UniProtKB - Q8N5G2 (MACOI_HUMAN)
Protein
Macoilin
Gene
MACO1
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in the regulation of neuronal activity.1 Publication
GO - Molecular functioni
- actin filament binding Source: GO_Central
- microtubule binding Source: GO_Central
GO - Biological processi
- brain development Source: Ensembl
- chemotaxis Source: GO_Central
- neuronal signal transduction Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q8N5G2 |
Protein family/group databases
TCDBi | 8.A.38.1.1, the animal macoilin regulator of ion channels (macoilin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Macoilin1 PublicationAlternative name(s): Macoilin-1Imported Transmembrane protein 57 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25572, MACO1 |
MIMi | 610301, gene |
neXtProti | NX_Q8N5G2 |
VEuPathDBi | HostDB:ENSG00000204178.9 |
Subcellular locationi
Nucleus
- Nucleus membrane By similarity; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- Rough endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Other locations
- axon By similarity
Note: Detected in the nucleus membrane of non-neuronal cells and in axonal outgrowths of neuronal cells.By similarity
Endoplasmic reticulum
- rough endoplasmic reticulum membrane Source: UniProtKB
Nucleus
- nuclear membrane Source: BHF-UCL
- nucleus Source: BHF-UCL
Other locations
- axon Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
- neuron projection terminus Source: BHF-UCL
- synapse Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 28 – 48 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 75 – 95 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 120 – 140 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 154 – 174 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell projection, Endoplasmic reticulum, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55219 |
OpenTargetsi | ENSG00000204178 |
PharmGKBi | PA142670773 |
Miscellaneous databases
Pharosi | Q8N5G2, Tbio |
Genetic variation databases
BioMutai | TMEM57 |
DMDMi | 74728992 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070266 | 1 – 664 | MacoilinAdd BLAST | 664 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 305 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 324 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 332 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 340 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 452 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 631 | PhosphoserineCombined sources | 1 | |
Modified residuei | 634 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 655 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q8N5G2 |
jPOSTi | Q8N5G2 |
MassIVEi | Q8N5G2 |
MaxQBi | Q8N5G2 |
PaxDbi | Q8N5G2 |
PeptideAtlasi | Q8N5G2 |
PRIDEi | Q8N5G2 |
ProteomicsDBi | 72049 [Q8N5G2-1] 72050 [Q8N5G2-2] 72051 [Q8N5G2-3] |
PTM databases
GlyGeni | Q8N5G2, 4 sites |
iPTMneti | Q8N5G2 |
PhosphoSitePlusi | Q8N5G2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204178, Expressed in forebrain and 224 other tissues |
ExpressionAtlasi | Q8N5G2, baseline and differential |
Genevisiblei | Q8N5G2, HS |
Organism-specific databases
HPAi | ENSG00000204178, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8N5G2
GO - Molecular functioni
- actin filament binding Source: GO_Central
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 120515, 89 interactors |
IntActi | Q8N5G2, 52 interactors |
MINTi | Q8N5G2 |
STRINGi | 9606.ENSP00000363463 |
Miscellaneous databases
RNActi | Q8N5G2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the macoilin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1821, Eukaryota |
GeneTreei | ENSGT00390000016613 |
HOGENOMi | CLU_051352_0_0_1 |
InParanoidi | Q8N5G2 |
OMAi | DLETECK |
OrthoDBi | 1227984at2759 |
PhylomeDBi | Q8N5G2 |
TreeFami | TF324023 |
Family and domain databases
InterProi | View protein in InterPro IPR019130, Macoilin |
PANTHERi | PTHR47464:SF3, PTHR47464:SF3, 1 hit |
Pfami | View protein in Pfam PF09726, Macoilin, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N5G2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKRRNADCSK LRRPLKRNRI TEGIYGSTFL YLKFLVVWAL VLLADFVLEF
60 70 80 90 100
RFEYLWPFWL FIRSVYDSFR YQGLAFSVFF VCVAFTSNII CLLFIPIQWL
110 120 130 140 150
FFAASTYVWV QYVWHTERGV CLPTVSLWIL FVYIEAAIRF KDLKNFHVDL
160 170 180 190 200
CRPFAAHCIG YPVVTLGFGF KSYVSYKMRL RKQKEVQKEN EFYMQLLQQA
210 220 230 240 250
LPPEQQMLQK QEKEAEEAAK GLPDMDSSIL IHHNGGIPAN KKLSTTLPEI
260 270 280 290 300
EYREKGKEKD KDAKKHNLGI NNNNILQPVD SKIQEIEYME NHINSKRLNN
310 320 330 340 350
DLVGSTENLL KEDSCTASSK NYKNASGVVN SSPRSHSATN GSIPSSSSKN
360 370 380 390 400
EKKQKCTSKS PSTHKDLMEN CIPNNQLSKP DALVRLEQDI KKLKADLQAS
410 420 430 440 450
RQVEQELRSQ ISSLSSTERG IRSEMGQLRQ ENELLQNKLH NAVQMKQKDK
460 470 480 490 500
QNISQLEKKL KAEQEARSFV EKQLMEEKKR KKLEEATAAR AVAFAAASRG
510 520 530 540 550
ECTETLRNRI RELEAEGKKL TMDMKVKEDQ IRELELKVQE LRKYKENEKD
560 570 580 590 600
TEVLMSALSA MQDKTQHLEN SLSAETRIKL DLFSALGDAK RQLEIAQGQI
610 620 630 640 650
LQKDQEIKDL KQKIAEVMAV MPSITYSAAT SPLSPVSPHY SSKFVETSPS
660
GLDPNASVYQ PLKK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITD2 | A0A3B3ITD2_HUMAN | Macoilin | MACO1 | 386 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 577 | R → I in BAA91786 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017203 | 27 – 384 | Missing in isoform 2. 1 PublicationAdd BLAST | 358 | |
Alternative sequenceiVSP_017204 | 158 | C → W in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_017205 | 159 – 385 | Missing in isoform 3. 1 PublicationAdd BLAST | 227 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY845015 mRNA Translation: AAX11913.1 AY845036 mRNA Translation: AAX11934.1 AY845035 mRNA Translation: AAX11933.1 AK001609 mRNA Translation: BAA91786.1 AL031284 Genomic DNA No translation available. BX572623 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07876.1 BC032427 mRNA Translation: AAH32427.1 |
CCDSi | CCDS30638.1 [Q8N5G2-1] CCDS60034.1 [Q8N5G2-3] |
RefSeqi | NP_001269493.1, NM_001282564.1 [Q8N5G2-3] NP_060672.2, NM_018202.5 [Q8N5G2-1] |
Genome annotation databases
Ensembli | ENST00000374343; ENSP00000363463; ENSG00000204178 [Q8N5G2-1] ENST00000399766; ENSP00000382668; ENSG00000204178 [Q8N5G2-3] |
GeneIDi | 55219 |
KEGGi | hsa:55219 |
UCSCi | uc001bkk.5, human [Q8N5G2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY845015 mRNA Translation: AAX11913.1 AY845036 mRNA Translation: AAX11934.1 AY845035 mRNA Translation: AAX11933.1 AK001609 mRNA Translation: BAA91786.1 AL031284 Genomic DNA No translation available. BX572623 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07876.1 BC032427 mRNA Translation: AAH32427.1 |
CCDSi | CCDS30638.1 [Q8N5G2-1] CCDS60034.1 [Q8N5G2-3] |
RefSeqi | NP_001269493.1, NM_001282564.1 [Q8N5G2-3] NP_060672.2, NM_018202.5 [Q8N5G2-1] |
3D structure databases
SMRi | Q8N5G2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120515, 89 interactors |
IntActi | Q8N5G2, 52 interactors |
MINTi | Q8N5G2 |
STRINGi | 9606.ENSP00000363463 |
Protein family/group databases
TCDBi | 8.A.38.1.1, the animal macoilin regulator of ion channels (macoilin) family |
PTM databases
GlyGeni | Q8N5G2, 4 sites |
iPTMneti | Q8N5G2 |
PhosphoSitePlusi | Q8N5G2 |
Genetic variation databases
BioMutai | TMEM57 |
DMDMi | 74728992 |
Proteomic databases
EPDi | Q8N5G2 |
jPOSTi | Q8N5G2 |
MassIVEi | Q8N5G2 |
MaxQBi | Q8N5G2 |
PaxDbi | Q8N5G2 |
PeptideAtlasi | Q8N5G2 |
PRIDEi | Q8N5G2 |
ProteomicsDBi | 72049 [Q8N5G2-1] 72050 [Q8N5G2-2] 72051 [Q8N5G2-3] |
Protocols and materials databases
Antibodypediai | 15928, 80 antibodies |
Genome annotation databases
Ensembli | ENST00000374343; ENSP00000363463; ENSG00000204178 [Q8N5G2-1] ENST00000399766; ENSP00000382668; ENSG00000204178 [Q8N5G2-3] |
GeneIDi | 55219 |
KEGGi | hsa:55219 |
UCSCi | uc001bkk.5, human [Q8N5G2-1] |
Organism-specific databases
CTDi | 55219 |
DisGeNETi | 55219 |
GeneCardsi | MACO1 |
HGNCi | HGNC:25572, MACO1 |
HPAi | ENSG00000204178, Low tissue specificity |
MIMi | 610301, gene |
neXtProti | NX_Q8N5G2 |
OpenTargetsi | ENSG00000204178 |
PharmGKBi | PA142670773 |
VEuPathDBi | HostDB:ENSG00000204178.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1821, Eukaryota |
GeneTreei | ENSGT00390000016613 |
HOGENOMi | CLU_051352_0_0_1 |
InParanoidi | Q8N5G2 |
OMAi | DLETECK |
OrthoDBi | 1227984at2759 |
PhylomeDBi | Q8N5G2 |
TreeFami | TF324023 |
Enzyme and pathway databases
PathwayCommonsi | Q8N5G2 |
Miscellaneous databases
BioGRID-ORCSi | 55219, 9 hits in 999 CRISPR screens |
ChiTaRSi | MACO1, human |
GenomeRNAii | 55219 |
Pharosi | Q8N5G2, Tbio |
PROi | PR:Q8N5G2 |
RNActi | Q8N5G2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204178, Expressed in forebrain and 224 other tissues |
ExpressionAtlasi | Q8N5G2, baseline and differential |
Genevisiblei | Q8N5G2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019130, Macoilin |
PANTHERi | PTHR47464:SF3, PTHR47464:SF3, 1 hit |
Pfami | View protein in Pfam PF09726, Macoilin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MACOI_HUMAN | |
Accessioni | Q8N5G2Primary (citable) accession number: Q8N5G2 Secondary accession number(s): B1AK00 Q9NVG6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 7, 2006 |
Last sequence update: | October 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families