UniProtKB - Q8N5N7 (RM50_HUMAN)

BLAST

>sp|Q8N5N7|RM50_HUMAN 39S ribosomal protein L50, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL50 PE=1 SV=2
MAARSVSGITRRVFMWTVSGTPCREFWSRFRKEKEPVVVETVEEKKEPILVCPPLRSRAY
TPPEDLQSRLESYVKEVFGSSLPSNWQDISLEDSRLKFNLLAHLADDLGHVVPNSRLHQM
CRVRDVLDFYNVPIQDRSKFDELSASNLPPNLKITWSY

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History
Entry version 127 (07 Nov 2018)
Sequence version 2 (28 Nov 2006)
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Protein

39S ribosomal protein L50, mitochondrial

Gene

MRPL50

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Biological processⁱ

mitochondrial translational elongation Source: Reactome
mitochondrial translational termination Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 39S ribosomal protein L50, mitochondrial Short name: L50mt Short name: MRP-L50 Alternative name(s): Mitochondrial large ribosomal subunit protein mL501 Publication
Gene namesⁱ	Name:MRPL50
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136897.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16654 MRPL50
MIMⁱ	611854 gene
neXtProtⁱ	NX_Q8N5N7

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000136897
PharmGKBⁱ	PA30983

Polymorphism and mutation databases

BioMutaⁱ	MRPL50
DMDMⁱ	118573685

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000261659	1 – 158	39S ribosomal protein L50, mitochondrialAdd BLAST		158

Proteomic databases

EPDⁱ	Q8N5N7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N5N7
PaxDbⁱ	Q8N5N7
PeptideAtlas More...PeptideAtlasⁱ	Q8N5N7
PRIDEⁱ	Q8N5N7
ProteomicsDBⁱ	72078
TopDownProteomicsⁱ	Q8N5N7-1 [Q8N5N7-1]

PTM databases

iPTMnetⁱ	Q8N5N7
PhosphoSitePlusⁱ	Q8N5N7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136897 Expressed in 210 organ(s), highest expression level in testis
CleanExⁱ	HS_MRPL50
Genevisibleⁱ	Q8N5N7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA022925 HPA056854

HPAⁱ

HPA022925
HPA056854

Interactionⁱ

Subunit structureⁱ

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Protein-protein interaction databases

BioGridⁱ	120021, 115 interactors
CORUMⁱ	Q8N5N7
IntActⁱ	Q8N5N7, 96 interactors
Molecular INTeraction database More...MINTⁱ	Q8N5N7
STRINGⁱ	9606.ENSP00000363999

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	66 – 77	Combined sources	12
Helixⁱ	86 – 88	Combined sources	3
Helixⁱ	94 – 108	Combined sources	15
Turnⁱ	114 – 119	Combined sources	6
Helixⁱ	123 – 129	Combined sources	7
Helixⁱ	139 – 143	Combined sources	5
Beta strandⁱ	152 – 154	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8N5N7
SMRⁱ	Q8N5N7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the mitochondrion-specific ribosomal protein mL50 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410J127 Eukaryota ENOG4111QY3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004279
HOGENOMⁱ	HOG000231606
HOVERGENⁱ	HBG093900
InParanoidⁱ	Q8N5N7
KEGG Orthology (KO) More...KOⁱ	K17431
OMAⁱ	APRREFW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q8N5N7
TreeFamⁱ	TF105895

Family and domain databases

InterProⁱ	View protein in InterPro IPR018305 Ribosomal_L50_mt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10501 Ribosomal_L50, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8N5N7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARSVSGIT RRVFMWTVSG TPCREFWSRF RKEKEPVVVE TVEEKKEPIL 
        60         70         80         90        100
VCPPLRSRAY TPPEDLQSRL ESYVKEVFGS SLPSNWQDIS LEDSRLKFNL 
       110        120        130        140        150
LAHLADDLGH VVPNSRLHQM CRVRDVLDFY NVPIQDRSKF DELSASNLPP 

NLKITWSY

Length:158

Mass (Da):18,325

Last modified:November 28, 2006 - v2

Checksum:ⁱF8FD54809C08EF0E

Isoform 2 (identifier: Q8N5N7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
123-158: VRDVLDFYNVPIQDRSKFDELSASNLPPNLKITWSY → GYSFEEGKIQLGI

« Hide

        10         20         30         40         50
MAARSVSGIT RRVFMWTVSG TPCREFWSRF RKEKEPVVVE TVEEKKEPIL 
        60         70         80         90        100
VCPPLRSRAY TPPEDLQSRL ESYVKEVFGS SLPSNWQDIS LEDSRLKFNL 
       110        120        130 
LAHLADDLGH VVPNSRLHQM CRGYSFEEGK IQLGI

Note: No experimental confirmation available.

Show »

Length:135

Mass (Da):15,524

Checksum:ⁱD242D9E74F11E062

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029474	127	L → F1 PublicationCorresponds to variant dbSNP:rs8131Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056091	123 – 158	VRDVL…ITWSY → GYSFEEGKIQLGI in isoform 2. 1 PublicationAdd BLAST		36

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000500 mRNA Translation: BAA91207.1 AK025643 mRNA Translation: BAB15200.1 AK295521 mRNA Translation: BAH12094.1 AL353621 Genomic DNA No translation available. BC032008 mRNA Translation: AAH32008.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6753.1 [Q8N5N7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_061924.1, NM_019051.2 [Q8N5N7-1]
UniGeneⁱ	Hs.288224 Hs.713644

Genome annotation databases

Ensemblⁱ	ENST00000374865; ENSP00000363999; ENSG00000136897 [Q8N5N7-1]
GeneIDⁱ	54534
KEGGⁱ	hsa:54534
UCSC genome browser More...UCSCⁱ	uc004bbe.3 human [Q8N5N7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N5N7	39S ribosomal protein L50, mitochondrial		PONAB		158	UniRef90_Q8N5N7
Mitochondrial ribosomal protein L50		GORGO		160
39S ribosomal protein L50, mitochondrial		MACMU		158
Uncharacterized protein		MACFA		158
Uncharacterized protein		PAPAN		158
+16

Protein	Similar proteins		Species	Score	Length	Source
Q8N5N7	39S ribosomal protein L50, mitochondrial		PONAB		158	UniRef50_Q8N5N7
39S ribosomal protein L50, mitochondrial		BOVIN		159
Mitochondrial ribosomal protein L50		GORGO		160
MRPL50 isoform 1		PANTR		158
Uncharacterized protein		RHIRO		158
+155

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000500 mRNA Translation: BAA91207.1 AK025643 mRNA Translation: BAB15200.1 AK295521 mRNA Translation: BAH12094.1 AL353621 Genomic DNA No translation available. BC032008 mRNA Translation: AAH32008.1
CCDSⁱ	CCDS6753.1 [Q8N5N7-1]
RefSeqⁱ	NP_061924.1, NM_019051.2 [Q8N5N7-1]
UniGeneⁱ	Hs.288224 Hs.713644

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3J7Y	electron microscopy	3.40	h	1-158	[»]
	3J9M	electron microscopy	3.50	h	1-158	[»]
	5OOL	electron microscopy	3.06	h	1-158	[»]
	5OOM	electron microscopy	3.03	h	1-158	[»]
ProteinModelPortalⁱ	Q8N5N7
SMRⁱ	Q8N5N7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120021, 115 interactors
CORUMⁱ	Q8N5N7
IntActⁱ	Q8N5N7, 96 interactors
MINTⁱ	Q8N5N7
STRINGⁱ	9606.ENSP00000363999

PTM databases

iPTMnetⁱ	Q8N5N7
PhosphoSitePlusⁱ	Q8N5N7

Polymorphism and mutation databases

BioMutaⁱ	MRPL50
DMDMⁱ	118573685

Proteomic databases

EPDⁱ	Q8N5N7
MaxQBⁱ	Q8N5N7
PaxDbⁱ	Q8N5N7
PeptideAtlasⁱ	Q8N5N7
PRIDEⁱ	Q8N5N7
ProteomicsDBⁱ	72078
TopDownProteomicsⁱ	Q8N5N7-1 [Q8N5N7-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	54534
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000374865; ENSP00000363999; ENSG00000136897 [Q8N5N7-1]
GeneIDⁱ	54534
KEGGⁱ	hsa:54534
UCSCⁱ	uc004bbe.3 human [Q8N5N7-1]

Organism-specific databases

CTDⁱ	54534
EuPathDBⁱ	HostDB:ENSG00000136897.7
GeneCardsⁱ	MRPL50
HGNCⁱ	HGNC:16654 MRPL50
HPAⁱ	HPA022925 HPA056854
MIMⁱ	611854 gene
neXtProtⁱ	NX_Q8N5N7
OpenTargetsⁱ	ENSG00000136897
PharmGKBⁱ	PA30983
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J127 Eukaryota ENOG4111QY3 LUCA
GeneTreeⁱ	ENSGT00390000004279
HOGENOMⁱ	HOG000231606
HOVERGENⁱ	HBG093900
InParanoidⁱ	Q8N5N7
KOⁱ	K17431
OMAⁱ	APRREFW
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q8N5N7
TreeFamⁱ	TF105895

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

GenomeRNAiⁱ	54534
Protein Ontology More...PROⁱ	PR:Q8N5N7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136897 Expressed in 210 organ(s), highest expression level in testis
CleanExⁱ	HS_MRPL50
Genevisibleⁱ	Q8N5N7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR018305 Ribosomal_L50_mt
Pfamⁱ	View protein in Pfam PF10501 Ribosomal_L50, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RM50_HUMAN
Accessionⁱ	Q8N5N7Primary (citable) accession number: Q8N5N7 Secondary accession number(s): B7Z358, Q5T7E0, Q9NX15
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	November 28, 2006
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Ribosomal proteins
Ribosomal proteins families and list of entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniProtKB - Q8N5N7 (RM50_HUMAN)

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39S ribosomal protein L50, mitochondrial

MRPL50

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ