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Protein

Macoilin

Gene

MACO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of neuronal activity.1 Publication

GO - Biological processi

  • brain development Source: Ensembl
  • neuronal signal transduction Source: UniProtKB

Protein family/group databases

TCDBi8.A.38.1.1 the animal macoilin regulator of ion channels (macoilin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Macoilin1 Publication
Alternative name(s):
Macoilin-1Imported
Transmembrane protein 57
Gene namesi
Name:MACO1Imported
Synonyms:TMEM57Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000204178.9
HGNCiHGNC:25572 MACO1
MIMi610301 gene
neXtProtiNX_Q8N5G2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55219
OpenTargetsiENSG00000204178
PharmGKBiPA142670773

Polymorphism and mutation databases

DMDMi74728992

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702661 – 664MacoilinAdd BLAST664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei305PhosphoserineCombined sources1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei332PhosphoserineCombined sources1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei631PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Glycosylationi655N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8N5G2
MaxQBiQ8N5G2
PaxDbiQ8N5G2
PeptideAtlasiQ8N5G2
PRIDEiQ8N5G2
ProteomicsDBi72049
72050 [Q8N5G2-2]
72051 [Q8N5G2-3]

PTM databases

iPTMnetiQ8N5G2
PhosphoSitePlusiQ8N5G2

Expressioni

Gene expression databases

BgeeiENSG00000204178 Expressed in 211 organ(s), highest expression level in forebrain
CleanExiHS_TMEM57
GenevisibleiQ8N5G2 HS

Organism-specific databases

HPAiHPA019680

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120515, 24 interactors
IntActiQ8N5G2, 36 interactors
MINTiQ8N5G2
STRINGi9606.ENSP00000363463

Structurei

3D structure databases

ProteinModelPortaliQ8N5G2
SMRiQ8N5G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the macoilin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1821 Eukaryota
ENOG410XRFG LUCA
GeneTreeiENSGT00390000016613
HOGENOMiHOG000049147
HOVERGENiHBG059955
InParanoidiQ8N5G2
OMAiSAHKDLM
OrthoDBiEOG091G04NF
PhylomeDBiQ8N5G2
TreeFamiTF324023

Family and domain databases

InterProiView protein in InterPro
IPR019130 Macoilin
PfamiView protein in Pfam
PF09726 Macoilin, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N5G2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRRNADCSK LRRPLKRNRI TEGIYGSTFL YLKFLVVWAL VLLADFVLEF
60 70 80 90 100
RFEYLWPFWL FIRSVYDSFR YQGLAFSVFF VCVAFTSNII CLLFIPIQWL
110 120 130 140 150
FFAASTYVWV QYVWHTERGV CLPTVSLWIL FVYIEAAIRF KDLKNFHVDL
160 170 180 190 200
CRPFAAHCIG YPVVTLGFGF KSYVSYKMRL RKQKEVQKEN EFYMQLLQQA
210 220 230 240 250
LPPEQQMLQK QEKEAEEAAK GLPDMDSSIL IHHNGGIPAN KKLSTTLPEI
260 270 280 290 300
EYREKGKEKD KDAKKHNLGI NNNNILQPVD SKIQEIEYME NHINSKRLNN
310 320 330 340 350
DLVGSTENLL KEDSCTASSK NYKNASGVVN SSPRSHSATN GSIPSSSSKN
360 370 380 390 400
EKKQKCTSKS PSTHKDLMEN CIPNNQLSKP DALVRLEQDI KKLKADLQAS
410 420 430 440 450
RQVEQELRSQ ISSLSSTERG IRSEMGQLRQ ENELLQNKLH NAVQMKQKDK
460 470 480 490 500
QNISQLEKKL KAEQEARSFV EKQLMEEKKR KKLEEATAAR AVAFAAASRG
510 520 530 540 550
ECTETLRNRI RELEAEGKKL TMDMKVKEDQ IRELELKVQE LRKYKENEKD
560 570 580 590 600
TEVLMSALSA MQDKTQHLEN SLSAETRIKL DLFSALGDAK RQLEIAQGQI
610 620 630 640 650
LQKDQEIKDL KQKIAEVMAV MPSITYSAAT SPLSPVSPHY SSKFVETSPS
660
GLDPNASVYQ PLKK
Length:664
Mass (Da):76,178
Last modified:October 1, 2002 - v1
Checksum:iC0F16B66E13AC281
GO
Isoform 2 (identifier: Q8N5G2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-384: Missing.

Show »
Length:306
Mass (Da):35,026
Checksum:i7E4942B918C8C88A
GO
Isoform 3 (identifier: Q8N5G2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-158: C → W
     159-385: Missing.

Show »
Length:437
Mass (Da):50,791
Checksum:i91381E4E67C52F25
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti577R → I in BAA91786 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01720327 – 384Missing in isoform 2. 1 PublicationAdd BLAST358
Alternative sequenceiVSP_017204158C → W in isoform 3. 1 Publication1
Alternative sequenceiVSP_017205159 – 385Missing in isoform 3. 1 PublicationAdd BLAST227

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY845015 mRNA Translation: AAX11913.1
AY845036 mRNA Translation: AAX11934.1
AY845035 mRNA Translation: AAX11933.1
AK001609 mRNA Translation: BAA91786.1
AL031284 Genomic DNA No translation available.
BX572623 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07876.1
BC032427 mRNA Translation: AAH32427.1
CCDSiCCDS30638.1 [Q8N5G2-1]
CCDS60034.1 [Q8N5G2-3]
RefSeqiNP_001269493.1, NM_001282564.1 [Q8N5G2-3]
NP_060672.2, NM_018202.5 [Q8N5G2-1]
UniGeneiHs.189782

Genome annotation databases

EnsembliENST00000374343; ENSP00000363463; ENSG00000204178 [Q8N5G2-1]
ENST00000399766; ENSP00000382668; ENSG00000204178 [Q8N5G2-3]
GeneIDi55219
KEGGihsa:55219
UCSCiuc001bkk.5 human [Q8N5G2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMACOI_HUMAN
AccessioniPrimary (citable) accession number: Q8N5G2
Secondary accession number(s): B1AK00
, Q2TLX5, Q2TLX6, Q9NVG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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