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Protein

DnaJ homolog subfamily C member 22

Gene

DNAJC22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a co-chaperone.

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 22
Gene namesi
Name:DNAJC22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000178401.14
HGNCiHGNC:25802 DNAJC22
neXtProtiNX_Q8N4W6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178401
PharmGKBiPA162383905

Polymorphism and mutation databases

BioMutaiDNAJC22
DMDMi74728914

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258621 – 341DnaJ homolog subfamily C member 22Add BLAST341

Proteomic databases

PaxDbiQ8N4W6
PeptideAtlasiQ8N4W6
PRIDEiQ8N4W6
ProteomicsDBi71983

PTM databases

iPTMnetiQ8N4W6
PhosphoSitePlusiQ8N4W6

Expressioni

Gene expression databases

BgeeiENSG00000178401 Expressed in 197 organ(s), highest expression level in liver
CleanExiHS_DNAJC22
ExpressionAtlasiQ8N4W6 baseline and differential
GenevisibleiQ8N4W6 HS

Organism-specific databases

HPAiHPA039953

Interactioni

Protein-protein interaction databases

IntActiQ8N4W6, 1 interactor
STRINGi9606.ENSP00000378508

Structurei

3D structure databases

ProteinModelPortaliQ8N4W6
SMRiQ8N4W6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 341JPROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0714 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00390000012136
HOGENOMiHOG000007152
HOVERGENiHBG107813
InParanoidiQ8N4W6
KOiK19370
OMAiLASAWWT
OrthoDBiEOG091G0GZ6
PhylomeDBiQ8N4W6
TreeFamiTF324581

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR007829 TM2
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF05154 TM2, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N4W6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKGLLVTYA LWAVGGPAGL HHLYLGRDSH ALLWMLTLGG GGLGWLWEFW
60 70 80 90 100
KLPSFVAQAN RAQGQRQSPR GVTPPLSPIR FAAQVIVGIY FGLVALISLS
110 120 130 140 150
SMVNFYIVAL PLAVGLGVLL VAAVGNQTSD FKNTLGSAFL TSPIFYGRPI
160 170 180 190 200
AILPISVAAS ITAQRHRRYK ALVASEPLSV RLYRLGLAYL AFTGPLAYSA
210 220 230 240 250
LCNTAATLSY VAETFGSFLN WFSFFPLLGR LMEFVLLLPY RIWRLLMGET
260 270 280 290 300
GFNSSCFQEW AKLYEFVHSF QDEKRQLAYQ VLGLSEGATN EEIHRSYQEL
310 320 330 340
VKVWHPDHNL DQTEEAQRHF LEIQAAYEVL SQPRKPWGSR R
Length:341
Mass (Da):38,086
Last modified:October 1, 2002 - v1
Checksum:i0246AFCB12D09917
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055747 mRNA Translation: BAG51566.1
CH471111 Genomic DNA Translation: EAW58066.1
BC033236 mRNA Translation: AAH33236.1
CCDSiCCDS8785.1
RefSeqiNP_001291873.1, NM_001304944.1
NP_079178.2, NM_024902.3
UniGeneiHs.659300

Genome annotation databases

EnsembliENST00000395069; ENSP00000378508; ENSG00000178401
ENST00000549441; ENSP00000446830; ENSG00000178401
GeneIDi79962
KEGGihsa:79962
UCSCiuc001rua.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055747 mRNA Translation: BAG51566.1
CH471111 Genomic DNA Translation: EAW58066.1
BC033236 mRNA Translation: AAH33236.1
CCDSiCCDS8785.1
RefSeqiNP_001291873.1, NM_001304944.1
NP_079178.2, NM_024902.3
UniGeneiHs.659300

3D structure databases

ProteinModelPortaliQ8N4W6
SMRiQ8N4W6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N4W6, 1 interactor
STRINGi9606.ENSP00000378508

PTM databases

iPTMnetiQ8N4W6
PhosphoSitePlusiQ8N4W6

Polymorphism and mutation databases

BioMutaiDNAJC22
DMDMi74728914

Proteomic databases

PaxDbiQ8N4W6
PeptideAtlasiQ8N4W6
PRIDEiQ8N4W6
ProteomicsDBi71983

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395069; ENSP00000378508; ENSG00000178401
ENST00000549441; ENSP00000446830; ENSG00000178401
GeneIDi79962
KEGGihsa:79962
UCSCiuc001rua.4 human

Organism-specific databases

CTDi79962
EuPathDBiHostDB:ENSG00000178401.14
GeneCardsiDNAJC22
HGNCiHGNC:25802 DNAJC22
HPAiHPA039953
neXtProtiNX_Q8N4W6
OpenTargetsiENSG00000178401
PharmGKBiPA162383905
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0714 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00390000012136
HOGENOMiHOG000007152
HOVERGENiHBG107813
InParanoidiQ8N4W6
KOiK19370
OMAiLASAWWT
OrthoDBiEOG091G0GZ6
PhylomeDBiQ8N4W6
TreeFamiTF324581

Miscellaneous databases

ChiTaRSiDNAJC22 human
GenomeRNAii79962
PROiPR:Q8N4W6

Gene expression databases

BgeeiENSG00000178401 Expressed in 197 organ(s), highest expression level in liver
CleanExiHS_DNAJC22
ExpressionAtlasiQ8N4W6 baseline and differential
GenevisibleiQ8N4W6 HS

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR036869 J_dom_sf
IPR007829 TM2
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF05154 TM2, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDJC22_HUMAN
AccessioniPrimary (citable) accession number: Q8N4W6
Secondary accession number(s): B3KP54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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