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UniProtKB - Q8N5R6 (CCD33_HUMAN)

Entry version 132 (10 Feb 2021)
Sequence version 3 (22 Jul 2008)
Previous versions | rss
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Protein

Coiled-coil domain-containing protein 33

Gene

CCDC33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N5R6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 33
Alternative name(s):
Cancer/testis antigen 61
Short name:
CT61
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC33
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26552, CCDC33

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618525, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N5R6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140481.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		80125

Open Targets

More...OpenTargetsi		ENSG00000140481

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672188

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N5R6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCDC33

Domain mapping of disease mutations (DMDM)

More...DMDMi		205646145

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003076431 – 958Coiled-coil domain-containing protein 33Add BLAST958

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N5R6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N5R6

PeptideAtlas

More...PeptideAtlasi		Q8N5R6

PRoteomics IDEntifications database

More...PRIDEi		Q8N5R6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72082 [Q8N5R6-1]
72083 [Q8N5R6-2]
72084 [Q8N5R6-4]
72085 [Q8N5R6-5]
72086 [Q8N5R6-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N5R6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N5R6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140481, Expressed in right uterine tube and 84 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N5R6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N5R6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140481, Group enriched (fallopian tube, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123126, 186 interactors

Protein interaction database and analysis system

More...IntActi		Q8N5R6, 51 interactors

Molecular INTeraction database

More...MINTi		Q8N5R6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000381795

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N5R6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N5R6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini214 – 353C2PROSITE-ProRule annotationAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili632 – 774Sequence analysisAdd BLAST143
Coiled coili859 – 899Sequence analysisAdd BLAST41

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3544, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017366

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_067728_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N5R6

Identification of Orthologs from Complete Genome Data

More...OMAi		RDTEMNN

Database of Orthologous Groups

More...OrthoDBi		1379192at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N5R6

TreeFam database of animal gene trees

More...TreeFami		TF328975

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR039889, CCD33

The PANTHER Classification System

More...PANTHERi		PTHR21623, PTHR21623, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N5R6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFRGPEPWV SASLLRQRLK AEEKTLDLEF EVLSVGFNEA GRYALRLSAE 
        60         70         80         90        100
NPLQVGSGAG VQLQVNDGDP FPACSAITDV IEQQEPGQSL TLTRSKFIFT 
       110        120        130        140        150
LPKGFCKNDG QHDAQLHVEA LRLDEPLGRA AQRVGEAIFP IYPRPDQPRM 
       160        170        180        190        200
NPKAQDHEDL YRYCGNLALL RASTDPTARH CGSLAYSVAF HVHRGPQPPV 
       210        220        230        240        250
SDSPPRAGQP ELMSPEEPLI ASQSTEPEIG HLSPSKKETI MVTLHGATNL 
       260        270        280        290        300
PACKDGSEPW PYVVVKSTSE EKNNQSSKAV TSVTSEPTRA PIWGDTVNVE 
       310        320        330        340        350
IQAEDAGQED VILKVVDNRK KQELLSYKIP IKYLRVFHPY HFELVKPTES 
       360        370        380        390        400
GKADEATAKT QLYATVVRKS SFIPRYIGCN HMALEIFLRG VNEPLANNPN 
       410        420        430        440        450
PIVVIARVVP NYKEFKVSQA NRDLASVGLP ITPLSFPIPS MMNFDVPRVS 
       460        470        480        490        500
QNGCPQLSKP GGPPEQPLWN QSFLFQGRDG ATSFSEDTAL VLEYYSSTSM 
       510        520        530        540        550
KGSQPWTLNQ PLGISVLPLK SRLYQKMLTG KGLDGLHVER LPIMDTSLKT 
       560        570        580        590        600
INDEAPTVAL SFQLLSSERP ENFLTPNNSK ALPTLDPKIL DKKLRTIQES 
       610        620        630        640        650
WSKDTVSSTM DLSTSTPREA EEEPLVPEMS HDTEMNNYRR AMQKMAEDIL 
       660        670        680        690        700
SLRRQASILE GENRILRSRL AQQEEEEGQG KASEAQNTVS MKQKLLLSEL 
       710        720        730        740        750
DMKKLRDRVQ HLQNELIRKN DREKELLLLY QAQQPQAALL KQYQGKLQKM 
       760        770        780        790        800
KALEETVRHQ EKVIEKMERV LEDRLQDRSK PPPLNRQQGK PYTGFPMLSA 
       810        820        830        840        850
SGLPLGSMGE NLPVELYSVL LAENAKLRTE LDKNRHQQAP IILQQQALPD 
       860        870        880        890        900
LLSGTSDKFN LLAKLEHAQS RILSLESQLE DSARRWGREK QDLATRLQEQ 
       910        920        930        940        950
EKGFRHPSNS IIIEQPSALT HSMDLKQPSE LEPLLPSSDS KLNKPLSPQK 

ETANSQQT
Length:958
Mass (Da):107,216
Last modified:July 22, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F8A9284396424CA
GO
Isoform 2 (identifier: Q8N5R6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
     917-958: SALTHSMDLK...QKETANSQQT → PYSLPPAPGA...FHLPQNIYHV

Show »
Length:1,023
Mass (Da):114,065
Checksum:i0B1233CF38EDC0F1
GO
Isoform 4 (identifier: Q8N5R6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
     917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP

Show »
Length:333
Mass (Da):37,440
Checksum:i540C809CD62CEF28
GO
Isoform 5 (identifier: Q8N5R6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-610: Missing.
     611-633: DLSTSTPREAEEEPLVPEMSHDT → MGEPGPPSPPAPKAAPGLIDSFS
     849-849: P → PVDPGELGAGGDLTERLQETHGPGHSECTETLPAQ
     917-958: SALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT → VSDPPGVAPRGSGGGAGSHRTPKVTGP

Show »
Length:367
Mass (Da):40,924
Checksum:iCD44E943A7C40A79
GO
Isoform 6 (identifier: Q8N5R6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     204-214: PPRAGQPELMS → MGLKNKKNTED

Show »
Length:755
Mass (Da):84,952
Checksum:i13B4BCF196C06C44
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMB8H0YMB8_HUMAN
Coiled-coil domain-containing prote...
CCDC33
701Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV97A0A1B0GV97_HUMAN
Coiled-coil domain-containing prote...
CCDC33
279Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti237Missing in BAG51911 (PubMed:14702039).Curated1
Sequence conflicti531K → E in BAG51911 (PubMed:14702039).Curated1
Sequence conflicti775L → P in BAF83398 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_045602635M → V. Corresponds to variant dbSNP:rs2277603Ensembl.1
Natural variantiVAR_045603640R → L. Corresponds to variant dbSNP:rs2277604Ensembl.1
Natural variantiVAR_036625683S → N1 PublicationCorresponds to variant dbSNP:rs1564782Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0287551 – 610Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST610
Alternative sequenceiVSP_0402581 – 203Missing in isoform 6. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_040259204 – 214PPRAGQPELMS → MGLKNKKNTED in isoform 6. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_028756611 – 633DLSTS…MSHDT → MGEPGPPSPPAPKAAPGLID SFS in isoform 4 and isoform 5. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_028757849P → PVDPGELGAGGDLTERLQET HGPGHSECTETLPAQ in isoform 2 and isoform 5. 1 Publication1
Alternative sequenceiVSP_028758917 – 958SALTH…NSQQT → PYSLPPAPGASIFGKPRATV DPGGWREEAFQSRGQGDGPL PDPEKKQGHQRPALLGNTRE ACPFHLPQNIYHV in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_028759917 – 958SALTH…NSQQT → VSDPPGVAPRGSGGGAGSHR TPKVTGP in isoform 4 and isoform 5. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK057417 mRNA Translation: BAG51911.1
AK026821 mRNA Translation: BAB15564.1
AK290709 mRNA Translation: BAF83398.1
AC023300 Genomic DNA No translation available.
AC090826 Genomic DNA No translation available.
BC031684 mRNA Translation: AAH31684.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42058.1 [Q8N5R6-6]
CCDS42059.1 [Q8N5R6-5]
CCDS73753.1 [Q8N5R6-4]

NCBI Reference Sequences

More...RefSeqi		NP_001274110.1, NM_001287181.1 [Q8N5R6-4]
NP_079331.3, NM_025055.4 [Q8N5R6-6]
NP_877592.2, NM_182791.3 [Q8N5R6-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000268082; ENSP00000268082; ENSG00000140481 [Q8N5R6-5]
ENST00000321374; ENSP00000325661; ENSG00000140481 [Q8N5R6-4]
ENST00000398814; ENSP00000381795; ENSG00000140481 [Q8N5R6-6]
ENST00000558821; ENSP00000452817; ENSG00000140481 [Q8N5R6-4]
ENST00000672175; ENSP00000500783; ENSG00000288407 [Q8N5R6-6]
ENST00000672263; ENSP00000500591; ENSG00000288407 [Q8N5R6-4]
ENST00000673214; ENSP00000500272; ENSG00000288407 [Q8N5R6-5]
ENST00000673517; ENSP00000500223; ENSG00000288407 [Q8N5R6-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		80125

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:80125

UCSC genome browser

More...UCSCi		uc002axo.4, human [Q8N5R6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057417 mRNA Translation: BAG51911.1
AK026821 mRNA Translation: BAB15564.1
AK290709 mRNA Translation: BAF83398.1
AC023300 Genomic DNA No translation available.
AC090826 Genomic DNA No translation available.
BC031684 mRNA Translation: AAH31684.1
CCDSiCCDS42058.1 [Q8N5R6-6]
CCDS42059.1 [Q8N5R6-5]
CCDS73753.1 [Q8N5R6-4]
RefSeqiNP_001274110.1, NM_001287181.1 [Q8N5R6-4]
NP_079331.3, NM_025055.4 [Q8N5R6-6]
NP_877592.2, NM_182791.3 [Q8N5R6-5]

3D structure databases

SMRiQ8N5R6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123126, 186 interactors
IntActiQ8N5R6, 51 interactors
MINTiQ8N5R6
STRINGi9606.ENSP00000381795

PTM databases

iPTMnetiQ8N5R6
PhosphoSitePlusiQ8N5R6

Genetic variation databases

BioMutaiCCDC33
DMDMi205646145

Proteomic databases

EPDiQ8N5R6
PaxDbiQ8N5R6
PeptideAtlasiQ8N5R6
PRIDEiQ8N5R6
ProteomicsDBi72082 [Q8N5R6-1]
72083 [Q8N5R6-2]
72084 [Q8N5R6-4]
72085 [Q8N5R6-5]
72086 [Q8N5R6-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		52555, 50 antibodies

Genome annotation databases

EnsembliENST00000268082; ENSP00000268082; ENSG00000140481 [Q8N5R6-5]
ENST00000321374; ENSP00000325661; ENSG00000140481 [Q8N5R6-4]
ENST00000398814; ENSP00000381795; ENSG00000140481 [Q8N5R6-6]
ENST00000558821; ENSP00000452817; ENSG00000140481 [Q8N5R6-4]
ENST00000672175; ENSP00000500783; ENSG00000288407 [Q8N5R6-6]
ENST00000672263; ENSP00000500591; ENSG00000288407 [Q8N5R6-4]
ENST00000673214; ENSP00000500272; ENSG00000288407 [Q8N5R6-5]
ENST00000673517; ENSP00000500223; ENSG00000288407 [Q8N5R6-4]
GeneIDi80125
KEGGihsa:80125
UCSCiuc002axo.4, human [Q8N5R6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80125
DisGeNETi80125

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCDC33
HGNCiHGNC:26552, CCDC33
HPAiENSG00000140481, Group enriched (fallopian tube, testis)
MIMi618525, gene
neXtProtiNX_Q8N5R6
OpenTargetsiENSG00000140481
PharmGKBiPA142672188
VEuPathDBiHostDB:ENSG00000140481.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3544, Eukaryota
GeneTreeiENSGT00390000017366
HOGENOMiCLU_067728_0_0_1
InParanoidiQ8N5R6
OMAiRDTEMNN
OrthoDBi1379192at2759
PhylomeDBiQ8N5R6
TreeFamiTF328975

Enzyme and pathway databases

PathwayCommonsiQ8N5R6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		80125, 8 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCDC33, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		80125
PharosiQ8N5R6, Tdark

Protein Ontology

More...PROi		PR:Q8N5R6
RNActiQ8N5R6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140481, Expressed in right uterine tube and 84 other tissues
ExpressionAtlasiQ8N5R6, baseline and differential
GenevisibleiQ8N5R6, HS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR039889, CCD33
PANTHERiPTHR21623, PTHR21623, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD33_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N5R6
Secondary accession number(s): A8K3U4
, A8MPQ6, A8MV61, A8MVU9, B3KQ49, Q8TAX6, Q9H5Q6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 22, 2008
Last modified: February 10, 2021
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. Human entries with genetic variants
    List of human entries with genetic variants
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