ZGPAT

Functionⁱ

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.1 Publication

Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	175 – 201	C3H1-typePROSITE-ProRule annotationAdd BLAST		27

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19644445
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 19644445
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 19644445
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19644445

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of epidermal growth factor-activated receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19644445
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 19644445
negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 19644445

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger CCCH-type with G patch domain-containing protein Alternative name(s): G patch domain-containing protein 6 Zinc finger CCCH domain-containing protein 9 Zinc finger and G patch domain-containing protein
Gene namesⁱ	Name:ZGPAT Synonyms:GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, ZIP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197114.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15948 ZGPAT
neXtProtⁱ	NX_Q8N5A5

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84619
Open Targets More...OpenTargetsⁱ	ENSG00000197114
PharmGKBⁱ	PA134881248

Polymorphism and mutation databases

BioMutaⁱ	ZGPAT
DMDMⁱ	147744602

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000213894	1 – 531	Zinc finger CCCH-type with G patch domain-containing proteinAdd BLAST		531

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1
Modified residueⁱ	373	PhosphoserineBy similarity		1

Post-translational modificationⁱ

Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8N5A5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N5A5
PaxDbⁱ	Q8N5A5
PeptideAtlas More...PeptideAtlasⁱ	Q8N5A5
PRIDEⁱ	Q8N5A5
ProteomicsDBⁱ	72025 72026 [Q8N5A5-2] 72027 [Q8N5A5-3]

PTM databases

iPTMnetⁱ	Q8N5A5
PhosphoSitePlusⁱ	Q8N5A5

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Inductionⁱ

Down-regulated in breast carcinomas.

Gene expression databases

Bgeeⁱ	ENSG00000197114 Expressed in 93 organ(s), highest expression level in liver
CleanExⁱ	HS_ZGPAT
ExpressionAtlasⁱ	Q8N5A5 baseline and differential
Genevisibleⁱ	Q8N5A5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA056705

HPAⁱ

HPA056705

Interactionⁱ

Subunit structureⁱ

Interacts with CHD4/Mi-2; the interaction is direct.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AES	Q08117	3	EBI-3439227,EBI-717810
AES	Q08117-2	7	EBI-10183064,EBI-11741437
AIMP2	Q13155	8	EBI-10183064,EBI-745226
AMOTL2	Q9Y2J4	3	EBI-10183064,EBI-746752
AMOTL2	Q9Y2J4-4	3	EBI-3439227,EBI-10187270
BEND5	Q7L4P6	3	EBI-3439227,EBI-724373
BLZF1	Q9H2G9	6	EBI-10183064,EBI-2548012
CCDC57	Q2TAC2	3	EBI-3439227,EBI-2808286
CCNDBP1	O95273	4	EBI-3439227,EBI-748961
CDCA7L	Q96GN5	7	EBI-10183064,EBI-5278764
CDR2	Q01850	5	EBI-10183064,EBI-1181367
CEP70	Q8NHQ1	8	EBI-10183064,EBI-739624
DHX15	O43143	10	EBI-10183064,EBI-1237044
DYDC1	Q8WWB3	3	EBI-3439227,EBI-740680
FAM9B	Q8IZU0	3	EBI-3439227,EBI-10175124
GOLGA2	Q08379	11	EBI-10183064,EBI-618309
IKZF3	Q9UKT9	3	EBI-10183064,EBI-747204
KIFC3	Q9BVG8	4	EBI-3439227,EBI-2125614
KIFC3	Q9BVG8-5	5	EBI-10183064,EBI-14069005
KRT15	P19012	3	EBI-10183064,EBI-739566
KRT40	Q6A162	6	EBI-10183064,EBI-10171697
LDOC1	O95751	3	EBI-3439227,EBI-740738
LZTS2	Q9BRK4	8	EBI-10183064,EBI-741037
MID2	Q9UJV3-2	8	EBI-10183064,EBI-10172526
MIPOL1	Q8TD10	6	EBI-10183064,EBI-2548751
NEBL	O76041	3	EBI-10183064,EBI-2880203
PHC2	Q8IXK0	3	EBI-3439227,EBI-713786
SSX2IP	Q9Y2D8	4	EBI-3439227,EBI-2212028
STAC3	Q96MF2	3	EBI-3439227,EBI-745680
TFIP11	Q9UBB9	8	EBI-10183064,EBI-1105213
TP53BP2	Q05BL1	5	EBI-10183064,EBI-11952721
TP53BP2	Q13625-3	3	EBI-10183064,EBI-10175039
TRIM27	P14373	8	EBI-10183064,EBI-719493
TRIM54	Q9BYV2	3	EBI-3439227,EBI-2130429
ZBTB8A	Q96BR9	3	EBI-3439227,EBI-742740

Protein-protein interaction databases

BioGridⁱ	124150, 61 interactors
IntActⁱ	Q8N5A5, 89 interactors
Molecular INTeraction database More...MINTⁱ	Q8N5A5
STRINGⁱ	9606.ENSP00000332013

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	133 – 138	Combined sources	6
Beta strandⁱ	146 – 157	Combined sources	12
Beta strandⁱ	163 – 171	Combined sources	9
Helixⁱ	175 – 177	Combined sources	3
Helixⁱ	183 – 185	Combined sources	3
Beta strandⁱ	195 – 197	Combined sources	3
Beta strandⁱ	200 – 203	Combined sources	4
Helixⁱ	204 – 206	Combined sources	3
Beta strandⁱ	223 – 227	Combined sources	5
Beta strandⁱ	233 – 244	Combined sources	12
Beta strandⁱ	246 – 252	Combined sources	7
Beta strandⁱ	258 – 260	Combined sources	3
Helixⁱ	262 – 264	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8N5A5
SMRⁱ	Q8N5A5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	333 – 379	G-patchPROSITE-ProRule annotationAdd BLAST		47

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	119 – 128	Poly-Glu		10

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	175 – 201	C3H1-typePROSITE-ProRule annotationAdd BLAST		27

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2185 Eukaryota ENOG410Z4ZI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000732
HOVERGENⁱ	HBG056371
InParanoidⁱ	Q8N5A5
OMAⁱ	HNAMIVG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FZN
PhylomeDBⁱ	Q8N5A5
TreeFamⁱ	TF105970

Family and domain databases

InterProⁱ	View protein in InterPro IPR000467 G_patch_dom IPR000571 Znf_CCCH IPR036855 Znf_CCCH_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01585 G-patch, 1 hit
SMARTⁱ	View protein in SMART SM00443 G_patch, 1 hit SM00356 ZnF_C3H1, 1 hit
SUPFAMⁱ	SSF90229 SSF90229, 1 hit
PROSITEⁱ	View protein in PROSITE PS50174 G_PATCH, 1 hit PS50103 ZF_C3H1, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8N5A5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEESLESAL QTYRAQLQQV ELALGAGLDS SEQADLRQLQ GDLKELIELT 
        60         70         80         90        100
EASLVSVRKS SLLAALDEER PGRQEDAEYQ AFREAITEAV EAPAAARGSG 
       110        120        130        140        150
SETVPKAEAG PESAAGGQEE EEGEDEEELS GTKVSAPYYS SWGTLEYHNA 
       160        170        180        190        200
MVVGTEEAED GSAGVRVLYL YPTHKSLKPC PFFLEGKCRF KENCRFSHGQ 
       210        220        230        240        250
VVSLDELRPF QDPDLSSLQA GSACLAKHQD GLWHAARITD VDNGYYTVKF 
       260        270        280        290        300
DSLLLREAVV EGDGILPPLR TEATESDSDS DGTGDSSYAR VVGSDAVDSA 
       310        320        330        340        350
QSSALCPSLA VVGSDAVDSG TCSSAFAGWE VHTRGIGSRL LTKMGYEFGK 
       360        370        380        390        400
GLGRHAEGRV EPIHAVVLPR GKSLDQCVET LQKQTRVGKA GTNKPPRCRG 
       410        420        430        440        450
RGARPGGRPA PRNVFDFLNE KLQGQAPGAL EAGAAPAGRR SKDMYHASKS 
       460        470        480        490        500
AKRALSLRLF QTEEKIERTQ RDIRSIQEAL ARNAGRHSVA SAQLQEKLAG 
       510        520        530 
AQRQLGQLRA QEAGLQQEQR KADTHKKMTE F

Note: No experimental confirmation available.

Length:531

Mass (Da):57,359

Last modified:May 15, 2007 - v3

Checksum:ⁱ36572156BABDA876

GO

Isoform 2 (identifier: Q8N5A5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
291-310: Missing.

« Hide

        10         20         30         40         50
MDEESLESAL QTYRAQLQQV ELALGAGLDS SEQADLRQLQ GDLKELIELT 
        60         70         80         90        100
EASLVSVRKS SLLAALDEER PGRQEDAEYQ AFREAITEAV EAPAAARGSG 
       110        120        130        140        150
SETVPKAEAG PESAAGGQEE EEGEDEEELS GTKVSAPYYS SWGTLEYHNA 
       160        170        180        190        200
MVVGTEEAED GSAGVRVLYL YPTHKSLKPC PFFLEGKCRF KENCRFSHGQ 
       210        220        230        240        250
VVSLDELRPF QDPDLSSLQA GSACLAKHQD GLWHAARITD VDNGYYTVKF 
       260        270        280        290        300
DSLLLREAVV EGDGILPPLR TEATESDSDS DGTGDSSYAR VVGSDAVDSG 
       310        320        330        340        350
TCSSAFAGWE VHTRGIGSRL LTKMGYEFGK GLGRHAEGRV EPIHAVVLPR 
       360        370        380        390        400
GKSLDQCVET LQKQTRVGKA GTNKPPRCRG RGARPGGRPA PRNVFDFLNE 
       410        420        430        440        450
KLQGQAPGAL EAGAAPAGRR SKDMYHASKS AKRALSLRLF QTEEKIERTQ 
       460        470        480        490        500
RDIRSIQEAL ARNAGRHSVA SAQLQEKLAG AQRQLGQLRA QEAGLQQEQR 
       510 
KADTHKKMTE F

Show »

Length:511

Mass (Da):55,500

Checksum:ⁱ5007C362ECC2CD79

GO

Isoform 3 (identifier: Q8N5A5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
282-310: Missing.

« Hide

        10         20         30         40         50
MDEESLESAL QTYRAQLQQV ELALGAGLDS SEQADLRQLQ GDLKELIELT 
        60         70         80         90        100
EASLVSVRKS SLLAALDEER PGRQEDAEYQ AFREAITEAV EAPAAARGSG 
       110        120        130        140        150
SETVPKAEAG PESAAGGQEE EEGEDEEELS GTKVSAPYYS SWGTLEYHNA 
       160        170        180        190        200
MVVGTEEAED GSAGVRVLYL YPTHKSLKPC PFFLEGKCRF KENCRFSHGQ 
       210        220        230        240        250
VVSLDELRPF QDPDLSSLQA GSACLAKHQD GLWHAARITD VDNGYYTVKF 
       260        270        280        290        300
DSLLLREAVV EGDGILPPLR TEATESDSDS DVVGSDAVDS GTCSSAFAGW 
       310        320        330        340        350
EVHTRGIGSR LLTKMGYEFG KGLGRHAEGR VEPIHAVVLP RGKSLDQCVE 
       360        370        380        390        400
TLQKQTRVGK AGTNKPPRCR GRGARPGGRP APRNVFDFLN EKLQGQAPGA 
       410        420        430        440        450
LEAGAAPAGR RSKDMYHASK SAKRALSLRL FQTEEKIERT QRDIRSIQEA 
       460        470        480        490        500
LARNAGRHSV ASAQLQEKLA GAQRQLGQLR AQEAGLQQEQ RKADTHKKMT 

EF

Note: No experimental confirmation available.

Show »

Length:502

Mass (Da):54,605

Checksum:ⁱ8DD60FEEDB37D2F9

GO

Isoform 4 (identifier: Q8N5A5-4) [UniParc]FASTA Add to basket

Also known as: sZIP

The sequence of this isoform differs from the canonical sequence as follows:
1-343: Missing.

« Hide

        10         20         30         40         50
MGYEFGKGLG RHAEGRVEPI HAVVLPRGKS LDQCVETLQK QTRVGKAGTN 
        60         70         80         90        100
KPPRCRGRGA RPGGRPAPRN VFDFLNEKLQ GQAPGALEAG AAPAGRRSKD 
       110        120        130        140        150
MYHASKSAKR ALSLRLFQTE EKIERTQRDI RSIQEALARN AGRHSVASAQ 
       160        170        180 
LQEKLAGAQR QLGQLRAQEA GLQQEQRKAD THKKMTEF

Show »

Length:188

Mass (Da):20,697

Checksum:ⁱ00ABC2D9BC65E7C9

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	X6RGY1	X6RGY1_HUMAN		Zinc finger CCCH-type with G patch ... Zinc finger CCCH-type with G patch domain-containing protein	ZGPAT	97	Annotation score:

Sequence cautionⁱ

The sequence BAB47476 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence BAC11317 differs from that shown. Reason: Frameshift at position 290.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	184	L → Q in BAB55426 (PubMed:14702039).Curated	1
Sequence conflictⁱ	188	C → R in BAC11317 (PubMed:14702039).Curated	1
Sequence conflictⁱ	344	M → V in BAB55426 (PubMed:14702039).Curated	1
Sequence conflictⁱ	433	G → R in AAH19338 (PubMed:15489334).Curated	1
Sequence conflictⁱ	519	Q → R in BAB55426 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_025539	61	S → R4 PublicationsCorresponds to variant dbSNP:rs1291212Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053599	1 – 343	Missing in isoform 4. CuratedAdd BLAST	343
Alternative sequenceⁱVSP_038121	282 – 310	Missing in isoform 3. 1 PublicationAdd BLAST	29
Alternative sequenceⁱVSP_007754	291 – 310	Missing in isoform 2. 2 PublicationsAdd BLAST	20

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB058750 mRNA Translation: BAB47476.3 Different initiation. AK027878 mRNA Translation: BAB55426.1 AK074961 mRNA Translation: BAC11317.1 Frameshift. AL121845 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75223.1 CH471077 Genomic DNA Translation: EAW75226.1 BC019338 mRNA Translation: AAH19338.1 BC032612 mRNA Translation: AAH32612.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13534.1 [Q8N5A5-1] CCDS13535.1 [Q8N5A5-2] CCDS56203.1 [Q8N5A5-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001076582.1, NM_001083113.1 [Q8N5A5-2] NP_001182582.1, NM_001195653.1 [Q8N5A5-2] NP_001182583.1, NM_001195654.1 [Q8N5A5-3] NP_115916.3, NM_032527.4 [Q8N5A5-1] NP_852150.2, NM_181485.2 [Q8N5A5-2]
UniGeneⁱ	Hs.590868

Genome annotation databases

Ensemblⁱ	ENST00000328969; ENSP00000332013; ENSG00000197114 [Q8N5A5-1] ENST00000355969; ENSP00000348242; ENSG00000197114 [Q8N5A5-2] ENST00000357119; ENSP00000349634; ENSG00000197114 [Q8N5A5-3] ENST00000369967; ENSP00000358984; ENSG00000197114 [Q8N5A5-2] ENST00000448100; ENSP00000391176; ENSG00000197114 [Q8N5A5-2]
GeneIDⁱ	84619
KEGGⁱ	hsa:84619
UCSC genome browser More...UCSCⁱ	uc002ygi.3 human [Q8N5A5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8N5A5	Zinc finger CCCH-type with G patch domain-containing protein (Fragment)		HUMAN		97	UniRef100_Q8N5A5
Isoform 4 of Zinc finger CCCH-type with G patch domain-containing protein		HUMAN		188
Q8N5A5-2	Zinc finger CCCH-type with G patch domain isoform 1 (Fragment)		HUMAN		511	UniRef100_Q8N5A5-2

Protein	Similar proteins		Species	Score	Length	Source
Q8N5A5	Zinc finger CCCH-type with G patch domain-containing protein (Fragment)		HUMAN		97	UniRef90_Q8N5A5
Zinc finger CCCH-type and G-patch domain containing		PANTR		531
Uncharacterized protein		PANPA		531
Zinc finger CCCH-type and G-patch domain containing		GORGO		531
Zinc finger CCCH-type and G-patch domain containing		CHLSB		530
+3
Q8N5A5-2	Zinc finger CCCH-type with G patch domain isoform 1 (Fragment)		HUMAN		511	UniRef90_Q8N5A5-2
Uncharacterized protein		PAPAN		527
Zinc finger and G patch domain-containing protein		MACMU		522
Uncharacterized protein		NOMLE		520
Zinc finger, CCCH-type with G patch domain		PANTR		511
+45
Q8N5A5-3	Isoform 2 of Zinc finger CCCH-type with G patch domain-containing protein		HUMAN		511	UniRef90_Q8N5A5-2
Uncharacterized protein		PAPAN		527
Zinc finger and G patch domain-containing protein		MACMU		522
Uncharacterized protein		NOMLE		520
Zinc finger, CCCH-type with G patch domain		PANTR		511
+45

Protein	Similar proteins		Species	Score	Length	Source
Q8N5A5	Zinc finger CCCH-type with G patch domain-containing protein		BOVIN		513	UniRef50_Q8N5A5
Zinc finger CCCH-type with G patch domain-containing protein		XENTR		514
Zinc finger CCCH-type with G patch domain-containing protein		XENLA		524
Zinc finger CCCH-type with G patch domain-containing protein		SALSA		527
Zinc finger CCCH-type with G patch domain-containing protein		MOUSE		511
+381

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB058750 mRNA Translation: BAB47476.3 Different initiation. AK027878 mRNA Translation: BAB55426.1 AK074961 mRNA Translation: BAC11317.1 Frameshift. AL121845 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75223.1 CH471077 Genomic DNA Translation: EAW75226.1 BC019338 mRNA Translation: AAH19338.1 BC032612 mRNA Translation: AAH32612.1
CCDSⁱ	CCDS13534.1 [Q8N5A5-1] CCDS13535.1 [Q8N5A5-2] CCDS56203.1 [Q8N5A5-3]
RefSeqⁱ	NP_001076582.1, NM_001083113.1 [Q8N5A5-2] NP_001182582.1, NM_001195653.1 [Q8N5A5-2] NP_001182583.1, NM_001195654.1 [Q8N5A5-3] NP_115916.3, NM_032527.4 [Q8N5A5-1] NP_852150.2, NM_181485.2 [Q8N5A5-2]
UniGeneⁱ	Hs.590868

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4II1	X-ray	2.65	A/B/C/D	120-268	[»]
ProteinModelPortalⁱ	Q8N5A5
SMRⁱ	Q8N5A5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124150, 61 interactors
IntActⁱ	Q8N5A5, 89 interactors
MINTⁱ	Q8N5A5
STRINGⁱ	9606.ENSP00000332013

PTM databases

iPTMnetⁱ	Q8N5A5
PhosphoSitePlusⁱ	Q8N5A5

Polymorphism and mutation databases

BioMutaⁱ	ZGPAT
DMDMⁱ	147744602

Proteomic databases

EPDⁱ	Q8N5A5
MaxQBⁱ	Q8N5A5
PaxDbⁱ	Q8N5A5
PeptideAtlasⁱ	Q8N5A5
PRIDEⁱ	Q8N5A5
ProteomicsDBⁱ	72025 72026 [Q8N5A5-2] 72027 [Q8N5A5-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84619
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000328969; ENSP00000332013; ENSG00000197114 [Q8N5A5-1] ENST00000355969; ENSP00000348242; ENSG00000197114 [Q8N5A5-2] ENST00000357119; ENSP00000349634; ENSG00000197114 [Q8N5A5-3] ENST00000369967; ENSP00000358984; ENSG00000197114 [Q8N5A5-2] ENST00000448100; ENSP00000391176; ENSG00000197114 [Q8N5A5-2]
GeneIDⁱ	84619
KEGGⁱ	hsa:84619
UCSCⁱ	uc002ygi.3 human [Q8N5A5-1]

Organism-specific databases

CTDⁱ	84619
DisGeNETⁱ	84619
EuPathDBⁱ	HostDB:ENSG00000197114.11
GeneCardsⁱ	ZGPAT
H-InvDBⁱ	HIX0138076
HGNCⁱ	HGNC:15948 ZGPAT
HPAⁱ	HPA056705
neXtProtⁱ	NX_Q8N5A5
OpenTargetsⁱ	ENSG00000197114
PharmGKBⁱ	PA134881248
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2185 Eukaryota ENOG410Z4ZI LUCA
GeneTreeⁱ	ENSGT00390000000732
HOVERGENⁱ	HBG056371
InParanoidⁱ	Q8N5A5
OMAⁱ	HNAMIVG
OrthoDBⁱ	EOG091G0FZN
PhylomeDBⁱ	Q8N5A5
TreeFamⁱ	TF105970

Miscellaneous databases

ChiTaRSⁱ	ZGPAT human
GeneWikiⁱ	ZGPAT
GenomeRNAiⁱ	84619
Protein Ontology More...PROⁱ	PR:Q8N5A5

Gene expression databases

Bgeeⁱ	ENSG00000197114 Expressed in 93 organ(s), highest expression level in liver
CleanExⁱ	HS_ZGPAT
ExpressionAtlasⁱ	Q8N5A5 baseline and differential
Genevisibleⁱ	Q8N5A5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000467 G_patch_dom IPR000571 Znf_CCCH IPR036855 Znf_CCCH_sf
Pfamⁱ	View protein in Pfam PF01585 G-patch, 1 hit
SMARTⁱ	View protein in SMART SM00443 G_patch, 1 hit SM00356 ZnF_C3H1, 1 hit
SUPFAMⁱ	SSF90229 SSF90229, 1 hit
PROSITEⁱ	View protein in PROSITE PS50174 G_PATCH, 1 hit PS50103 ZF_C3H1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZGPAT_HUMAN
Accessionⁱ	Q8N5A5Primary (citable) accession number: Q8N5A5 Secondary accession number(s): E1P5K1 Q9H401
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
	Last sequence update:	May 15, 2007
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q8N5A5 (ZGPAT_HUMAN)

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Zinc finger CCCH-type with G patch domain-containing protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Gene expression databases

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3D structure databases

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Zinc finger

Keywords - Domaini

Phylogenomic databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ