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UniProtKB - Q8N5F7 (NKAP_HUMAN)

Entry version 148 (02 Jun 2021)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
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Protein

NF-kappa-B-activating protein

Gene

NKAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor (PubMed:14550261, PubMed:19409814, PubMed:31587868).

Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development (PubMed:19409814).

Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processNotch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N5F7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NF-kappa-B-activating protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NKAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29873, NKAP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300766, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N5F7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000101882.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Intellectual developmental disorder, X-linked, syndromic, Hackman-Di Donato type (MRXSHD)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn X-linked recessive disorder characterized by impaired intellectual development, global developmental delay, hypotonia, joint contractures, behavioral abnormalities, Marfanoid habitus, scoliosis, and mildly dysmorphic facies.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083895330R → C in MRXSHD. 1 PublicationCorresponds to variant dbSNP:rs1603379781EnsemblClinVar.1
Natural variantiVAR_083896330R → H in MRXSHD. 1 PublicationCorresponds to variant dbSNP:rs1603379780EnsemblClinVar.1
Natural variantiVAR_083897333R → Q in MRXSHD; unknown pathological significance. 2 Publications1
Natural variantiVAR_083898337I → T in MRXSHD. 1 PublicationCorresponds to variant dbSNP:rs1603379772EnsemblClinVar.1
Natural variantiVAR_083899361R → Q in MRXSHD; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		79576

MalaCards human disease database

More...MalaCardsi		NKAP
MIMi301039, phenotype

Open Targets

More...OpenTargetsi		ENSG00000101882

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162397584

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N5F7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NKAP

Domain mapping of disease mutations (DMDM)

More...DMDMi		74728990

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002596451 – 415NF-kappa-B-activating proteinAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7PhosphoserineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei112N6-acetyllysineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei161PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki283Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N5F7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N5F7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N5F7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N5F7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N5F7

PeptideAtlas

More...PeptideAtlasi		Q8N5F7

PRoteomics IDEntifications database

More...PRIDEi		Q8N5F7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72046

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N5F7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N5F7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000101882, Expressed in quadriceps femoris and 204 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N5F7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N5F7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000101882, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Notch corepressor complex.

Interacts with CIR1 and HDAC3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122723, 83 interactors

Protein interaction database and analysis system

More...IntActi		Q8N5F7, 65 interactors

Molecular INTeraction database

More...MINTi		Q8N5F7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360464

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N5F7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N5F7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 311DisorderedSequence analysisAdd BLAST311
Regioni179 – 272Necessary for interaction with CIR11 PublicationAdd BLAST94
Regioni273 – 415Necessary for interaction with HDAC3 and transcriptional repression1 PublicationAdd BLAST143

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 44Basic residuesSequence analysisAdd BLAST20
Compositional biasi49 – 73Polar residuesSequence analysisAdd BLAST25
Compositional biasi115 – 140Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi153 – 187Basic and acidic residuesSequence analysisAdd BLAST35
Compositional biasi188 – 206Basic residuesSequence analysisAdd BLAST19
Compositional biasi233 – 257Basic residuesSequence analysisAdd BLAST25
Compositional biasi258 – 290Basic and acidic residuesSequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NKAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2812, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160787

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032439_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N5F7

Identification of Orthologs from Complete Genome Data

More...OMAi		VERWPND

Database of Orthologous Groups

More...OrthoDBi		1561377at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N5F7

TreeFam database of animal gene trees

More...TreeFami		TF315333

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040466, NKAP
IPR009269, NKAP_C

The PANTHER Classification System

More...PANTHERi		PTHR13087, PTHR13087, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06047, Nkap_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8N5F7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPVSGSRSP DREASGSGGR RRSSSKSPKP SKSARSPRGR RSRSHSCSRS 
        60         70         80         90        100
GDRNGLTHQL GGLSQGSRNQ SYRSRSRSRS RERPSAPRGI PFASASSSVY 
       110        120        130        140        150
YGSYSRPYGS DKPWPSLLDK EREESLRQKR LSERERIGEL GAPEVWGLSP 
       160        170        180        190        200
KNPEPDSDEH TPVEDEEPKK STTSASTSEE EKKKKSSRSK ERSKKRRKKK 
       210        220        230        240        250
SSKRKHKKYS EDSDSDSDSE TDSSDEDNKR RAKKAKKKEK KKKHRSKKYK 
       260        270        280        290        300
KKRSKKSRKE SSDSSSKESQ EEFLENPWKD RTKAEEPSDL IGPEAPKTLT 
       310        320        330        340        350
SQDDKPLNYG HALLPGEGAA MAEYVKAGKR IPRRGEIGLT SEEIASFECS 
       360        370        380        390        400
GYVMSGSRHR RMEAVRLRKE NQIYSADEKR ALASFNQEER RKRENKILAS 
       410 
FREMVYRKTK GKDDK
Length:415
Mass (Da):47,138
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44BD1DE20F7ED35A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C050A0A494C050_HUMAN
NF-kappa-B-activating protein
NKAP
414Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH71686 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57T → A in BAB15428 (PubMed:14702039).Curated1
Sequence conflicti280D → Y in AAH15354 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053799115P → H. Corresponds to variant dbSNP:rs34728541Ensembl.1
Natural variantiVAR_083895330R → C in MRXSHD. 1 PublicationCorresponds to variant dbSNP:rs1603379781EnsemblClinVar.1
Natural variantiVAR_083896330R → H in MRXSHD. 1 PublicationCorresponds to variant dbSNP:rs1603379780EnsemblClinVar.1
Natural variantiVAR_083897333R → Q in MRXSHD; unknown pathological significance. 2 Publications1
Natural variantiVAR_083898337I → T in MRXSHD. 1 PublicationCorresponds to variant dbSNP:rs1603379772EnsemblClinVar.1
Natural variantiVAR_083899361R → Q in MRXSHD; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY388958 mRNA Translation: AAQ90402.1
AK026279 mRNA Translation: BAB15428.1
BC015354 mRNA Translation: AAH15354.1
BC032442 mRNA Translation: AAH32442.1
BC071686 mRNA Translation: AAH71686.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14592.1

NCBI Reference Sequences

More...RefSeqi		NP_078804.2, NM_024528.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371410; ENSP00000360464; ENSG00000101882

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79576

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79576

UCSC genome browser

More...UCSCi		uc004esh.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY388958 mRNA Translation: AAQ90402.1
AK026279 mRNA Translation: BAB15428.1
BC015354 mRNA Translation: AAH15354.1
BC032442 mRNA Translation: AAH32442.1
BC071686 mRNA Translation: AAH71686.1 Sequence problems.
CCDSiCCDS14592.1
RefSeqiNP_078804.2, NM_024528.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6QDVelectron microscopy3.30Z329-358[»]
SMRiQ8N5F7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122723, 83 interactors
IntActiQ8N5F7, 65 interactors
MINTiQ8N5F7
STRINGi9606.ENSP00000360464

PTM databases

iPTMnetiQ8N5F7
PhosphoSitePlusiQ8N5F7

Genetic variation databases

BioMutaiNKAP
DMDMi74728990

Proteomic databases

EPDiQ8N5F7
jPOSTiQ8N5F7
MassIVEiQ8N5F7
MaxQBiQ8N5F7
PaxDbiQ8N5F7
PeptideAtlasiQ8N5F7
PRIDEiQ8N5F7
ProteomicsDBi72046

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		364, 137 antibodies

The DNASU plasmid repository

More...DNASUi		79576

Genome annotation databases

EnsembliENST00000371410; ENSP00000360464; ENSG00000101882
GeneIDi79576
KEGGihsa:79576
UCSCiuc004esh.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79576
DisGeNETi79576

GeneCards: human genes, protein and diseases

More...GeneCardsi		NKAP
HGNCiHGNC:29873, NKAP
HPAiENSG00000101882, Low tissue specificity
MalaCardsiNKAP
MIMi300766, gene
301039, phenotype
neXtProtiNX_Q8N5F7
OpenTargetsiENSG00000101882
PharmGKBiPA162397584
VEuPathDBiHostDB:ENSG00000101882.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2812, Eukaryota
GeneTreeiENSGT00940000160787
HOGENOMiCLU_032439_1_0_1
InParanoidiQ8N5F7
OMAiVERWPND
OrthoDBi1561377at2759
PhylomeDBiQ8N5F7
TreeFamiTF315333

Enzyme and pathway databases

PathwayCommonsiQ8N5F7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79576, 367 hits in 625 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NKAP, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NKAP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79576
PharosiQ8N5F7, Tbio

Protein Ontology

More...PROi		PR:Q8N5F7
RNActiQ8N5F7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000101882, Expressed in quadriceps femoris and 204 other tissues
ExpressionAtlasiQ8N5F7, baseline and differential
GenevisibleiQ8N5F7, HS

Family and domain databases

InterProiView protein in InterPro
IPR040466, NKAP
IPR009269, NKAP_C
PANTHERiPTHR13087, PTHR13087, 1 hit
PfamiView protein in Pfam
PF06047, Nkap_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNKAP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N5F7
Secondary accession number(s): Q6IPW6, Q96BQ2, Q9H638
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2002
Last modified: June 2, 2021
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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