UniProtKB - Q8N5N7 (RM50_HUMAN)
39S ribosomal protein L50, mitochondrial
MRPL50
Functioni
GO - Biological processi
- mitochondrial translational elongation Source: Reactome
- mitochondrial translational termination Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | Q8N5N7 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | Q8N5N7 |
Names & Taxonomyi
Protein namesi | Recommended name: 39S ribosomal protein L50, mitochondrialShort name: L50mt Short name: MRP-L50 Alternative name(s): Mitochondrial large ribosomal subunit protein mL501 Publication |
Gene namesi | Name:MRPL50 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16654, MRPL50 |
MIMi | 611854, gene |
neXtProti | NX_Q8N5N7 |
VEuPathDBi | HostDB:ENSG00000136897.7 |
Subcellular locationi
Mitochondrion
- Mitochondrion 3 Publications
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial large ribosomal subunit Source: UniProtKB
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000136897 |
PharmGKBi | PA30983 |
Miscellaneous databases
Pharosi | Q8N5N7, Tdark |
Genetic variation databases
BioMutai | MRPL50 |
DMDMi | 118573685 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000261659 | 1 – 158 | 39S ribosomal protein L50, mitochondrialAdd BLAST | 158 |
Proteomic databases
EPDi | Q8N5N7 |
jPOSTi | Q8N5N7 |
MassIVEi | Q8N5N7 |
MaxQBi | Q8N5N7 |
PaxDbi | Q8N5N7 |
PeptideAtlasi | Q8N5N7 |
PRIDEi | Q8N5N7 |
ProteomicsDBi | 6492 72078 [Q8N5N7-1] |
TopDownProteomicsi | Q8N5N7-1 [Q8N5N7-1] |
PTM databases
iPTMneti | Q8N5N7 |
PhosphoSitePlusi | Q8N5N7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000136897, Expressed in testis and 219 other tissues |
Genevisiblei | Q8N5N7, HS |
Organism-specific databases
HPAi | ENSG00000136897, Low tissue specificity |
Interactioni
Subunit structurei
Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
3 PublicationsProtein-protein interaction databases
BioGRIDi | 120021, 188 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | Q8N5N7 |
IntActi | Q8N5N7, 114 interactors |
MINTi | Q8N5N7 |
STRINGi | 9606.ENSP00000363999 |
Miscellaneous databases
RNActi | Q8N5N7, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8N5N7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502S27V, Eukaryota |
GeneTreei | ENSGT00390000004279 |
HOGENOMi | CLU_137129_0_0_1 |
InParanoidi | Q8N5N7 |
OMAi | NLKITWN |
OrthoDBi | 1586864at2759 |
PhylomeDBi | Q8N5N7 |
TreeFami | TF105895 |
Family and domain databases
InterProi | View protein in InterPro IPR018305, Ribosomal_L50_mt |
PANTHERi | PTHR31542, PTHR31542, 1 hit |
Pfami | View protein in Pfam PF10501, Ribosomal_L50, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAARSVSGIT RRVFMWTVSG TPCREFWSRF RKEKEPVVVE TVEEKKEPIL
60 70 80 90 100
VCPPLRSRAY TPPEDLQSRL ESYVKEVFGS SLPSNWQDIS LEDSRLKFNL
110 120 130 140 150
LAHLADDLGH VVPNSRLHQM CRVRDVLDFY NVPIQDRSKF DELSASNLPP
NLKITWSY
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029474 | 127 | L → F1 PublicationCorresponds to variant dbSNP:rs8131Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056091 | 123 – 158 | VRDVL…ITWSY → GYSFEEGKIQLGI in isoform 2. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000500 mRNA Translation: BAA91207.1 AK025643 mRNA Translation: BAB15200.1 AK295521 mRNA Translation: BAH12094.1 AL353621 Genomic DNA No translation available. BC032008 mRNA Translation: AAH32008.1 |
CCDSi | CCDS6753.1 [Q8N5N7-1] |
RefSeqi | NP_061924.1, NM_019051.2 [Q8N5N7-1] |
Genome annotation databases
Ensembli | ENST00000374865; ENSP00000363999; ENSG00000136897 [Q8N5N7-1] |
GeneIDi | 54534 |
KEGGi | hsa:54534 |
UCSCi | uc004bbe.3, human [Q8N5N7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000500 mRNA Translation: BAA91207.1 AK025643 mRNA Translation: BAB15200.1 AK295521 mRNA Translation: BAH12094.1 AL353621 Genomic DNA No translation available. BC032008 mRNA Translation: AAH32008.1 |
CCDSi | CCDS6753.1 [Q8N5N7-1] |
RefSeqi | NP_061924.1, NM_019051.2 [Q8N5N7-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J7Y | electron microscopy | 3.40 | h | 1-158 | [»] | |
3J9M | electron microscopy | 3.50 | h | 1-158 | [»] | |
5OOL | electron microscopy | 3.06 | h | 1-158 | [»] | |
5OOM | electron microscopy | 3.03 | h | 1-158 | [»] | |
6I9R | electron microscopy | 3.90 | h | 1-158 | [»] | |
6NU2 | electron microscopy | 3.90 | h | 56-158 | [»] | |
6NU3 | electron microscopy | 4.40 | h | 1-158 | [»] | |
6VLZ | electron microscopy | 2.97 | h | 1-158 | [»] | |
6VMI | electron microscopy | 2.96 | h | 1-158 | [»] | |
6ZM5 | electron microscopy | 2.89 | h | 1-158 | [»] | |
6ZM6 | electron microscopy | 2.59 | h | 1-158 | [»] | |
6ZS9 | electron microscopy | 4.00 | h | 1-158 | [»] | |
6ZSA | electron microscopy | 4.00 | h | 1-158 | [»] | |
6ZSB | electron microscopy | 4.50 | h | 1-158 | [»] | |
6ZSC | electron microscopy | 3.50 | h | 1-158 | [»] | |
6ZSD | electron microscopy | 3.70 | h | 1-158 | [»] | |
6ZSE | electron microscopy | 5.00 | h | 1-158 | [»] | |
6ZSG | electron microscopy | 4.00 | h | 1-158 | [»] | |
7A5F | electron microscopy | 4.40 | h3 | 1-158 | [»] | |
7A5G | electron microscopy | 4.33 | h3 | 1-158 | [»] | |
7A5H | electron microscopy | 3.30 | h | 1-158 | [»] | |
7A5I | electron microscopy | 3.70 | h3 | 1-158 | [»] | |
7A5J | electron microscopy | 3.10 | h | 1-158 | [»] | |
7A5K | electron microscopy | 3.70 | h3 | 1-158 | [»] | |
SMRi | Q8N5N7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120021, 188 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | Q8N5N7 |
IntActi | Q8N5N7, 114 interactors |
MINTi | Q8N5N7 |
STRINGi | 9606.ENSP00000363999 |
PTM databases
iPTMneti | Q8N5N7 |
PhosphoSitePlusi | Q8N5N7 |
Genetic variation databases
BioMutai | MRPL50 |
DMDMi | 118573685 |
Proteomic databases
EPDi | Q8N5N7 |
jPOSTi | Q8N5N7 |
MassIVEi | Q8N5N7 |
MaxQBi | Q8N5N7 |
PaxDbi | Q8N5N7 |
PeptideAtlasi | Q8N5N7 |
PRIDEi | Q8N5N7 |
ProteomicsDBi | 6492 72078 [Q8N5N7-1] |
TopDownProteomicsi | Q8N5N7-1 [Q8N5N7-1] |
Protocols and materials databases
Antibodypediai | 14646, 136 antibodies |
DNASUi | 54534 |
Genome annotation databases
Ensembli | ENST00000374865; ENSP00000363999; ENSG00000136897 [Q8N5N7-1] |
GeneIDi | 54534 |
KEGGi | hsa:54534 |
UCSCi | uc004bbe.3, human [Q8N5N7-1] |
Organism-specific databases
CTDi | 54534 |
GeneCardsi | MRPL50 |
HGNCi | HGNC:16654, MRPL50 |
HPAi | ENSG00000136897, Low tissue specificity |
MIMi | 611854, gene |
neXtProti | NX_Q8N5N7 |
OpenTargetsi | ENSG00000136897 |
PharmGKBi | PA30983 |
VEuPathDBi | HostDB:ENSG00000136897.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S27V, Eukaryota |
GeneTreei | ENSGT00390000004279 |
HOGENOMi | CLU_137129_0_0_1 |
InParanoidi | Q8N5N7 |
OMAi | NLKITWN |
OrthoDBi | 1586864at2759 |
PhylomeDBi | Q8N5N7 |
TreeFami | TF105895 |
Enzyme and pathway databases
PathwayCommonsi | Q8N5N7 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | Q8N5N7 |
Miscellaneous databases
BioGRID-ORCSi | 54534, 259 hits in 996 CRISPR screens |
ChiTaRSi | MRPL50, human |
GenomeRNAii | 54534 |
Pharosi | Q8N5N7, Tdark |
PROi | PR:Q8N5N7 |
RNActi | Q8N5N7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136897, Expressed in testis and 219 other tissues |
Genevisiblei | Q8N5N7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018305, Ribosomal_L50_mt |
PANTHERi | PTHR31542, PTHR31542, 1 hit |
Pfami | View protein in Pfam PF10501, Ribosomal_L50, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RM50_HUMAN | |
Accessioni | Q8N5N7Primary (citable) accession number: Q8N5N7 Secondary accession number(s): B7Z358, Q5T7E0, Q9NX15 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | November 28, 2006 | |
Last modified: | April 7, 2021 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families