UniProtKB - Q8N4Y2 (EFC4A_HUMAN)
Protein
EF-hand calcium-binding domain-containing protein 4A
Gene
CRACR2B
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in store-operated Ca2+ entry (SOCE).1 Publication
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- cellular protein localization Source: Ensembl
- regulation of store-operated calcium entry Source: Ensembl
- store-operated calcium entry Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q8N4Y2 |
Names & Taxonomyi
Protein namesi | Recommended name: EF-hand calcium-binding domain-containing protein 4AAlternative name(s): Calcium release-activated calcium channel regulator 2B Short name: CRAC channel regulator 2B Calcium release-activated channel regulator 2B |
Gene namesi | Name:CRACR2B Synonyms:EFCAB4A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28703, CRACR2B |
MIMi | 614177, gene |
neXtProti | NX_Q8N4Y2 |
VEuPathDBi | HostDB:ENSG00000177685.16 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 283229 |
OpenTargetsi | ENSG00000177685 |
PharmGKBi | PA144596437 |
Miscellaneous databases
Pharosi | Q8N4Y2, Tbio |
Genetic variation databases
BioMutai | CRACR2B |
DMDMi | 300669695 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000283044 | 1 – 399 | EF-hand calcium-binding domain-containing protein 4AAdd BLAST | 399 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 3 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q8N4Y2 |
MassIVEi | Q8N4Y2 |
MaxQBi | Q8N4Y2 |
PaxDbi | Q8N4Y2 |
PeptideAtlasi | Q8N4Y2 |
PRIDEi | Q8N4Y2 |
ProteomicsDBi | 71990 [Q8N4Y2-1] 71991 [Q8N4Y2-2] 71992 [Q8N4Y2-3] |
PTM databases
iPTMneti | Q8N4Y2 |
PhosphoSitePlusi | Q8N4Y2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177685, Expressed in saliva-secreting gland and 149 other tissues |
ExpressionAtlasi | Q8N4Y2, baseline and differential |
Genevisiblei | Q8N4Y2, HS |
Organism-specific databases
HPAi | ENSG00000177685, Group enriched (pancreas, salivary gland) |
Interactioni
Binary interactionsi
Hide detailsQ8N4Y2
With | #Exp. | IntAct |
---|---|---|
TCEANC [Q8N8B7] | 3 | EBI-10267893,EBI-954696 |
Isoform 3 [Q8N4Y2-3]
Protein-protein interaction databases
BioGRIDi | 129503, 20 interactors |
IntActi | Q8N4Y2, 14 interactors |
STRINGi | 9606.ENSP00000435299 |
Miscellaneous databases
RNActi | Q8N4Y2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 61 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Domaini | 67 – 95 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 29 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 181 – 358 | Sequence analysisAdd BLAST | 178 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 378 – 383 | Cys-rich | 6 |
Sequence similaritiesi
Belongs to the EFCAB4 family.Curated
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | ENOG502QRXK, Eukaryota |
GeneTreei | ENSGT00440000033504 |
HOGENOMi | CLU_047014_0_0_1 |
InParanoidi | Q8N4Y2 |
OMAi | IRFTQIL |
OrthoDBi | 679137at2759 |
PhylomeDBi | Q8N4Y2 |
TreeFami | TF329556 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8N4Y2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASPGKPGAD EAQEEEGELE GGSAGPRAAI LEQAEELFLL CDKEAKGFIT
60 70 80 90 100
KHDLQGLQSD LPLTPEQLEA VFESLDRAHT GFLTAREFCL GLGMFVGVAS
110 120 130 140 150
AQGANPCRTP EETFESGGLD VQGTAGSLDE EEEEEERFHT VLEQLGVAPV
160 170 180 190 200
LGKQRAVRTL WARLQRERPE LLGSFEDVLI RASACLEEAA RERDGLEQAL
210 220 230 240 250
RRRESEHERE VRALYEETEQ LREQSRRPPS QNFARGERRS RLELELQSRE
260 270 280 290 300
QDLERAGLRQ RELEQQLHAQ AAEHLEAQAQ NSQLWRAHEA LRTQLEGAQE
310 320 330 340 350
QIRRLESEAR GRQEQTQRDV VAVSRNMQKE KVSLLRQLEL LRELNTRLRD
360 370 380 390
DRDACEARRA GSSCRKALTT ARLPGPTCCC CCCWARPPRR GSGHLPSAR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PPF3 | E9PPF3_HUMAN | EF-hand calcium-binding domain-cont... | CRACR2B | 88 | Annotation score: | ||
E9PHZ8 | E9PHZ8_HUMAN | EF-hand calcium-binding domain-cont... | CRACR2B | 53 | Annotation score: | ||
E9PK04 | E9PK04_HUMAN | EF-hand calcium-binding domain-cont... | CRACR2B | 81 | Annotation score: | ||
E9PRE5 | E9PRE5_HUMAN | EF-hand calcium-binding domain-cont... | CRACR2B | 34 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031479 | 77 | R → Q1 PublicationCorresponds to variant dbSNP:rs7126805Ensembl. | 1 | |
Natural variantiVAR_031480 | 153 | K → E1 PublicationCorresponds to variant dbSNP:rs28558789Ensembl. | 1 | |
Natural variantiVAR_031481 | 173 | G → S. Corresponds to variant dbSNP:rs35567200Ensembl. | 1 | |
Natural variantiVAR_031482 | 248 | S → I2 PublicationsCorresponds to variant dbSNP:rs4075289Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024290 | 1 – 89 | Missing in isoform 2. 1 PublicationAdd BLAST | 89 | |
Alternative sequenceiVSP_024291 | 90 – 92 | LGL → MPA in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_024292 | 153 | K → DSRPPSR in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_024293 | 263 – 399 | LEQQL…LPSAR → VSTRPLPCPHGRPCTLPLCL SVPGLSGAWGTRSTPGKRGR SSPVSILPPSS in isoform 2. 1 PublicationAdd BLAST | 137 | |
Alternative sequenceiVSP_039545 | 263 – 399 | LEQQL…LPSAR → RRGRRLQEHAERESQPATAT GAAQGAEYTAAG in isoform 3. 1 PublicationAdd BLAST | 137 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU952799 mRNA Translation: ADD96763.1 AK075180 mRNA Translation: BAC11455.1 AP006621 Genomic DNA No translation available. BC033196 mRNA Translation: AAH33196.1 BC073821 mRNA Translation: AAH73821.1 |
CCDSi | CCDS41588.1 [Q8N4Y2-3] CCDS65995.1 [Q8N4Y2-1] |
RefSeqi | NP_001273535.1, NM_001286606.1 [Q8N4Y2-1] NP_775855.3, NM_173584.4 [Q8N4Y2-3] XP_016873088.1, XM_017017599.1 [Q8N4Y2-3] |
Genome annotation databases
Ensembli | ENST00000450448; ENSP00000409256; ENSG00000177685 [Q8N4Y2-3] ENST00000525077; ENSP00000435299; ENSG00000177685 [Q8N4Y2-1] ENST00000528542; ENSP00000432334; ENSG00000177685 [Q8N4Y2-3] |
GeneIDi | 283229 |
KEGGi | hsa:283229 |
UCSCi | uc001lrv.3, human [Q8N4Y2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU952799 mRNA Translation: ADD96763.1 AK075180 mRNA Translation: BAC11455.1 AP006621 Genomic DNA No translation available. BC033196 mRNA Translation: AAH33196.1 BC073821 mRNA Translation: AAH73821.1 |
CCDSi | CCDS41588.1 [Q8N4Y2-3] CCDS65995.1 [Q8N4Y2-1] |
RefSeqi | NP_001273535.1, NM_001286606.1 [Q8N4Y2-1] NP_775855.3, NM_173584.4 [Q8N4Y2-3] XP_016873088.1, XM_017017599.1 [Q8N4Y2-3] |
3D structure databases
SMRi | Q8N4Y2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129503, 20 interactors |
IntActi | Q8N4Y2, 14 interactors |
STRINGi | 9606.ENSP00000435299 |
PTM databases
iPTMneti | Q8N4Y2 |
PhosphoSitePlusi | Q8N4Y2 |
Genetic variation databases
BioMutai | CRACR2B |
DMDMi | 300669695 |
Proteomic databases
jPOSTi | Q8N4Y2 |
MassIVEi | Q8N4Y2 |
MaxQBi | Q8N4Y2 |
PaxDbi | Q8N4Y2 |
PeptideAtlasi | Q8N4Y2 |
PRIDEi | Q8N4Y2 |
ProteomicsDBi | 71990 [Q8N4Y2-1] 71991 [Q8N4Y2-2] 71992 [Q8N4Y2-3] |
Protocols and materials databases
Antibodypediai | 42026, 54 antibodies |
DNASUi | 283229 |
Genome annotation databases
Ensembli | ENST00000450448; ENSP00000409256; ENSG00000177685 [Q8N4Y2-3] ENST00000525077; ENSP00000435299; ENSG00000177685 [Q8N4Y2-1] ENST00000528542; ENSP00000432334; ENSG00000177685 [Q8N4Y2-3] |
GeneIDi | 283229 |
KEGGi | hsa:283229 |
UCSCi | uc001lrv.3, human [Q8N4Y2-1] |
Organism-specific databases
CTDi | 283229 |
DisGeNETi | 283229 |
GeneCardsi | CRACR2B |
HGNCi | HGNC:28703, CRACR2B |
HPAi | ENSG00000177685, Group enriched (pancreas, salivary gland) |
MIMi | 614177, gene |
neXtProti | NX_Q8N4Y2 |
OpenTargetsi | ENSG00000177685 |
PharmGKBi | PA144596437 |
VEuPathDBi | HostDB:ENSG00000177685.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRXK, Eukaryota |
GeneTreei | ENSGT00440000033504 |
HOGENOMi | CLU_047014_0_0_1 |
InParanoidi | Q8N4Y2 |
OMAi | IRFTQIL |
OrthoDBi | 679137at2759 |
PhylomeDBi | Q8N4Y2 |
TreeFami | TF329556 |
Enzyme and pathway databases
PathwayCommonsi | Q8N4Y2 |
Miscellaneous databases
BioGRID-ORCSi | 283229, 9 hits in 992 CRISPR screens |
ChiTaRSi | CRACR2B, human |
GenomeRNAii | 283229 |
Pharosi | Q8N4Y2, Tbio |
PROi | PR:Q8N4Y2 |
RNActi | Q8N4Y2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177685, Expressed in saliva-secreting gland and 149 other tissues |
ExpressionAtlasi | Q8N4Y2, baseline and differential |
Genevisiblei | Q8N4Y2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EFC4A_HUMAN | |
Accessioni | Q8N4Y2Primary (citable) accession number: Q8N4Y2 Secondary accession number(s): D5LPR2, Q8NBW8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | July 13, 2010 | |
Last modified: | April 7, 2021 | |
This is version 147 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families