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Entry version 131 (07 Apr 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Ribonuclease P protein subunit p25-like protein

Gene

RPP25L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a component of ribonuclease P or MRP.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • tRNA 5'-leader removal Source: GO_Central

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N5L8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease P protein subunit p25-like protein
Short name:
RNase P protein subunit-like p25
Alternative name(s):
Rpp25-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPP25L
Synonyms:C9orf23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19909, RPP25L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N5L8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000164967.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000164967

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134989644

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N5L8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPP25L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751030

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002710321 – 163Ribonuclease P protein subunit p25-like proteinAdd BLAST163

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N5L8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N5L8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N5L8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N5L8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N5L8

PeptideAtlas

More...
PeptideAtlasi
Q8N5L8

PRoteomics IDEntifications database

More...
PRIDEi
Q8N5L8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72072

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N5L8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N5L8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164967, Expressed in quadriceps femoris and 210 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N5L8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164967, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126519, 51 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N5L8, 25 interactors

Molecular INTeraction database

More...
MINTi
Q8N5L8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000297613

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N5L8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2567, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002564

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_096311_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N5L8

Identification of Orthologs from Complete Genome Data

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OMAi
GRPLCRQ

Database of Orthologous Groups

More...
OrthoDBi
1075123at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N5L8

TreeFam database of animal gene trees

More...
TreeFami
TF325688

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.110.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036882, Alba-like_dom_sf
IPR002775, DNA/RNA-bd_Alba-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01918, Alba, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82704, SSF82704, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8N5L8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHYRKAGSV ELPAPSPMPQ LPPDTLEMRV RDGSKIRNLL GLALGRLEGG
60 70 80 90 100
SARHVVFSGS GRAAGKAVSC AEIVKRRVPG LHQLTKLRFL QTEDSWVPAS
110 120 130 140 150
PDTGLDPLTV RRHVPAVWVL LSRDPLDPNE CGYQPPGAPP GLGSMPSSSC
160
GPRSRRRARD TRS
Length:163
Mass (Da):17,631
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i442C8727191A0BCE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL160270 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58443.1
CH471071 Genomic DNA Translation: EAW58444.1
BC032136 mRNA Translation: AAH32136.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6559.1

NCBI Reference Sequences

More...
RefSeqi
NP_680544.1, NM_148178.2
NP_680545.1, NM_148179.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000297613; ENSP00000297613; ENSG00000164967
ENST00000378959; ENSP00000368242; ENSG00000164967

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
138716

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:138716

UCSC genome browser

More...
UCSCi
uc003zuu.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160270 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58443.1
CH471071 Genomic DNA Translation: EAW58444.1
BC032136 mRNA Translation: AAH32136.1
CCDSiCCDS6559.1
RefSeqiNP_680544.1, NM_148178.2
NP_680545.1, NM_148179.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126519, 51 interactors
IntActiQ8N5L8, 25 interactors
MINTiQ8N5L8
STRINGi9606.ENSP00000297613

PTM databases

iPTMnetiQ8N5L8
PhosphoSitePlusiQ8N5L8

Genetic variation databases

BioMutaiRPP25L
DMDMi74751030

Proteomic databases

EPDiQ8N5L8
jPOSTiQ8N5L8
MassIVEiQ8N5L8
MaxQBiQ8N5L8
PaxDbiQ8N5L8
PeptideAtlasiQ8N5L8
PRIDEiQ8N5L8
ProteomicsDBi72072

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
55898, 76 antibodies

The DNASU plasmid repository

More...
DNASUi
138716

Genome annotation databases

EnsembliENST00000297613; ENSP00000297613; ENSG00000164967
ENST00000378959; ENSP00000368242; ENSG00000164967
GeneIDi138716
KEGGihsa:138716
UCSCiuc003zuu.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
138716

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RPP25L
HGNCiHGNC:19909, RPP25L
HPAiENSG00000164967, Tissue enhanced (skeletal)
neXtProtiNX_Q8N5L8
OpenTargetsiENSG00000164967
PharmGKBiPA134989644
VEuPathDBiHostDB:ENSG00000164967.9

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2567, Eukaryota
GeneTreeiENSGT00390000002564
HOGENOMiCLU_096311_0_0_1
InParanoidiQ8N5L8
OMAiGRPLCRQ
OrthoDBi1075123at2759
PhylomeDBiQ8N5L8
TreeFamiTF325688

Enzyme and pathway databases

PathwayCommonsiQ8N5L8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
138716, 192 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RPP25L, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
138716
PharosiQ8N5L8, Tdark

Protein Ontology

More...
PROi
PR:Q8N5L8
RNActiQ8N5L8, protein

Gene expression databases

BgeeiENSG00000164967, Expressed in quadriceps femoris and 210 other tissues
GenevisibleiQ8N5L8, HS

Family and domain databases

Gene3Di3.30.110.20, 1 hit
InterProiView protein in InterPro
IPR036882, Alba-like_dom_sf
IPR002775, DNA/RNA-bd_Alba-like
PfamiView protein in Pfam
PF01918, Alba, 1 hit
SUPFAMiSSF82704, SSF82704, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRP25L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N5L8
Secondary accession number(s): D3DRM5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: April 7, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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