisiblei | Q8N5R6, HS |
Organism-specific databases
HPAi | ENSG00000140481, Group enriched (fallopian tube, testis) |
Interactioni
Binary interactionsi
Q8N5R6
With | #Exp. | IntAct |
---|---|---|
HOOK2 [Q96ED9] | 2 | EBI-740841,EBI-743290 |
Protein-protein interaction databases
BioGRIDi | 123126, 186 interactors |
IntActi | Q8N5R6, 51 interactors |
MINTi | Q8N5R6 |
STRINGi | 9606.ENSP00000381795 |
Miscellaneous databases
RNActi | Q8N5R6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 214 – 353 | C2PROSITE-ProRule annotationAdd BLAST | 140 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 632 – 774 | Sequence analysisAdd BLAST | 143 | |
Coiled coili | 859 – 899 | Sequence analysisAdd BLAST | 41 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00390000017366 |
HOGENOMi | CLU_067728_0_0_1 |
InParanoidi | Q8N5R6 |
OMAi | RDTEMNN |
OrthoDBi | 1379192at2759 |
PhylomeDBi | Q8N5R6 |
TreeFami | TF328975 |
Family and domain databases
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR039889, CCD33 |
PANTHERi | PTHR21623, PTHR21623, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAFRGPEPWV SASLLRQRLK AEEKTLDLEF EVLSVGFNEA GRYALRLSAE
60 70 80 90 100
NPLQVGSGAG VQLQVNDGDP FPACSAITDV IEQQEPGQSL TLTRSKFIFT
110 120 130 140 150
LPKGFCKNDG QHDAQLHVEA LRLDEPLGRA AQRVGEAIFP IYPRPDQPRM
160 170 180 190 200
NPKAQDHEDL YRYCGNLALL RASTDPTARH CGSLAYSVAF HVHRGPQPPV
210 220 230 240 250
SDSPPRAGQP ELMSPEEPLI ASQSTEPEIG HLSPSKKETI MVTLHGATNL
260 270 280 290 300
PACKDGSEPW PYVVVKSTSE EKNNQSSKAV TSVTSEPTRA PIWGDTVNVE
310 320 330 340 350
IQAEDAGQED VILKVVDNRK KQELLSYKIP IKYLRVFHPY HFELVKPTES
360 370 380 390 400
GKADEATAKT QLYATVVRKS SFIPRYIGCN HMALEIFLRG VNEPLANNPN
410 420 430 440 450
PIVVIARVVP NYKEFKVSQA NRDLASVGLP ITPLSFPIPS MMNFDVPRVS
460 470 480 490 500
QNGCPQLSKP GGPPEQPLWN QSFLFQGRDG ATSFSEDTAL VLEYYSSTSM
510 520 530 540 550
KGSQPWTLNQ PLGISVLPLK SRLYQKMLTG KGLDGLHVER LPIMDTSLKT
560 570 580 590 600
INDEAPTVAL SFQLLSSERP ENFLTPNNSK ALPTLDPKIL DKKLRTIQES
610 620 630 640 650
WSKDTVSSTM DLSTSTPREA EEEPLVPEMS HDTEMNNYRR AMQKMAEDIL
660 670 680 690 700
SLRRQASILE GENRILRSRL AQQEEEEGQG KASEAQNTVS MKQKLLLSEL
710 720 730 740 750
DMKKLRDRVQ HLQNELIRKN DREKELLLLY QAQQPQAALL KQYQGKLQKM
760 770 780 790 800
KALEETVRHQ EKVIEKMERV LEDRLQDRSK PPPLNRQQGK PYTGFPMLSA
810 820 830 840 850
SGLPLGSMGE NLPVELYSVL LAENAKLRTE LDKNRHQQAP IILQQQALPD
860 870 880 890 900
LLSGTSDKFN LLAKLEHAQS RILSLESQLE DSARRWGREK QDLATRLQEQ
910 920 930 940 950
EKGFRHPSNS IIIEQPSALT HSMDLKQPSE LEPLLPSSDS KLNKPLSPQK
ETANSQQT
The sequence of this isoform differs from the canonical sequence as follows:
1-610: Missing.
611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YMB8 | H0YMB8_HUMAN | Coiled-coil domain-containing prote... | CCDC33 | 701 | Annotation score: | ||
A0A1B0GV97 | A0A1B0GV97_HUMAN | Coiled-coil domain-containing prote... | CCDC33 | 279 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 237 | Missing in BAG51911 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 531 | K → E in BAG51911 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 775 | L → P in BAF83398 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_045602 | 635 | M → V. Corresponds to variant dbSNP:rs2277603Ensembl. | 1 | |
Natural variantiVAR_045603 | 640 | R → L. Corresponds to variant dbSNP:rs2277604Ensembl. | 1 | |
Natural variantiVAR_036625 | 683 | S → N1 PublicationCorresponds to variant dbSNP:rs1564782Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028755 | 1 – 610 | Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 610 | |
Alternative sequenceiVSP_040258 | 1 – 203 | Missing in isoform 6. 1 PublicationAdd BLAST | 203 | |
Alternative sequenceiVSP_040259 | 204 – 214 | PPRAGQPELMS → MGLKNKKNTED in isoform 6. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_028756 | 611 – 633 | DLSTS…MSHDT → MGEPGPPSPPAPKAAPGLID SFS in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_028757 | 849 | P → PVDPGELGAGGDLTERLQET HGPGHSECTETLPAQ in isoform 2 and isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_028758 | 917 – 958 | SALTH…NSQQT → PYSLPPAPGASIFGKPRATV DPGGWREEAFQSRGQGDGPL PDPEKKQGHQRPALLGNTRE ACPFHLPQNIYHV in isoform 2. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_028759 | 917 – 958 | SALTH…NSQQT → VSDPPGVAPRGSGGGAGSHR TPKVTGP in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057417 mRNA Translation: BAG51911.1 AK026821 mRNA Translation: BAB15564.1 AK290709 mRNA Translation: BAF83398.1 AC023300 Genomic DNA No translation available. AC090826 Genomic DNA No translation available. BC031684 mRNA Translation: AAH31684.1 |
CCDSi | CCDS42058.1 [Q8N5R6-6] CCDS42059.1 [Q8N5R6-5] CCDS73753.1 [Q8N5R6-4] |
RefSeqi | NP_001274110.1, NM_001287181.1 [Q8N5R6-4] NP_079331.3, NM_025055.4 [Q8N5R6-6] NP_877592.2, NM_182791.3 [Q8N5R6-5] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057417 mRNA Translation: BAG51911.1 AK026821 mRNA Translation: BAB15564.1 AK290709 mRNA Translation: BAF83398.1 AC023300 Genomic DNA No translation available. AC090826 Genomic DNA No translation available. BC031684 mRNA Translation: AAH31684.1 |
CCDSi | CCDS42058.1 [Q8N5R6-6] CCDS42059.1 [Q8N5R6-5] CCDS73753.1 [Q8N5R6-4] |
RefSeqi | NP_001274110.1, NM_001287181.1 [Q8N5R6-4] NP_079331.3, NM_025055.4 [Q8N5R6-6] NP_877592.2, NM_182791.3 [Q8N5R6-5] |
3D structure databases
SMRi | Q8N5R6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123126, 186 interactors |
IntActi | Q8N5R6, 51 interactors |
MINTi | Q8N5R6 |
STRINGi | 9606.ENSP00000381795 |
PTM databases
iPTMneti | Q8N5R6 |
PhosphoSitePlusi | Q8N5R6 |
Genetic variation databases
BioMutai | CCDC33 |
DMDMi | 205646145 |
Proteomic databases
EPDi | Q8N5R6 |
PaxDbi | Q8N5R6 |
PeptideAtlasi | Q8N5R6 |
PRIDEi | Q8N5R6 |
ProteomicsDBi | 72082 [Q8N5R6-1] 72083 [Q8N5R6-2] 72084 [Q8N5R6-4] 72085 [Q8N5R6-5] 72086 [Q8N5R6-6] |
Protocols and materials databases
Antibodypediai | 52555, 50 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 80125 |
DisGeNETi | 80125 |
GeneCardsi | CCDC33 |
HGNCi | HGNC:26552, CCDC33 |
HPAi | ENSG00000140481, Group enriched (fallopian tube, testis) |
MIMi | 618525, gene |
neXtProti | NX_Q8N5R6 |
OpenTargetsi | ENSG00000140481 |
PharmGKBi | PA142672188 |
VEuPathDBi | HostDB:ENSG00000140481.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00390000017366 |
HOGENOMi | CLU_067728_0_0_1 |
InParanoidi | Q8N5R6 |
OMAi | RDTEMNN |
OrthoDBi | 1379192at2759 |
PhylomeDBi | Q8N5R6 |
TreeFami | TF328975 |
Enzyme and pathway databases
PathwayCommonsi | Q8N5R6 |
Miscellaneous databases
BioGRID-ORCSi | 80125, 8 hits in 874 CRISPR screens |
ChiTaRSi | CCDC33, human |
GenomeRNAii | 80125 |
Pharosi | Q8N5R6, Tdark |
PROi | PR:Q8N5R6 |
RNActi | Q8N5R6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140481, Expressed in right uterine tube and 84 other tissues |
ExpressionAtlasi | Q8N5R6, baseline and differential |
Genevisiblei | Q8N5R6, HS |
Family and domain databases
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR039889, CCD33 |
PANTHERi | PTHR21623, PTHR21623, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCD33_HUMAN | |
Accessioni | Q8N5R6Primary (citable) accession number: Q8N5R6 Secondary accession number(s): A8K3U4 Q9H5Q6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | July 22, 2008 | |
Last modified: | February 10, 2021 | |
This is version 132 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants