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Entry version 157 (16 Oct 2019)
Sequence version 2 (22 Jul 2008)
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Protein

Zinc finger protein 808

Gene

ZNF808

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri231 – 253C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 589C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri595 – 617C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri623 – 645C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri651 – 673C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri735 – 757C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri763 – 785C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri791 – 813C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri819 – 841C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri847 – 869C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri875 – 897C2H2-type 24PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 808
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF808
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33230 ZNF808

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N4W9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162410633

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N4W9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF808

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212288109

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003049911 – 903Zinc finger protein 808Add BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N4W9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N4W9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N4W9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N4W9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N4W9

PeptideAtlas

More...
PeptideAtlasi
Q8N4W9

PRoteomics IDEntifications database

More...
PRIDEi
Q8N4W9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71984 [Q8N4W9-1]
71985 [Q8N4W9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N4W9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N4W9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198482 Expressed in 193 organ(s), highest expression level in cerebellar hemisphere

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N4W9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N4W9 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
132741, 4 interactors

Protein interaction database and analysis system

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IntActi
Q8N4W9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352846

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N4W9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 98KRABPROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri231 – 253C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 365C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri399 – 421C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri427 – 449C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri455 – 477C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri483 – 505C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri511 – 533C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri539 – 561C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri567 – 589C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri595 – 617C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri623 – 645C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri651 – 673C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri735 – 757C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri763 – 785C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri791 – 813C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri819 – 841C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri847 – 869C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri875 – 897C2H2-type 24PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182851

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N4W9

Identification of Orthologs from Complete Genome Data

More...
OMAi
YSITNEA

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N4W9

TreeFam database of animal gene trees

More...
TreeFami
TF343410

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 23 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 14 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 23 hits
PS50157 ZINC_FINGER_C2H2_2, 24 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N4W9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLREEAAQKR KGKESGMALP QGRLTFRDVA IEFSLAEWKF LNPAQRALYR
60 70 80 90 100
EVMLENYRNL EAVDISSKHM MKEVLSTGQG NREVIHTGTL QRHQSYHIGD
110 120 130 140 150
FCFQEIEKEI HNIEFQCQED ERNGHEAPTT KIKKLTGSTD QHDHRHAGNK
160 170 180 190 200
PIKDQLGSSF YSHLPELHIF QIKGEIANQL EKSTSDASSV STSQRISCRP
210 220 230 240 250
QIHISNNYGN NPLNSSLLPQ KQEVHMREKS FPCNESGKAF NCSSLLRKHQ
260 270 280 290 300
IPHLGDKQYK CDVCGKLFNH KQYLACHRRC HTGEKPYKCK ECGKSFSYKS
310 320 330 340 350
SLTCHHRLHT GVKPYKCNEC GKVFRQNSAL VIHKAIHTGE KPYKCNECGK
360 370 380 390 400
AFNQQSHLSR HQRLHTGVKP YKCKICEKAF ACHSYLANHT RIHSGEKTYK
410 420 430 440 450
CNECGKAFNH QSSLARHHIL HTGEKPYKCE ECDKVFSQKS TLERHKRIHT
460 470 480 490 500
GEKPYKCKVC DTAFTCNSQL ARHRRIHTGE KTYKCNECRK TFSRRSSLLC
510 520 530 540 550
HRRLHSGEKP YKCNQCGNTF RHRASLVYHR RLHTLEKSYK CTVCNKVFMR
560 570 580 590 600
NSVLAVHTRI HTAKKPYKCN ECGKAFNQQS HLSRHRRLHT GEKPYKCEAC
610 620 630 640 650
DKVFGQKSAL ESHKRIHTGE KPYRCQVCDT AFTWNSQLAR HTRIHTGEKT
660 670 680 690 700
YKCNECGKTF SYKSSLVWHR RLHGGEKSYK CKVCDKAFVC RSYVAKHTRI
710 720 730 740 750
HSGMKPYKCN ECSKTFSNRS SLVCHRRIHS GEKPYKCSEC SKTFSQKATL
760 770 780 790 800
LCHRRLHSGE KPYKCNDCGN TFRHWSSLVY HRRLHTGEKS YKCTVCDKAF
810 820 830 840 850
VRNSYLARHI RIHTAEKPYK CNECGKAFNE QSHLSRHHRI HTGEKPYKCE
860 870 880 890 900
ACDKVFSRKS HLKRHRIIHT GEKPYKCNEC GKAFSDRSTL IHHQAIHGIG

KFD
Length:903
Mass (Da):104,825
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA38357A1D5A5CBA
GO
Isoform 2 (identifier: Q8N4W9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Show »
Length:834
Mass (Da):96,803
Checksum:i5CD2918D6ED0A673
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IZE3C9IZE3_HUMAN
Zinc finger protein 808
ZNF808
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVX0C9JVX0_HUMAN
Zinc finger protein 808
ZNF808
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0J5C9J0J5_HUMAN
Zinc finger protein 808
ZNF808
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J871C9J871_HUMAN
Zinc finger protein 808
ZNF808
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH33230 differs from that shown. In 3'-UTR.Curated
The sequence AAI30352 differs from that shown. In 3'-UTR.Curated
The sequence AAI30354 differs from that shown. In 3'-UTR.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_045823134K → N. Corresponds to variant dbSNP:rs329964Ensembl.1
Natural variantiVAR_045824262D → N. Corresponds to variant dbSNP:rs329965Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0349461 – 69Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR749856 mRNA Translation: CAH18701.1
AC022150 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72084.1
BC033230 mRNA Translation: AAH33230.1 Sequence problems.
BC130351 mRNA Translation: AAI30352.1 Sequence problems.
BC130353 mRNA Translation: AAI30354.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46167.1 [Q8N4W9-1]
CCDS86799.1 [Q8N4W9-2]

NCBI Reference Sequences

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RefSeqi
NP_001034975.2, NM_001039886.3 [Q8N4W9-1]
NP_001308353.1, NM_001321424.1 [Q8N4W9-1]
NP_001308354.1, NM_001321425.1 [Q8N4W9-1]
XP_005258966.1, XM_005258909.3 [Q8N4W9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000359798; ENSP00000352846; ENSG00000198482 [Q8N4W9-1]
ENST00000487863; ENSP00000420522; ENSG00000198482 [Q8N4W9-2]
ENST00000652567; ENSP00000498920; ENSG00000198482 [Q8N4W9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
388558

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:388558

UCSC genome browser

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UCSCi
uc002pzq.3 human [Q8N4W9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749856 mRNA Translation: CAH18701.1
AC022150 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72084.1
BC033230 mRNA Translation: AAH33230.1 Sequence problems.
BC130351 mRNA Translation: AAI30352.1 Sequence problems.
BC130353 mRNA Translation: AAI30354.1 Sequence problems.
CCDSiCCDS46167.1 [Q8N4W9-1]
CCDS86799.1 [Q8N4W9-2]
RefSeqiNP_001034975.2, NM_001039886.3 [Q8N4W9-1]
NP_001308353.1, NM_001321424.1 [Q8N4W9-1]
NP_001308354.1, NM_001321425.1 [Q8N4W9-1]
XP_005258966.1, XM_005258909.3 [Q8N4W9-2]

3D structure databases

SMRiQ8N4W9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi132741, 4 interactors
IntActiQ8N4W9, 1 interactor
STRINGi9606.ENSP00000352846

PTM databases

iPTMnetiQ8N4W9
PhosphoSitePlusiQ8N4W9

Polymorphism and mutation databases

BioMutaiZNF808
DMDMi212288109

Proteomic databases

EPDiQ8N4W9
jPOSTiQ8N4W9
MassIVEiQ8N4W9
MaxQBiQ8N4W9
PaxDbiQ8N4W9
PeptideAtlasiQ8N4W9
PRIDEiQ8N4W9
ProteomicsDBi71984 [Q8N4W9-1]
71985 [Q8N4W9-2]

Genome annotation databases

EnsembliENST00000359798; ENSP00000352846; ENSG00000198482 [Q8N4W9-1]
ENST00000487863; ENSP00000420522; ENSG00000198482 [Q8N4W9-2]
ENST00000652567; ENSP00000498920; ENSG00000198482 [Q8N4W9-2]
GeneIDi388558
KEGGihsa:388558
UCSCiuc002pzq.3 human [Q8N4W9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
388558

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF808
HGNCiHGNC:33230 ZNF808
neXtProtiNX_Q8N4W9
PharmGKBiPA162410633

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00950000182851
HOGENOMiHOG000234617
InParanoidiQ8N4W9
OMAiYSITNEA
OrthoDBi1318335at2759
PhylomeDBiQ8N4W9
TreeFamiTF343410

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF808 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
388558
PharosiQ8N4W9

Protein Ontology

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PROi
PR:Q8N4W9

Gene expression databases

BgeeiENSG00000198482 Expressed in 193 organ(s), highest expression level in cerebellar hemisphere
ExpressionAtlasiQ8N4W9 baseline and differential
GenevisibleiQ8N4W9 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 23 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 14 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 23 hits
PS50157 ZINC_FINGER_C2H2_2, 24 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN808_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N4W9
Secondary accession number(s): Q68CN7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 22, 2008
Last modified: October 16, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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