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Protein

Zinc finger protein 561

Gene

ZNF561

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 247C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri253 – 275C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 561
Gene namesi
Name:ZNF561
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171469.10
HGNCiHGNC:28684 ZNF561
neXtProtiNX_Q8N587

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171469
PharmGKBiPA134935834

Polymorphism and mutation databases

BioMutaiZNF561
DMDMi82582592

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476501 – 486Zinc finger protein 561Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki424Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8N587
MaxQBiQ8N587
PaxDbiQ8N587
PeptideAtlasiQ8N587
PRIDEiQ8N587
ProteomicsDBi72021

PTM databases

iPTMnetiQ8N587
PhosphoSitePlusiQ8N587

Expressioni

Gene expression databases

BgeeiENSG00000171469 Expressed in 199 organ(s), highest expression level in kidney
ExpressionAtlasiQ8N587 baseline and differential
GenevisibleiQ8N587 HS

Organism-specific databases

HPAiHPA055332
HPA062397

Interactioni

Protein-protein interaction databases

BioGridi125005, 4 interactors
STRINGi9606.ENSP00000303915

Structurei

3D structure databases

ProteinModelPortaliQ8N587
SMRiQ8N587
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 112KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri118 – 140C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 247C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri253 – 275C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144146
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N587
KOiK09228
OMAiSCLNDHI
OrthoDBiEOG091G02KC
PhylomeDBiQ8N587
TreeFamiTF341966

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8N587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAIYLSRGF FSREPICPFE EKTKVERMVE DYLASGYQDS VTFDDVAVDF
60 70 80 90 100
TPEEWALLDT TEKYLYRDVM LENYMNLASV EWEIQPRTKR SSLQQGFLKN
110 120 130 140 150
QIFSGIQMTR GYSGWKLCDC KNCGEVFREQ FCLKTHMRVQ NGGNTSEGNC
160 170 180 190 200
YGKDTLSVHK EASTGQELSK FNPCGKVFTL TPGLAVHLEV LNARQPYKCK
210 220 230 240 250
ECGKGFKYFA SLDNHMGIHT DEKLCEFQEY GRAVTASSHL KQCVAVHTGK
260 270 280 290 300
KSKKTKKCGK SFTNFSQLYA PVKTHKGEKS FECKECGRSF RNSSCLNDHI
310 320 330 340 350
QIHTGIKPHK CTYCGKAFTR STQLTEHVRT HTGIKPYECK ECGQAFAQYS
360 370 380 390 400
GLSIHIRSHS GKKPYQCKEC GKAFTTSTSL IQHTRIHTGE KPYECVECGK
410 420 430 440 450
TFITSSRRSK HLKTHSGEKP FVCKICGKAF LYSSRLNVHL RTHTGEKPFV
460 470 480
CKECGKAFAV SSRLSRHERI HTGEKPYECK DMSVTI
Length:486
Mass (Da):55,197
Last modified:November 22, 2005 - v2
Checksum:i108E8C7BBAEC764C
GO
Isoform 2 (identifier: Q8N587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):39,225
Checksum:i9183026F3331593F
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IZJ4C9IZJ4_HUMAN
Zinc finger protein 561
ZNF561
287Annotation score:
C9J7U2C9J7U2_HUMAN
Zinc finger protein 561
ZNF561
76Annotation score:
F8W7U5F8W7U5_HUMAN
Zinc finger protein 561
ZNF561
90Annotation score:
A8KAD9A8KAD9_HUMAN
Zinc finger protein 561
ZNF561
417Annotation score:
F8WBU1F8WBU1_HUMAN
Zinc finger protein 561
ZNF561
61Annotation score:
F8WAU2F8WAU2_HUMAN
Zinc finger protein 561
ZNF561
38Annotation score:
C9JQP3C9JQP3_HUMAN
Zinc finger protein 561
ZNF561
41Annotation score:
F2Z3H5F2Z3H5_HUMAN
Zinc finger protein 561
ZNF561
43Annotation score:

Sequence cautioni

The sequence AAH12144 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH32668 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559641 – 136Missing in isoform 2. 1 PublicationAdd BLAST136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304383 mRNA Translation: BAG65220.1
AC008759 Genomic DNA No translation available.
BC012144 mRNA Translation: AAH12144.1 Sequence problems.
BC032668 mRNA Translation: AAH32668.1 Different initiation.
CCDSiCCDS12216.2 [Q8N587-1]
RefSeqiNP_001317294.1, NM_001330365.1
NP_689502.2, NM_152289.2 [Q8N587-1]
XP_005260207.1, XM_005260150.2 [Q8N587-1]
XP_016882968.1, XM_017027479.1
XP_016882970.1, XM_017027481.1
XP_016882971.1, XM_017027482.1 [Q8N587-2]
UniGeneiHs.720081

Genome annotation databases

EnsembliENST00000302851; ENSP00000303915; ENSG00000171469 [Q8N587-1]
GeneIDi93134
KEGGihsa:93134
UCSCiuc002mlu.4 human [Q8N587-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304383 mRNA Translation: BAG65220.1
AC008759 Genomic DNA No translation available.
BC012144 mRNA Translation: AAH12144.1 Sequence problems.
BC032668 mRNA Translation: AAH32668.1 Different initiation.
CCDSiCCDS12216.2 [Q8N587-1]
RefSeqiNP_001317294.1, NM_001330365.1
NP_689502.2, NM_152289.2 [Q8N587-1]
XP_005260207.1, XM_005260150.2 [Q8N587-1]
XP_016882968.1, XM_017027479.1
XP_016882970.1, XM_017027481.1
XP_016882971.1, XM_017027482.1 [Q8N587-2]
UniGeneiHs.720081

3D structure databases

ProteinModelPortaliQ8N587
SMRiQ8N587
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125005, 4 interactors
STRINGi9606.ENSP00000303915

PTM databases

iPTMnetiQ8N587
PhosphoSitePlusiQ8N587

Polymorphism and mutation databases

BioMutaiZNF561
DMDMi82582592

Proteomic databases

EPDiQ8N587
MaxQBiQ8N587
PaxDbiQ8N587
PeptideAtlasiQ8N587
PRIDEiQ8N587
ProteomicsDBi72021

Protocols and materials databases

DNASUi93134
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302851; ENSP00000303915; ENSG00000171469 [Q8N587-1]
GeneIDi93134
KEGGihsa:93134
UCSCiuc002mlu.4 human [Q8N587-1]

Organism-specific databases

CTDi93134
EuPathDBiHostDB:ENSG00000171469.10
GeneCardsiZNF561
HGNCiHGNC:28684 ZNF561
HPAiHPA055332
HPA062397
neXtProtiNX_Q8N587
OpenTargetsiENSG00000171469
PharmGKBiPA134935834
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144146
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N587
KOiK09228
OMAiSCLNDHI
OrthoDBiEOG091G02KC
PhylomeDBiQ8N587
TreeFamiTF341966

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii93134
PROiPR:Q8N587

Gene expression databases

BgeeiENSG00000171469 Expressed in 199 organ(s), highest expression level in kidney
ExpressionAtlasiQ8N587 baseline and differential
GenevisibleiQ8N587 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN561_HUMAN
AccessioniPrimary (citable) accession number: Q8N587
Secondary accession number(s): B4E2Q8, Q6PJS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 12, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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