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Entry version 161 (08 May 2019)
Sequence version 2 (16 Jan 2004)
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Protein

WD and tetratricopeptide repeats protein 1

Gene

WDTC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664 Neddylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8N5D0

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD and tetratricopeptide repeats protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDTC1
Synonyms:KIAA1037
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29175 WDTC1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N5D0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23038

Open Targets

More...
OpenTargetsi
ENSG00000142784

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134981539

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDTC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
41018470

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000514341 – 677WD and tetratricopeptide repeats protein 1Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei353PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N5D0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N5D0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N5D0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N5D0

PeptideAtlas

More...
PeptideAtlasi
Q8N5D0

PRoteomics IDEntifications database

More...
PRIDEi
Q8N5D0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72037
72038 [Q8N5D0-2]
72039 [Q8N5D0-3]
72040 [Q8N5D0-4]
72041 [Q8N5D0-5]
72042 [Q8N5D0-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N5D0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N5D0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142784 Expressed in 227 organ(s), highest expression level in muscle of leg

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N5D0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N5D0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028177
HPA028180
HPA028182

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DDB1Q165312EBI-15821254,EBI-350322

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116677, 45 interactors

Database of interacting proteins

More...
DIPi
DIP-31627N

Protein interaction database and analysis system

More...
IntActi
Q8N5D0, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000317971

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1677
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I7NX-ray2.80B5-17[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N5D0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8N5D0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati45 – 84WD 1Add BLAST40
Repeati88 – 129WD 2Add BLAST42
Repeati132 – 172WD 3Add BLAST41
Repeati182 – 222WD 4Add BLAST41
Repeati265 – 305WD 5Add BLAST41
Repeati362 – 395TPR 1Add BLAST34
Repeati397 – 432TPR 2Add BLAST36
Repeati535 – 575WD 6Add BLAST41
Repeati578 – 617WD 7Add BLAST40

Keywords - Domaini

Repeat, TPR repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1310 Eukaryota
KOG1334 Eukaryota
ENOG410XWAR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182900

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231334

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N5D0

KEGG Orthology (KO)

More...
KOi
K11807

Identification of Orthologs from Complete Genome Data

More...
OMAi
SFFIWDR

Database of Orthologous Groups

More...
OrthoDBi
1270484at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N5D0

TreeFam database of animal gene trees

More...
TreeFami
TF320710

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 3 hits
SM00320 WD40, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50293 TPR_REGION, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N5D0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKVNITRDL IRRQIKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV
60 70 80 90 100
NCLEWNEKGD LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP
110 120 130 140 150
HAGDRILITG AADSKVHVHD LTVKETIHMF GDHTNRVKRI ATAPMWPNTF
160 170 180 190 200
WSAAEDGLIR QYDLRENSKH SEVLIDLTEY CGQLVEAKCL TVNPQDNNCL
210 220 230 240 250
AVGASGPFVR LYDIRMIHNH RKSMKQSPSA GVHTFCDRQK PLPDGAAQYY
260 270 280 290 300
VAGHLPVKLP DYNNRLRVLV ATYVTFSPNG TELLVNMGGE QVYLFDLTYK
310 320 330 340 350
QRPYTFLLPR KCHSSGEVQN GKMSTNGVSN GVSNGLHLHS NGFRLPESRG
360 370 380 390 400
HVSPQVELPP YLERVKQQAN EAFACQQWTQ AIQLYSKAVQ RAPHNAMLYG
410 420 430 440 450
NRAAAYMKRK WDGDHYDALR DCLKAISLNP CHLKAHFRLA RCLFELKYVA
460 470 480 490 500
EALECLDDFK GKFPEQAHSS ACDALGRDIT AALFSKNDGE EKKGPGGGAP
510 520 530 540 550
VRLRSTSRKD SISEDEMVLR ERSYDYQFRY CGHCNTTTDI KEANFFGSNA
560 570 580 590 600
QYIVSGSDDG SFFIWEKETT NLVRVLQGDE SIVNCLQPHP SYCFLATSGI
610 620 630 640 650
DPVVRLWNPR PESEDLTGRV VEDMEGASQA NQRRMNADPL EVMLLNMGYR
660 670
ITGLSSGGAG ASDDEDSSEG QVQCRPS
Note: No experimental confirmation available.
Length:677
Mass (Da):75,920
Last modified:January 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BDFA8061B2C266C
GO
Isoform 2 (identifier: Q8N5D0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     548-677: SNAQYIVSGS...SEGQVQCRPS → RRPPTWSVCS...RVLHRPTSGA

Note: No experimental confirmation available.
Show »
Length:615
Mass (Da):69,065
Checksum:i67FBA050EB7AD4E7
GO
Isoform 3 (identifier: Q8N5D0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     548-677: SNAQYIVSGS...SEGQVQCRPS → RSEALKRRVQ...WANGFTFVSL

Note: No experimental confirmation available.
Show »
Length:597
Mass (Da):67,590
Checksum:i330E6A5A2BB525B6
GO
Isoform 4 (identifier: Q8N5D0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-317: Missing.

Note: No experimental confirmation available.
Show »
Length:676
Mass (Da):75,791
Checksum:i25FFD27AD1E90F3E
GO
Isoform 5 (identifier: Q8N5D0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-317: Missing.
     548-677: SNAQYIVSGS...SEGQVQCRPS → RSEALKRRVQ...WANGFTFVSL

Note: No experimental confirmation available.
Show »
Length:596
Mass (Da):67,461
Checksum:i58DB84890ECED479
GO
Isoform 6 (identifier: Q8N5D0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-317: Missing.
     548-677: SNAQYIVSGS...SEGQVQCRPS → RRPPTWSVCS...RVLHRPTSGA

Note: No experimental confirmation available.
Show »
Length:614
Mass (Da):68,936
Checksum:iA81D1F64FC48A772
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEI6H0YEI6_HUMAN
WD and tetratricopeptide repeats pr...
WDTC1
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti456L → P in BAA91868 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009290317Missing in isoform 4, isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_009292548 – 677SNAQY…QCRPS → RRPPTWSVCSKGMSPLSTAC SHTPATASWPPVASILLCGS GTPDQRVKTSQAESWKIWRV LHRPTSGA in isoform 2 and isoform 6. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_009291548 – 677SNAQY…QCRPS → RSEALKRRVQPSWQREVEWG VLGHNGFREESQIPALPLYP WANGFTFVSL in isoform 3 and isoform 5. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001734 mRNA Translation: BAA91868.1
AL590640 Genomic DNA No translation available.
FO393419 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07770.1
CH471059 Genomic DNA Translation: EAX07771.1
BC032523 mRNA Translation: AAH32523.1
AB028960 mRNA Translation: BAA82989.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS296.1 [Q8N5D0-4]
CCDS60044.1 [Q8N5D0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001263181.1, NM_001276252.1 [Q8N5D0-1]
NP_055838.2, NM_015023.4 [Q8N5D0-4]
XP_011539359.1, XM_011541057.1 [Q8N5D0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319394; ENSP00000317971; ENSG00000142784 [Q8N5D0-1]
ENST00000361771; ENSP00000355317; ENSG00000142784 [Q8N5D0-4]
ENST00000447062; ENSP00000434578; ENSG00000142784 [Q8N5D0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23038

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23038

UCSC genome browser

More...
UCSCi
uc001bno.5 human [Q8N5D0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001734 mRNA Translation: BAA91868.1
AL590640 Genomic DNA No translation available.
FO393419 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07770.1
CH471059 Genomic DNA Translation: EAX07771.1
BC032523 mRNA Translation: AAH32523.1
AB028960 mRNA Translation: BAA82989.1
CCDSiCCDS296.1 [Q8N5D0-4]
CCDS60044.1 [Q8N5D0-1]
RefSeqiNP_001263181.1, NM_001276252.1 [Q8N5D0-1]
NP_055838.2, NM_015023.4 [Q8N5D0-4]
XP_011539359.1, XM_011541057.1 [Q8N5D0-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I7NX-ray2.80B5-17[»]
SMRiQ8N5D0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116677, 45 interactors
DIPiDIP-31627N
IntActiQ8N5D0, 7 interactors
STRINGi9606.ENSP00000317971

PTM databases

iPTMnetiQ8N5D0
PhosphoSitePlusiQ8N5D0

Polymorphism and mutation databases

BioMutaiWDTC1
DMDMi41018470

Proteomic databases

EPDiQ8N5D0
jPOSTiQ8N5D0
MaxQBiQ8N5D0
PaxDbiQ8N5D0
PeptideAtlasiQ8N5D0
PRIDEiQ8N5D0
ProteomicsDBi72037
72038 [Q8N5D0-2]
72039 [Q8N5D0-3]
72040 [Q8N5D0-4]
72041 [Q8N5D0-5]
72042 [Q8N5D0-6]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23038
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319394; ENSP00000317971; ENSG00000142784 [Q8N5D0-1]
ENST00000361771; ENSP00000355317; ENSG00000142784 [Q8N5D0-4]
ENST00000447062; ENSP00000434578; ENSG00000142784 [Q8N5D0-2]
GeneIDi23038
KEGGihsa:23038
UCSCiuc001bno.5 human [Q8N5D0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23038
DisGeNETi23038

GeneCards: human genes, protein and diseases

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GeneCardsi
WDTC1
HGNCiHGNC:29175 WDTC1
HPAiHPA028177
HPA028180
HPA028182
neXtProtiNX_Q8N5D0
OpenTargetsiENSG00000142784
PharmGKBiPA134981539

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1310 Eukaryota
KOG1334 Eukaryota
ENOG410XWAR LUCA
GeneTreeiENSGT00950000182900
HOGENOMiHOG000231334
InParanoidiQ8N5D0
KOiK11807
OMAiSFFIWDR
OrthoDBi1270484at2759
PhylomeDBiQ8N5D0
TreeFamiTF320710

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-8951664 Neddylation
SignaLinkiQ8N5D0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WDTC1 human
EvolutionaryTraceiQ8N5D0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23038

Protein Ontology

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PROi
PR:Q8N5D0

Gene expression databases

BgeeiENSG00000142784 Expressed in 227 organ(s), highest expression level in muscle of leg
ExpressionAtlasiQ8N5D0 baseline and differential
GenevisibleiQ8N5D0 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SM00320 WD40, 6 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDTC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N5D0
Secondary accession number(s): D3DPL5
, Q5SSC5, Q9NV87, Q9UPW4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: May 8, 2019
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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