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UniProtKB - Q8N4V2 (SVOP_HUMAN)
Protein
Synaptic vesicle 2-related protein
Gene
SVOP
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8N4V2 |
SignaLinki | Q8N4V2 |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptic vesicle 2-related proteinShort name: SV2-related protein |
Gene namesi | Name:SVOP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25417, SVOP |
MIMi | 611699, gene |
neXtProti | NX_Q8N4V2 |
VEuPathDBi | HostDB:ENSG00000166111 |
Subcellular locationi
Other locations
- synaptic vesicle membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- integral component of membrane Source: UniProtKB-KW
- synaptic vesicle Source: HGNC-UCL
- synaptic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 87 | CytoplasmicSequence analysisAdd BLAST | 87 | |
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 109 – 122 | VesicularSequence analysisAdd BLAST | 14 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 144 – 156 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 157 – 177 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 180 | VesicularSequence analysis | 3 | |
Transmembranei | 181 – 201 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 202 – 209 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 210 – 230 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 231 – 238 | VesicularSequence analysis | 8 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 260 – 316 | CytoplasmicSequence analysisAdd BLAST | 57 | |
Transmembranei | 317 – 337 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 338 – 373 | VesicularSequence analysisAdd BLAST | 36 | |
Transmembranei | 374 – 394 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 395 – 401 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 402 – 422 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 423 – 424 | VesicularSequence analysis | 2 | |
Transmembranei | 425 – 445 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 446 – 457 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 458 – 478 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 479 – 489 | VesicularSequence analysisAdd BLAST | 11 | |
Transmembranei | 490 – 510 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 511 – 548 | CytoplasmicSequence analysisAdd BLAST | 38 |
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, Membrane, SynapsePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000166111 |
PharmGKBi | PA142670848 |
Miscellaneous databases
Pharosi | Q8N4V2, Tbio |
Genetic variation databases
BioMutai | SVOP |
DMDMi | 74751007 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279452 | 1 – 548 | Synaptic vesicle 2-related proteinAdd BLAST | 548 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineBy similarity | 1 | |
Modified residuei | 31 | PhosphoserineBy similarity | 1 | |
Modified residuei | 542 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q8N4V2 |
PaxDbi | Q8N4V2 |
PeptideAtlasi | Q8N4V2 |
PRIDEi | Q8N4V2 |
ProteomicsDBi | 71980 |
PTM databases
iPTMneti | Q8N4V2 |
PhosphoSitePlusi | Q8N4V2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166111, Expressed in endothelial cell and 112 other tissues |
ExpressionAtlasi | Q8N4V2, baseline and differential |
Genevisiblei | Q8N4V2, HS |
Organism-specific databases
HPAi | ENSG00000166111, Group enriched (brain, pituitary gland, retina) |
Interactioni
Binary interactionsi
Q8N4V2
With | #Exp. | IntAct |
---|---|---|
FXYD6 [Q9H0Q3] | 4 | EBI-12883142,EBI-713304 |
Protein-protein interaction databases
BioGRIDi | 120701, 9 interactors |
IntActi | Q8N4V2, 5 interactors |
MINTi | Q8N4V2 |
STRINGi | 9606.ENSP00000479104 |
Miscellaneous databases
RNActi | Q8N4V2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0253, Eukaryota KOG0255, Eukaryota |
GeneTreei | ENSGT00940000155403 |
HOGENOMi | CLU_001265_46_0_1 |
InParanoidi | Q8N4V2 |
OMAi | EIFPTKD |
OrthoDBi | 1430447at2759 |
PhylomeDBi | Q8N4V2 |
TreeFami | TF313465 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004749, Orgcat_transp/SVOP |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00898, 2A0119, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8N4V2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEDLFQLRQ LPVVKFRRTG ESARSEDDTA SGEHEVQIEG VHVGLEAVEL
60 70 80 90 100
DDGAAVPKEF ANPTDDTFMV EDAVEAIGFG KFQWKLSVLT GLAWMADAME
110 120 130 140 150
MMILSILAPQ LHCEWRLPSW QVALLTSVVF VGMMSSSTLW GNISDQYGRK
160 170 180 190 200
TGLKISVLWT LYYGILSAFA PVYSWILVLR GLVGFGIGGV PQSVTLYAEF
210 220 230 240 250
LPMKARAKCI LLIEVFWAIG TVFEVVLAVF VMPSLGWRWL LILSAVPLLL
260 270 280 290 300
FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
310 320 330 340 350
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCGI
360 370 380 390 400
SSRKKAVEAK CSLACEYLSE EDYMDLLWTT LSEFPGVLVT LWIIDRLGRK
410 420 430 440 450
KTMALCFVIF SFCSLLLFIC VGRNVLTLLL FIARAFISGG FQAAYVYTPE
460 470 480 490 500
VYPTATRALG LGTCSGMARV GALITPFIAQ VMLESSVYLT LAVYSGCCLL
510 520 530 540
AALASCFLPI ETKGRGLQES SHREWGQEMV GRGMHGAGVT RSNSGSQE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YHK4 | H0YHK4_HUMAN | Synaptic vesicle 2-related protein | SVOP | 155 | Annotation score: | ||
H0YHQ5 | H0YHQ5_HUMAN | Synaptic vesicle 2-related protein | SVOP | 104 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC033587 mRNA Translation: AAH33587.1 BC094722 mRNA Translation: AAH94722.1 AL359592 mRNA Translation: CAB94878.3 |
CCDSi | CCDS73520.1 |
PIRi | T50622 |
RefSeqi | NP_061181.1, NM_018711.4 |
Genome annotation databases
Ensembli | ENST00000610966.5; ENSP00000479104.1; ENSG00000166111.10 |
GeneIDi | 55530 |
KEGGi | hsa:55530 |
MANE-Selecti | ENST00000610966.5; ENSP00000479104.1; NM_018711.5; NP_061181.1 |
UCSCi | uc031zmo.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC033587 mRNA Translation: AAH33587.1 BC094722 mRNA Translation: AAH94722.1 AL359592 mRNA Translation: CAB94878.3 |
CCDSi | CCDS73520.1 |
PIRi | T50622 |
RefSeqi | NP_061181.1, NM_018711.4 |
3D structure databases
AlphaFoldDBi | Q8N4V2 |
SMRi | Q8N4V2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120701, 9 interactors |
IntActi | Q8N4V2, 5 interactors |
MINTi | Q8N4V2 |
STRINGi | 9606.ENSP00000479104 |
PTM databases
iPTMneti | Q8N4V2 |
PhosphoSitePlusi | Q8N4V2 |
Genetic variation databases
BioMutai | SVOP |
DMDMi | 74751007 |
Proteomic databases
MassIVEi | Q8N4V2 |
PaxDbi | Q8N4V2 |
PeptideAtlasi | Q8N4V2 |
PRIDEi | Q8N4V2 |
ProteomicsDBi | 71980 |
Protocols and materials databases
Antibodypediai | 9307, 125 antibodies from 25 providers |
DNASUi | 55530 |
Genome annotation databases
Ensembli | ENST00000610966.5; ENSP00000479104.1; ENSG00000166111.10 |
GeneIDi | 55530 |
KEGGi | hsa:55530 |
MANE-Selecti | ENST00000610966.5; ENSP00000479104.1; NM_018711.5; NP_061181.1 |
UCSCi | uc031zmo.2, human |
Organism-specific databases
CTDi | 55530 |
GeneCardsi | SVOP |
HGNCi | HGNC:25417, SVOP |
HPAi | ENSG00000166111, Group enriched (brain, pituitary gland, retina) |
MIMi | 611699, gene |
neXtProti | NX_Q8N4V2 |
OpenTargetsi | ENSG00000166111 |
PharmGKBi | PA142670848 |
VEuPathDBi | HostDB:ENSG00000166111 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0253, Eukaryota KOG0255, Eukaryota |
GeneTreei | ENSGT00940000155403 |
HOGENOMi | CLU_001265_46_0_1 |
InParanoidi | Q8N4V2 |
OMAi | EIFPTKD |
OrthoDBi | 1430447at2759 |
PhylomeDBi | Q8N4V2 |
TreeFami | TF313465 |
Enzyme and pathway databases
PathwayCommonsi | Q8N4V2 |
SignaLinki | Q8N4V2 |
Miscellaneous databases
BioGRID-ORCSi | 55530, 7 hits in 244 CRISPR screens |
ChiTaRSi | SVOP, human |
GenomeRNAii | 55530 |
Pharosi | Q8N4V2, Tbio |
PROi | PR:Q8N4V2 |
RNActi | Q8N4V2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166111, Expressed in endothelial cell and 112 other tissues |
ExpressionAtlasi | Q8N4V2, baseline and differential |
Genevisiblei | Q8N4V2, HS |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR004749, Orgcat_transp/SVOP |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00898, 2A0119, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SVOP_HUMAN | |
Accessioni | Q8N4V2Primary (citable) accession number: Q8N4V2 Secondary accession number(s): Q9NPW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families