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Protein

T-complex protein 11-like protein 2

Gene

TCP11L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 11-like protein 2
Gene namesi
Name:TCP11L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166046.10
HGNCiHGNC:28627 TCP11L2
neXtProtiNX_Q8N4U5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166046
PharmGKBiPA142670825

Polymorphism and mutation databases

BioMutaiTCP11L2
DMDMi74728903

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003137501 – 519T-complex protein 11-like protein 2Add BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N4U5
MaxQBiQ8N4U5
PaxDbiQ8N4U5
PeptideAtlasiQ8N4U5
PRIDEiQ8N4U5
ProteomicsDBi71977

PTM databases

iPTMnetiQ8N4U5
PhosphoSitePlusiQ8N4U5

Expressioni

Gene expression databases

BgeeiENSG00000166046 Expressed in 183 organ(s), highest expression level in corpus callosum
CleanExiHS_TCP11L2
ExpressionAtlasiQ8N4U5 baseline and differential
GenevisibleiQ8N4U5 HS

Organism-specific databases

HPAiHPA039483
HPA042188

Interactioni

Protein-protein interaction databases

BioGridi129100, 12 interactors
IntActiQ8N4U5, 5 interactors
STRINGi9606.ENSP00000299045

Structurei

3D structure databases

ProteinModelPortaliQ8N4U5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 55Ser-richAdd BLAST40

Sequence similaritiesi

Belongs to the TCP11 family.Curated

Phylogenomic databases

eggNOGiKOG1981 Eukaryota
ENOG410ZDEH LUCA
GeneTreeiENSGT00390000008958
HOGENOMiHOG000231350
HOVERGENiHBG008348
InParanoidiQ8N4U5
OMAiEVSSMFK
OrthoDBiEOG091G07AC
PhylomeDBiQ8N4U5
TreeFamiTF313385

Family and domain databases

InterProiView protein in InterPro
IPR008862 Tcp11
PANTHERiPTHR12832 PTHR12832, 1 hit
PfamiView protein in Pfam
PF05794 Tcp11, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q8N4U5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPFNGEKQCV GEDQPSDSDS SRFSESMASL SDYECSRQSF ASDSSSKSSS
60 70 80 90 100
PASTSPPRVV TFDEVMATAR NLSNLTLAHE IAVNENFQLK QEALPEKSLA
110 120 130 140 150
GRVKHIVHQA FWDVLDSELN ADPPEFEHAI KLFEEIREIL LSFLTPGGNR
160 170 180 190 200
LRNQICEVLD TDLIRQQAEH SAVDIQGLAN YVISTMGKLC APVRDNDIRE
210 220 230 240 250
LKATGNIVEV LRQIFHVLDL MQMDMANFTI MSLRPHLQRQ LVEYERTKFQ
260 270 280 290 300
EILEETPSAL DQTTEWIKES VNEELFSLSE SALTPGAENT SKPSLSPTLV
310 320 330 340 350
LNNSYLKLLQ WDYQKKELPE TLMTDGARLQ ELTEKLNQLK IIACLSLITN
360 370 380 390 400
NMVGAITGGL PELASRLTRI SAVLLEGMNK ETFNLKEVLN SIGIQTCVEV
410 420 430 440 450
NKTLMERGLP TLNAEIQANL IGQFSSIEEE DNPIWSLIDK RIKLYMRRLL
460 470 480 490 500
CLPSPQKCMP PMPGGLAVIQ QELEALGSQY ANIVNLNKQV YGPFYANILR
510
KLLFNEEAMG KVDASPPTN
Length:519
Mass (Da):58,091
Last modified:October 1, 2002 - v1
Checksum:iDB21CEDFECA17900
GO
Isoform 2 (identifier: Q8N4U5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-266: SALDQTTEW → RKAEVAGAS
     267-519: Missing.

Note: Gene prediction based on EST data.
Show »
Length:266
Mass (Da):29,870
Checksum:i733885D7A8C4339F
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W1M6F8W1M6_HUMAN
T-complex protein 11-like protein 2
TCP11L2
97Annotation score:
G3V1Z2G3V1Z2_HUMAN
T-complex 11 (Mouse) like 2, isofor...
TCP11L2 hCG_1813015
272Annotation score:
F8VRQ3F8VRQ3_HUMAN
T-complex protein 11-like protein 2
TCP11L2
234Annotation score:
F8W0R5F8W0R5_HUMAN
T-complex protein 11-like protein 2
TCP11L2
131Annotation score:
F8VU20F8VU20_HUMAN
T-complex protein 11-like protein 2
TCP11L2
60Annotation score:
F8VW27F8VW27_HUMAN
T-complex protein 11-like protein 2
TCP11L2
17Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137R → G in BAG36762 (PubMed:14702039).Curated1
Sequence conflicti158V → A in BAG36762 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03772841A → T1 PublicationCorresponds to variant dbSNP:rs4964460Ensembl.1
Natural variantiVAR_03772982A → S. Corresponds to variant dbSNP:rs11837375Ensembl.1
Natural variantiVAR_037730261D → N. Corresponds to variant dbSNP:rs17218950Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055736258 – 266SALDQTTEW → RKAEVAGAS in isoform 2. Curated9
Alternative sequenceiVSP_055737267 – 519Missing in isoform 2. CuratedAdd BLAST253

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314055 mRNA Translation: BAG36762.1
AC079174 Genomic DNA No translation available.
AC080012 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97774.1
CH471054 Genomic DNA Translation: EAW97775.1
BC033617 mRNA Translation: AAH33617.1
CCDSiCCDS66456.1 [Q8N4U5-2]
CCDS9104.1 [Q8N4U5-1]
RefSeqiNP_001273191.1, NM_001286262.1 [Q8N4U5-2]
NP_689985.1, NM_152772.2 [Q8N4U5-1]
XP_005268824.1, XM_005268767.4 [Q8N4U5-1]
XP_005268825.1, XM_005268768.4 [Q8N4U5-1]
XP_011536431.1, XM_011538129.2 [Q8N4U5-1]
XP_011536432.1, XM_011538130.2 [Q8N4U5-1]
XP_016874616.1, XM_017019127.1 [Q8N4U5-1]
XP_016874617.1, XM_017019128.1 [Q8N4U5-1]
XP_016874618.1, XM_017019129.1 [Q8N4U5-1]
XP_016874619.1, XM_017019130.1 [Q8N4U5-1]
XP_016874620.1, XM_017019131.1 [Q8N4U5-1]
UniGeneiHs.696047
Hs.736922

Genome annotation databases

EnsembliENST00000299045; ENSP00000299045; ENSG00000166046 [Q8N4U5-1]
ENST00000547153; ENSP00000448952; ENSG00000166046 [Q8N4U5-2]
GeneIDi255394
KEGGihsa:255394
UCSCiuc001tlm.5 human [Q8N4U5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiT11L2_HUMAN
AccessioniPrimary (citable) accession number: Q8N4U5
Secondary accession number(s): B2RA65, G3V1Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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