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Protein

Zinc finger protein 276

Gene

ZNF276

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri434 – 458C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri465 – 490C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri496 – 518C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 577C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 276
Short name:
Zfp-276
Alternative name(s):
Zinc finger protein 477
Gene namesi
Name:ZNF276
Synonyms:CENP-Z, ZFP276, ZNF477
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000158805.11
HGNCiHGNC:23330 ZNF276
MIMi608460 gene
neXtProtiNX_Q8N554

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000158805
PharmGKBiPA134935042

Polymorphism and mutation databases

BioMutaiZNF276
DMDMi296453082

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473231 – 614Zinc finger protein 276Add BLAST614

Proteomic databases

EPDiQ8N554
MaxQBiQ8N554
PaxDbiQ8N554
PeptideAtlasiQ8N554
PRIDEiQ8N554
ProteomicsDBi72002
72003 [Q8N554-2]

PTM databases

iPTMnetiQ8N554
PhosphoSitePlusiQ8N554

Expressioni

Gene expression databases

BgeeiENSG00000158805 Expressed in 180 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_ZNF276
ExpressionAtlasiQ8N554 baseline and differential
GenevisibleiQ8N554 HS

Organism-specific databases

HPAiHPA021309
HPA022255

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi124982, 12 interactors
IntActiQ8N554, 8 interactors
MINTiQ8N554
STRINGi9606.ENSP00000415836

Structurei

3D structure databases

ProteinModelPortaliQ8N554
SMRiQ8N554
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 153ZADAdd BLAST75

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri434 – 458C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri465 – 490C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri496 – 518C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 577C2H2-type 5PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063153
HOGENOMiHOG000155790
HOVERGENiHBG061026
InParanoidiQ8N554
OMAiGCDQGHD
OrthoDBiEOG091G04WK
PhylomeDBiQ8N554
TreeFamiTF332664

Family and domain databases

InterProiView protein in InterPro
IPR012934 Znf_AD
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF07776 zf-AD, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N554-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRDRLGRFL SPGSSRQCGA SDGGGGVSRT RGRPSLSGGP RVDGATARRA
60 70 80 90 100
WGPVGSCGDA GEDGADEAGA GRALAMGHCR LCHGKFSSRS LRSISERAPG
110 120 130 140 150
ASMERPSAEE RVLVRDFQRL LGVAVRQDPT LSPFVCKSCH AQFYQCHSLL
160 170 180 190 200
KSFLQRVNAS PAGRRKPCAK VGAQPPTGAE EGACLVDLIT SSPQCLHGLV
210 220 230 240 250
GWVHGHAASC GALPHLQRTL SSEYCGVIQV VWGCDQGHDY TMDTSSSCKA
260 270 280 290 300
FLLDSALAVK WPWDKETAPR LPQHRGWNPG DAPQTSQGRG TGTPVGAETK
310 320 330 340 350
TLPSTDVAQP PSDSDAVGPR SGFPPQPSLP LCRAPGQLGE KQLPSSTSDD
360 370 380 390 400
RVKDEFSDLS EGDVLSEDEN DKKQNAQSSD ESFEPYPERK VSGKKSESKE
410 420 430 440 450
AKKSEEPRIR KKPGPKPGWK KKLRCEREEL PTIYKCPYQG CTAVYRGADG
460 470 480 490 500
MKKHIKEHHE EVRERPCPHP GCNKVFMIDR YLQRHVKLIH TEVRNYICDE
510 520 530 540 550
CGQTFKQRKH LLVHQMRHSG AKPLQCEVCG FQCRQRASLK YHMTKHKAET
560 570 580 590 600
ELDFACDQCG RRFEKAHNLN VHMSMVHPLT QTQDKALPLE AEPPPGPPSP
610
SVTTEGQAVK PEPT
Length:614
Mass (Da):67,219
Last modified:May 18, 2010 - v4
Checksum:iD63256CFD7DC5040
GO
Isoform 2 (identifier: Q8N554-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Show »
Length:539
Mass (Da):59,850
Checksum:iCA08E6D3F3534F37
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BTK0H3BTK0_HUMAN
Zinc finger protein 276
ZNF276
433Annotation score:
H3BPT7H3BPT7_HUMAN
Zinc finger protein 276
ZNF276
280Annotation score:
H3BTT0H3BTT0_HUMAN
Zinc finger protein 276
ZNF276
355Annotation score:
H3BPJ6H3BPJ6_HUMAN
Zinc finger protein 276
ZNF276
94Annotation score:

Sequence cautioni

The sequence AAH32781 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI10349 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104E → V in AK026482 (PubMed:15616553).Curated1
Sequence conflicti180E → G in AK026482 (PubMed:15616553).Curated1
Sequence conflicti413P → Q in AAQ15128 (PubMed:15489334).Curated1
Sequence conflicti413P → Q in AAQ15129 (PubMed:15489334).Curated1
Sequence conflicti434Y → H in AAI07604 (PubMed:14605947).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032708263W → R2 PublicationsCorresponds to variant dbSNP:rs6500437Ensembl.1
Natural variantiVAR_019125275R → W May increase breast cancer risk. 1 Publication1
Natural variantiVAR_032709351R → W1 PublicationCorresponds to variant dbSNP:rs17719249Ensembl.1
Natural variantiVAR_019126605E → D1 PublicationCorresponds to variant dbSNP:rs17227424Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0261041 – 75Missing in isoform 2. 2 PublicationsAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354755 mRNA Translation: AAQ15128.1
AF354756 mRNA Translation: AAQ15129.1
AC005360 Genomic DNA No translation available.
AC010538 Genomic DNA No translation available.
BC032781 mRNA Translation: AAH32781.2 Different initiation.
BC107603 mRNA Translation: AAI07604.1
BC110348 mRNA Translation: AAI10349.1 Different initiation.
AK026482 mRNA No translation available.
CCDSiCCDS10986.1 [Q8N554-2]
CCDS45554.1 [Q8N554-1]
RefSeqiNP_001106997.1, NM_001113525.1 [Q8N554-1]
NP_689500.2, NM_152287.3 [Q8N554-2]
UniGeneiHs.290154

Genome annotation databases

EnsembliENST00000289816; ENSP00000289816; ENSG00000158805 [Q8N554-2]
ENST00000443381; ENSP00000415836; ENSG00000158805 [Q8N554-1]
GeneIDi92822
KEGGihsa:92822
UCSCiuc002foq.5 human [Q8N554-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF354755 mRNA Translation: AAQ15128.1
AF354756 mRNA Translation: AAQ15129.1
AC005360 Genomic DNA No translation available.
AC010538 Genomic DNA No translation available.
BC032781 mRNA Translation: AAH32781.2 Different initiation.
BC107603 mRNA Translation: AAI07604.1
BC110348 mRNA Translation: AAI10349.1 Different initiation.
AK026482 mRNA No translation available.
CCDSiCCDS10986.1 [Q8N554-2]
CCDS45554.1 [Q8N554-1]
RefSeqiNP_001106997.1, NM_001113525.1 [Q8N554-1]
NP_689500.2, NM_152287.3 [Q8N554-2]
UniGeneiHs.290154

3D structure databases

ProteinModelPortaliQ8N554
SMRiQ8N554
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124982, 12 interactors
IntActiQ8N554, 8 interactors
MINTiQ8N554
STRINGi9606.ENSP00000415836

PTM databases

iPTMnetiQ8N554
PhosphoSitePlusiQ8N554

Polymorphism and mutation databases

BioMutaiZNF276
DMDMi296453082

Proteomic databases

EPDiQ8N554
MaxQBiQ8N554
PaxDbiQ8N554
PeptideAtlasiQ8N554
PRIDEiQ8N554
ProteomicsDBi72002
72003 [Q8N554-2]

Protocols and materials databases

DNASUi92822
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289816; ENSP00000289816; ENSG00000158805 [Q8N554-2]
ENST00000443381; ENSP00000415836; ENSG00000158805 [Q8N554-1]
GeneIDi92822
KEGGihsa:92822
UCSCiuc002foq.5 human [Q8N554-1]

Organism-specific databases

CTDi92822
EuPathDBiHostDB:ENSG00000158805.11
GeneCardsiZNF276
HGNCiHGNC:23330 ZNF276
HPAiHPA021309
HPA022255
MIMi608460 gene
neXtProtiNX_Q8N554
OpenTargetsiENSG00000158805
PharmGKBiPA134935042
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063153
HOGENOMiHOG000155790
HOVERGENiHBG061026
InParanoidiQ8N554
OMAiGCDQGHD
OrthoDBiEOG091G04WK
PhylomeDBiQ8N554
TreeFamiTF332664

Miscellaneous databases

ChiTaRSiZNF276 human
GenomeRNAii92822
PROiPR:Q8N554
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158805 Expressed in 180 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_ZNF276
ExpressionAtlasiQ8N554 baseline and differential
GenevisibleiQ8N554 HS

Family and domain databases

InterProiView protein in InterPro
IPR012934 Znf_AD
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF07776 zf-AD, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN276_HUMAN
AccessioniPrimary (citable) accession number: Q8N554
Secondary accession number(s): Q0VGA1, Q2TBE8, Q3B7H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: May 18, 2010
Last modified: October 10, 2018
This is version 131 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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