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Entry version 155 (26 Feb 2020)
Sequence version 2 (20 Apr 2010)
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Protein

Oxidation resistance protein 1

Gene

OXR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in protection from oxidative damage.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processStress response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxidation resistance protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OXR1
ORF Names:Nbla00307
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15822 OXR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605609 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N573

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55074

Open Targets

More...
OpenTargetsi
ENSG00000164830

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32856

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N573 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OXR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
294862456

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002316451 – 874Oxidation resistance protein 1Add BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei91PhosphoserineCombined sources1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei201PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei334PhosphoserineBy similarity1
Modified residuei336PhosphoserineBy similarity1
Modified residuei341PhosphothreonineBy similarity1
Modified residuei346PhosphoserineBy similarity1
Modified residuei496PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N573

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N573

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N573

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N573

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N573

PeptideAtlas

More...
PeptideAtlasi
Q8N573

PRoteomics IDEntifications database

More...
PRIDEi
Q8N573

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72011 [Q8N573-1]
72012 [Q8N573-2]
72013 [Q8N573-3]
72014 [Q8N573-4]
72015 [Q8N573-5]
72016 [Q8N573-6]
72017 [Q8N573-7]
72018 [Q8N573-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N573

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N573

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By heat shock and oxidative stress.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164830 Expressed in parietal lobe and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N573 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N573 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027375
HPA027380
HPA027395

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q141453EBI-10265887,EBI-751001

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120391, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N573, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000405424

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N573 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N573

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini99 – 142LysMPROSITE-ProRule annotationAdd BLAST44
Domaini208 – 275GRAMAdd BLAST68
Domaini713 – 874TLDcPROSITE-ProRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni551 – 578Mediates oxidative antimutator activityAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OXR1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2372 Eukaryota
ENOG4111QBZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155187

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007095_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N573

Identification of Orthologs from Complete Genome Data

More...
OMAi
SGKDFCH

Database of Orthologous Groups

More...
OrthoDBi
767847at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N573

TreeFam database of animal gene trees

More...
TreeFami
TF313530

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00118 LysM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.350.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR006571 TLDc_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01476 LysM, 1 hit
PF07534 TLD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00257 LysM, 1 hit
SM00584 TLDc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51782 LYSM, 1 hit
PS51886 TLDC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N573-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTKDKNSPGL KKKSQSVDIN APGFNPLAGA GKQTPQASKP PAPKTPIIEE
60 70 80 90 100
EQNNAANTQK HPSRRSELKR FYTIDTGQKK TLDKKDGRRM SFQKPKGTIE
110 120 130 140 150
YTVESRDSLN SIALKFDTTP NELVQLNKLF SRAVVTGQVL YVPDPEYVSS
160 170 180 190 200
VESSPSLSPV SPLSPTSSEA EFDKTTNPDV HPTEATPSST FTGIRPARVV
210 220 230 240 250
SSTSEEEEAF TEKFLKINCK YITSGKGTVS GVLLVTPNNI MFDPHKNDPL
260 270 280 290 300
VQENGCEEYG IMCPMEEVMS AAMYKEILDS KIKESLPIDI DQLSGRDFCH
310 320 330 340 350
SKKMTGSNTE EIDSRIRDAG NDSASTAPRS TEESLSEDVF TESELSPIRE
360 370 380 390 400
ELVSSDELRQ DKSSGASSES VQTVNQAEVE SLTVKSESTG TPGHLRSDTE
410 420 430 440 450
HSTNEVGTLC HKTDLNNLEM AIKEDQIADN FQGISGPKED STSIKGNSDQ
460 470 480 490 500
DSFLHENSLH QEESQKENMP CGETAEFKQK QSVNKGKQGK EQNQDSQTEA
510 520 530 540 550
EELRKLWKTH TMQQTKQQRE NIQQVSQKEA KHKITSADGH IESSALLKEK
560 570 580 590 600
QRHRLHKFLC LRVGKPMRKT FVSQASATMQ QYAQRDKKHE YWFAVPQERT
610 620 630 640 650
DHLYAFFIQW SPEIYAEDTG EYTREPGFIV VKKIEESETI EDSSNQAAAR
660 670 680 690 700
EWEVVSVAEY HRRIDALNTE ELRTLCRRLQ ITTREDINSK QVATVKADLE
710 720 730 740 750
SESFRPNLSD PSELLLPDQI EKLTKHLPPR TIGYPWTLVY GTGKHGTSLK
760 770 780 790 800
TLYRTMTGLD TPVLMVIKDS DGQVFGALAS EPLKVSDGFY GTGETFVFTF
810 820 830 840 850
CPEFEVFKWT GDNMFFIKGD MDSLAFGGGG GEFALWLDGD LYHGRSHSCK
860 870
TFGNRTLSKK EDFFIQDIEI WAFE
Length:874
Mass (Da):97,970
Last modified:April 20, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4231D07369CE2D36
GO
Isoform 2 (identifier: Q8N573-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: MTKDKNSPGL...RSELKRFYTI → MDYLTTFTEK...PPAPSSPEGP
     654-680: Missing.

Show »
Length:839
Mass (Da):93,734
Checksum:i930AB9A7CA7648DC
GO
Isoform 3 (identifier: Q8N573-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     69-74: KRFYTI → MFCQRK
     544-571: SALLKEKQRHRLHKFLCLRVGKPMRKTF → KCYRVNEVSSSNCMVSPSFLTDSKAAVP
     572-874: Missing.

Show »
Length:503
Mass (Da):55,698
Checksum:i13A23028C9B7AF83
GO
Isoform 4 (identifier: Q8N573-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-631: Missing.
     632-653: KKIEESETIEDSSNQAAAREWE → MSRLWYGKKGRRHQPINHKYTL

Show »
Length:243
Mass (Da):27,691
Checksum:i530B2F0DF5B0DA8A
GO
Isoform 5 (identifier: Q8N573-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MTKDKNSPG → MSVSNLSW
     654-680: Missing.

Show »
Length:846
Mass (Da):94,692
Checksum:i3CBCE47C558A548B
GO
Isoform 6 (identifier: Q8N573-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-511: Missing.
     654-722: Missing.

Show »
Length:294
Mass (Da):33,774
Checksum:iB2635225195EBF96
GO
Isoform 7 (identifier: Q8N573-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MTKDKNSPGLKKKSQSVDINAP → MSRLWYGKKGRRHQPINHKYTL
     23-680: Missing.

Show »
Length:216
Mass (Da):24,468
Checksum:i42F3BFA4328550AA
GO
Isoform 8 (identifier: Q8N573-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MTKDKNSPG → MSVSNLSW

Show »
Length:873
Mass (Da):97,916
Checksum:i72E8B301BC705FDA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RII8E5RII8_HUMAN
Oxidation resistance protein 1
OXR1
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC07H0YC07_HUMAN
Oxidation resistance protein 1
OXR1
518Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JY63C9JY63_HUMAN
Oxidation resistance protein 1
OXR1
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLW2E9PLW2_HUMAN
Oxidation resistance protein 1
OXR1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFD1E5RFD1_HUMAN
Oxidation resistance protein 1
OXR1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG25715 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH32710 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAY26396 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA91456 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAF85588 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAI46186 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti154S → P in BAC04711 (PubMed:14702039).Curated1
Sequence conflicti495D → V in AAG25715 (PubMed:11114193).Curated1
Sequence conflicti681I → N in AAG25715 (PubMed:11114193).Curated1
Sequence conflicti727L → F in AAG25715 (PubMed:11114193).Curated1
Sequence conflicti813N → D in BAA91456 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025861100E → G1 PublicationCorresponds to variant dbSNP:rs28921397Ensembl.1
Natural variantiVAR_025862360Q → P1 PublicationCorresponds to variant dbSNP:rs28921419Ensembl.1
Natural variantiVAR_025863516K → R1 PublicationCorresponds to variant dbSNP:rs28921420Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0390041 – 631Missing in isoform 4. 1 PublicationAdd BLAST631
Alternative sequenceiVSP_0390051 – 511Missing in isoform 6. 1 PublicationAdd BLAST511
Alternative sequenceiVSP_0390061 – 74MTKDK…RFYTI → MDYLTTFTEKSGRLLRGTAN RLLGFGGGGEARQVRFEDYL REPAQGDLGCGSPPHRPPAP SSPEGP in isoform 2. 3 PublicationsAdd BLAST74
Alternative sequenceiVSP_0390071 – 68Missing in isoform 3. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_0436321 – 22MTKDK…DINAP → MSRLWYGKKGRRHQPINHKY TL in isoform 7. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_0390081 – 9MTKDKNSPG → MSVSNLSW in isoform 5 and isoform 8. 2 Publications9
Alternative sequenceiVSP_04363323 – 680Missing in isoform 7. 2 PublicationsAdd BLAST658
Alternative sequenceiVSP_03900969 – 74KRFYTI → MFCQRK in isoform 3. 1 Publication6
Alternative sequenceiVSP_039010544 – 571SALLK…MRKTF → KCYRVNEVSSSNCMVSPSFL TDSKAAVP in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_039011572 – 874Missing in isoform 3. 1 PublicationAdd BLAST303
Alternative sequenceiVSP_039012632 – 653KKIEE…AREWE → MSRLWYGKKGRRHQPINHKY TL in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_039014654 – 722Missing in isoform 6. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_039013654 – 680Missing in isoform 2 and isoform 5. 3 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
FN650108 mRNA Translation: CBI84064.1
FN650109 mRNA Translation: CBI84065.1
AB075503 mRNA Translation: BAE45753.1
AK000987 mRNA Translation: BAA91456.1 Different initiation.
AK096148 mRNA Translation: BAC04711.1
AK124441 mRNA Translation: BAC85852.1
AK127563 mRNA Translation: BAG54523.1
AK292899 mRNA Translation: BAF85588.1 Different initiation.
AK296561 mRNA Translation: BAH12388.1
AK303695 mRNA Translation: BAH14021.1
AK316153 mRNA Translation: BAH14524.1
DQ020202 Genomic DNA Translation: AAY26396.1 Sequence problems.
AC023344 Genomic DNA No translation available.
AC027031 Genomic DNA No translation available.
AC090579 Genomic DNA No translation available.
AP000430 Genomic DNA No translation available.
AP002090 Genomic DNA No translation available.
BC032710 mRNA Translation: AAH32710.1 Different initiation.
AF309387 mRNA Translation: AAG25715.1 Different initiation.
AL833193 mRNA Translation: CAI46186.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS47909.1 [Q8N573-5]
CCDS56547.1 [Q8N573-8]
CCDS56548.1 [Q8N573-1]
CCDS56549.1 [Q8N573-4]
CCDS56550.1 [Q8N573-7]
CCDS6304.2 [Q8N573-2]

NCBI Reference Sequences

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RefSeqi
NP_001185461.1, NM_001198532.1 [Q8N573-1]
NP_001185462.1, NM_001198533.1 [Q8N573-8]
NP_001185463.1, NM_001198534.1 [Q8N573-4]
NP_001185464.1, NM_001198535.1 [Q8N573-7]
NP_060472.2, NM_018002.3 [Q8N573-5]
NP_851999.2, NM_181354.4 [Q8N573-2]
XP_016869083.1, XM_017013594.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000297447; ENSP00000297447; ENSG00000164830 [Q8N573-4]
ENST00000312046; ENSP00000311026; ENSG00000164830 [Q8N573-2]
ENST00000442977; ENSP00000405424; ENSG00000164830 [Q8N573-1]
ENST00000449762; ENSP00000408659; ENSG00000164830 [Q8N573-7]
ENST00000497705; ENSP00000431014; ENSG00000164830 [Q8N573-3]
ENST00000517566; ENSP00000429205; ENSG00000164830 [Q8N573-8]
ENST00000531443; ENSP00000431966; ENSG00000164830 [Q8N573-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55074

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55074

UCSC genome browser

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UCSCi
uc003ymf.4 human [Q8N573-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN650108 mRNA Translation: CBI84064.1
FN650109 mRNA Translation: CBI84065.1
AB075503 mRNA Translation: BAE45753.1
AK000987 mRNA Translation: BAA91456.1 Different initiation.
AK096148 mRNA Translation: BAC04711.1
AK124441 mRNA Translation: BAC85852.1
AK127563 mRNA Translation: BAG54523.1
AK292899 mRNA Translation: BAF85588.1 Different initiation.
AK296561 mRNA Translation: BAH12388.1
AK303695 mRNA Translation: BAH14021.1
AK316153 mRNA Translation: BAH14524.1
DQ020202 Genomic DNA Translation: AAY26396.1 Sequence problems.
AC023344 Genomic DNA No translation available.
AC027031 Genomic DNA No translation available.
AC090579 Genomic DNA No translation available.
AP000430 Genomic DNA No translation available.
AP002090 Genomic DNA No translation available.
BC032710 mRNA Translation: AAH32710.1 Different initiation.
AF309387 mRNA Translation: AAG25715.1 Different initiation.
AL833193 mRNA Translation: CAI46186.1 Different initiation.
CCDSiCCDS47909.1 [Q8N573-5]
CCDS56547.1 [Q8N573-8]
CCDS56548.1 [Q8N573-1]
CCDS56549.1 [Q8N573-4]
CCDS56550.1 [Q8N573-7]
CCDS6304.2 [Q8N573-2]
RefSeqiNP_001185461.1, NM_001198532.1 [Q8N573-1]
NP_001185462.1, NM_001198533.1 [Q8N573-8]
NP_001185463.1, NM_001198534.1 [Q8N573-4]
NP_001185464.1, NM_001198535.1 [Q8N573-7]
NP_060472.2, NM_018002.3 [Q8N573-5]
NP_851999.2, NM_181354.4 [Q8N573-2]
XP_016869083.1, XM_017013594.1

3D structure databases

SMRiQ8N573
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120391, 11 interactors
IntActiQ8N573, 5 interactors
STRINGi9606.ENSP00000405424

PTM databases

iPTMnetiQ8N573
PhosphoSitePlusiQ8N573

Polymorphism and mutation databases

BioMutaiOXR1
DMDMi294862456

Proteomic databases

EPDiQ8N573
jPOSTiQ8N573
MassIVEiQ8N573
MaxQBiQ8N573
PaxDbiQ8N573
PeptideAtlasiQ8N573
PRIDEiQ8N573
ProteomicsDBi72011 [Q8N573-1]
72012 [Q8N573-2]
72013 [Q8N573-3]
72014 [Q8N573-4]
72015 [Q8N573-5]
72016 [Q8N573-6]
72017 [Q8N573-7]
72018 [Q8N573-8]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55074

Genome annotation databases

EnsembliENST00000297447; ENSP00000297447; ENSG00000164830 [Q8N573-4]
ENST00000312046; ENSP00000311026; ENSG00000164830 [Q8N573-2]
ENST00000442977; ENSP00000405424; ENSG00000164830 [Q8N573-1]
ENST00000449762; ENSP00000408659; ENSG00000164830 [Q8N573-7]
ENST00000497705; ENSP00000431014; ENSG00000164830 [Q8N573-3]
ENST00000517566; ENSP00000429205; ENSG00000164830 [Q8N573-8]
ENST00000531443; ENSP00000431966; ENSG00000164830 [Q8N573-5]
GeneIDi55074
KEGGihsa:55074
UCSCiuc003ymf.4 human [Q8N573-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55074
DisGeNETi55074

GeneCards: human genes, protein and diseases

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GeneCardsi
OXR1
HGNCiHGNC:15822 OXR1
HPAiHPA027375
HPA027380
HPA027395
MIMi605609 gene
neXtProtiNX_Q8N573
OpenTargetsiENSG00000164830
PharmGKBiPA32856

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2372 Eukaryota
ENOG4111QBZ LUCA
GeneTreeiENSGT00940000155187
HOGENOMiCLU_007095_2_0_1
InParanoidiQ8N573
OMAiSGKDFCH
OrthoDBi767847at2759
PhylomeDBiQ8N573
TreeFamiTF313530

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
OXR1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
OXR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55074
PharosiQ8N573 Tbio

Protein Ontology

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PROi
PR:Q8N573
RNActiQ8N573 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164830 Expressed in parietal lobe and 230 other tissues
ExpressionAtlasiQ8N573 baseline and differential
GenevisibleiQ8N573 HS

Family and domain databases

CDDicd00118 LysM, 1 hit
Gene3Di3.10.350.10, 1 hit
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR006571 TLDc_dom
PfamiView protein in Pfam
PF01476 LysM, 1 hit
PF07534 TLD, 1 hit
SMARTiView protein in SMART
SM00257 LysM, 1 hit
SM00584 TLDc, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 1 hit
PS51886 TLDC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOXR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N573
Secondary accession number(s): A6NK11
, A8KA34, B3KXL1, B7Z402, B7Z8N5, D3HIS6, Q3LIB5, Q6ZVK9, Q8N8V0, Q9H266, Q9NWC7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 20, 2010
Last modified: February 26, 2020
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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