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Entry version 108 (11 Dec 2019)
Sequence version 3 (03 May 2011)
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Protein

Protein FAM71E2

Gene

FAM71E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM71E2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM71E2
Synonyms:C19orf16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000180043.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25278 FAM71E2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N5Q1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000180043

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164719912

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N5Q1 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM71E2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
332278208

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003413691 – 922Protein FAM71E2Add BLAST922

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N5Q1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N5Q1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N5Q1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N5Q1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N5Q1

PeptideAtlas

More...
PeptideAtlasi
Q8N5Q1

PRoteomics IDEntifications database

More...
PRIDEi
Q8N5Q1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72081
72995

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N5Q1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N5Q1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180043 Expressed in 13 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N5Q1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N5Q1 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129870, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N5Q1, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000398617

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N5Q1 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi364 – 554Pro-richAdd BLAST191
Compositional biasi442 – 497Ala-richAdd BLAST56

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM71 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J1KZ Eukaryota
ENOG41118M4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163150

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000207887

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N5Q1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPTIPQK

Database of Orthologous Groups

More...
OrthoDBi
602525at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N5Q1

TreeFam database of animal gene trees

More...
TreeFami
TF337884

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022168 DUF3699

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12480 DUF3699, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N5Q1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIWLRNRRCL EPLQGTPKWV PVLGELQKTL QKGEYLPLRP LPMFESNFVQ
60 70 80 90 100
VTHQGGPVFV NHRTNRLAMG VAASLPGLVL PDILLIGQPA EDRDCSGLVL
110 120 130 140 150
TRMIPLDLVH LCVHDLSAWR LKLRLVSGRQ YYLALDAPDN EVGFLFHCWV
160 170 180 190 200
RLINLLQEPA PTWTPRTTRT APLDMPLAEA PASTWHLQDQ PISRHAVRVA
210 220 230 240 250
ERNFPHKTVA AQRQRKAKAL KRSFKSQAVG DSVPLIWSQL EHADVRKKPA
260 270 280 290 300
EKKSHSDPRP DRTHTQIRLP EKTSITTWTI FSIISSTANQ TQSSPKACTS
310 320 330 340 350
ASDEATGQGH VVESPSHCVS ADSPDGFFLG SCSSLDPCLW HQDTEDLMDS
360 370 380 390 400
GGSTLSSAAS GLAPYPPAAC LSTPYSSIPR GREKAGPMGS HQGPGPPPCQ
410 420 430 440 450
KAPSGLVTSC KAPFLVDQSQ KLPAVPASSW KPPPGLAPPQ KAPAASAPPR
460 470 480 490 500
KAPAVPAPSQ KAPAVPAPSQ KAPAIPAPSR KASAASASPR KASAVPAPPQ
510 520 530 540 550
KTPPPSQKAP SVPTIPQKAV SPTAPKKKSL LLPAPSQKAL PTSPTEYQMA
560 570 580 590 600
LSPPASRGKL PGDFDVLPTG IPGRAVLERS QSGGKPEPVV TVRTQETDVV
610 620 630 640 650
EMTTQAKSPE SPFTVTKKES KDILISQTKE VTLEAFRGQG KLEDWAHWAK
660 670 680 690 700
LEERSPDLPG VRSKELEQRK RWVKAKELAV EGPSQEHSRP FSVEALTLTK
710 720 730 740 750
LMITANSKEQ PSKSALVSLP SWLLATPQAS ATSMMASVPS RPGQLSLLEG
760 770 780 790 800
KPVVVREQPE SHTWVKEGKR PWGEMKEQPW GEMKEPPWDP KGPPKVPFRS
810 820 830 840 850
KPTSASLKRE GISQAPIPLT ASPWEDLRPS PLSETLISKM EATARASQQP
860 870 880 890 900
KRVSQEPMRM PAQHPLATVG SSSEILLPML LELETVRNTA TKAEEIQEES
910 920
GVLNLLPSLQ HSQHSEWPDA GA
Length:922
Mass (Da):99,915
Last modified:May 3, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE358F3AC121E25D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMA1K7EMA1_HUMAN
Protein FAM71E2
FAM71E2
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH31875 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH31875 differs from that shown. Reason: Frameshift.Curated
The sequence CAD38986 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti406L → P in CAD38986 (PubMed:17974005).Curated1
Sequence conflicti546E → Q in CAD38986 (PubMed:17974005).Curated1
Sequence conflicti546E → Q in AK128284 (PubMed:14702039).Curated1
Sequence conflicti629K → E in CAD38986 (PubMed:17974005).Curated1
Sequence conflicti629K → E in AK128284 (PubMed:14702039).Curated1
Sequence conflicti711P → R in CAD38986 (PubMed:17974005).Curated1
Sequence conflicti711P → R in AK128284 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070950778 – 785Missing 2 PublicationsCorresponds to variant dbSNP:rs35996821EnsemblClinVar.8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC020922 Genomic DNA No translation available.
BC031875 mRNA Translation: AAH31875.1 Sequence problems.
AL834316 mRNA Translation: CAD38986.2 Different initiation.
AK128284 mRNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001138874.1, NM_001145402.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000424985; ENSP00000398617; ENSG00000180043

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
284418

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:284418

UCSC genome browser

More...
UCSCi
uc002qkr.3 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020922 Genomic DNA No translation available.
BC031875 mRNA Translation: AAH31875.1 Sequence problems.
AL834316 mRNA Translation: CAD38986.2 Different initiation.
AK128284 mRNA No translation available.
RefSeqiNP_001138874.1, NM_001145402.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi129870, 4 interactors
IntActiQ8N5Q1, 2 interactors
STRINGi9606.ENSP00000398617

PTM databases

iPTMnetiQ8N5Q1
PhosphoSitePlusiQ8N5Q1

Polymorphism and mutation databases

BioMutaiFAM71E2
DMDMi332278208

Proteomic databases

EPDiQ8N5Q1
jPOSTiQ8N5Q1
MassIVEiQ8N5Q1
MaxQBiQ8N5Q1
PaxDbiQ8N5Q1
PeptideAtlasiQ8N5Q1
PRIDEiQ8N5Q1
ProteomicsDBi72081
72995

Genome annotation databases

EnsembliENST00000424985; ENSP00000398617; ENSG00000180043
GeneIDi284418
KEGGihsa:284418
UCSCiuc002qkr.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284418
EuPathDBiHostDB:ENSG00000180043.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM71E2
HGNCiHGNC:25278 FAM71E2
neXtProtiNX_Q8N5Q1
OpenTargetsiENSG00000180043
PharmGKBiPA164719912

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J1KZ Eukaryota
ENOG41118M4 LUCA
GeneTreeiENSGT00940000163150
HOGENOMiHOG000207887
InParanoidiQ8N5Q1
OMAiVPTIPQK
OrthoDBi602525at2759
PhylomeDBiQ8N5Q1
TreeFamiTF337884

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM71E2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
284418
PharosiQ8N5Q1 Tdark

Protein Ontology

More...
PROi
PR:Q8N5Q1
RNActiQ8N5Q1 protein

Gene expression databases

BgeeiENSG00000180043 Expressed in 13 organ(s), highest expression level in right testis
ExpressionAtlasiQ8N5Q1 baseline and differential
GenevisibleiQ8N5Q1 HS

Family and domain databases

InterProiView protein in InterPro
IPR022168 DUF3699
PfamiView protein in Pfam
PF12480 DUF3699, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF71E2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N5Q1
Secondary accession number(s): Q8ND99
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 3, 2011
Last modified: December 11, 2019
This is version 108 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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