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UniProtKB - Q8N4Y2 (EFC4A_HUMAN)

Entry version 147 (07 Apr 2021)
Sequence version 3 (13 Jul 2010)
Previous versions | rss
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Protein

EF-hand calcium-binding domain-containing protein 4A

Gene

CRACR2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in store-operated Ca2+ entry (SOCE).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8N4Y2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 4A
Alternative name(s):
Calcium release-activated calcium channel regulator 2B
Short name:
CRAC channel regulator 2B
Calcium release-activated channel regulator 2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRACR2B
Synonyms:EFCAB4A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28703, CRACR2B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614177, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8N4Y2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000177685.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		283229

Open Targets

More...OpenTargetsi		ENSG00000177685

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA144596437

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8N4Y2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CRACR2B

Domain mapping of disease mutations (DMDM)

More...DMDMi		300669695

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002830441 – 399EF-hand calcium-binding domain-containing protein 4AAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8N4Y2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8N4Y2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8N4Y2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8N4Y2

PeptideAtlas

More...PeptideAtlasi		Q8N4Y2

PRoteomics IDEntifications database

More...PRIDEi		Q8N4Y2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71990 [Q8N4Y2-1]
71991 [Q8N4Y2-2]
71992 [Q8N4Y2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8N4Y2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8N4Y2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000177685, Expressed in saliva-secreting gland and 149 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8N4Y2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8N4Y2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000177685, Group enriched (pancreas, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129503, 20 interactors

Protein interaction database and analysis system

More...IntActi		Q8N4Y2, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000435299

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8N4Y2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8N4Y2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 61EF-hand 1PROSITE-ProRule annotationAdd BLAST29
Domaini67 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili181 – 358Sequence analysisAdd BLAST178

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi378 – 383Cys-rich6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EFCAB4 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRXK, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00440000033504

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_047014_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8N4Y2

Identification of Orthologs from Complete Genome Data

More...OMAi		IRFTQIL

Database of Orthologous Groups

More...OrthoDBi		679137at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8N4Y2

TreeFam database of animal gene trees

More...TreeFami		TF329556

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50222, EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N4Y2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPGKPGAD EAQEEEGELE GGSAGPRAAI LEQAEELFLL CDKEAKGFIT 
        60         70         80         90        100
KHDLQGLQSD LPLTPEQLEA VFESLDRAHT GFLTAREFCL GLGMFVGVAS 
       110        120        130        140        150
AQGANPCRTP EETFESGGLD VQGTAGSLDE EEEEEERFHT VLEQLGVAPV 
       160        170        180        190        200
LGKQRAVRTL WARLQRERPE LLGSFEDVLI RASACLEEAA RERDGLEQAL 
       210        220        230        240        250
RRRESEHERE VRALYEETEQ LREQSRRPPS QNFARGERRS RLELELQSRE 
       260        270        280        290        300
QDLERAGLRQ RELEQQLHAQ AAEHLEAQAQ NSQLWRAHEA LRTQLEGAQE 
       310        320        330        340        350
QIRRLESEAR GRQEQTQRDV VAVSRNMQKE KVSLLRQLEL LRELNTRLRD 
       360        370        380        390 
DRDACEARRA GSSCRKALTT ARLPGPTCCC CCCWARPPRR GSGHLPSAR
Length:399
Mass (Da):44,956
Last modified:July 13, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i116E54FD8B3F98CA
GO
Isoform 2 (identifier: Q8N4Y2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: Missing.
     90-92: LGL → MPA
     153-153: K → DSRPPSR
     263-399: LEQQLHAQAA...RGSGHLPSAR → VSTRPLPCPH...SPVSILPPSS

Show »
Length:230
Mass (Da):25,685
Checksum:i5D5F3FE5170AF852
GO
Isoform 3 (identifier: Q8N4Y2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-399: LEQQLHAQAA...RGSGHLPSAR → RRGRRLQEHAERESQPATATGAAQGAEYTAAG

Show »
Length:294
Mass (Da):32,746
Checksum:i83B10BF18E8717B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PPF3E9PPF3_HUMAN
EF-hand calcium-binding domain-cont...
CRACR2B
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHZ8E9PHZ8_HUMAN
EF-hand calcium-binding domain-cont...
CRACR2B
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK04E9PK04_HUMAN
EF-hand calcium-binding domain-cont...
CRACR2B
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRE5E9PRE5_HUMAN
EF-hand calcium-binding domain-cont...
CRACR2B
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03147977R → Q1 PublicationCorresponds to variant dbSNP:rs7126805Ensembl.1
Natural variantiVAR_031480153K → E1 PublicationCorresponds to variant dbSNP:rs28558789Ensembl.1
Natural variantiVAR_031481173G → S. Corresponds to variant dbSNP:rs35567200Ensembl.1
Natural variantiVAR_031482248S → I2 PublicationsCorresponds to variant dbSNP:rs4075289Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0242901 – 89Missing in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_02429190 – 92LGL → MPA in isoform 2. 1 Publication3
Alternative sequenceiVSP_024292153K → DSRPPSR in isoform 2. 1 Publication1
Alternative sequenceiVSP_024293263 – 399LEQQL…LPSAR → VSTRPLPCPHGRPCTLPLCL SVPGLSGAWGTRSTPGKRGR SSPVSILPPSS in isoform 2. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_039545263 – 399LEQQL…LPSAR → RRGRRLQEHAERESQPATAT GAAQGAEYTAAG in isoform 3. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
GU952799 mRNA Translation: ADD96763.1
AK075180 mRNA Translation: BAC11455.1
AP006621 Genomic DNA No translation available.
BC033196 mRNA Translation: AAH33196.1
BC073821 mRNA Translation: AAH73821.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41588.1 [Q8N4Y2-3]
CCDS65995.1 [Q8N4Y2-1]

NCBI Reference Sequences

More...RefSeqi		NP_001273535.1, NM_001286606.1 [Q8N4Y2-1]
NP_775855.3, NM_173584.4 [Q8N4Y2-3]
XP_016873088.1, XM_017017599.1 [Q8N4Y2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000450448; ENSP00000409256; ENSG00000177685 [Q8N4Y2-3]
ENST00000525077; ENSP00000435299; ENSG00000177685 [Q8N4Y2-1]
ENST00000528542; ENSP00000432334; ENSG00000177685 [Q8N4Y2-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		283229

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:283229

UCSC genome browser

More...UCSCi		uc001lrv.3, human [Q8N4Y2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU952799 mRNA Translation: ADD96763.1
AK075180 mRNA Translation: BAC11455.1
AP006621 Genomic DNA No translation available.
BC033196 mRNA Translation: AAH33196.1
BC073821 mRNA Translation: AAH73821.1
CCDSiCCDS41588.1 [Q8N4Y2-3]
CCDS65995.1 [Q8N4Y2-1]
RefSeqiNP_001273535.1, NM_001286606.1 [Q8N4Y2-1]
NP_775855.3, NM_173584.4 [Q8N4Y2-3]
XP_016873088.1, XM_017017599.1 [Q8N4Y2-3]

3D structure databases

SMRiQ8N4Y2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129503, 20 interactors
IntActiQ8N4Y2, 14 interactors
STRINGi9606.ENSP00000435299

PTM databases

iPTMnetiQ8N4Y2
PhosphoSitePlusiQ8N4Y2

Genetic variation databases

BioMutaiCRACR2B
DMDMi300669695

Proteomic databases

jPOSTiQ8N4Y2
MassIVEiQ8N4Y2
MaxQBiQ8N4Y2
PaxDbiQ8N4Y2
PeptideAtlasiQ8N4Y2
PRIDEiQ8N4Y2
ProteomicsDBi71990 [Q8N4Y2-1]
71991 [Q8N4Y2-2]
71992 [Q8N4Y2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		42026, 54 antibodies

The DNASU plasmid repository

More...DNASUi		283229

Genome annotation databases

EnsembliENST00000450448; ENSP00000409256; ENSG00000177685 [Q8N4Y2-3]
ENST00000525077; ENSP00000435299; ENSG00000177685 [Q8N4Y2-1]
ENST00000528542; ENSP00000432334; ENSG00000177685 [Q8N4Y2-3]
GeneIDi283229
KEGGihsa:283229
UCSCiuc001lrv.3, human [Q8N4Y2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		283229
DisGeNETi283229

GeneCards: human genes, protein and diseases

More...GeneCardsi		CRACR2B
HGNCiHGNC:28703, CRACR2B
HPAiENSG00000177685, Group enriched (pancreas, salivary gland)
MIMi614177, gene
neXtProtiNX_Q8N4Y2
OpenTargetsiENSG00000177685
PharmGKBiPA144596437
VEuPathDBiHostDB:ENSG00000177685.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRXK, Eukaryota
GeneTreeiENSGT00440000033504
HOGENOMiCLU_047014_0_0_1
InParanoidiQ8N4Y2
OMAiIRFTQIL
OrthoDBi679137at2759
PhylomeDBiQ8N4Y2
TreeFamiTF329556

Enzyme and pathway databases

PathwayCommonsiQ8N4Y2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		283229, 9 hits in 992 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CRACR2B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		283229
PharosiQ8N4Y2, Tbio

Protein Ontology

More...PROi		PR:Q8N4Y2
RNActiQ8N4Y2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000177685, Expressed in saliva-secreting gland and 149 other tissues
ExpressionAtlasiQ8N4Y2, baseline and differential
GenevisibleiQ8N4Y2, HS

Family and domain databases

InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEFC4A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N4Y2
Secondary accession number(s): D5LPR2, Q8NBW8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 13, 2010
Last modified: April 7, 2021
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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