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UniProtKB - Q8N5A5 (ZGPAT_HUMAN)

Entry version 166 (07 Apr 2021)
Sequence version 3 (15 May 2007)
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Protein

Zinc finger CCCH-type with G patch domain-containing protein

Gene

ZGPAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.1 Publication
Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri175 – 201C3H1-typePROSITE-ProRule annotationAdd BLAST27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N5A5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCCH-type with G patch domain-containing protein
Alternative name(s):
G patch domain-containing protein 6
Zinc finger CCCH domain-containing protein 9
Zinc finger and G patch domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZGPAT
Synonyms:GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, ZIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15948, ZGPAT

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N5A5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197114.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		84619

Open Targets

More...OpenTargetsi		ENSG00000197114

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134881248

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N5A5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZGPAT

Domain mapping of disease mutations (DMDM)

More...DMDMi		147744602

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002138941 – 531Zinc finger CCCH-type with G patch domain-containing proteinAdd BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei373PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8N5A5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N5A5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N5A5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N5A5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N5A5

PeptideAtlas

More...PeptideAtlasi		Q8N5A5

PRoteomics IDEntifications database

More...PRIDEi		Q8N5A5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		72025 [Q8N5A5-1]
72026 [Q8N5A5-2]
72027 [Q8N5A5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N5A5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N5A5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in breast carcinomas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197114, Expressed in liver and 117 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N5A5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N5A5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197114, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHD4/Mi-2; the interaction is direct.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8N5A5
With#Exp.IntAct
AIMP2 [Q13155]3EBI-3439227,EBI-745226
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-3439227,EBI-10187270
BEND5 [Q7L4P6]3EBI-3439227,EBI-724373
BLZF1 [Q9H2G9]3EBI-3439227,EBI-2548012
CCDC57 [Q2TAC2]3EBI-3439227,EBI-2808286
CCNDBP1 [O95273]4EBI-3439227,EBI-748961
CEP70 [Q8NHQ1]4EBI-3439227,EBI-739624
DHX15 [O43143]6EBI-3439227,EBI-1237044
DYDC1 [Q8WWB3]3EBI-3439227,EBI-740680
FAM9B [Q8IZU0]3EBI-3439227,EBI-10175124
GOLGA2 [Q08379]3EBI-3439227,EBI-618309
IKZF3 [Q9UKT9]3EBI-3439227,EBI-747204
KIFC3 [Q9BVG8]4EBI-3439227,EBI-2125614
KRT15 [P19012]3EBI-3439227,EBI-739566
KRT40 [Q6A162]3EBI-3439227,EBI-10171697
LDOC1 [O95751]5EBI-3439227,EBI-740738
LZTS2 [Q9BRK4]3EBI-3439227,EBI-741037
MID2 - isoform 2 [Q9UJV3-2]3EBI-3439227,EBI-10172526
MIPOL1 [Q8TD10]3EBI-3439227,EBI-2548751
PHC2 [Q8IXK0]3EBI-3439227,EBI-713786
SSX2IP [Q9Y2D8]4EBI-3439227,EBI-2212028
STAC3 [Q96MF2]3EBI-3439227,EBI-745680
TFIP11 [Q9UBB9]5EBI-3439227,EBI-1105213
TLE5 [Q08117]4EBI-3439227,EBI-717810
TP53BP2 - isoform 3 [Q13625-3]3EBI-3439227,EBI-10175039
TRIM27 [P14373]4EBI-3439227,EBI-719493
TRIM54 [Q9BYV2]3EBI-3439227,EBI-2130429
ZBTB8A [Q96BR9]3EBI-3439227,EBI-742740
Isoform 2 [Q8N5A5-2]
With#Exp.IntAct
AIMP2 [Q13155]12EBI-10183064,EBI-745226
AMOTL2 [Q9Y2J4]3EBI-10183064,EBI-746752
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-10183064,EBI-10187270
BLZF1 [Q9H2G9]6EBI-10183064,EBI-2548012
C1D [Q13901]3EBI-10183064,EBI-3844053
CARD9 - isoform 2 [Q9H257-2]3EBI-10183064,EBI-11530605
CAVIN4 [Q5BKX8]3EBI-10183064,EBI-12836558
CCDC13 [Q8IYE1]3EBI-10183064,EBI-10961312
CCDC196 [A0A1B0GWI1]3EBI-10183064,EBI-10181422
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-10183064,EBI-10961624
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-10183064,EBI-10175300
CDCA7L [Q96GN5]9EBI-10183064,EBI-5278764
CDR2 [Q01850]6EBI-10183064,EBI-1181367
CEP70 [Q8NHQ1]9EBI-10183064,EBI-739624
CNKSR1 [Q969H4]3EBI-10183064,EBI-741671
CTNNA3 - isoform 2 [Q9UI47-2]3EBI-10183064,EBI-11962928
DHX15 [O43143]12EBI-10183064,EBI-1237044
EP400 [A0A0A0MR80]3EBI-10183064,EBI-12089140
FAM9B [Q8IZU0]3EBI-10183064,EBI-10175124
GATAD2B [Q8WXI9]3EBI-10183064,EBI-923440
GOLGA2 [Q08379]12EBI-10183064,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-10183064,EBI-5916454
HOOK2 - isoform 2 [Q96ED9-2]3EBI-10183064,EBI-10961706
HSF2BP [O75031]3EBI-10183064,EBI-7116203
IKZF3 [Q9UKT9]3EBI-10183064,EBI-747204
KIAA1328 [Q86T90]5EBI-10183064,EBI-3437878
KIFC3 [Q9BVG8]3EBI-10183064,EBI-2125614
KIFC3 - isoform 4 [Q9BVG8-5]6EBI-10183064,EBI-14069005
KRT15 [P19012]3EBI-10183064,EBI-739566
KRT31 [Q15323]3EBI-10183064,EBI-948001
KRT40 [Q6A162]6EBI-10183064,EBI-10171697
LCA5L [O95447]3EBI-10183064,EBI-8473670
LDOC1 [O95751]3EBI-10183064,EBI-740738
LNX1 [Q8TBB1]3EBI-10183064,EBI-739832
LZTS1 [Q9Y250]3EBI-10183064,EBI-1216080
LZTS2 [Q9BRK4]9EBI-10183064,EBI-741037
MID2 - isoform 2 [Q9UJV3-2]9EBI-10183064,EBI-10172526
MIPOL1 [Q8TD10]6EBI-10183064,EBI-2548751
MNS1 [Q8NEH6]3EBI-10183064,EBI-743811
NEBL [O76041]3EBI-10183064,EBI-2880203
OPTN [Q96CV9]3EBI-10183064,EBI-748974
PHC2 [Q8IXK0]3EBI-10183064,EBI-713786
PPP1R13B [Q96KQ4]3EBI-10183064,EBI-1105153
S100A10 [P60903]3EBI-10183064,EBI-717048
SCNM1 [Q9BWG6]3EBI-10183064,EBI-748391
SERTAD3 [Q9UJW9]3EBI-10183064,EBI-748621
SNRPA1 [P09661]3EBI-10183064,EBI-876439
SSX2IP [Q9Y2D8]3EBI-10183064,EBI-2212028
STAC3 [Q96MF2]3EBI-10183064,EBI-745680
TADA2B - isoform 3 [Q86TJ2-3]3EBI-10183064,EBI-18173581
TCF19 [Q9Y242]3EBI-10183064,EBI-7413767
TFIP11 [Q9UBB9]9EBI-10183064,EBI-1105213
THAP1 [Q9NVV9]3EBI-10183064,EBI-741515
THAP6 [Q8TBB0]3EBI-10183064,EBI-3925505
TLE5 [Q08117]3EBI-10183064,EBI-717810
TLE5 - isoform 2 [Q08117-2]9EBI-10183064,EBI-11741437
TP53BP2 [Q05BL1]6EBI-10183064,EBI-11952721
TP53BP2 - isoform 3 [Q13625-3]3EBI-10183064,EBI-10175039
TRIM14 [Q14142]3EBI-10183064,EBI-2820256
TRIM27 [P14373]9EBI-10183064,EBI-719493
UBXN11 - isoform 6 [Q5T124-6]3EBI-10183064,EBI-11524408
ZC2HC1B [Q5TFG8]3EBI-10183064,EBI-12275374
ZNF177 - isoform 2 [Q13360-2]3EBI-10183064,EBI-12272076
ZNF24 [P17028]3EBI-10183064,EBI-707773
ZNF329 [Q86UD4]3EBI-10183064,EBI-7233259
ZNF35 [P13682]3EBI-10183064,EBI-11041653
ZNF426 [Q9BUY5]3EBI-10183064,EBI-743265
ZNF587 [Q96SQ5]3EBI-10183064,EBI-6427977
ZNF688 [P0C7X2]3EBI-10183064,EBI-4395732
ZNF71 [Q9NQZ8]3EBI-10183064,EBI-7138235
ZSCAN22 [P10073]3EBI-10183064,EBI-10178224
ZXDB [P98169]3EBI-10183064,EBI-17493569

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124150, 136 interactors

Protein interaction database and analysis system

More...IntActi		Q8N5A5, 113 interactors

Molecular INTeraction database

More...MINTi		Q8N5A5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000332013

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N5A5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1531
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N5A5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini333 – 379G-patchPROSITE-ProRule annotationAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi119 – 128Poly-Glu10

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri175 – 201C3H1-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2185, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000732

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_040504_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N5A5

Identification of Orthologs from Complete Genome Data

More...OMAi		QMGYEFG

Database of Orthologous Groups

More...OrthoDBi		1238995at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N5A5

TreeFam database of animal gene trees

More...TreeFami		TF105970

Family and domain databases

Conserved Domains Database

More...CDDi		cd04508, TUDOR, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000467, G_patch_dom
IPR002999, Tudor
IPR043560, ZGPAT
IPR041367, Znf-CCCH_4
IPR000571, Znf_CCCH
IPR036855, Znf_CCCH_sf

The PANTHER Classification System

More...PANTHERi		PTHR46297, PTHR46297, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01585, G-patch, 1 hit
PF18044, zf-CCCH_4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00443, G_patch, 1 hit
SM00356, ZnF_C3H1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF90229, SSF90229, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50174, G_PATCH, 1 hit
PS50103, ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N5A5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEESLESAL QTYRAQLQQV ELALGAGLDS SEQADLRQLQ GDLKELIELT 
        60         70         80         90        100
EASLVSVRKS SLLAALDEER PGRQEDAEYQ AFREAITEAV EAPAAARGSG 
       110        120        130        140        150
SETVPKAEAG PESAAGGQEE EEGEDEEELS GTKVSAPYYS SWGTLEYHNA 
       160        170        180        190        200
MVVGTEEAED GSAGVRVLYL YPTHKSLKPC PFFLEGKCRF KENCRFSHGQ 
       210        220        230        240        250
VVSLDELRPF QDPDLSSLQA GSACLAKHQD GLWHAARITD VDNGYYTVKF 
       260        270        280        290        300
DSLLLREAVV EGDGILPPLR TEATESDSDS DGTGDSSYAR VVGSDAVDSA 
       310        320        330        340        350
QSSALCPSLA VVGSDAVDSG TCSSAFAGWE VHTRGIGSRL LTKMGYEFGK 
       360        370        380        390        400
GLGRHAEGRV EPIHAVVLPR GKSLDQCVET LQKQTRVGKA GTNKPPRCRG 
       410        420        430        440        450
RGARPGGRPA PRNVFDFLNE KLQGQAPGAL EAGAAPAGRR SKDMYHASKS 
       460        470        480        490        500
AKRALSLRLF QTEEKIERTQ RDIRSIQEAL ARNAGRHSVA SAQLQEKLAG 
       510        520        530 
AQRQLGQLRA QEAGLQQEQR KADTHKKMTE F
Length:531
Mass (Da):57,359
Last modified:May 15, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36572156BABDA876
GO
Isoform 2 (identifier: Q8N5A5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     291-310: Missing.

Show »
Length:511
Mass (Da):55,500
Checksum:i5007C362ECC2CD79
GO
Isoform 3 (identifier: Q8N5A5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     282-310: Missing.

Show »
Length:502
Mass (Da):54,605
Checksum:i8DD60FEEDB37D2F9
GO
Isoform 4 (identifier: Q8N5A5-4) [UniParc]FASTAAdd to basket
Also known as: sZIP

The sequence of this isoform differs from the canonical sequence as follows:
     1-343: Missing.

Show »
Length:188
Mass (Da):20,697
Checksum:i00ABC2D9BC65E7C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RGY1X6RGY1_HUMAN
Zinc finger CCCH-type with G patch ...
ZGPAT
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47476 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC11317 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti184L → Q in BAB55426 (PubMed:14702039).Curated1
Sequence conflicti188C → R in BAC11317 (PubMed:14702039).Curated1
Sequence conflicti344M → V in BAB55426 (PubMed:14702039).Curated1
Sequence conflicti433G → R in AAH19338 (PubMed:15489334).Curated1
Sequence conflicti519Q → R in BAB55426 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02553961S → R4 PublicationsCorresponds to variant dbSNP:rs1291212Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0535991 – 343Missing in isoform 4. CuratedAdd BLAST343
Alternative sequenceiVSP_038121282 – 310Missing in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_007754291 – 310Missing in isoform 2. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB058750 mRNA Translation: BAB47476.3 Different initiation.
AK027878 mRNA Translation: BAB55426.1
AK074961 mRNA Translation: BAC11317.1 Frameshift.
AL121845 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75223.1
CH471077 Genomic DNA Translation: EAW75226.1
BC019338 mRNA Translation: AAH19338.1
BC032612 mRNA Translation: AAH32612.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13534.1 [Q8N5A5-1]
CCDS13535.1 [Q8N5A5-2]
CCDS56203.1 [Q8N5A5-3]

NCBI Reference Sequences

More...RefSeqi		NP_001076582.1, NM_001083113.1 [Q8N5A5-2]
NP_001182582.1, NM_001195653.1 [Q8N5A5-2]
NP_001182583.1, NM_001195654.1 [Q8N5A5-3]
NP_115916.3, NM_032527.4 [Q8N5A5-1]
NP_852150.2, NM_181485.2 [Q8N5A5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000328969; ENSP00000332013; ENSG00000197114 [Q8N5A5-1]
ENST00000355969; ENSP00000348242; ENSG00000197114 [Q8N5A5-2]
ENST00000357119; ENSP00000349634; ENSG00000197114 [Q8N5A5-3]
ENST00000369967; ENSP00000358984; ENSG00000197114 [Q8N5A5-2]
ENST00000448100; ENSP00000391176; ENSG00000197114 [Q8N5A5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84619

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84619

UCSC genome browser

More...UCSCi		uc002ygi.3, human [Q8N5A5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058750 mRNA Translation: BAB47476.3 Different initiation.
AK027878 mRNA Translation: BAB55426.1
AK074961 mRNA Translation: BAC11317.1 Frameshift.
AL121845 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75223.1
CH471077 Genomic DNA Translation: EAW75226.1
BC019338 mRNA Translation: AAH19338.1
BC032612 mRNA Translation: AAH32612.1
CCDSiCCDS13534.1 [Q8N5A5-1]
CCDS13535.1 [Q8N5A5-2]
CCDS56203.1 [Q8N5A5-3]
RefSeqiNP_001076582.1, NM_001083113.1 [Q8N5A5-2]
NP_001182582.1, NM_001195653.1 [Q8N5A5-2]
NP_001182583.1, NM_001195654.1 [Q8N5A5-3]
NP_115916.3, NM_032527.4 [Q8N5A5-1]
NP_852150.2, NM_181485.2 [Q8N5A5-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4II1X-ray2.65A/B/C/D120-268[»]
SMRiQ8N5A5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124150, 136 interactors
IntActiQ8N5A5, 113 interactors
MINTiQ8N5A5
STRINGi9606.ENSP00000332013

PTM databases

iPTMnetiQ8N5A5
PhosphoSitePlusiQ8N5A5

Genetic variation databases

BioMutaiZGPAT
DMDMi147744602

Proteomic databases

EPDiQ8N5A5
jPOSTiQ8N5A5
MassIVEiQ8N5A5
MaxQBiQ8N5A5
PaxDbiQ8N5A5
PeptideAtlasiQ8N5A5
PRIDEiQ8N5A5
ProteomicsDBi72025 [Q8N5A5-1]
72026 [Q8N5A5-2]
72027 [Q8N5A5-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q8N5A5, 5 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29857, 113 antibodies

The DNASU plasmid repository

More...DNASUi		84619

Genome annotation databases

EnsembliENST00000328969; ENSP00000332013; ENSG00000197114 [Q8N5A5-1]
ENST00000355969; ENSP00000348242; ENSG00000197114 [Q8N5A5-2]
ENST00000357119; ENSP00000349634; ENSG00000197114 [Q8N5A5-3]
ENST00000369967; ENSP00000358984; ENSG00000197114 [Q8N5A5-2]
ENST00000448100; ENSP00000391176; ENSG00000197114 [Q8N5A5-2]
GeneIDi84619
KEGGihsa:84619
UCSCiuc002ygi.3, human [Q8N5A5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84619
DisGeNETi84619

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZGPAT
HGNCiHGNC:15948, ZGPAT
HPAiENSG00000197114, Tissue enhanced (liver)
neXtProtiNX_Q8N5A5
OpenTargetsiENSG00000197114
PharmGKBiPA134881248
VEuPathDBiHostDB:ENSG00000197114.11

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2185, Eukaryota
GeneTreeiENSGT00390000000732
HOGENOMiCLU_040504_1_0_1
InParanoidiQ8N5A5
OMAiQMGYEFG
OrthoDBi1238995at2759
PhylomeDBiQ8N5A5
TreeFamiTF105970

Enzyme and pathway databases

PathwayCommonsiQ8N5A5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84619, 14 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZGPAT, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZGPAT

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84619
PharosiQ8N5A5, Tbio

Protein Ontology

More...PROi		PR:Q8N5A5
RNActiQ8N5A5, protein

Gene expression databases

BgeeiENSG00000197114, Expressed in liver and 117 other tissues
ExpressionAtlasiQ8N5A5, baseline and differential
GenevisibleiQ8N5A5, HS

Family and domain databases

CDDicd04508, TUDOR, 1 hit
InterProiView protein in InterPro
IPR000467, G_patch_dom
IPR002999, Tudor
IPR043560, ZGPAT
IPR041367, Znf-CCCH_4
IPR000571, Znf_CCCH
IPR036855, Znf_CCCH_sf
PANTHERiPTHR46297, PTHR46297, 1 hit
PfamiView protein in Pfam
PF01585, G-patch, 1 hit
PF18044, zf-CCCH_4, 1 hit
SMARTiView protein in SMART
SM00443, G_patch, 1 hit
SM00356, ZnF_C3H1, 1 hit
SUPFAMiSSF90229, SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50174, G_PATCH, 1 hit
PS50103, ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZGPAT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N5A5
Secondary accession number(s): E1P5K1
, Q4VXN9, Q5JWI9, Q5JWJ0, Q8NC55, Q8WUV4, Q96JI0, Q96JU4, Q9H401
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: May 15, 2007
Last modified: April 7, 2021
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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