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Protein

DTW domain-containing protein 1

Gene

DTWD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
DTW domain-containing protein 1
Gene namesi
Name:DTWD1
ORF Names:MDS009
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000104047.14
HGNCiHGNC:30926 DTWD1
neXtProtiNX_Q8N5C7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104047
PharmGKBiPA142671942

Polymorphism and mutation databases

BioMutaiDTWD1
DMDMi74728976

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003082122 – 304DTW domain-containing protein 1Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8N5C7
MaxQBiQ8N5C7
PaxDbiQ8N5C7
PeptideAtlasiQ8N5C7
PRIDEiQ8N5C7
ProteomicsDBi72032
72033 [Q8N5C7-2]
72034 [Q8N5C7-3]
TopDownProteomicsiQ8N5C7-2 [Q8N5C7-2]

PTM databases

iPTMnetiQ8N5C7
PhosphoSitePlusiQ8N5C7

Expressioni

Gene expression databases

BgeeiENSG00000104047 Expressed in 199 organ(s), highest expression level in endocervix
CleanExiHS_DTWD1
ExpressionAtlasiQ8N5C7 baseline and differential
GenevisibleiQ8N5C7 HS

Organism-specific databases

HPAiHPA042214

Interactioni

Protein-protein interaction databases

BioGridi121303, 2 interactors
IntActiQ8N5C7, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8N5C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi206 – 209DXTW4

Domaini

Contains 1 DXTW motif.

Sequence similaritiesi

Belongs to the DTW family.Curated

Phylogenomic databases

eggNOGiKOG3795 Eukaryota
ENOG4111F3J LUCA
GeneTreeiENSGT00510000047544
HOGENOMiHOG000045368
HOVERGENiHBG099835
InParanoidiQ8N5C7
OMAiRSRKFFC
OrthoDBiEOG091G07PH
PhylomeDBiQ8N5C7
TreeFamiTF324733

Family and domain databases

InterProiView protein in InterPro
IPR005636 DTW
PfamiView protein in Pfam
PF03942 DTW, 1 hit
SMARTiView protein in SMART
SM01144 DTW, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N5C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLNPPIFLK RSEENSSKFV ETKQSQTTSI ASEDPLQNLC LASQEVLQKA
60 70 80 90 100
QQSGRSKCLK CGGSRMFYCY TCYVPVENVP IEQIPLVKLP LKIDIIKHPN
110 120 130 140 150
ETDGKSTAIH AKLLAPEFVN IYTYPCIPEY EEKDHEVALI FPGPQSISIK
160 170 180 190 200
DISFHLQKRI QNNVRGKNDD PDKPSFKRKR TEEQEFCDLN DSKCKGTTLK
210 220 230 240 250
KIIFIDSTWN QTNKIFTDER LQGLLQVELK TRKTCFWRHQ KGKPDTFLST
260 270 280 290 300
IEAIYYFLVD YHTDILKEKY RGQYDNLLFF YSFMYQLIKN AKCSGDKETG

KLTH
Length:304
Mass (Da):35,248
Last modified:October 1, 2002 - v1
Checksum:i8756C5CE34BA0C28
GO
Isoform 2 (identifier: Q8N5C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MSLNPPIFLK...VPIEQIPLVK → M

Note: No experimental confirmation available.
Show »
Length:217
Mass (Da):25,522
Checksum:i141BE335CAFE0BF9
GO
Isoform 3 (identifier: Q8N5C7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-304: LPLKIDIIKH...GDKETGKLTH → FSLYHLGQSMVSSASKITCIG

Note: No experimental confirmation available.
Show »
Length:109
Mass (Da):12,087
Checksum:i070ECED227DE2E92
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YML0H0YML0_HUMAN
DTW domain-containing protein 1
DTWD1
152Annotation score:
H0YL61H0YL61_HUMAN
DTW domain-containing protein 1
DTWD1
193Annotation score:
H0YK73H0YK73_HUMAN
DTW domain-containing protein 1
DTWD1
94Annotation score:
H0YMP4H0YMP4_HUMAN
DTW domain-containing protein 1
DTWD1
102Annotation score:

Sequence cautioni

The sequence AAF87319 differs from that shown. Reason: Frameshift at positions 132, 182, 187, 188, 192, 194, 196, 199, 204, 207 and 209.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0367579L → P. Corresponds to variant dbSNP:rs11539522Ensembl.1
Natural variantiVAR_03675813E → K. Corresponds to variant dbSNP:rs11539519Ensembl.1
Natural variantiVAR_03675925S → P. Corresponds to variant dbSNP:rs11539521Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0289221 – 88MSLNP…IPLVK → M in isoform 2. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_02892389 – 304LPLKI…GKLTH → FSLYHLGQSMVSSASKITCI G in isoform 3. 1 PublicationAdd BLAST216

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168717 mRNA Translation: AAF87319.1 Frameshift.
AC018927 Genomic DNA No translation available.
BC018028 mRNA Translation: AAH18028.1
BC032535 mRNA Translation: AAH32535.1
BC093073 mRNA Translation: AAH93073.1
CCDSiCCDS10132.1 [Q8N5C7-1]
RefSeqiNP_001138427.1, NM_001144955.1 [Q8N5C7-1]
NP_064619.2, NM_020234.5 [Q8N5C7-1]
XP_016877908.1, XM_017022419.1 [Q8N5C7-1]
XP_016877909.1, XM_017022420.1 [Q8N5C7-1]
XP_016877910.1, XM_017022421.1 [Q8N5C7-1]
XP_016877911.1, XM_017022422.1 [Q8N5C7-1]
XP_016877916.1, XM_017022427.1 [Q8N5C7-2]
XP_016877917.1, XM_017022428.1 [Q8N5C7-2]
XP_016877918.1, XM_017022429.1 [Q8N5C7-2]
XP_016877919.1, XM_017022430.1 [Q8N5C7-2]
XP_016877920.1, XM_017022431.1
UniGeneiHs.127432
Hs.594784

Genome annotation databases

EnsembliENST00000251250; ENSP00000251250; ENSG00000104047 [Q8N5C7-1]
ENST00000403028; ENSP00000385399; ENSG00000104047 [Q8N5C7-1]
ENST00000557968; ENSP00000452628; ENSG00000104047 [Q8N5C7-3]
ENST00000558653; ENSP00000453529; ENSG00000104047 [Q8N5C7-1]
GeneIDi56986
KEGGihsa:56986
UCSCiuc001zxq.4 human [Q8N5C7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168717 mRNA Translation: AAF87319.1 Frameshift.
AC018927 Genomic DNA No translation available.
BC018028 mRNA Translation: AAH18028.1
BC032535 mRNA Translation: AAH32535.1
BC093073 mRNA Translation: AAH93073.1
CCDSiCCDS10132.1 [Q8N5C7-1]
RefSeqiNP_001138427.1, NM_001144955.1 [Q8N5C7-1]
NP_064619.2, NM_020234.5 [Q8N5C7-1]
XP_016877908.1, XM_017022419.1 [Q8N5C7-1]
XP_016877909.1, XM_017022420.1 [Q8N5C7-1]
XP_016877910.1, XM_017022421.1 [Q8N5C7-1]
XP_016877911.1, XM_017022422.1 [Q8N5C7-1]
XP_016877916.1, XM_017022427.1 [Q8N5C7-2]
XP_016877917.1, XM_017022428.1 [Q8N5C7-2]
XP_016877918.1, XM_017022429.1 [Q8N5C7-2]
XP_016877919.1, XM_017022430.1 [Q8N5C7-2]
XP_016877920.1, XM_017022431.1
UniGeneiHs.127432
Hs.594784

3D structure databases

ProteinModelPortaliQ8N5C7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121303, 2 interactors
IntActiQ8N5C7, 1 interactor

PTM databases

iPTMnetiQ8N5C7
PhosphoSitePlusiQ8N5C7

Polymorphism and mutation databases

BioMutaiDTWD1
DMDMi74728976

Proteomic databases

EPDiQ8N5C7
MaxQBiQ8N5C7
PaxDbiQ8N5C7
PeptideAtlasiQ8N5C7
PRIDEiQ8N5C7
ProteomicsDBi72032
72033 [Q8N5C7-2]
72034 [Q8N5C7-3]
TopDownProteomicsiQ8N5C7-2 [Q8N5C7-2]

Protocols and materials databases

DNASUi56986
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251250; ENSP00000251250; ENSG00000104047 [Q8N5C7-1]
ENST00000403028; ENSP00000385399; ENSG00000104047 [Q8N5C7-1]
ENST00000557968; ENSP00000452628; ENSG00000104047 [Q8N5C7-3]
ENST00000558653; ENSP00000453529; ENSG00000104047 [Q8N5C7-1]
GeneIDi56986
KEGGihsa:56986
UCSCiuc001zxq.4 human [Q8N5C7-1]

Organism-specific databases

CTDi56986
EuPathDBiHostDB:ENSG00000104047.14
GeneCardsiDTWD1
HGNCiHGNC:30926 DTWD1
HPAiHPA042214
neXtProtiNX_Q8N5C7
OpenTargetsiENSG00000104047
PharmGKBiPA142671942
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3795 Eukaryota
ENOG4111F3J LUCA
GeneTreeiENSGT00510000047544
HOGENOMiHOG000045368
HOVERGENiHBG099835
InParanoidiQ8N5C7
OMAiRSRKFFC
OrthoDBiEOG091G07PH
PhylomeDBiQ8N5C7
TreeFamiTF324733

Miscellaneous databases

ChiTaRSiDTWD1 human
GeneWikiiDTWD1
GenomeRNAii56986
PROiPR:Q8N5C7

Gene expression databases

BgeeiENSG00000104047 Expressed in 199 organ(s), highest expression level in endocervix
CleanExiHS_DTWD1
ExpressionAtlasiQ8N5C7 baseline and differential
GenevisibleiQ8N5C7 HS

Family and domain databases

InterProiView protein in InterPro
IPR005636 DTW
PfamiView protein in Pfam
PF03942 DTW, 1 hit
SMARTiView protein in SMART
SM01144 DTW, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDTWD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N5C7
Secondary accession number(s): Q567Q3, Q8WVG9, Q9NRU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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