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Entry version 144 (07 Apr 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Rho guanine nucleotide exchange factor 39

Gene

ARHGEF39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes cell proliferation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • positive regulation of cell migration Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8N4T4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193648, NRAGE signals death through JNK
R-HSA-194840, Rho GTPase cycle
R-HSA-416482, G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 39
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF39
Synonyms:C9orf100
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25909, ARHGEF39

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N4T4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000137135.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84904

Open Targets

More...
OpenTargetsi
ENSG00000137135

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134939297

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N4T4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGEF39

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74759886

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002918641 – 335Rho guanine nucleotide exchange factor 39Add BLAST335

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N4T4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N4T4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N4T4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N4T4

PeptideAtlas

More...
PeptideAtlasi
Q8N4T4

PRoteomics IDEntifications database

More...
PRIDEi
Q8N4T4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71971 [Q8N4T4-1]
71972 [Q8N4T4-2]
71973 [Q8N4T4-3]
71974 [Q8N4T4-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N4T4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N4T4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in hepatocellular carcinoma (HCC) compared with their non-cancerous counterparts.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137135, Expressed in tibial artery and 118 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N4T4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137135, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124343, 48 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N4T4, 22 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367638

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8N4T4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N4T4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 197DHPROSITE-ProRule annotationAdd BLAST176
Domaini227 – 331PHPROSITE-ProRule annotationAdd BLAST105

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTR5, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000033863

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1453899_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N4T4

Identification of Orthologs from Complete Genome Data

More...
OMAi
DQEELSH

Database of Orthologous Groups

More...
OrthoDBi
711970at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N4T4

TreeFam database of animal gene trees

More...
TreeFami
TF350447

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042987, ARHGEF39
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR47056, PTHR47056, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N4T4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELSCPGSRC PVQEQRARWE RKRACTAREL LETERRYQEQ LGLVATYFLG
60 70 80 90 100
ILKAKGTLRP PERQALFGSW ELIYGASQEL LPYLEGGCWG QGLEGFCRHL
110 120 130 140 150
ELYNQFAANS ERSQTTLQEQ LKKNKGFRRF VRLQEGRPEF GGLQLQDLLP
160 170 180 190 200
LPLQRLQQYE NLVVALAENT GPNSPDHQQL TRAARLISET AQRVHTIGQK
210 220 230 240 250
QKNDQHLRRV QALLSGRQAK GLTSGRWFLR QGWLLVVPPH GEPRPRMFFL
260 270 280 290 300
FTDVLLMAKP RPPLHLLRSG TFACKALYPM AQCHLSRVFG HSGGPCGGLL
310 320 330
SLSFPHEKLL LMSTDQEELS RWYHSLTWAI SSQKN
Length:335
Mass (Da):38,295
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D8C8D8068AE651E
GO
Isoform 2 (identifier: Q8N4T4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     37-46: YQEQLGLVAT → MLGVCQTLKQ

Show »
Length:299
Mass (Da):33,979
Checksum:iC83C7BCF16A63A4C
GO
Isoform 3 (identifier: Q8N4T4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-186: RAARL → PVLPS
     187-335: Missing.

Show »
Length:186
Mass (Da):21,315
Checksum:iB07479B0BA7B8EC8
GO
Isoform 4 (identifier: Q8N4T4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-305: SLSFP → TVLPS
     306-335: Missing.

Show »
Length:305
Mass (Da):34,647
Checksum:iE7D9184ADAB03485
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAR01010 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAR01011 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti139E → G in BAB55192 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0618015C → F. Corresponds to variant dbSNP:rs45567235Ensembl.1
Natural variantiVAR_032876306H → R. Corresponds to variant dbSNP:rs2297879Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0262811 – 36Missing in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_02628237 – 46YQEQLGLVAT → MLGVCQTLKQ in isoform 2. 1 Publication10
Alternative sequenceiVSP_026283182 – 186RAARL → PVLPS in isoform 3. 1 Publication5
Alternative sequenceiVSP_026284187 – 335Missing in isoform 3. 1 PublicationAdd BLAST149
Alternative sequenceiVSP_026285301 – 305SLSFP → TVLPS in isoform 4. 1 Publication5
Alternative sequenceiVSP_026286306 – 335Missing in isoform 4. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY390225 mRNA Translation: AAR01010.1 Different initiation.
AY390226 mRNA Translation: AAR01011.1 Different initiation.
AL357874 Genomic DNA No translation available.
BC033666 mRNA Translation: AAH33666.1
BC038673 mRNA No translation available.
AK027548 mRNA Translation: BAB55192.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6584.2 [Q8N4T4-1]

NCBI Reference Sequences

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RefSeqi
NP_116207.2, NM_032818.2 [Q8N4T4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378387; ENSP00000367638; ENSG00000137135 [Q8N4T4-1]
ENST00000475323; ENSP00000436519; ENSG00000137135 [Q8N4T4-3]
ENST00000490638; ENSP00000436756; ENSG00000137135 [Q8N4T4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84904

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84904

UCSC genome browser

More...
UCSCi
uc003zxl.4, human [Q8N4T4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY390225 mRNA Translation: AAR01010.1 Different initiation.
AY390226 mRNA Translation: AAR01011.1 Different initiation.
AL357874 Genomic DNA No translation available.
BC033666 mRNA Translation: AAH33666.1
BC038673 mRNA No translation available.
AK027548 mRNA Translation: BAB55192.1
CCDSiCCDS6584.2 [Q8N4T4-1]
RefSeqiNP_116207.2, NM_032818.2 [Q8N4T4-1]

3D structure databases

SMRiQ8N4T4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124343, 48 interactors
IntActiQ8N4T4, 22 interactors
STRINGi9606.ENSP00000367638

PTM databases

iPTMnetiQ8N4T4
PhosphoSitePlusiQ8N4T4

Genetic variation databases

BioMutaiARHGEF39
DMDMi74759886

Proteomic databases

jPOSTiQ8N4T4
MassIVEiQ8N4T4
MaxQBiQ8N4T4
PaxDbiQ8N4T4
PeptideAtlasiQ8N4T4
PRIDEiQ8N4T4
ProteomicsDBi71971 [Q8N4T4-1]
71972 [Q8N4T4-2]
71973 [Q8N4T4-3]
71974 [Q8N4T4-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25913, 83 antibodies

Genome annotation databases

EnsembliENST00000378387; ENSP00000367638; ENSG00000137135 [Q8N4T4-1]
ENST00000475323; ENSP00000436519; ENSG00000137135 [Q8N4T4-3]
ENST00000490638; ENSP00000436756; ENSG00000137135 [Q8N4T4-2]
GeneIDi84904
KEGGihsa:84904
UCSCiuc003zxl.4, human [Q8N4T4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84904
DisGeNETi84904

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGEF39
HGNCiHGNC:25909, ARHGEF39
HPAiENSG00000137135, Tissue enhanced (lymphoid)
neXtProtiNX_Q8N4T4
OpenTargetsiENSG00000137135
PharmGKBiPA134939297
VEuPathDBiHostDB:ENSG00000137135.17

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QTR5, Eukaryota
GeneTreeiENSGT00440000033863
HOGENOMiCLU_1453899_0_0_1
InParanoidiQ8N4T4
OMAiDQEELSH
OrthoDBi711970at2759
PhylomeDBiQ8N4T4
TreeFamiTF350447

Enzyme and pathway databases

PathwayCommonsiQ8N4T4
ReactomeiR-HSA-193648, NRAGE signals death through JNK
R-HSA-194840, Rho GTPase cycle
R-HSA-416482, G alpha (12/13) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84904, 6 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGEF39, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84904
PharosiQ8N4T4, Tdark

Protein Ontology

More...
PROi
PR:Q8N4T4
RNActiQ8N4T4, protein

Gene expression databases

BgeeiENSG00000137135, Expressed in tibial artery and 118 other tissues
GenevisibleiQ8N4T4, HS

Family and domain databases

Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR042987, ARHGEF39
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR47056, PTHR47056, 1 hit
PfamiView protein in Pfam
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARG39_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N4T4
Secondary accession number(s): Q49AG0, Q6TPQ2, Q96ST6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: April 7, 2021
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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