UniProtKB - Q8N5C6 (SRBD1_HUMAN)
Protein
S1 RNA-binding domain-containing protein 1
Gene
SRBD1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- mRNA binding Source: GO_Central
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- nucleobase-containing compound metabolic process Source: InterPro
- translation Source: GO_Central
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8N5C6 |
Names & Taxonomyi
Protein namesi | Recommended name: S1 RNA-binding domain-containing protein 1 |
Gene namesi | Name:SRBD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25521, SRBD1 |
neXtProti | NX_Q8N5C6 |
VEuPathDBi | HostDB:ENSG00000068784.12 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55133 |
OpenTargetsi | ENSG00000068784 |
PharmGKBi | PA144596269 |
Miscellaneous databases
Pharosi | Q8N5C6, Tbio |
Genetic variation databases
BioMutai | SRBD1 |
DMDMi | 145566960 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284357 | 1 – 995 | S1 RNA-binding domain-containing protein 1Add BLAST | 995 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 84 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 134 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 166 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 167 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 183 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 185 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 185 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 861 | PhosphoserineCombined sources | 1 | |
Cross-linki | 955 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 964 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8N5C6 |
jPOSTi | Q8N5C6 |
MassIVEi | Q8N5C6 |
MaxQBi | Q8N5C6 |
PaxDbi | Q8N5C6 |
PeptideAtlasi | Q8N5C6 |
PRIDEi | Q8N5C6 |
ProteomicsDBi | 72030 [Q8N5C6-1] 72031 [Q8N5C6-2] |
PTM databases
iPTMneti | Q8N5C6 |
PhosphoSitePlusi | Q8N5C6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000068784, Expressed in stomach and 181 other tissues |
Genevisiblei | Q8N5C6, HS |
Organism-specific databases
HPAi | ENSG00000068784, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120439, 59 interactors |
IntActi | Q8N5C6, 30 interactors |
MINTi | Q8N5C6 |
STRINGi | 9606.ENSP00000263736 |
Miscellaneous databases
RNActi | Q8N5C6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 919 – 992 | S1 motifPROSITE-ProRule annotationAdd BLAST | 74 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 258 – 288 | Sequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 80 – 83 | Poly-Val | 4 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1857, Eukaryota |
GeneTreei | ENSGT00510000047850 |
HOGENOMi | CLU_009833_1_0_1 |
InParanoidi | Q8N5C6 |
OMAi | RWAWRTR |
OrthoDBi | 56990at2759 |
PhylomeDBi | Q8N5C6 |
TreeFami | TF313600 |
Family and domain databases
CDDi | cd05685, S1_Tex, 1 hit |
Gene3Di | 1.10.10.650, 1 hit 1.10.3500.10, 1 hit 3.30.420.140, 1 hit |
InterProi | View protein in InterPro IPR041692, HHH_9 IPR012340, NA-bd_OB-fold IPR012337, RNaseH-like_sf IPR010994, RuvA_2-like IPR022967, S1_dom IPR003029, S1_domain IPR044146, S1_Tex IPR023323, Tex-like_dom_sf IPR023319, Tex-like_HTH_dom_sf IPR018974, Tex-like_N IPR032639, Tex_YqgF IPR006641, YqgF/RNaseH-like_dom IPR037027, YqgF/RNaseH-like_dom_sf |
Pfami | View protein in Pfam PF17674, HHH_9, 1 hit PF00575, S1, 1 hit PF09371, Tex_N, 1 hit PF16921, Tex_YqgF, 1 hit |
SMARTi | View protein in SMART SM00316, S1, 1 hit SM00732, YqgFc, 1 hit |
SUPFAMi | SSF47781, SSF47781, 2 hits SSF50249, SSF50249, 1 hit SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50126, S1, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8N5C6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSLPRRAKV QVQDVVLKDE FSSFSELSSA SEEDDKEDSA WEPQKKVPRS
60 70 80 90 100
RKQPPPKESK PKRMPRVKKN APQISDGSEV VVVKEELNSS VAIADTALED
110 120 130 140 150
RKNKLDTVQT LKTAKTKQKC AAQPHTVRRT KKLKVEEETS KASNLEGESN
160 170 180 190 200
SSETPSTSTV WGGTCKKEEN DDDFTFGQSA LKKIKTETYP QGQPVKFPAN
210 220 230 240 250
ANSTKEEVEM NWDMVQVLSE RTNIEPWVCA NIIRLFNDDN TIPFIIRYRK
260 270 280 290 300
ELINNLDADS LREVQQTLEE LRAVAKKVHS TIQKIKKEGK MSECLLKAML
310 320 330 340 350
NCKTFEELEH VSAPYKTGSK GTKAQRARQL GLEGAARALL EKPGELSLLS
360 370 380 390 400
YIRPDVKGLS TLQDIEIGVQ HILADMIAKD KDTLDFIRNL CQKRHVCIQS
410 420 430 440 450
SLAKVSSKKV NEKDVDKFLL YQHFSCNIRN IHHHQILAIN RGENLKVLTV
460 470 480 490 500
KVNISDGVKD EFCRWCIQNR WRPRSFARPE LMKILYNSLN DSFKRLIYPL
510 520 530 540 550
LCREFRAKLT SDAEKESVMM FGRNLRQLLL TSPVPGRTLM GVDPGYKHGC
560 570 580 590 600
KLAIISPTSQ ILHTDVVYLH CGQGFREAEK IKTLLLNFNC STVVIGNGTA
610 620 630 640 650
CRETEAYFAD LIMKNYFAPL DVVYCIVSEA GASIYSVSPE ANKEMPGLDP
660 670 680 690 700
NLRSAVSIAR RVQDPLAELV KIEPKHIGVG MYQHDVSQTL LKATLDSVVE
710 720 730 740 750
ECVSFVGVDI NICSEVLLRH IAGLNANRAK NIIEWREKNG PFINREQLKK
760 770 780 790 800
VKGLGPKSFQ QCAGFIRINQ DYIRTFCSQQ TETSGQIQGV AVTSSADVEV
810 820 830 840 850
TNEKQGKKKS KTAVNVLLKP NPLDQTCIHP ESYDIAMRFL SSIGGTLYEV
860 870 880 890 900
GKPEMQQKIN SFLEKEGMEK IAERLQTTVH TLQVIIDGLS QPESFDFRTD
910 920 930 940 950
FDKPDFKRSI VCLEDLQIGT VLTGKVENAT LFGIFVDIGV GKSGLIPIRN
960 970 980 990
VTEAKLSKTK KRRSLGLGPG ERVEVQVLNI DIPRSRITLD LIRVL
Sequence cautioni
The sequence AAY14821 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 597 | N → S in BAA91577 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 638 | S → G in AK056536 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 795 | S → P in BAA91577 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056995 | 361 | T → M. Corresponds to variant dbSNP:rs6544834Ensembl. | 1 | |
Natural variantiVAR_056996 | 798 | V → F. Corresponds to variant dbSNP:rs3755073Ensembl. | 1 | |
Natural variantiVAR_056997 | 811 | K → R. Corresponds to variant dbSNP:rs3755072Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024461 | 1 – 375 | Missing in isoform 2. 2 PublicationsAdd BLAST | 375 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001241 mRNA Translation: BAA91577.1 AK056536 mRNA No translation available. AC012072 Genomic DNA Translation: AAY14821.1 Sequence problems. AC008179 Genomic DNA Translation: AAK52078.1 BC032538 mRNA Translation: AAH32538.1 |
CCDSi | CCDS1823.1 [Q8N5C6-1] |
RefSeqi | NP_060549.4, NM_018079.4 [Q8N5C6-1] |
Genome annotation databases
Ensembli | ENST00000263736; ENSP00000263736; ENSG00000068784 [Q8N5C6-1] |
GeneIDi | 55133 |
KEGGi | hsa:55133 |
UCSCi | uc002rus.4, human [Q8N5C6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001241 mRNA Translation: BAA91577.1 AK056536 mRNA No translation available. AC012072 Genomic DNA Translation: AAY14821.1 Sequence problems. AC008179 Genomic DNA Translation: AAK52078.1 BC032538 mRNA Translation: AAH32538.1 |
CCDSi | CCDS1823.1 [Q8N5C6-1] |
RefSeqi | NP_060549.4, NM_018079.4 [Q8N5C6-1] |
3D structure databases
SMRi | Q8N5C6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120439, 59 interactors |
IntActi | Q8N5C6, 30 interactors |
MINTi | Q8N5C6 |
STRINGi | 9606.ENSP00000263736 |
PTM databases
iPTMneti | Q8N5C6 |
PhosphoSitePlusi | Q8N5C6 |
Genetic variation databases
BioMutai | SRBD1 |
DMDMi | 145566960 |
Proteomic databases
EPDi | Q8N5C6 |
jPOSTi | Q8N5C6 |
MassIVEi | Q8N5C6 |
MaxQBi | Q8N5C6 |
PaxDbi | Q8N5C6 |
PeptideAtlasi | Q8N5C6 |
PRIDEi | Q8N5C6 |
ProteomicsDBi | 72030 [Q8N5C6-1] 72031 [Q8N5C6-2] |
Protocols and materials databases
Antibodypediai | 29937, 118 antibodies |
DNASUi | 55133 |
Genome annotation databases
Ensembli | ENST00000263736; ENSP00000263736; ENSG00000068784 [Q8N5C6-1] |
GeneIDi | 55133 |
KEGGi | hsa:55133 |
UCSCi | uc002rus.4, human [Q8N5C6-1] |
Organism-specific databases
CTDi | 55133 |
DisGeNETi | 55133 |
GeneCardsi | SRBD1 |
HGNCi | HGNC:25521, SRBD1 |
HPAi | ENSG00000068784, Low tissue specificity |
neXtProti | NX_Q8N5C6 |
OpenTargetsi | ENSG00000068784 |
PharmGKBi | PA144596269 |
VEuPathDBi | HostDB:ENSG00000068784.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1857, Eukaryota |
GeneTreei | ENSGT00510000047850 |
HOGENOMi | CLU_009833_1_0_1 |
InParanoidi | Q8N5C6 |
OMAi | RWAWRTR |
OrthoDBi | 56990at2759 |
PhylomeDBi | Q8N5C6 |
TreeFami | TF313600 |
Enzyme and pathway databases
PathwayCommonsi | Q8N5C6 |
Miscellaneous databases
BioGRID-ORCSi | 55133, 724 hits in 1003 CRISPR screens |
ChiTaRSi | SRBD1, human |
GenomeRNAii | 55133 |
Pharosi | Q8N5C6, Tbio |
PROi | PR:Q8N5C6 |
RNActi | Q8N5C6, protein |
Gene expression databases
Bgeei | ENSG00000068784, Expressed in stomach and 181 other tissues |
Genevisiblei | Q8N5C6, HS |
Family and domain databases
CDDi | cd05685, S1_Tex, 1 hit |
Gene3Di | 1.10.10.650, 1 hit 1.10.3500.10, 1 hit 3.30.420.140, 1 hit |
InterProi | View protein in InterPro IPR041692, HHH_9 IPR012340, NA-bd_OB-fold IPR012337, RNaseH-like_sf IPR010994, RuvA_2-like IPR022967, S1_dom IPR003029, S1_domain IPR044146, S1_Tex IPR023323, Tex-like_dom_sf IPR023319, Tex-like_HTH_dom_sf IPR018974, Tex-like_N IPR032639, Tex_YqgF IPR006641, YqgF/RNaseH-like_dom IPR037027, YqgF/RNaseH-like_dom_sf |
Pfami | View protein in Pfam PF17674, HHH_9, 1 hit PF00575, S1, 1 hit PF09371, Tex_N, 1 hit PF16921, Tex_YqgF, 1 hit |
SMARTi | View protein in SMART SM00316, S1, 1 hit SM00732, YqgFc, 1 hit |
SUPFAMi | SSF47781, SSF47781, 2 hits SSF50249, SSF50249, 1 hit SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50126, S1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SRBD1_HUMAN | |
Accessioni | Q8N5C6Primary (citable) accession number: Q8N5C6 Secondary accession number(s): Q53T56, Q96TA4, Q9NW11 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | April 17, 2007 | |
Last modified: | April 7, 2021 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports