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Entry version 164 (17 Jun 2020)
Sequence version 2 (24 Jan 2006)
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Protein

Carboxypeptidase A6

Gene

CPA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II (PubMed:18178555). Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine (PubMed:20855895).2 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=266 µM for 3-(2-furyl)acryloyl-Phe-Phe1 Publication
  2. KM=100 µM for 3-(2-furyl)acryloyl-Phe-Tyr1 Publication
  3. KM=386 µM for 3-(2-furyl)acryloyl-Phe-Leu1 Publication
  4. KM=339 µM for 3-(2-furyl)acryloyl-Phe-Trp1 Publication
  5. KM=786 µM for 3-(2-furyl)acryloyl-Phe-Met1 Publication

    pH dependencei

    Optimum pH is 8.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi196Zinc; catalyticBy similarity1
    Metal bindingi199Zinc; catalyticBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei254SubstrateBy similarity1
    Metal bindingi324Zinc; catalyticBy similarity1
    Binding sitei376SubstrateBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei398Proton donor/acceptorBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
    LigandMetal-binding, Zinc

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M14.018

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Carboxypeptidase A6 (EC:3.4.17.-)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CPA6
    Synonyms:CPAH
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000165078.11

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:17245 CPA6

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    609562 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8N4T0

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    A chromosomal aberration involving CPA6 was found in a patient with Duane retraction syndrome. Translocation t(6;8)(q26;q13).
    Epilepsy, familial temporal lobe, 5 (ETL5)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066946267G → R in ETL5; affects protein secretion presumably by altering protein folding or stability. 1 PublicationCorresponds to variant dbSNP:rs61738009EnsemblClinVar.1
    Febrile seizures, familial, 11 (FEB11)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionSeizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_066947270A → V in FEB11; affects protein secretion presumably by altering protein folding or stability. 1 PublicationCorresponds to variant dbSNP:rs114402678EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation, Epilepsy

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    57094

    MalaCards human disease database

    More...
    MalaCardsi
    CPA6
    MIMi614417 phenotype
    614418 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000165078

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    163717 Benign familial mesial temporal lobe epilepsy
    165805 Familial mesial temporal lobe epilepsy with febrile seizures

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA38444

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q8N4T0 Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    CPA6

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    85683250

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000436531 – 129Activation peptideBy similarityAdd BLAST99
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000004366130 – 437Carboxypeptidase A6Add BLAST308

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi265 ↔ 288By similarity
    Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8N4T0

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8N4T0

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q8N4T0

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8N4T0

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8N4T0

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8N4T0

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    71968 [Q8N4T0-1]
    71969 [Q8N4T0-2]
    71970 [Q8N4T0-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8N4T0

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8N4T0

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in the hippocampus, nucleus raphe, and cortex.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000165078 Expressed in buccal mucosa cell and 50 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8N4T0 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000165078 Tissue enhanced (intestine, prostate, retina)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    121362, 16 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8N4T0, 12 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000297770

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q8N4T0 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8N4T0

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni196 – 199Substrate bindingBy similarity4
    Regioni271 – 272Substrate bindingBy similarity2
    Regioni325 – 326Substrate bindingBy similarity2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M14 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2650 Eukaryota
    COG2866 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000159307

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_019326_0_3_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8N4T0

    KEGG Orthology (KO)

    More...
    KOi
    K08782

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HQHAREH

    Database of Orthologous Groups

    More...
    OrthoDBi
    524270at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8N4T0

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF317197

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.70.340, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036990 M14A-like_propep
    IPR003146 M14A_act_pep
    IPR000834 Peptidase_M14

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00246 Peptidase_M14, 1 hit
    PF02244 Propep_M14, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00765 CRBOXYPTASEA

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00631 Zn_pept, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00133 CARBOXYPEPT_ZN_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 1 (identifier: Q8N4T0-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKCLGKRRGQ AAAFLPLCWL FLKILQPGHS HLYNNRYAGD KVIRFIPKTE
    60 70 80 90 100
    EEAYALKKIS YQLKVDLWQP SSISYVSEGT VTDVHIPQNG SRALLAFLQE
    110 120 130 140 150
    ANIQYKVLIE DLQKTLEKGS SLHTQRNRRS LSGYNYEVYH SLEEIQNWMH
    160 170 180 190 200
    HLNKTHSGLI HMFSIGRSYE GRSLFILKLG RRSRLKRAVW IDCGIHAREW
    210 220 230 240 250
    IGPAFCQWFV KEALLTYKSD PAMRKMLNHL YFYIMPVFNV DGYHFSWTND
    260 270 280 290 300
    RFWRKTRSRN SRFRCRGVDA NRNWKVKWCD EGASMHPCDD TYCGPFPESE
    310 320 330 340 350
    PEVKAVANFL RKHRKHIRAY LSFHAYAQML LYPYSYKYAT IPNFRCVESA
    360 370 380 390 400
    AYKAVNALQS VYGVRYRYGP ASTTLYVSSG SSMDWAYKNG IPYAFAFELR
    410 420 430
    DTGYFGFLLP EMLIKPTCTE TMLAVKNITM HLLKKCP
    Length:437
    Mass (Da):51,008
    Last modified:January 24, 2006 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C21780D4B7D0A98
    GO
    Isoform 2 (identifier: Q8N4T0-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         280-437: DEGASMHPCD...ITMHLLKKCP → GKFGTNWDPD...SHGRLMFFCM

    Note: May be due to intron retention.Curated
    Show »
    Length:315
    Mass (Da):37,070
    Checksum:iECAA4B2F7F822684
    GO
    Isoform 3 (identifier: Q8N4T0-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         65-92: VDLWQPSSISYVSEGTVTDVHIPQNGSR → GPHRRSSENTGEGKQLAHPEKPKIPLWI
         93-437: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
    Show »
    Length:92
    Mass (Da):10,612
    Checksum:iAEBBD1313BB8F61C
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAK84941 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_02424145F → L. Corresponds to variant dbSNP:rs10957393EnsemblClinVar.1
    Natural variantiVAR_025003173S → C2 PublicationsCorresponds to variant dbSNP:rs17853192EnsemblClinVar.1
    Natural variantiVAR_048597249N → S. Corresponds to variant dbSNP:rs17343819EnsemblClinVar.1
    Natural variantiVAR_066946267G → R in ETL5; affects protein secretion presumably by altering protein folding or stability. 1 PublicationCorresponds to variant dbSNP:rs61738009EnsemblClinVar.1
    Natural variantiVAR_066947270A → V in FEB11; affects protein secretion presumably by altering protein folding or stability. 1 PublicationCorresponds to variant dbSNP:rs114402678EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05837565 – 92VDLWQ…QNGSR → GPHRRSSENTGEGKQLAHPE KPKIPLWI in isoform 3. 1 PublicationAdd BLAST28
    Alternative sequenceiVSP_05837693 – 437Missing in isoform 3. 1 PublicationAdd BLAST345
    Alternative sequenceiVSP_008808280 – 437DEGAS…LKKCP → GKFGTNWDPDPKVSAGFTLQ NMSPEDSHGRLMFFCM in isoform 2. 1 PublicationAdd BLAST158

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

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    EMBLi

    GenBank nucleotide sequence database

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    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

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    DDBJi
    Links Updated
    AF466284 Genomic DNA Translation: AAM19307.1
    BK000188 mRNA Translation: DAA00037.1
    AY044833 mRNA Translation: AAK84941.1 Sequence problems.
    AF221594 mRNA Translation: AAF91231.1
    BC033684 mRNA Translation: AAH33684.1

    The Consensus CDS (CCDS) project

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    CCDSi
    CCDS6200.1 [Q8N4T0-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_065094.3, NM_020361.4 [Q8N4T0-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000297770; ENSP00000297770; ENSG00000165078 [Q8N4T0-1]
    ENST00000479862; ENSP00000419016; ENSG00000165078 [Q8N4T0-3]
    ENST00000638254; ENSP00000491129; ENSG00000165078 [Q8N4T0-3]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    57094

    KEGG: Kyoto Encyclopedia of Genes and Genomes

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    KEGGi
    hsa:57094

    UCSC genome browser

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    UCSCi
    uc003xxq.5 human [Q8N4T0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF466284 Genomic DNA Translation: AAM19307.1
    BK000188 mRNA Translation: DAA00037.1
    AY044833 mRNA Translation: AAK84941.1 Sequence problems.
    AF221594 mRNA Translation: AAF91231.1
    BC033684 mRNA Translation: AAH33684.1
    CCDSiCCDS6200.1 [Q8N4T0-1]
    RefSeqiNP_065094.3, NM_020361.4 [Q8N4T0-1]

    3D structure databases

    SMRiQ8N4T0
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi121362, 16 interactors
    IntActiQ8N4T0, 12 interactors
    STRINGi9606.ENSP00000297770

    Protein family/group databases

    MEROPSiM14.018

    PTM databases

    iPTMnetiQ8N4T0
    PhosphoSitePlusiQ8N4T0

    Polymorphism and mutation databases

    BioMutaiCPA6
    DMDMi85683250

    Proteomic databases

    EPDiQ8N4T0
    jPOSTiQ8N4T0
    MassIVEiQ8N4T0
    PaxDbiQ8N4T0
    PeptideAtlasiQ8N4T0
    PRIDEiQ8N4T0
    ProteomicsDBi71968 [Q8N4T0-1]
    71969 [Q8N4T0-2]
    71970 [Q8N4T0-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    42507 164 antibodies

    Genome annotation databases

    EnsembliENST00000297770; ENSP00000297770; ENSG00000165078 [Q8N4T0-1]
    ENST00000479862; ENSP00000419016; ENSG00000165078 [Q8N4T0-3]
    ENST00000638254; ENSP00000491129; ENSG00000165078 [Q8N4T0-3]
    GeneIDi57094
    KEGGihsa:57094
    UCSCiuc003xxq.5 human [Q8N4T0-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    57094
    DisGeNETi57094
    EuPathDBiHostDB:ENSG00000165078.11

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    CPA6
    HGNCiHGNC:17245 CPA6
    HPAiENSG00000165078 Tissue enhanced (intestine, prostate, retina)
    MalaCardsiCPA6
    MIMi609562 gene
    614417 phenotype
    614418 phenotype
    neXtProtiNX_Q8N4T0
    OpenTargetsiENSG00000165078
    Orphaneti163717 Benign familial mesial temporal lobe epilepsy
    165805 Familial mesial temporal lobe epilepsy with febrile seizures
    PharmGKBiPA38444

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2650 Eukaryota
    COG2866 LUCA
    GeneTreeiENSGT00940000159307
    HOGENOMiCLU_019326_0_3_1
    InParanoidiQ8N4T0
    KOiK08782
    OMAiHQHAREH
    OrthoDBi524270at2759
    PhylomeDBiQ8N4T0
    TreeFamiTF317197

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    57094 5 hits in 785 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    CPA6 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Carboxypeptidase_A6

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    57094
    PharosiQ8N4T0 Tbio

    Protein Ontology

    More...
    PROi
    PR:Q8N4T0
    RNActiQ8N4T0 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000165078 Expressed in buccal mucosa cell and 50 other tissues
    GenevisibleiQ8N4T0 HS

    Family and domain databases

    Gene3Di3.30.70.340, 1 hit
    InterProiView protein in InterPro
    IPR036990 M14A-like_propep
    IPR003146 M14A_act_pep
    IPR000834 Peptidase_M14
    PfamiView protein in Pfam
    PF00246 Peptidase_M14, 1 hit
    PF02244 Propep_M14, 1 hit
    PRINTSiPR00765 CRBOXYPTASEA
    SMARTiView protein in SMART
    SM00631 Zn_pept, 1 hit
    PROSITEiView protein in PROSITE
    PS00133 CARBOXYPEPT_ZN_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBPA6_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N4T0
    Secondary accession number(s): Q8NEX8, Q8TDE8, Q9NRI9
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: January 24, 2006
    Last modified: June 17, 2020
    This is version 164 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    6. Peptidase families
      Classification of peptidase families and list of entries
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