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UniProtKB - Q8N5C6 (SRBD1_HUMAN)

Entry version 146 (07 Apr 2021)
Sequence version 2 (17 Apr 2007)
Previous versions | rss
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Protein

S1 RNA-binding domain-containing protein 1

Gene

SRBD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N5C6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
S1 RNA-binding domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRBD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25521, SRBD1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N5C6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000068784.12

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55133

Open Targets

More...OpenTargetsi		ENSG00000068784

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA144596269

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N5C6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SRBD1

Domain mapping of disease mutations (DMDM)

More...DMDMi		145566960

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002843571 – 995S1 RNA-binding domain-containing protein 1Add BLAST995

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki84Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki166Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki183Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei861PhosphoserineCombined sources1
Cross-linki955Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei964PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N5C6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N5C6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N5C6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N5C6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N5C6

PeptideAtlas

More...PeptideAtlasi		Q8N5C6

PRoteomics IDEntifications database

More...PRIDEi		Q8N5C6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72030 [Q8N5C6-1]
72031 [Q8N5C6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N5C6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N5C6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000068784, Expressed in stomach and 181 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N5C6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000068784, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120439, 59 interactors

Protein interaction database and analysis system

More...IntActi		Q8N5C6, 30 interactors

Molecular INTeraction database

More...MINTi		Q8N5C6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263736

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N5C6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N5C6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini919 – 992S1 motifPROSITE-ProRule annotationAdd BLAST74

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili258 – 288Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi80 – 83Poly-Val4

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1857, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000047850

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009833_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N5C6

Identification of Orthologs from Complete Genome Data

More...OMAi		RWAWRTR

Database of Orthologous Groups

More...OrthoDBi		56990at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N5C6

TreeFam database of animal gene trees

More...TreeFami		TF313600

Family and domain databases

Conserved Domains Database

More...CDDi		cd05685, S1_Tex, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.650, 1 hit
1.10.3500.10, 1 hit
3.30.420.140, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041692, HHH_9
IPR012340, NA-bd_OB-fold
IPR012337, RNaseH-like_sf
IPR010994, RuvA_2-like
IPR022967, S1_dom
IPR003029, S1_domain
IPR044146, S1_Tex
IPR023323, Tex-like_dom_sf
IPR023319, Tex-like_HTH_dom_sf
IPR018974, Tex-like_N
IPR032639, Tex_YqgF
IPR006641, YqgF/RNaseH-like_dom
IPR037027, YqgF/RNaseH-like_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17674, HHH_9, 1 hit
PF00575, S1, 1 hit
PF09371, Tex_N, 1 hit
PF16921, Tex_YqgF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00316, S1, 1 hit
SM00732, YqgFc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47781, SSF47781, 2 hits
SSF50249, SSF50249, 1 hit
SSF53098, SSF53098, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50126, S1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N5C6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSLPRRAKV QVQDVVLKDE FSSFSELSSA SEEDDKEDSA WEPQKKVPRS 
        60         70         80         90        100
RKQPPPKESK PKRMPRVKKN APQISDGSEV VVVKEELNSS VAIADTALED 
       110        120        130        140        150
RKNKLDTVQT LKTAKTKQKC AAQPHTVRRT KKLKVEEETS KASNLEGESN 
       160        170        180        190        200
SSETPSTSTV WGGTCKKEEN DDDFTFGQSA LKKIKTETYP QGQPVKFPAN 
       210        220        230        240        250
ANSTKEEVEM NWDMVQVLSE RTNIEPWVCA NIIRLFNDDN TIPFIIRYRK 
       260        270        280        290        300
ELINNLDADS LREVQQTLEE LRAVAKKVHS TIQKIKKEGK MSECLLKAML 
       310        320        330        340        350
NCKTFEELEH VSAPYKTGSK GTKAQRARQL GLEGAARALL EKPGELSLLS 
       360        370        380        390        400
YIRPDVKGLS TLQDIEIGVQ HILADMIAKD KDTLDFIRNL CQKRHVCIQS 
       410        420        430        440        450
SLAKVSSKKV NEKDVDKFLL YQHFSCNIRN IHHHQILAIN RGENLKVLTV 
       460        470        480        490        500
KVNISDGVKD EFCRWCIQNR WRPRSFARPE LMKILYNSLN DSFKRLIYPL 
       510        520        530        540        550
LCREFRAKLT SDAEKESVMM FGRNLRQLLL TSPVPGRTLM GVDPGYKHGC 
       560        570        580        590        600
KLAIISPTSQ ILHTDVVYLH CGQGFREAEK IKTLLLNFNC STVVIGNGTA 
       610        620        630        640        650
CRETEAYFAD LIMKNYFAPL DVVYCIVSEA GASIYSVSPE ANKEMPGLDP 
       660        670        680        690        700
NLRSAVSIAR RVQDPLAELV KIEPKHIGVG MYQHDVSQTL LKATLDSVVE 
       710        720        730        740        750
ECVSFVGVDI NICSEVLLRH IAGLNANRAK NIIEWREKNG PFINREQLKK 
       760        770        780        790        800
VKGLGPKSFQ QCAGFIRINQ DYIRTFCSQQ TETSGQIQGV AVTSSADVEV 
       810        820        830        840        850
TNEKQGKKKS KTAVNVLLKP NPLDQTCIHP ESYDIAMRFL SSIGGTLYEV 
       860        870        880        890        900
GKPEMQQKIN SFLEKEGMEK IAERLQTTVH TLQVIIDGLS QPESFDFRTD 
       910        920        930        940        950
FDKPDFKRSI VCLEDLQIGT VLTGKVENAT LFGIFVDIGV GKSGLIPIRN 
       960        970        980        990 
VTEAKLSKTK KRRSLGLGPG ERVEVQVLNI DIPRSRITLD LIRVL
Length:995
Mass (Da):111,776
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB286FB734708C55
GO
Isoform 2 (identifier: Q8N5C6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-375: Missing.

Show »
Length:620
Mass (Da):69,714
Checksum:iFB472BF51F89E75F
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY14821 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti597N → S in BAA91577 (PubMed:14702039).Curated1
Sequence conflicti638S → G in AK056536 (PubMed:14702039).Curated1
Sequence conflicti795S → P in BAA91577 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056995361T → M. Corresponds to variant dbSNP:rs6544834Ensembl.1
Natural variantiVAR_056996798V → F. Corresponds to variant dbSNP:rs3755073Ensembl.1
Natural variantiVAR_056997811K → R. Corresponds to variant dbSNP:rs3755072Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0244611 – 375Missing in isoform 2. 2 PublicationsAdd BLAST375

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK001241 mRNA Translation: BAA91577.1
AK056536 mRNA No translation available.
AC012072 Genomic DNA Translation: AAY14821.1 Sequence problems.
AC008179 Genomic DNA Translation: AAK52078.1
BC032538 mRNA Translation: AAH32538.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1823.1 [Q8N5C6-1]

NCBI Reference Sequences

More...RefSeqi		NP_060549.4, NM_018079.4 [Q8N5C6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263736; ENSP00000263736; ENSG00000068784 [Q8N5C6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55133

UCSC genome browser

More...UCSCi		uc002rus.4, human [Q8N5C6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001241 mRNA Translation: BAA91577.1
AK056536 mRNA No translation available.
AC012072 Genomic DNA Translation: AAY14821.1 Sequence problems.
AC008179 Genomic DNA Translation: AAK52078.1
BC032538 mRNA Translation: AAH32538.1
CCDSiCCDS1823.1 [Q8N5C6-1]
RefSeqiNP_060549.4, NM_018079.4 [Q8N5C6-1]

3D structure databases

SMRiQ8N5C6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120439, 59 interactors
IntActiQ8N5C6, 30 interactors
MINTiQ8N5C6
STRINGi9606.ENSP00000263736

PTM databases

iPTMnetiQ8N5C6
PhosphoSitePlusiQ8N5C6

Genetic variation databases

BioMutaiSRBD1
DMDMi145566960

Proteomic databases

EPDiQ8N5C6
jPOSTiQ8N5C6
MassIVEiQ8N5C6
MaxQBiQ8N5C6
PaxDbiQ8N5C6
PeptideAtlasiQ8N5C6
PRIDEiQ8N5C6
ProteomicsDBi72030 [Q8N5C6-1]
72031 [Q8N5C6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29937, 118 antibodies

The DNASU plasmid repository

More...DNASUi		55133

Genome annotation databases

EnsembliENST00000263736; ENSP00000263736; ENSG00000068784 [Q8N5C6-1]
GeneIDi55133
KEGGihsa:55133
UCSCiuc002rus.4, human [Q8N5C6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55133
DisGeNETi55133

GeneCards: human genes, protein and diseases

More...GeneCardsi		SRBD1
HGNCiHGNC:25521, SRBD1
HPAiENSG00000068784, Low tissue specificity
neXtProtiNX_Q8N5C6
OpenTargetsiENSG00000068784
PharmGKBiPA144596269
VEuPathDBiHostDB:ENSG00000068784.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1857, Eukaryota
GeneTreeiENSGT00510000047850
HOGENOMiCLU_009833_1_0_1
InParanoidiQ8N5C6
OMAiRWAWRTR
OrthoDBi56990at2759
PhylomeDBiQ8N5C6
TreeFamiTF313600

Enzyme and pathway databases

PathwayCommonsiQ8N5C6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55133, 724 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SRBD1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55133
PharosiQ8N5C6, Tbio

Protein Ontology

More...PROi		PR:Q8N5C6
RNActiQ8N5C6, protein

Gene expression databases

BgeeiENSG00000068784, Expressed in stomach and 181 other tissues
GenevisibleiQ8N5C6, HS

Family and domain databases

CDDicd05685, S1_Tex, 1 hit
Gene3Di1.10.10.650, 1 hit
1.10.3500.10, 1 hit
3.30.420.140, 1 hit
InterProiView protein in InterPro
IPR041692, HHH_9
IPR012340, NA-bd_OB-fold
IPR012337, RNaseH-like_sf
IPR010994, RuvA_2-like
IPR022967, S1_dom
IPR003029, S1_domain
IPR044146, S1_Tex
IPR023323, Tex-like_dom_sf
IPR023319, Tex-like_HTH_dom_sf
IPR018974, Tex-like_N
IPR032639, Tex_YqgF
IPR006641, YqgF/RNaseH-like_dom
IPR037027, YqgF/RNaseH-like_dom_sf
PfamiView protein in Pfam
PF17674, HHH_9, 1 hit
PF00575, S1, 1 hit
PF09371, Tex_N, 1 hit
PF16921, Tex_YqgF, 1 hit
SMARTiView protein in SMART
SM00316, S1, 1 hit
SM00732, YqgFc, 1 hit
SUPFAMiSSF47781, SSF47781, 2 hits
SSF50249, SSF50249, 1 hit
SSF53098, SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50126, S1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRBD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N5C6
Secondary accession number(s): Q53T56, Q96TA4, Q9NW11
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: April 7, 2021
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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